The immunogen recognized by this antibody maps to a region between residue 1160 and the C-terminus (residue 1210) of human G9A (Euchromatic Histone-Lysine N-methyltransferase 2) using the numbering given in entry NP_006700.2 (GeneID 10919).
This antibody is useful for Western Blot Not recommended for Immunoprecipitation. While trace amounts of G9A/EHMT2 can be immunoprecipitated by this antibody, the efficiency is very low. Use in Rat reported in customer review.
Read 1 Review rated 3 using NB100-40825 in the following application:
histone-lysine N-methyltransferase, H3 lysine-9 specific 3
HLA-B associated transcript 8
Lysine N-methyltransferase 1C
G9A antibody contains ankyrin repeats, suggesting involvement in intracellular protein-protein interaction. G9A is a histone methyltransferase that preferentially methylates Lys-9 of histone H3 and Lys-27 of histone H3 (in vitro). H3 Lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. G9A is probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.