FXR/NR1H4 Antibody [FITC]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
FITC

FXR/NR1H4 Antibody [FITC] Summary

Immunogen
A synthetic peptide made to the C-terminus of the human FXR protein. [UniProt# Q96RI1]
Localization
Cytoplasmic, nuclear
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NR1H4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
Application Notes
This FXR antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot analysis, where a band is seen at ~66 kDa. In ICC/IF nuclear and cytoplasmic staining was observed.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 29491146).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for FXR/NR1H4 Antibody [FITC]

  • BAR
  • bile acid receptor
  • farnesoid X receptor
  • Farnesoid X-activated receptor
  • Farnesol receptor HRR-1
  • FXR
  • FXRBAR
  • HRR-1
  • HRR1MGC163445
  • NR1H4
  • Nuclear receptor subfamily 1 group H member 4
  • nuclear receptor subfamily 1, group H, member 4
  • Retinoid X receptor-interacting protein 14
  • RIP14
  • RIP14RXR-interacting protein 14

Background

FXR (farnesoid X receptor; NR1H4) belongs to nuclear receptor superfamily of ligand-activated transcription factors (NR1 subfamily) and acts as a receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. FXR is mainly expressed in liver, intestine, kidney, and adrenal glands. FXR heterodimerizes with retinoid X receptor (RXR alpha/NR2B1), associates with FXREs (FXR response elements) that are usually but not exclusively inverted repeat-1 (IR-1), and regulates the transcription of its target genes. FXR interacts with CARM1, SMARD1 and after activation by agonist binding, it interacts with a coactivator, NCOA1 or NCOA2. FXR has been shown to repress transcription of CYP7A1 (cholesterol 7-alpha-hydroxylase gene) through induction of NR0B2 or FGF19 expression, via two distinct mechanisms. FXR activates the intestinal bile acid-binding protein (IBABP) and transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. Altogether, FXR is critical for maintaining a homeostasis in bile acid, cholesterol, lipoprotein, and triglyceride metabolism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for FXR/NR1H4 Antibody (NB400-153F) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NB400-153AF350
Alexa Fluor 405 NB400-153AF405
Alexa Fluor 488 NB400-153AF488
Alexa Fluor 532 NB400-153AF532
Alexa Fluor 594 NB400-153AF594
Alexa Fluor 647 NB400-153AF647
Alexa Fluor 700 NB400-153AF700
Alexa Fluor 750 NB400-153AF750
Biotin NB400-153B
DyLight 350 NB400-153UV
DyLight 405 NB400-153V
DyLight 488 NB400-153G
DyLight 550 NB400-153R
DyLight 594 NB400-153DL594
DyLight 650 NB400-153C
DyLight 680 NB400-153FR
DyLight 755 NB400-153IR
FITC NB400-153F
HRP NB400-153H
Janelia Fluor 549 NB400-153JF549
Janelia Fluor 646 NB400-153JF646

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Bioinformatics Tool for FXR/NR1H4 Antibody (NB400-153F)

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Bioinformatics

Gene Symbol NR1H4