GLP/EHMT1 Antibody (B0422) [Unconjugated] Summary
Recombinant mouse GLP/EHMT1
This antibody specifically recognizes mouse GLP and cross-reacts with human GLP. Not yet tested in other species.
Test in a species/application not listed above to receive a full credit towards a future purchase.
Western Blot Immunohistochemistry Immunoprecipitation Direct ELISA
Packaging, Storage & Formulations
This antibody is stable for greater than six months when held at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
A liquid formulation in physiologic saline with 0.1% NaN
0.1% Sodium Azide
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for GLP/EHMT1 Antibody (B0422) [Unconjugated]
DEL9q34 EC 2.1.1.- EC 22.214.171.124 EHMT1 euchromatic histone-lysine N-methyltransferase 1H3-K9-HMTase 5 Eu-HMTase1 Eu-HMTase1DEL9q34 EUHMTASE1FP13812 FLJ12879 G9a-like protein 1 GLP GLP1 H3 lysine-9 specific 5 KIAA1876euchromatic histone methyltransferase 1 KMT1D KMT1DDKFZp667M072 Lysine N-methyltransferase 1D Background
Histone H3 Lys 9 (H3-K9) methylation is a crucial epigenetic marker for transcriptional silencing. G9a is the major mammalian H3-K9 methyltransferase that targets euchromatic regions and is essential for murine embryogenesis. There is a single G9a-related methyltransferase in mammals, called GLP/Eu-HMTase1.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
for 1 year from date of receipt.
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Publications for GLP/EHMT1 Antibody (PP-B0422-00)(9)
We have publications tested in 3 confirmed species: Human, Mouse, Rat.
We have publications tested in 4 applications: IHC, IHC - Not specified, IP, WB.
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Publications using PP-B0422-00
JJ Zylicz, M Borensztei, FC Wong, Y Huang, C Lee, S Dietmann, MA Surani G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst Elife, 2018;7(0):. 2018 [PMID: 29745895] (IHC,, Mouse) IHC
Shengjiang Tu Co-repressor CBFA2T2 regulates pluripotency and germline development Nature, 2016;534(7607):387-90. 2016 [PMID: 27281218] (IHC - Not specified,, Mouse) IHC - Not specified
Liu J, Magri L, Zhang F, Marsh N, Albrecht S, Huynh J, Kaur J, Kuhlmann T, Zhang W, Slesinger P, Casaccia P Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation. J Neurosci, 2015;35(1):352-65. 2015 [PMID: 25568127] (IP,, Rat) IP
Loh S, Ng W, Yeo K, Lim Y, Ea C Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatment. PLoS ONE, 2014;9(7):e103915. 2014 [PMID: 25079219] (WB,, Human) WB
Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, Zhang R, Krosl J, Yung E, Kirschner J, Rosten P, Underhill T, Jin J, Hebert J, Sauvageau G, Humphries R, Rossi F The methyltransferase G9a regulates HoxA9-dependent transcription in AML. Genes Dev, 2014;28(4):317-27. 2014 [PMID: 24532712] (WB,, Human) WB
Ea C, Hao S, Yeo K, Baltimore D EHMT1 protein binds to nuclear factor-kappaB p50 and represses gene expression. J Biol Chem, 2012;287(37):31207-17. 2012 [PMID: 22801426] (IP,, Human) IP
Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferre F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, Beroukhim R, Mermel CH, Loda M, Ait-Si-Ali S, Garraway LA, Young RA, Zon LI The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature, 2011;471(7339):513-7. 2011 [PMID: 21430779] (WB,, Human) WB
Schaefer A, Sampath SC, Intrator A Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron, 2009;64(5):678-91. 2009 [PMID: 20005824] (IHC - Not specified,, Mouse) IHC - Not specified
Dong K, Maksakova I, Mohn F, Leung D, Appanah R, Lee S, Yang H, Lam L, Mager D, Schubeler D, Tachibana M, Shinkai Y, Lorincz M DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J, 0;27(20):2691-701. 0 [PMID: 18818693] (WB,, Mouse) WB
GLP/EHMT1 Antibody (PP-B0422-00) (5)
Average Rating: 4.2
(Based on 5 reviews)
We have 5 reviews tested in 1 species: Human.
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Reviews using PP-B0422-00:
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Application Chromatin Immunoprecipitation Sample Tested B cells Species Human Lot A-2
Application Western Blot Sample Tested 293T Species Human Lot A-2
Application Immunocytochemistry Sample Tested Human Dermal Microvascular Endothelial cells - Paraformaldehyde fixed cells Species Human Lot A-2
Application Immunoprecipitation Sample Tested Human Dermal Microvascular Endothelial whole cell lysate Species Human Lot A-2
Application Western Blot Sample Tested Human Dermal Microvascular Endothelial whole cell lysate Species Human Lot A-2
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