The NLRP3 Inflammasome: Macrophage Activator & Pathology Driver

Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release

NLRP3/NALP3 - Sensing and responding to pathogen infection

The inflammasome is a multi protein complex that is an important component of the innate immune response. The inflammasome is able to sense and respond to pathogen infections by recognizing pathogen-associated molecular patterns and mediating the secretion of inflammatory cytokines. Of the various types of inflammasomes, NLRP3/NALP3 is unique because of the diverse range of microbes it is able to detect (1).