MyD88 Antibody (OTI2B2)

Images

 
Western Blot: MyD88 Antibody (2B2) [NBP2-03369] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MyD88 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates ...read more
Immunocytochemistry/ Immunofluorescence: MyD88 Antibody (2B2) [NBP2-03369] Staining of COS7 cells transiently transfected by pCMV6-ENTRY MyD88.
Immunohistochemistry-Paraffin: MyD88 Antibody (2B2) [NBP2-03369] - Staining of paraffin-embedded Human thyroid tissue using anti-MyD88 mouse monoclonal antibody.
Flow Cytometry: MyD88 Antibody (2B2) [NBP2-03369] - Analysis of Jurkat cells, using antiMYD88 antibody, (Red), compared to a nonspecific negative control antibody, (Blue).
Immunohistochemistry-Paraffin: MyD88 Antibody (2B2) [NBP2-03369] - Staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-MyD88 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: MyD88 Antibody (2B2) [NBP2-03369] - Staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-MyD88 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: MyD88 Antibody (2B2) [NBP2-03369] - Staining of paraffin-embedded Human Kidney tissue using anti-MyD88 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: MyD88 Antibody (2B2) [NBP2-03369] - Staining of paraffin-embedded Human lymph node tissue using anti-MyD88 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: MyD88 Antibody (2B2) [NBP2-03369] - Staining of paraffin-embedded Human prostate tissue using anti-MyD88 mouse monoclonal antibody.
Flow Cytometry: MyD88 Antibody (2B2) [NBP2-03369] - HEK293T cells transfected with either overexpression plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-MyD88 antibody, and then analyzed ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, IHC-P
Clone
OTI2B2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

MyD88 Antibody (OTI2B2) Summary

Immunogen
Full length human recombinant protein of human MYD88 (NP_002459) produced in HEK293T cell.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
MYD88
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000
  • Flow Cytometry 1:100
  • Immunocytochemistry/Immunofluorescence 1:100
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:150
Theoretical MW
33.1 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Antagonist
Control
MyD88 Knockout HeLa Cell Lysate
MyD88 Knockout A549 Cell Lysate

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Affinity purified

Alternate Names for MyD88 Antibody (OTI2B2)

  • MyD88
  • MYD88D
  • myeloid differentiation primary response gene (88)
  • myeloid differentiation primary response protein MyD88

Background

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq].

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MyD88 Antibody (NBP2-03369) (0)

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for MyD88 Antibody (NBP2-03369) (0)

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-72842AF350
Alexa Fluor 405 NBP2-72842AF405
Alexa Fluor 488 NBP2-72842AF488
Alexa Fluor 532 NBP2-72842AF532
Alexa Fluor 594 NBP2-72842AF594
Alexa Fluor 647 NBP2-72842AF647
Alexa Fluor 700 NBP2-72842AF700
Alexa Fluor 750 NBP2-72842AF750
Allophycocyanin NBP2-72842APC
Biotin NBP2-72842B
DyLight 350 NBP2-72842UV
DyLight 405 NBP2-72842V
DyLight 488 NBP2-72842G
DyLight 550 NBP2-72842R
DyLight 594 NBP2-72842DL594
DyLight 650 NBP2-72842C
DyLight 680 NBP2-72842FR
DyLight 755 NBP2-72842IR
FITC NBP2-72842F
HRP NBP2-72842H
Janelia Fluor 549 NBP2-72842JF549
Janelia Fluor 646 NBP2-72842JF646
PE NBP2-72842PE
PerCP NBP2-72842PCP

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Bioinformatics Tool for MyD88 Antibody (NBP2-03369)

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Blogs on MyD88.

Toll-like receptors in the intestinal epithelial cells
By Jamshed Arslan, Pharm. D., PhD. Toll-like receptors (TLRs) are microbe-sensing proteins that act as first responders to danger signals. TLRs help the intestinal epithelial cells (IECs) recognize commensal bacteria...  Read full blog post.

The role of STING/TMEM173 in gamma and encephalitis Herpes Simplex Virus (HSV)
Stimulator of interferon genes (STING), also known as TMEM173, promotes the production of the interferon’s IFN-alpha and IFN-beta.  STING possesses three functional domains: a cytoplasmic C-terminal tail, a central globular domain, and four N-...  Read full blog post.

TRIF/TICAM1 and mitochondrial dynamics in the innate immune response
TRIF, also known as toll like receptor adaptor molecule 1 or TICAM1, is known for its role in invading foreign pathogens as part of our innate immune response. TRIF/TICAM1 is a TIR-domain adaptor protein (toll/interleukin-1 receptor) that interacts...  Read full blog post.

The role of TLR4 in breast cancer
Toll like receptors (TLRs) are highly conserved proteins that are first known for their role in pathogen recognition and immune response activation.  In order to elicit the necessary immune response in reaction to a foreign pathogen, TLRs trigger cy...  Read full blog post.

MYD88 Expression and Tumorigenesis
MyD88, also called myeloid differentiation primary response gene 88, encodes a cytosolic adapter protein that plays an essential role in innate and adaptive immune responses. The innate immune system recognizes the presence of bacterial pathogens thro...  Read full blog post.

TLR7 and Immune Response Regulation
Toll-like receptor 7 (TLR7) is a protein encoded by the TLR7 gene in humans and is a member of TLR family. TLRs controls host immune response against pathogens (e.g. viruses, bacteria and fungi) through recognition of pathogen-associated molecular pat...  Read full blog post.

MYD88: Fanning Inflammation and Immune Responses
Myeloid differentiation primary response gene 88 (MYD88) encodes a cytosolic adapter protein that plays an essential role in innate and adaptive immune responses. MYD88 protein functions as an essential signal transducer in the interleukin-1 and in To...  Read full blog post.

MyD88 Antibodies for IL Signaling and Immunity Research
The myeloid differentiation protein MyD88 (myeloid differentiation primary response protein) was originally identified and characterized as a primary upregulated response gene in interleukin-6 mediated myeloid differentiation. Now, MyD88 is known to b...  Read full blog post.

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Bioinformatics

Gene Symbol MYD88
Entrez