RBFOX3/NeuN Antibody (1B7) [Biotin]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, BvSpecies Glossary
Applications WB, ICC/IF, IHC-Fr, IHC-P
Clone
1B7
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin

RBFOX3/NeuN Antibody (1B7) [Biotin] Summary

Immunogen
The N-terminal 100 amino acids of human RBFOX3/NeuN as expressed in and purified from E. coli. [UniProt# A6NFN3]
Localization
Nucleus. Cytoplasm.
Marker
Neuronal Marker
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
RBFOX3
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Readout System

Reactivity Notes

Human, bovine, porcine, mouse, rat and other mammals.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for RBFOX3/NeuN Antibody (1B7) [Biotin]

  • FLJ56884
  • FLJ58356
  • Fox-1 homolog C
  • FOX3
  • FOX-3
  • hexaribonucleotide binding protein 3
  • HRNBP3
  • NeuN
  • neuronal nuclei
  • RBFOX3
  • RNA binding protein fox-1 homolog 3
  • RNA binding protein, fox-1 homolog (C. elegans) 3

Background

RBFOX3/NeuN (RNA binding protein FOX-1 homolog 3/ Neuronal nuclei) is a RNA-binding protein localized in the nucleus as well as cytoplasm that regulates alternative splicing events. It is a member of RNA-binding FOX (RBFOX) family of splicing regulators which comprises RBFOX1 (Fox-1 or A2BP1), RBFOX2 (Fox-2 or RBM9), and RBFOX3 (Fox-3, HRNBP3, or NeuN). All of these Fox protein have single central RNA recognition motif RNA-binding domain which detects sequence (U)GCAUG observed within introns flanking alternative exons. (U)GCAUG motif position corresponding to the alternative exon dictates RBFOX's effects on splicing process. A motif localized upstream from alternative exon generally repress RBFOX-dependent exon inclusion, whereas, a downstream stream motif will usually promote inclusion. Neurons, heart, and muscle express RBFOX 1, whereas, RBFOX3 is limited to neurons only, and RBFOX2 is expressed in these tissues alongwith expression in embryos, hematopoietic cells, and embryonic stem cells. Defects in alternative splicing are known to result in neurological and neuromuscular diseases such as frontotemporal dementia and myotonic dystrophy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for RBFOX3/NeuN Antibody (NBP1-92693B) (0)

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Secondary Antibodies

 

Isotype Controls

Additional RBFOX3/NeuN Products

Bioinformatics Tool for RBFOX3/NeuN Antibody (NBP1-92693B)

Discover related pathways, diseases and genes to RBFOX3/NeuN Antibody (NBP1-92693B). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for RBFOX3/NeuN Antibody (NBP1-92693B)

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Pathways for RBFOX3/NeuN Antibody (NBP1-92693B)

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Research Areas for RBFOX3/NeuN Antibody (NBP1-92693B)

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Blogs on RBFOX3/NeuN.

RBFOX3: Binding RNA, like a FOX
NeuN is a RNA-binding protein that modulates alternative splicing and is localized both to the nucleus and cytoplasm. It is a member of the RNA-binding FOX (RBFOX) family of splicing regulators which includes RBFOX1 (Fox-1/A2BP1) and RBFOX2 (Fox-2/RBM...  Read full blog post.

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Bioinformatics

Gene Symbol RBFOX3