This antibody is stable for greater than six months when stored at -20 °C in a
manual defrost freezer or at -70 °C. Upon thawing, the antibody can be
stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid
repeated freeze-thaw cycles.
A liquid formulation in physiologic saline with 0.1% NaN3.
0.1% Sodium Azide
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for PXR/NR1I2 Antibody (H4417) [Unconjugated]
nuclear receptor subfamily 1 group I member 2
nuclear receptor subfamily 1, group I, member 2
Orphan nuclear receptor PAR1
Orphan nuclear receptor PXR
Pregnane X receptor
Steroid and xenobiotic receptor
Pregnane X Receptor (PXR; also known as SXR and NR1I2) is a 50 kDa
member of the Nuclear Receptor (NR1) subfamily of the Nuclear Hormone
Receptor family. It is a product of the PXR gene that gives rise to two basic
isoforms; a 434 amino acid (aa) PXR1 form and 473 aa PXR2 form. PXR2
differs from PXR1 in that PXR2 contains a 39 aa N-terminal extension. Six
PXR1 isoforms have been reported (Swiss Protein Accession # 075469). The
anti-human PXR antibody recognizes all isoforms except the "B" isoforms
which show a deletion of amino acids 1 - 55 (MEVRP...FNVM). PXR forms a
heterodimer with Retinoid X Receptor (RXR) and binds pregnanolone.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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