Immune Cell Metabolic Flux Influences Type I Diabetes

SUCNR1/GPR91 - a potential role in renovascular hypertension

SUCNR1 is the cognate receptor for the Kreb's citric acid cycle intermediate succinate. It is of interest to scientists because it is involved in not only energy metabolism but possibly also in renovascular hypertension, a condition linked to diabetes, renal failure, and atherosclerosis.  This G-protein coupled receptor is most highly expressed in the kidney - predominantly in the proximal tubules. Two signaling pathways have been identified downstream from SUCNR1: a pertussis-toxin-sensitive Gi/Go pathway, as well as a pertussis-toxin-insensitive Gq pathway.