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Autophagy Research Update: What a difference a year makes!

Autophagy Handbook provides an overview of molecular players and regulatory mechanisms involved in the process of autophagy.

By Christina Towers, PhD

Tags: 
Autophagy
Selective Autophagy
Cancer
NDP25
TBK1
ULK1
VPS34
Beclin1
Bcl2
p62/SQSTM1
WIPI2B
alpha Tubulin
PTEN
Ras
Raf
MEK
ERK
Christina Towers

Insulin signaling in brain’s subfornical organ is crucial for regulating cardiometabolic profile

Learn about cardiovascular biology resources from Bio-Techne

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Insulin
Insulin receptor
insulin-r-cd220
Cre
Cre recombinase
Metabolic syndrome
Jamshed Arslan

Gut-brain axis: microbiota influence behavior and mental well-being

Expression of Neurogranin in the rat brain hippocampus, a calmodulin-binding protein, and a neuron specific protein commonly found in postsynaptic terminals (dendritic spines).

By Jennifer Sokolowski, MD, PhD.

Tags: 
gut-brain axis
microbiome
caspase-3
CD11b
CD45
CD11c
aif-1-iba1
il-1-beta-il-1f2
corticosterone
IL-6
LPS
BDNF
neurogranin
Jennifer Sokolowski

Astrocytes: Diversity in type and function

In the CNS astrocytes have different functions including modulation of synaptic activity and synaptogenesis, communication with other astrocytes, oligodendrocytes and microglia, as well as modulation of the blood brain barrier.

By Michalina Hanzel, PhD

Tags: 
Astrocytes
Neurons
Neuroscience
GFAP
Michalina Hanzel

Muscle-specific UBE2O ablation requires activated AMPKα2 to protect against metabolic syndrome

Clearance of elevated glucose and fatty acids by skeletal muscle is affected by the development of insulin resistance.

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Lipid and Metabolism
Heart Disease
Diabetes
metabolism
Metabolic syndrome
ampk-alpha-2
ampk-beta
ampk-gamma
UBE2O
ampk-alpha-1
acetyl-coa-carboxylase-alpha-acaca
tbc1d1
Jamshed Arslan

Autophagy and Metastasis

EpCAM/TROP1 is localized by immunohistochemical analysis of human breast carcinoma tissue to the cell membrane and intercellular spaces.
 

By Christina Towers, PhD

Tags: 
Autophagy
Cancer
EMT
LC3
LC3-II
LC3B
p62/SQSTM1
Paxillin
Twist-1
epcam-trop1
Christina Towers

Metabolic Syndrome: Symptoms and associated disease states

The term, metabolism, refers to the totality of chemical reactions that occur in a biological system for the conversion of ingested nutrients into their basic constituents (i.e. proteins, lipids, nucleic acids and carbohydrates).
Tags: 
Lipid and Metabolism
Heart Disease
Diabetes
SREBP1
foxo1-fkhr
TNF-alpha
IL-6
adiponectin-acrp30
beta-3-adrenergic-r-adrb3
hormone-sensitive-lipase-hsl
glycogen-phosphorylase-muscle-form
Jamshed Arslan

Increased wild type FUS levels in ALS patients lead to a toxic microenvironment and motor neuron neurodegeneration

Dual expression of ALDH1L1-red and Vimentin-green identifies astrocytes which may be identified by their golden or red fluorescence. ALDH1L1 is expressed in the cell body and processes of astrocytes.

By Michalina Hanzel, PhD

Tags: 
Neuroscience
neurodegeneration
ALS
Amyotrophic Lateral Sclerosis
rela-nfkb-p65
il-1-beta-il-1f2
IL-6
TNF-alpha
COX-2
Michalina Hanzel

Detecting HIF alpha and beyond: Best controls for hypoxia Western blot analysis

Analysis of HIF-1 alpha expression in whole cell lysates from HeLa cells in culture treated or untreated with cobalt chloride and independent antibody validation where two different antibodies to HIF-1 alpha were used for immunoprecipitation and detection.

By Rosa Moreno, PhD.

Tags: 
Hypoxia
Cancer
Western blot
HIF-1-alpha
HIF-2-alpha-epas1
ARNT-HIF-1-beta
erythropoietin-epo
egln1-phd2
von-hippel-lindau
kat3b-p300
CREB
cobalt chloride
CoCl2
carbonic-anhydrase-ix-ca9
alpha-tubulin
igfbp-1
igf-ii-igf2
GLUT1
lactate-dehydrogenase-a-ldha
VEGF
lrp-1

Neurovascular signaling for repair enhances brain metastasis

High expression of GFAP (green) identifies astrocytes in rat cerebellum

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Cancer
Neuroscience
Metastasis
IHC
Immunohistochemistry
Flow cytometry
PTEN
VEGF
Angiopoietin
MMP
TGF-beta
GFP
Melanoma
Astrocytes
mTOR
EPH
Semaphorin
PPAR
rxr-alpha-nr2b1
Jamshed Arslan

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