TLR10 Antibody (3C10C5)

Images

 
Flow Cytometry: TLR10 Antibody (3C10C5) [NBP1-70343] - Analysis using the PE conjugate of NBP2-27214. Staining of Human PBMC were probed using 10 ul (1 ug) of TLR10 antibody and 1 ug of CD19 antibody.
Flow Cytometry: TLR10 Antibody (3C10C5) [NBP1-70343] - Analysis using the Alexa Fluor (R) 647 conjugate of NBP2-27214. Detection of TLR10 on human PBMC using 10 ul (1 ug) of TLR10 antibody and 1 ug of CD19 antibody.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
3C10C5
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.5 mg/ml

TLR10 Antibody (3C10C5) Summary

Immunogen
A partial recombinant protein containing amino acids 20-474 (extracellular domain) of human TLR10.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TLR10
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for TLR10 Antibody (3C10C5)

  • CD290 antigen
  • CD290
  • MGC104967
  • MGC126398
  • MGC126399
  • TLR10
  • toll-like receptor 10

Background

Toll-like receptors (TLRs) are one of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms (reviewed in 1). TLRs are primary transmembrane proteins of immune cells; they have an extracellular region which contains leucine-rich repeat motifs, and a cytoplasmic tail, which has a Toll/interleukin-1 (IL-1) receptor (TIR) domain. TLRs are pattern recognition receptors (PRRs ) that bind to pathogen-associated molecular patterns (PAMPs). Different TLRs recognize different surface and intracellular components of microorganisms or PAMPS. The interaction between a TLR and a microbial component or PAMP triggers the activation of the innate immune system, as well as the development of acquired immunity. Interaction of PAMPs with different TLRs induces distinct patters of gene expression through signal transduction pathways. TLR signaling occurs through the TIR domains which utilize adaptors such as MyD88, TIRAP, TRIF, and TRAM. NF-kapppa-B and JNK pathways are activated leading to the transcription of genes encoding pro-inflammatory cytokines. TLR-10, originally identified from a spleen cDNA library, is on chromosome 4p14 and has been found to be expressed in lung and in B-lymphocytes (2). TLR10 is thought to be a potential asthma candidate gene because early life innate immune responses to ubiquitous inhaled allergens and PAMPs may influence asthma susceptibility.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NBP2-27214APC
DyLight 350 Labeled NBP2-27214UV
DyLight 405 Labeled NBP2-27214V
DyLight 488 Labeled NBP2-27214G
DyLight 550 Labeled NBP2-27214R
DyLight 650 Labeled NBP2-27214C
DyLight 680 Labeled NBP2-27214FR
DyLight 755 Labeled NBP2-27214IR
PE Labeled NBP2-27244
PerCP Labeled NBP2-27214PCP

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Bioinformatics

Gene Symbol TLR10
Entrez
Uniprot