CAR/NR1I3 Antibody (N4111)


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Product Details

Reactivity HuSpecies Glossary
Applications WB, IHC, IP

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CAR/NR1I3 Antibody (N4111) Summary

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  • Immunohistochemistry
  • Immunoprecipitation
  • Western Blot
Read Publications using
PP-N4111-00 in the following applications:

Packaging, Storage & Formulations

Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
A liquid formulation in physiologic saline with 0.1% NaN3.
0.1% Sodium Azide


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CAR/NR1I3 Antibody (N4111)

  • CAR
  • Constitutive activator of retinoid response
  • constitutive active receptor
  • Constitutive active response
  • Constitutive androstane receptor
  • MB67
  • MGC150433
  • MGC97144
  • MGC97209
  • NR1I3
  • nuclear receptor subfamily 1 group I member 3
  • nuclear receptor subfamily 1, group I, member 3
  • orphan nuclear hormone receptor
  • Orphan nuclear receptor MB67


CAR, (MB67; NR1I3) is a 40 kDa member of the NR1 subfamily of the nuclear hormone receptor family. CAR is predominantly expressed in the liver and forms a heterodimer with RXR. The CAR/RXR heterodimer activates retinoic acid, xenobiotic and phenobarbital response elements. There are two isoforms of the CAR nuclear hormone receptor. Each contains a DNA-binding hinge and dimerization domain. One is full-length at 352 amino acids while the other shows a 4 amino acid truncation at the extreme C-terminus.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CAR/NR1I3 Antibody (PP-N4111-00)(8)

We have publications tested in 4 confirmed species: Human, Mouse, Primate - Chlorocebus aethiops (African Green Monkey), Rabbit.

We have publications tested in 5 applications: ChIP, ICC, IHC, IHC-P, Western Blot.

Filter By Application
Western Blot
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Primate - Chlorocebus aethiops (African Green Monkey)
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Showing Publications 1 - 8 of 8.
Publications using PP-N4111-00 Applications Species
MN Bwayi, E Garcia-Mal, SC Chai, B Xie, S Chodankar, AD Huber, J Wu, K Annu, WC Wright, HM Lee, J Seetharama, J Wang, CD Buchman, J Peng, T Chen Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation Nucleic Acids Research, 2022-04-08;0(0):. 2022-04-08 [PMID: 35212371] (Western Blot, Human) Western Blot Human
C Pan, J Kang, JS Hwang, J Li, AC Boese, X Wang, L Yang, TJ Boggon, GZ Chen, NF Saba, DM Shin, KR Magliocca, L Jin, S Kang Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1 Nature Communications, 2021-08-16;12(1):4960. 2021-08-16 [PMID: 34400618] (ICC, IHC, Human) ICC, IHC Human
Impaired Hepatic Adaptation to Chronic Cholestasis induced by Primary Sclerosing Cholangitis Sci Rep, 2016-12-23;6(0):39573. 2016-12-23 [PMID: 28008998] (Western Blot, Human) Western Blot Human
Chen , Tao, Laurenzana , Elizabet, Coslo , Denise M, Chen , Fengming, Omiecinski , Curtis J Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor. Biochem J, 2014-02-15;458(1):95-107. 2014-02-15 [PMID: 24224465] (Western Blot, Primate - Chlorocebus aethiops (African Green Monkey)) Western Blot Primate - Chlorocebus aethiops (African Green Monkey)
Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases. Mol Endocrinol, 2012-12-04;27(1):106-15. 2012-12-04 [PMID: 23211525] (ChIP, Human) ChIP Human
Mebis L, Eerdekens A, Guiza F, Princen L, Derde S, Vanwijngaerden YM, Vanhorebeek I, Darras VM, Van den Berghe G, Langouche L Contribution of nutritional deficit to the pathogenesis of the nonthyroidal illness syndrome in critical illness: a rabbit model study. Endocrinology, 2011-12-13;153(2):973-84. 2011-12-13 [PMID: 22166982] (IHC-P, Rabbit) IHC-P Rabbit
Sueyoshi T, Green WD, Vinal K, Woodrum TS, Moore R, Negishi M Garlic Extract Diallyl Sulfide (DAS) Activates Nuclear Receptor CAR to Induce the Sult1e1 Gene in Mouse Liver. PLoS ONE, 2011-06-15;6(6):e21229. 2011-06-15 [PMID: 21698271] (Western Blot, Mouse) Western Blot Mouse
Surapureddi S, Rana R, Reddy JK, Goldstein JA Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha. Mol. Pharmacol., 2008-06-13;74(3):913-23. 2008-06-13 [PMID: 18552123] (ChIP, Western Blot, Human) ChIP, Western Blot Human

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Gene Symbol NR1I3