Mouse IL-13 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IL-13 DuoSet ELISA, 15 Plate Summary

• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il13

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-13 DuoSet ELISA, 15 Plate

• ALRHMGC116789
• BHR1interleukin-13
• IL13
• IL-13
• IL-13MGC116788
• interleukin 13
• MGC116786
• NC30
• P600

Background

IL-13 (Interleukin-13) plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances by macrophages, fibroblasts, and endothelial cells. It promotes B cell activation, immunoglobulin class switching to IgE, and the upregulation of CD23/Fc epsilon RII. IL-13 signals through a receptor complex containing IL-13 R alpha 1 and IL-4 R alpha. This complex also functions as the type 2 IL-4 receptor. IL-13 R alpha 2 binds IL-13 and prevents IL-13 from signaling through the IL-13 R alpha 1/IL-4 R alpha complex. IL-13-bound IL-13 R alpha 2 can directly promote tumor cell invasiveness and the development of tissue fibrosis.

Publications for IL-13 (DY413)(121)

Publications using DY413

• AD Friedrich, J Leoni, ML Paz, DH González M Lipoteichoic Acid from Lacticaseibacillus rhamnosus GG Modulates Dendritic Cells and T Cells in the Gut Nutrients, 2022;14(3):. 2022 [PMID: 35277082] (Mouse)
• S Wang, L Gong, Y Mo, J Zhang, Z Jiang, Z Tian, C Shao Resveratrol attenuates inflammation and apoptosis through alleviating endoplasmic reticulum stress via Akt/mTOR pathway in fungus-induced allergic airways inflammation International immunopharmacology, 2021;103(0):108489. 2021 [PMID: 34968999] (Mouse)
• Y Wu, E Li, M Knight, G Adeniyi-Ip, LZ Song, AR Burns, AC Gazzinelli, R Fujiwara, ME Bottazzi, JE Weatherhea Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice PloS Neglected Tropical Diseases, 2021;15(12):e0010050. 2021 [PMID: 34914687] (Mouse)
• N Majumder, M Velayutham, D Bitounis, VK Kodali, MH Hasan Mazu, J Amedro, VV Khramtsov, A Erdely, T Nurkiewicz, P Demokritou, EE Kelley, S Hussain Oxidized carbon black nanoparticles induce endothelial damage through C-X-C chemokine receptor 3-mediated pathway Redox Biology, 2021;47(0):102161. 2021 [PMID: 34624601] (Mouse)
• J Ma, MX Liu, LC Chen, JJ Shen, ML Kuo Ding Chuan Tang Attenuates Airway Inflammation and Eosinophil Infiltration in Ovalbumin-Sensitized Asthmatic Mice BioMed Research International, 2021;2021(0):6692772. 2021 [PMID: 34595240] (Mouse)
• N Majumder, WT Goldsmith, VK Kodali, M Velayutham, SA Friend, VV Khramtsov, TR Nurkiewicz, A Erdely, PC Zeidler-Er, V Castranova, JR Harkema, EE Kelley, S Hussain Oxidant-induced epithelial alarmin pathway mediates lung inflammation and functional decline following ultrafine carbon and ozone inhalation co-exposure Redox Biology, 2021;46(0):102092. 2021 [PMID: 34418598] (Mouse)
• G Dunsmore, EP Rosero, S Shahbaz, DM Santer, J Jovel, P Lacy, S Houston, S Elahi Neutrophils promote T-cell activation through the regulated release of CD44-bound Galectin-9 from the cell surface during HIV infection PloS Biology, 2021;19(8):e3001387. 2021 [PMID: 34411088] (Human)
• Y Suzuki, T Hayashi, R Yokoyama, F Nakagawa, J Inoue, T Higashi, R Onodera, K Motoyama Fasting impairs type 2 helper T cell infiltration in the lung of an eosinophilic asthma mouse model FEBS Open Bio, 2021;0(0):. 2021 [PMID: 34363652] (Mouse)
• JC Chen, CC Chan, NC Ting, ML Kuo Allergen Exposure in Murine Neonates Promoted the Development of Asthmatic Lungs Biomedicines, 2021;9(6):. 2021 [PMID: 34207237] (Mouse)
• H Nunokawa, Y Murakami, T Ishii, T Narita, H Ishii, H Takizawa, N Yamashita Crucial role of stimulator of interferon genes-dependent signaling in house dust mite extract-induced IgE production Scientific Reports, 2021;11(1):13157. 2021 [PMID: 34162937] (Mouse)
• K Matsushita, X Li, Y Nakamura, D Dong, K Mukai, M Tsai, SB Montgomery, SJ Galli The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice JCI Insight, 2021;6(12):. 2021 [PMID: 34156030] (Mouse)
• S Wang, Z Jiang, L Li, J Zhang, C Zhang, C Shao Ameliorative effects of eosinophil deficiency on immune response, endoplasmic reticulum stress, apoptosis, and autophagy in fungus-induced allergic lung inflammation Respiratory Research, 2021;22(1):173. 2021 [PMID: 34098934] (Mouse)
• MD Ihrie, KS Duke, KA Shipkowski, DJ You, HY Lee, AJ Taylor-Jus, JC Bonner STAT6-Dependent Exacerbation of House Dust Mite-Induced Allergic Airway Disease in Mice by Multi-Walled Carbon Nanotubes NanoImpact, 2021;22(0):. 2021 [PMID: 33860111] (Mouse)
• A Sripada, K Sirohi, L Michalec, L Guo, JT McKay, S Yadav, M Verma, J Good, D Rollins, MM Gorska, R Alam Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases PloS Biology, 2021;19(3):e3001063. 2021 [PMID: 33684096] (Mouse)
• JPK Mukendi, R Nakamura, S Uematsu, S Hamano Interleukin (IL)-33 is dispensable for Schistosoma mansoni worm maturation and the maintenance of egg-induced pathology in intestines of infected mice Parasites & vectors, 2021;14(1):70. 2021 [PMID: 33482904] (Mouse)
• H Tallima, M Abou El Da, R El Ridi Specific Antibodies and Arachidonic Acid Mediate the Protection Induced by the Schistosoma mansoni Cysteine Peptidase-Based Vaccine in Mice Vaccines (Basel), 2020;8(4):. 2020 [PMID: 33207535] (Mouse)
• GA Lee, CM Chang, YC Wu, RY Ma, CY Chen, YT Hsue, NS Liao, HH Chang Chinese herbal medicine SS-1 inhibits T cell activation and abrogates TH responses in Sj�gren's syndrome J. Formos. Med. Assoc., 2020;0(0):. 2020 [PMID: 32741737] (Mouse)
• S Abdulnasse, M Hannig, DD Le, S Heck, M Leitner, AJ Omlor, I Tavernaro, A Kraegeloh, R Kautenburg, G Kickelbick, A Beilhack, M Bischoff, J Nguyen, M Sester, R Bals, QT Dinh High-dose intranasal application of titanium dioxide nanoparticles induces the systemic uptakes and allergic airway inflammation in asthmatic mice Respir. Res., 2020;21(1):168. 2020 [PMID: 32616045] (Mouse)
• L Li, Z Fang, X Liu, W Hu, W Lu, YK Lee, J Zhao, H Zhang, W Chen Lactobacillus reuteri attenuated allergic inflammation induced by HDM in the mouse and modulated gut microbes PLoS ONE, 2020;15(4):e0231865. 2020 [PMID: 32315360] (Mouse)
• CH Val, MC de Oliveir, DR Lacerda, A Barroso, NV Batista, Z Menezes-Ga, DRR de Assis, AT Cramer, F Brant, MM Teixeira, D Glória Sou, AM Ferreira, FS Machado SOCS2 modulates adipose tissue inflammation and expansion in mice J. Nutr. Biochem., 2019;76(0):108304. 2019 [PMID: 31816561] (Mouse)
• MC de Rezende, JMP Moreira, LLM Fernandes, VF Rodrigues, D Negrão-Cor Strongyloides venezuelensis-infection alters the profile of cytokines and liver inflammation in mice co-infected with Schistosoma mansoni Cytokine, 2019;127(0):154931. 2019 [PMID: 31783260] (Mouse)
• S Nomura, H Takahashi, J Suzuki, M Kuwahara, M Yamashita, T Sawasaki Pyrrothiogatain acts as an inhibitor of GATA family proteins and inhibits Th2 cell differentiation in vitro Sci Rep, 2019;9(1):17335. 2019 [PMID: 31758034] (Mouse)
• S Koch, L Knipfer, J Kölle, H Mirzakhani, A Graser, T Zimmermann, A Kiefer, VO Melichar, W Rascher, NG Papadopoul, RJ Rieker, BA Raby, ST Weiss, S Wirtz, S Finotto Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2) Sci Rep, 2019;9(1):15695. 2019 [PMID: 31666531] (Mouse)
• Y Lin, B Li, X Yang, T Liu, T Shi, B Deng, Y Zhang, L Jia, Z Jiang, R He Non-hematopoietic STAT6 induces epithelial tight junction dysfunction and promotes intestinal inflammation and tumorigenesis Mucosal Immunol, 2019;0(0):. 2019 [PMID: 31534167] (Mouse)
• JQ Yang, KW Kalim, Y Li, Y Zheng, F Guo Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation J. Leukoc. Biol., 2019;0(0):. 2019 [PMID: 31260596] (Mouse)
• JD Burleson, D Siniard, VK Yadagiri, X Chen, MT Weirauch, BP Ruff, EB Brandt, GKK Hershey, H Ji TET1 contributes to allergic airway inflammation and regulates interferon and aryl hydrocarbon receptor signaling pathways in bronchial epithelial cells Sci Rep, 2019;9(1):7361. 2019 [PMID: 31089182] (Mouse)
• CC Campa, RL Silva, JP Margaria, T Pirali, MS Mattos, LR Kraemer, DC Reis, G Grosa, F Copperi, EM Dalmarco, RCP Lima-Júnio, S Aprile, V Sala, F Dal Bello, DS Prado, JC Alves-Filh, C Medana, GD Cassali, GC Tron, MM Teixeira, E Ciraolo, RC Russo, E Hirsch Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis Nat Commun, 2018;9(1):5232. 2018 [PMID: 30542075] (Mouse)
• M Reitz, ML Brunn, D Voehringer, M Breloer Basophils are dispensable for the establishment of protective adaptive immunity against primary and challenge infection with the intestinal helminth parasite Strongyloides ratti PLoS Negl Trop Dis, 2018;12(11):e0006992. 2018 [PMID: 30496188] (Mouse)
• CF Hsu, CH Hsiao, SF Tseng, JR Chen, YJ Liao, SJ Chen, CS Lin, HK Sytwu, YP Chuang PrtA immunization fails to protect against pulmonary and invasive infection by Streptococcus pneumoniae Respir. Res., 2018;19(1):187. 2018 [PMID: 30253765] (Mouse)
• SP Keeler, EV Agapov, ME Hinojosa, AN Letvin, K Wu, MJ Holtzman Influenza A Virus Infection Causes Chronic Lung Disease Linked to Sites of Active Viral RNA Remnants J. Immunol., 2018;0(0):. 2018 [PMID: 30209189] (Mouse)
• MF Serra, AC Cotias, CRR Pão, JB Daleprane, PB Jurgilas, GC Couto, EA Anjos-Valo, RSB Cordeiro, VF Carvalho, PMR Silva, MA Martins Repeated Allergen Exposure in A/J Mice Causes Steroid-Insensitive Asthma via a Defect in Glucocorticoid Receptor Bioavailability J. Immunol., 2018;0(0):. 2018 [PMID: 29914889] (Mouse)
• A Ariyaratne, EK Szabo, J Bowron, CAM Finney Increases in helminth-induced IL-21 protein levels disappear upon sample freezing Cytokine, 2018;108(0):179-181. 2018 [PMID: 29684754] (Mouse)
• WY Chen, JL Yang, YH Wu, LC Li, RF Li, YT Chang, LH Dai, WC Wang, YJ Chang IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury Exp. Mol. Med., 2018;50(4):36. 2018 [PMID: 29674622] (Mouse)
• ST Kao, YH Kuo, SD Wang, HJ Hong, LJ Lin Analogous corticosteroids, 9A and EK100, derived from solid-state-cultured mycelium of Antrodia camphorata inhibit proinflammatory cytokine expression in macrophages Cytokine, 2018;108(0):136-144. 2018 [PMID: 29605763] (Mouse)
• D Fang, K Cui, G Hu, RK Gurram, C Zhong, AJ Oler, R Yagi, M Zhao, S Sharma, P Liu, B Sun, K Zhao, J Zhu Bcl11b, a novel GATA3-interacting protein, suppresses Th1 while limiting Th2 cell differentiation J. Exp. Med., 2018;0(0):. 2018 [PMID: 29514917] (Mouse)
• HT Groves, L Cuthbertso, P James, MF Moffatt, MJ Cox, JS Tregoning Respiratory Disease following Viral Lung Infection Alters the Murine Gut Microbiota Front Immunol, 2018;9(0):182. 2018 [PMID: 29483910] (Mouse)
• CFCG Nunes, JS Nogueira, FB Canto, PHO Vianna, BT Ciambarell, PMRE Silva, KR Miranda, LA Lobo, RMCP Domingues, M Busch, GC Atella, AM Vale, M Bellio, A Nóbrega, R Fucs Probiotic treatment during neonatal age provides optimal protection against experimental asthma through the modulation of microbiota and T cells: Neonatal exposure to probiotics prevents asthma Int. Immunol., 2018;0(0):. 2018 [PMID: 29420746] (ELISA Capture, Mouse)
• S Piñeiro-He, E Alfaro-Arn, JA Gregory, R Torrens, C Ruíz-Martí, M Adner, IP López, JG Pichel Characterization of the acute inflammatory profile and resolution of airway inflammation after Igf1r-gene targeting in a murine model of HDM-induced asthma PLoS ONE, 2017;12(12):e0190159. 2017 [PMID: 29272313] (Mouse)
• Verma M, Liu S, Michalec L, Sripada A, Gorska M, Alam R Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9<sup>+</sup> and IL-13<sup>+</sup> type 2 innate lymphoid cell subpopulations. J Allergy Clin Immunol, 0;0(0):. 0 [PMID: 29132961] (Mouse)
• Y Kannan, LJ Entwistle, VS Pelly, J Perez-Llor, AW Walker, SC Ley, MS Wilson TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus PLoS Pathog., 2017;13(7):e1006536. 2017 [PMID: 28759611] (Mouse)
• A Onodera, M Kiuchi, K Kokubo, M Kato, T Ogino, S Horiuchi, U Kanai, K Hirahara, T Nakayama Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells J. Immunol., 2017;0(0):. 2017 [PMID: 28659357] (Mouse)
• S Piñeiro-He, IP López, E Alfaro-Arn, R Torrens, M Iñiguez, L Alvarez-Er, C Ruíz-Martí, JG Pichel IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model Sci Rep, 2017;7(1):4290. 2017 [PMID: 28655914] (Mouse)
• S Qiu, X Fan, Y Yang, P Dong, W Zhou, Y Xu, Y Zhou, F Guo, Y Zheng, JQ Yang Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice PLoS ONE, 2017;12(6):e0179565. 2017 [PMID: 28614408] (Mouse)
• TB Oriss, M Raundhal, C Morse, RE Huff, S Das, R Hannum, MC Gauthier, KL Scholl, K Chakrabort, SM Nouraie, SE Wenzel, P Ray, A Ray IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice JCI Insight, 2017;2(10):. 2017 [PMID: 28515358] (Mouse)
• S Parande Sh, A Ebrahimby, A Dousty, M Maleki, A Movassaghi, H Borji, A Haghparast Somatic extracts of Marshallagia marshalli downregulate the Th2 associated immune responses in ovalbumin-induced airway inflammation in BALB/c mice Parasit Vectors, 2017;10(1):233. 2017 [PMID: 28494800] (Mouse)
• M Toussaint, DJ Jackson, D Swieboda, A Guedán, TD Tsouroukts, YM Ching, C Radermecke, H Makrinioti, J Aniscenko, MR Edwards, R Solari, F Farnir, V Papayannop, F Bureau, T Marichal, SL Johnston Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation Nat. Med., 2017;23(6):681-691. 2017 [PMID: 28459437] (Mouse)
• PC Chen, MH Hsieh, P Wen-ShuoKu, HF Kao, CL Hsu, JY Wang Water-soluble chitosan inhibits nerve growth factor and attenuates allergic inflammation in mite allergen-induced allergic rhinitis J. Allergy Clin. Immunol., 2017;0(0):. 2017 [PMID: 28412394] (Mouse)
• C Li, I Maillet, C Mackowiak, C Viala, F Di Padova, M Li, D Togbe, V Quesniaux, Y Lai, B Ryffel Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells Cell Death Dis, 2017;8(4):e2735. 2017 [PMID: 28383552] (Mouse)
• H Tallima, J Dvo?ák, S Kareem, M Abou El Da, N Abdel Aziz, JP Dalton, R El Ridi Protective immune responses against Schistosoma mansoni infection by immunization with functionally active gut-derived cysteine peptidases alone and in combination with glyceraldehyde 3-phosphate dehydrogenase PLoS Negl Trop Dis, 2017;11(3):e0005443. 2017 [PMID: 28346516] (Mouse)
• S Piñeiro-He, JA Gregory, IP López, R Torrens, C Ruíz-Martí, M Adner, JG Pichel Attenuated airway hyperresponsiveness and mucus secretion in HDM exposed Igf1r-deficient mice Allergy, 2017;0(0):. 2017 [PMID: 28207927] (Mouse)
• SC Sebag, OM Koval, JD Paschke, CJ Winters, OA Jaffer, R Dworski, FS Sutterwala, ME Anderson, IM Grumbach Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma JCI Insight, 2017;2(3):e88297. 2017 [PMID: 28194433] (Mouse)
• Flavia Regina Sobreira Corrêa Brazilian red propolis improves cutaneous wound healing suppressing inflammation-associated transcription factor NF?B Biomed. Pharmacother, 2016;86(0):162-171. 2016 [PMID: 27978495] (Mouse)
• Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner Sci Rep, 2016;6(0):39117. 2016 [PMID: 27974744] (Mouse)
• Ismé M de Kleer Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung Immunity, 2016;45(6):1285-1298. 2016 [PMID: 27939673] (Mouse)
• Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines EBioMedicine, 2016;0(0):. 2016 [PMID: 27919753] (Mouse)
• Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice PLoS ONE, 2016;11(11):e0166089. 2016 [PMID: 27820848] (Mouse)
• DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma JCI Insight, 2016;1(18):e88811. 2016 [PMID: 27812543] (Mouse)
• Gesine Hansen IL-27 Is Essential for Suppression of Experimental Allergic Asthma by the TLR7/8 Agonist R848 (Resiquimod) J. Immunol., 2016;0(0):. 2016 [PMID: 27799314] (Mouse)
• Adenovirus-mediated Foxp3 expression in lung epithelial cells reduces airway inflammation in ovalbumin and cockroach-induced asthma model Exp Mol Med, 2016;48(9):e259. 2016 [PMID: 27633092] (Mouse)
• Allergen-Induced IL-6 Regulates IL-9/IL-17A Balance in CD4+ T Cells in Allergic Airway Inflammation J Immunol, 2016;197(7):2653-64. 2016 [PMID: 27574298] (Mouse)
• Jeremy P Derrick Editor's Highlight: Subvisible Aggregates of Immunogenic Proteins Promote a Th1-Type Response Toxicol. Sci., 2016;153(2):258-70. 2016 [PMID: 27370416] (Mouse)
• Netali Ben Baruch Paired Ig-like Receptor B Inhibits IL-13-Driven Eosinophil Accumulation and Activation in the Esophagus J Immunol, 2016;0(0):. 2016 [PMID: 27324131] (Mouse)
• Exposure to Aedes aegypti Bites Induces a Mixed-Type Allergic Response following Salivary Antigens Challenge in Mice PLoS ONE, 2016;11(5):e0155454. 2016 [PMID: 27203689] (Mouse)
• T Nakano, R Kamei, T Fujimura, Y Takaoka, A Hori, CY Lai, KC Chiang, Y Shimada, N Ohmori, T Goto, K Ono, CL Chen, S Goto, S Kawamoto Impact of Histone H1 on the Progression of Allergic Rhinitis and Its Suppression by Neutralizing Antibody in Mice PLoS ONE, 2016;11(4):e0153630. 2016 [PMID: 27088594] (Mouse)
• JL Reyes, MR Fernando, F Lopes, G Leung, NL Mancini, CE Matisz, A Wang, DM McKay IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression PLoS Pathog, 2016;12(4):e1005481. 2016 [PMID: 27055194] (Mouse)
• Tsao C, Tsao P, Chen Y, Chuang Y Repeated Activation of Lung Invariant NKT Cells Results in Chronic Obstructive Pulmonary Disease-Like Symptoms. PLoS ONE, 2016;11(1):e0147710. 2016 [PMID: 26811900] (Mouse)
• Gonzalez Roldan N, Orinska Z, Ewers H, Bulfone-Paus S CD252 regulates mast cell mediated, CD1d-restricted NKT-cell activation in mice. Eur J Immunol, 2015;46(2):432-9. 2015 [PMID: 26564814] (Mouse)
• Mahapatra S, Albrecht M, Baru A, Sparwasser T, Herrick C, Dittrich A Superior Suppressive Capacity of Skin Tregs Compared with Lung Tregs in a Model of Epicutaneous Priming. J Invest Dermatol, 2015;135(10):2418-26. 2015 [PMID: 26358386] (Mouse)
• Jovicic N, Jeftic I, Jovanovic I, Radosavljevic G, Arsenijevic N, Lukic M, Pejnovic N Differential Immunometabolic Phenotype in Th1 and Th2 Dominant Mouse Strains in Response to High-Fat Feeding. PLoS ONE, 2015;10(7):e0134089. 2015 [PMID: 26218873] (Mouse)
• Onishi M, Ozasa K, Kobiyama K, Ohata K, Kitano M, Taniguchi K, Homma T, Kobayashi M, Sato A, Katakai Y, Yasutomi Y, Wijaya E, Igarashi Y, Nakatsu N, Ise W, Inoue T, Yamada H, Vandenbon A, Standley D, Kurosaki T, Coban C, Aoshi T, Kuroda E, Ishii K Hydroxypropyl-beta-cyclodextrin spikes local inflammation that induces Th2 cell and T follicular helper cell responses to the coadministered antigen. J Immunol, 2015;194(6):2673-82. 2015 [PMID: 25681338] (Mouse)
• Ballinger M, Newstead M, Zeng X, Bhan U, Mo X, Kunkel S, Moore B, Flavell R, Christman J, Standiford T IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury. J Immunol, 2015;194(4):1894-904. 2015 [PMID: 25595781]
• Zhou W, Goleniewska K, Zhang J, Dulek D, Toki S, Lotz M, Newcomb D, Boswell M, Polosukhin V, Milne G, Wu P, Moore M, FitzGerald G, Peebles R Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling. J Allergy Clin Immunol, 2014;134(3):698-705.e5. 2014 [PMID: 25042746] (Mouse)
• Petzold , Susanne, Averbeck , Marco, Simon , Jan C, Lehmann , Irina, Polte , Tobias Lifetime-dependent effects of bisphenol A on asthma development in an experimental mouse model. PLoS ONE, 2014;9(6):e100468. 2014 [PMID: 24950052] (Mouse)
• Tatano Y, Shimizu T, Tomioka H Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization. Sci Rep, 2014;4(0):4146. 2014 [PMID: 24553452] (Mouse)
• Blankenhaus B, Reitz M, Brenz Y, Eschbach M, Hartmann W, Haben I, Sparwasser T, Huehn J, Kuhl A, Feyerabend T, Rodewald H, Breloer M Foxp3(+) regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB/c but not in C57BL/6 mice. PLoS Pathog, 2014;10(2):e1003913. 2014 [PMID: 24516385] (Mouse)
• Mahapatra S, Albrecht M, Behrens B, Jirmo A, Behrens G, Hartwig C, Neumann D, Raap U, Bahre H, Herrick C, Dittrich A Delineating the role of histamine-1- and -4-receptors in a mouse model of Th2-dependent antigen-specific skin inflammation. PLoS ONE, 2014;9(2):e87296. 2014 [PMID: 24503582] (Mouse)
• Hams , Emily, Armstrong , Michelle, Barlow , Jillian, Saunders , Sean P, Schwartz , Christia, Cooke , Gordon, Fahy , Ruairi J, Crotty , Thomas B, Hirani , Nikhil, Flynn , Robin J, Voehringer , David, McKenzie , Andrew N, Donnelly , Seamas C, Fallon , Padraic IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. Proc Natl Acad Sci U S A, 2014;111(1):367-72. 2014 [PMID: 24344271] (Mouse)
• Ubel C, Sopel N, Graser A, Hildner K, Reinhardt C, Zimmermann T, Rieker R, Maier A, Neurath M, Murphy K, Finotto S The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), regulates lymphocyte- and mast cell-driven immune responses in the setting of allergic asthma. J Allergy Clin Immunol, 2014;133(1):198-206.e1-9. 2014 [PMID: 24290279] (Mouse)
• Tully J, Hoffman S, Lahue K, Nolin J, Anathy V, Lundblad L, Daphtary N, Aliyeva M, Black K, Dixon A, Poynter M, Irvin C, Janssen-Heininger Y Epithelial NF-kappaB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling. J Immunol, 2013;191(12):5811-21. 2013 [PMID: 24227776] (Mouse)
• Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song S, Hoshino T, Yagita H, Ohteki T, Iwata M Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Mucosal Immunol, 2014;7(4):786-801. 2014 [PMID: 24220301] (Mouse)
• McHedlidze T, Waldner M, Zopf S, Walker J, Rankin A, Schuchmann M, Voehringer D, McKenzie A, Neurath M, Pflanz S, Wirtz S Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Immunity, 2013;39(2):357-71. 2013 [PMID: 23954132] (Mouse)
• Kiwamoto T, Brummet M, Wu F, Motari M, Smith D, Schnaar R, Zhu Z, Bochner B Mice deficient in the St3gal3 gene product alpha2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation. J Allergy Clin Immunol, 2014;133(1):240-7.e1-3. 2014 [PMID: 23830412] (Mouse)
• Kong , Il Gyu, Sato , Ayuko, Yuki , Yoshikaz, Nochi , Tomonori, Takahashi , Haruko, Sawada , Shinichi, Mejima , Mio, Kurokawa , Shiho, Okada , Kazunari, Sato , Shintaro, Briles , David E, Kunisawa , Jun, Inoue , Yusuke, Yamamoto , Masafumi, Akiyoshi , Kazunari, Kiyono , Hiroshi Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae. Infect Immun, 2013;81(5):1625-34. 2013 [PMID: 23460513] (Mouse)
• Qiu Y, Davis M, Dayrit J, Hadd Z, Meister D, Osterholzer J, Williamson P, Olszewski M Immune Modulation Mediated by Cryptococcal Laccase Promotes Pulmonary Growth and Brain Dissemination of Virulent Cryptococcus neoformans in Mice. PLoS ONE, 2012;7(10):e47853. 2012 [PMID: 23110112] (Mouse)
• Kim J, Sohn J, Choi J, Lee J, Hong C, Lee J, Park J Alveolar Macrophages Play a Key Role in Cockroach-Induced Allergic Inflammation via TNF-alpha Pathway. PLoS ONE, 2012;7(10):e47971. 2012 [PMID: 23094102] (Mouse)
• Duncan F, Silva K, Johnson C, King B, Szatkiewicz J, Kamdar S, Ong D, Napoli J, Wang J, King L, Whiting D, McElwee K, Sundberg J, Everts H Endogenous retinoids in the pathogenesis of alopecia areata. J Invest Dermatol, 2013;133(2):334-43. 2013 [PMID: 23014334] (Mouse)
• Piehler D, Grahnert A, Eschke M, Richter T, Kohler G, Stenzel W, Alber G T1/ST2 promotes T helper 2 cell activation and polyfunctionality in bronchopulmonary mycosis. Mucosal Immunol, 2013;6(2):405-14. 2013 [PMID: 22990621] (Mouse)
• Paulissen G, El Hour M, Rocks N, Gueders M, Bureau F, Foidart J, Lopez-Otin C, Noel A, Cataldo D Control of allergen-induced inflammation and hyperresponsiveness by the metalloproteinase ADAMTS-12. J Immunol, 2012;189(8):4135-43. 2012 [PMID: 22962682] (Mouse)
• Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Korner H, Cua D, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide D, Matsumoto K, Nakae S Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, Is crucial for murine asthma. J Immunol, 2012;189(7):3641-52. 2012 [PMID: 22942422] (Mouse)
• Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J. Exp. Med., 2012;209(8):1505-17. 2012 [PMID: 22802353] (Mouse)
• Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J. Immunol., 2011;188(3):1503-13. 2011 [PMID: 22198948] (Mouse)
• Nakagome K, Imamura M, Kawahata K High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism. J. Immunol., 2011;187(10):5077-89. 2011 [PMID: 21998459] (Mouse)
• Swaidani S, Bulek K, Kang Z T cell-derived Act1 is necessary for IL-25-mediated Th2 responses and allergic airway inflammation. J. Immunol., 2011;187(6):3155-64. 2011 [PMID: 21856933] (Mouse)
• Moalli F, Paroni M, Veliz Rodriguez T, Riva F, Polentarutti N, Bottazzi B, Valentino S, Mantero S, Nebuloni M, Mantovani A, Bragonzi A, Garlanda C The Therapeutic Potential of the Humoral Pattern Recognition Molecule PTX3 in Chronic Lung Infection Caused by Pseudomonas aeruginosa. J. Immunol., 2011;186(9):5425-34. 2011 [PMID: 21441447] (Mouse)
• Nel HJ, Hams E, Saunders SP Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice. J. Immunol., 2011;186(8):4631-9. 2011 [PMID: 21398616] (Mouse)
• Chuang YH, Wang TC, Jen HY, Yu AL, Chiang BL Alpha-Galactosylceramide-induced airway eosinophilia is mediated through the activation of NKT cells. J. Immunol., 2010;186(8):4687-92. 2010 [PMID: 21383248] (Mouse)
• Zhang X, Schmudde I, Laumonnier Y, Pandey MK, Clark JR, Konig P, Gerard NP, Gerard C, Wills-Karp M, Kohl J A critical role for C5L2 in the pathogenesis of experimental allergic asthma. J. Immunol., 2010;185(11):6741-52. 2010 [PMID: 20974988] (Mouse)
• Graham BS, Kines RC, Corbett KS, Nicewonger J, Roberts JN, Schiller JT, Buck CB Mucosal delivery of human papillomavirus pseudovirus-encapsidated plasmids improves the potency of DNA vaccination. Mucosal Immunol, 2010;3(5):475-86. 2010 [PMID: 20555315] (Mouse)
• Sellge G, Magalhaes JG, Konradt C, Fritz JH, Salgado-Pabon W, Eberl G, Bandeira A, Di Santo JP, Sansonetti PJ, Phalipon A Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity. J. Immunol., 2010;184(4):2076-85. 2010 [PMID: 20089698] (Mouse)
• Vasconcelos JF, Teixeira MM, Barbosa-Filho JM, Agra MF, Nunes XP, Giulietti AM, Ribeiro-Dos-Santos R, Soares MB Effects of umbelliferone in a murine model of allergic airway inflammation. Eur. J. Pharmacol., 2009;609(1):126-31. 2009 [PMID: 19289114] (Mouse)
• Kearley J, Buckland KF, Mathie SA, Lloyd CM Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Am. J. Respir. Crit. Care Med., 2009;179(9):772-81. 2009 [PMID: 19179489] (Mouse)
• Kaya Z, Goser S, Buss SJ, Leuschner F, Ottl R, Li J, Volkers M, Zittrich S, Pfitzer G, Rose NR, Katus HA Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis. Circulation, 2008;118(20):2063-72. 2008 [PMID: 18955666] (Mouse)
• Rickel EA, Siegel LA, Yoon BR, Rottman JB, Kugler DG, Swart DA, Anders PM, Tocker JE, Comeau MR, Budelsky AL Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J. Immunol., 2008;181(6):4299-310. 2008 [PMID: 18768888] (Mouse)
• Wells SM, Buford MC, Migliaccio CT, Holian A Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice. Am. J. Respir. Cell Mol. Biol., 2009;40(2):179-88. 2009 [PMID: 18703795] (Mouse)
• Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT Induction of IL-33 expression and activity in central nervous system glia. J. Leukoc. Biol., 2008;84(3):631-43. 2008 [PMID: 18552204] (Mouse)
• Munitz A, Brandt EB, Mingler M, Finkelman FD, Rothenberg ME Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc. Natl. Acad. Sci. U.S.A., 2008;105(20):7240-5. 2008 [PMID: 18480254] (Mouse)
• Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME Surfactant protein D alters allergic lung responses in mice and human subjects. J. Allergy Clin. Immunol., 2008;121(5):1140-1147.e2. 2008 [PMID: 18355911] (Mouse)
• Fattouh R, Midence NG, Arias K, Johnson JR, Walker TD, Goncharova S, Souza KP, Gregory RC, Lonning S, Gauldie J, Jordana M Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling. Am. J. Respir. Crit. Care Med., 2008;177(6):593-603. 2008 [PMID: 18174546] (Mouse)
• Jenkins SJ, Perona-Wright G, Worsley AG, Ishii N, MacDonald AS Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo. J. Immunol., 2007;179(6):3515-23. 2007 [PMID: 17785785] (Mouse)
• Nakae S, Iikura M, Suto H, Akiba H, Umetsu DT, DeKruyff RH, Saito H, Galli SJ TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells. Blood, 2007;110(7):2565-8. 2007 [PMID: 17620455] (Mouse)
• Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Flaherty KR, Martinez FJ, Hogaboam CM Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Am. J. Pathol., 2007;170(4):1152-64. 2007 [PMID: 17392156] (Mouse)
• Coquet JM, Kyparissoudis K, Pellicci DG, Besra G, Berzins SP, Smyth MJ, Godfrey DI IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J. Immunol., 2007;178(5):2827-34. 2007 [PMID: 17312126] (Mouse)
• Moore F, Buonocore S, Aksoy E, Ouled-Haddou N, Goriely S, Lazarova E, Paulart F, Heirman C, Vaeremans E, Thielemans K, Goldman M, Flamand V An alternative pathway of NF-kappaB activation results in maturation and T cell priming activity of dendritic cells overexpressing a mutated IkappaBalpha. J. Immunol., 2007;178(3):1301-11. 2007 [PMID: 17237376] (Mouse)
• Schnyder-Candrian S, Togbe D, Couillin I, Mercier I, Brombacher F, Quesniaux V, Fossiez F, Ryffel B, Schnyder B Interleukin-17 is a negative regulator of established allergic asthma. J. Exp. Med., 2006;203(12):2715-25. 2006 [PMID: 17101734] (Mouse)
• Fulkerson PC, Fischetti CA, McBride ML, Hassman LM, Hogan SP, Rothenberg ME A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Proc. Natl. Acad. Sci. U.S.A., 2006;103(44):16418-23. 2006 [PMID: 17060636] (Mouse)
• Kouznetsova I, Chwieralski CE, Balder R, Hinz M, Braun A, Krug N, Hoffmann W Induced trefoil factor family 1 expression by trans-differentiating Clara cells in a murine asthma model. Am. J. Respir. Cell Mol. Biol., 2006;36(3):286-95. 2006 [PMID: 16990615] (Mouse)
• Nassenstein C, Dawbarn D, Pollock K, Allen SJ, Erpenbeck VJ, Spies E, Krug N, Braun A Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma. J. Allergy Clin. Immunol., 2006;118(3):597-605. 2006 [PMID: 16950277] (Mouse)
• Haas CS, Amin MA, Allen BB, Ruth JH, Haines GK, Woods JM, Koch AE Inhibition of angiogenesis by interleukin-4 gene therapy in rat adjuvant-induced arthritis. Arthritis Rheum., 2006;54(8):2402-14. 2006 [PMID: 16869003] (Rat)
• Luzina IG, Papadimitriou JC, Anderson R, Pochetuhen K, Atamas SP Induction of prolonged infiltration of T lymphocytes and transient T lymphocyte-dependent collagen deposition in mouse lungs following adenoviral gene transfer of CCL18. Arthritis Rheum., 2006;54(8):2643-55. 2006 [PMID: 16868995] (Mouse)
• Keller AC, Mucida D, Gomes E, Faquim-Mauro E, Faria AM, Rodriguez D, Russo M Hierarchical suppression of asthma-like responses by mucosal tolerance. J. Allergy Clin. Immunol., 2006;117(2):283-90. 2006 [PMID: 16461128] (Mouse)
• Metcalfe SM, Watson TJ, Shurey S, Adams E, Green CJ Leukemia inhibitory factor is linked to regulatory transplantation tolerance. Transplantation, 2005;79(6):726-30. 2005 [PMID: 15785381] (Mouse)

Bioinformatics

• Gene Symbol: Il13