TLR10 Antibody (3C10C5)

• Reactivity: Hu
• Applications: ELISA, Flow
• Clone: 3C10C5
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: 0.1 mg/ml

TLR10 Antibody (3C10C5) Summary

• Description: Novus Biologicals Mouse TLR10 Antibody (3C10C5) (NBP3-11234) is a monoclonal antibody validated for use in Flow. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: The extracellular domain of TLR10
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TLR10
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunoassay
• Application Notes: For Immunoassays and Flow Cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: 0.2 um filtered solution in PBS, 0.1% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.1 mg/ml
• Purity: Protein G purified

Alternate Names for TLR10 Antibody (3C10C5)

• CD290 antigen
• CD290
• MGC104967
• MGC126398
• MGC126399
• TLR10
• toll-like receptor 10

Background

The monoclonal antibody 3C10C5 reacts with human TLR-10, which is a type I transmembrane glycoprotein that consist of an extracellular domain, a single transmembrane segment and a cytoplasmic Toll/interleukin (IL)-1 receptor domain and has an apparent molecular mass of approximately 94kDa. In total humans possess 10 TLR family members (1-10). The TLR 10, 1, and 6 genes are tandemly arranged and seem to have arisen from duplication events. In accordance with their role in host defense, monocytes/macrophages express most TLRs, whereas the expression of individual TLRs in dendritic cells depends upon their subtype. The microbial agonists for TLRs include a wide variety of structures such as nucleic acids from bacteria and viruses, as well as outer membrane components of bacteria, fungi, and protozoan organisms. Despite extensive research on the TLRs, human TLR10 has remained an orphan receptor without a known agonist or function. Although recent studies have shown that the putative ligands include di- and triacetylated lipopeptides as can be found in bacteria. Variations in the TLR10 gene have been associated with several diseases such as papillary thyroid carcinoma, urothelial bladder cancer, and Crohn's disease. The monocalonal antibody 3C10C5 is suitable for immunoassay and flow cytometry.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TLR10