Home » PXR/NR1I2 » PXR/NR1I2 Antibodies » PXR/NR1I2 Antibody (H4417) [Unconjugated]

PXR/NR1I2 Antibody (H4417) [Unconjugated]

 (1 Publication)
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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP, ELISA
Clone
H4417
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Suitable Sample Type
23015

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PXR/NR1I2 Antibody (H4417) [Unconjugated] Summary

Immunogen
Recombinant human PXR/NR1I2
Specificity
This antibody specifically recognizes human PXR1 and human PXR2. Not yet tested in other species.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
NR1I2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Direct ELISA
  • Immunoprecipitation
  • Western Blot
Publications
Read Publication using
PP-H4417-00 in the following applications:

  • ICC
    1 publication

Packaging, Storage & Formulations

Storage
This antibody is stable for greater than six months when stored at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Buffer
A liquid formulation in physiologic saline with 0.1% NaN3.
Preservative
0.1% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PXR/NR1I2 Antibody (H4417) [Unconjugated]

  • BXR
  • NR1I2
  • nuclear receptor subfamily 1 group I member 2
  • nuclear receptor subfamily 1, group I, member 2
  • ONR1
  • Orphan nuclear receptor PAR1
  • Orphan nuclear receptor PXR
  • PAR
  • PAR1
  • PAR2
  • Pregnane X receptor
  • PRR
  • PXR
  • PXRPARq
  • SAR
  • Steroid and xenobiotic receptor
  • SXR
  • SXRBXR

Background

Pregnane X Receptor (PXR; also known as SXR and NR1I2) is a 50 kDa member of the Nuclear Receptor (NR1) subfamily of the Nuclear Hormone Receptor family. It is a product of the PXR gene that gives rise to two basic isoforms; a 434 amino acid (aa) PXR1 form and 473 aa PXR2 form. PXR2 differs from PXR1 in that PXR2 contains a 39 aa N-terminal extension. Six PXR1 isoforms have been reported (Swiss Protein Accession # 075469). The anti-human PXR antibody recognizes all isoforms except the "B" isoforms which show a deletion of amino acids 1 - 55 (MEVRP...FNVM). PXR forms a heterodimer with Retinoid X Receptor (RXR) and binds pregnanolone.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PXR/NR1I2 Antibody (PP-H4417-00)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC.


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Bioinformatics

Gene Symbol NR1I2