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Successful Transplantation of Friedreich Ataxia Induced Pluripotent Stem Cell (iPSC)-Derived Sensory Neurons in Dorsal Root Ganglia of Adult Rodents

3D rendering of neuronal induced pluripotent stem cells as a banner image.

Jamshed Arslan, Pharm D, PhD

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Dorsal Root Ganglia
Friedreich ataxia
Neuroscience
neurodegeneration
Stem Cells
hPSC
human pluripotent stem cells
iPSCs
Induced Pluripotent Stem Cells
Cell Replacement Therapy
Neurons
Glia
beta-III Tubulin
Calbindin D/S100G
CGRP
EFCBP2
GFAP
GFP
mCherry
NF-H
Osteopontin/OPN
Parvalbumin
Peripherin
Peripherin 2/PRPH 2
Plexin C1
Ret
s100b
Somatostatin
TAFA1/FAM19A1
TrkA
TrkB
TrkC
Tyrosine Hydroxylase
VGluT3
Jamshed Arslan

Staufen1 Overabundance and the Consequent mTOR Hyperactivity in Amyotrophic Lateral Sclerosis, Spinocerebellar Ataxia Type 2, Alzheimer’s, Parkinson’s, and Huntington’s Diseases

3D rendering of neurons as a banner image.

Jamshed Arslan, Pharm D, PhD

Tags: 
Amyotrophic Lateral Sclerosis
ALS
Spinocerebellar Ataxia Type 2
Alzheimer’s
Parkinson’s
Huntington’s
neurodegeneration
Autophagy
Neurons
Staufen
TOR/mTOR
Jamshed Arslan

HIV-associated neurocognitive disorders involve extracellular Nef-induced modification of lipid rafts and redistribution of Alzheimer’s disease-related proteins

Immunohistochemical staining of paraffin-embedded ovarian cancer tissue sample with lipid-related protein Apolipoprotein E/ApoE.

Jamshed Arslan, Pharm D, PhD

Tags: 
Alzheimer’s
Cholesterol
HIV
Human Immunodeficiency Virus
HAND
Lipid Raft
neurodegeneration
Neurons
Parkinson’s
ABCA1
Acetylcholinesterase/ACHE
alpha Synuclein
APP
Beta Amyloid 42
Tau
Jamshed Arslan

Methamphetamine with HIV induces mitochondrial dysfunction and neuronal injury through oxidative stress

Immunocytochemical staining of formalin-fixed, permeabilized PC12 cells with rabbit polyclonal DRP1 antibody and detected with Dylight 488 (green) and the nuclei counterstained with DAPI (blue).

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
HIV
Human Immunodeficiency Virus
Mitochondria
Mitophagy
ROS
Oxidative Stress
GP120
Tat
Methamphetamine
neurodegeneration
Neurons
LC3B
p62
Autophagy
MAP2
DRP1
Antioxidants
Jamshed Arslan

Astrocytes: Diversity in type and function

In the CNS astrocytes have different functions including modulation of synaptic activity and synaptogenesis, communication with other astrocytes, oligodendrocytes and microglia, as well as modulation of the blood brain barrier.

By Michalina Hanzel, PhD

Tags: 
Astrocytes
Neurons
Neuroscience
GFAP
Michalina Hanzel