Tired T cells: Hypoxia Drives T cell Exhaustion in the Tumor Microenvironment

Early T cell response is associated with mild COVID-19 and rapid SARS-CoV-2 clearance

Approved COVID-19 Vaccines: Delivery of Nucleic Acid Cargo and Immune Response

Success of combined IL-10 and IL-12 therapy in colon cancer depends on IFN-gamma and gut barrier integrity

You complete me: Natural killer cells need TGF-beta inhibition to effectively combat cancers

iNOS: The Nitric Oxide Boss

Nitric oxide (NO) is an inorganic, gaseous, and reactive free radical that acts as a biologic mediator in processes such as neurotransmission, vasorelaxation, and cytotoxicity. In addition, it has antimicrobial and anti-tumoral activities. NO production is mediated by members of the nitric oxide synthase (NOS) family. The NOS enzyme catalyzes the oxidization of L-arginine into L-citrulline and NO.  Several subtypes have been identified: two constitutive isoforms (type I brain/neuronal NOS, and type III endothelial) and one inducible isoform (iNOS, or type II).