TLR9 Antibody [DyLight 405]

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Product Details

Summary
Reactivity Hu, Rt, PmSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 405

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Catalog# & Conjugate Size Price

TLR9 Antibody [DyLight 405] Summary

Immunogen
Synthetic peptide made to an internal portion of the human TLR9 protein (within residues 1019-1032). [Swiss-Prot# Q9NR96]
Localization
Membrane; Single-pass type I membrane protein
Predicted Species
Rat (92%), Primate (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TLR9
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
This TLR9 antibody is useful for Western blot, where a band is seen ~120 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
120 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Agonist

Reactivity Notes

Human. Predicted to react with monkey based on 100% sequence homology. Immunogen sequence has 92% homology to rat, 86% homology to sheep, porcine and bovine and 85% homology to mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TLR9 Antibody [DyLight 405]

  • CD289 antigen
  • CD289
  • TLR9
  • toll-like receptor 9

Background

TLR9 (Toll-like receptor 9) belongs to TLRs proteins which are pattern recognition receptors known to recognize a wide array of pathogen-associated molecular patterns (PAMPs) for the initiation of innate immune responses upon pathogen recognition. It is highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. TLR9 is located intracellularly on the ER membrane, endosomes, lysosomes and phagosomes, however, has been reported to express extracellularly in lung tissue. It relocalizes from ER to endosome and lysosome upon stimulation with agonists. TLR9 is known to recognize microbial unmethylated 2'-deoxyribo cytidine-phosphate-guanosine DNA (CpG DNA). TLR9 acts via MYD88 and TRAF6, leading to NFkB activation, cytokine secretion followed by inflammatory response and has been shown to control lymphocyte response to Helicobacter infection. TLR9 interacts with MYD88, UNC93B1, CD300LH, BTK, CNPY3, HSP90B1 etc. and its interaction with CNPY3 /HSP90B1 is required for proper folding in ER and TLR9 interaction with CD300LH promote full activation of TLR9-triggered innate responses. The immune responses induced by TLR9 activation vary remarkably from one species to another e.g. stimulation is very potent in rodents, but less so in large animals including humans presumably due to differences in TLR9 expression between rodents and mammals.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TLR9 Antibody (NBP1-18284V) (0)

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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics Tool for TLR9 Antibody (NBP1-18284V)

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Blogs on TLR9.

Topics in CD11b: The innate immune response
Integrins are transmembrane receptors composed of alpha and beta chains, where beta-integrins are mainly expressed in leukocytes. Leukocytes are white blood cells that act in the immune system to defend our body against foreign pathogens.  Integrin...  Read full blog post.

MHC Class I and the Herpes Simplex Virus
MHC molecules (also known as major histocompatibility complex molecules) assist in the presentation of antigens to T cells in order to eradicate foreign pathogens.  These molecules are highly polymorphic, meaning that they exist in multiple varian...  Read full blog post.

The role of TLR4 in breast cancer
Toll like receptors (TLRs) are highly conserved proteins that are first known for their role in pathogen recognition and immune response activation.  In order to elicit the necessary immune response in reaction to a foreign pathogen, TLRs trigger cy...  Read full blog post.

IRAK4: The "master IRAK" critical for initiating immune responses
IRAK4, also known as Interleukin-1 receptor-associated kinase 4, is a serine/threonine-protein kinase that plays a critical role in initiating innate and adaptive immune responses against foreign pathogens. It activates NF-kappaB in both Toll-like rec...  Read full blog post.

TLR9: For Whom the Cell Tolls
The Toll-like receptor 9 (TLR9) protein, also known as CD289, belongs to the family of Toll-like receptor (TLR) proteins which play a large role in pathogen recognition and the activation of innate immunity. Scientists using TLR9 antibodies have found...  Read full blog post.

TLR9: Tollgate to Immunity
Toll-like receptors (TLRs) play an essential role in the activation of innate immunity, and TLRs are expressed in a large number of immune cells as well as in epithelial cells. TLR9 recognizes synthetic oligodeoxynucleotides (ODN) containing unmethyla...  Read full blog post.

TLR9, Infectious Disease and Cancer
Toll-like receptor 9 (TLR9) is a protein encoded by TLR9 gene in humans. It is also known as cluster of differentiation 289 (CD289) and is a member of TLR family. Proteins from TLR family are transmembrane proteins that expressed in both antigen-resen...  Read full blog post.

TLR9 Antibodies in Immunity Research
Toll-like receptor 9 (TLR9) is a member of the toll-like receptor family that plays a key role in pathogen recognition and activation of innate immunity. Scientists using TLR9 antibodies have found the protein is highly conserved from Drosophila to hu...  Read full blog post.

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Bioinformatics

Gene Symbol TLR9
Entrez