CAR/NR1I3 Antibody (N4111)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IP
Clone
N4111
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

CAR/NR1I3 Antibody (N4111) Summary

Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
NR1I3
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry
  • Immunoprecipitation
Publications
Read Publications using
PP-N4111-00 in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Buffer
A liquid formulation in physiologic saline with 0.1% NaN3.
Preservative
0.1% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CAR/NR1I3 Antibody (N4111)

  • CAR
  • CARCAR1
  • Constitutive activator of retinoid response
  • constitutive active receptor
  • Constitutive active response
  • Constitutive androstane receptor
  • MB67
  • MGC150433
  • MGC97144
  • MGC97209
  • NR1I3
  • nuclear receptor subfamily 1 group I member 3
  • nuclear receptor subfamily 1, group I, member 3
  • orphan nuclear hormone receptor
  • Orphan nuclear receptor MB67

Background

CAR, (MB67; NR1I3) is a 40 kDa member of the NR1 subfamily of the nuclear hormone receptor family. CAR is predominantly expressed in the liver and forms a heterodimer with RXR. The CAR/RXR heterodimer activates retinoic acid, xenobiotic and phenobarbital response elements. There are two isoforms of the CAR nuclear hormone receptor. Each contains a DNA-binding hinge and dimerization domain. One is full-length at 352 amino acids while the other shows a 4 amino acid truncation at the extreme C-terminus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CAR/NR1I3 Antibody (PP-N4111-00)(6)

We have publications tested in 4 confirmed species: Human, Mouse, Primate - Chlorocebus aethiops (African Green Monkey), Rabbit.

We have publications tested in 3 applications: ChIP, IHC Paraffin-embedded, WB.


Filter By Application
ChIP
(2)
IHC Paraffin-embedded
(1)
WB
(3)
All Applications
Filter By Species
Human
(3)
Mouse
(1)
Primate - Chlorocebus aethiops (African Green Monkey)
(1)
Rabbit
(1)
All Species
Showing Publications 1 - 6 of 6.
Publications using PP-N4111-00 Applications Species
Impaired Hepatic Adaptation to Chronic Cholestasis induced by Primary Sclerosing Cholangitis Sci Rep, 2016;6(0):39573. 2016 [PMID: 28008998] (WB,, Human) WB Human
Chen, Tao, Laurenzana, Elizabet, Coslo, Denise M, Chen, Fengming, Omiecinski, Curtis J Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor. Biochem J, 2014;458(1):95-107. 2014 [PMID: 24224465] (WB,, Primate - Chlorocebus aethiops (African Green Monkey)) WB Primate - Chlorocebus aethiops (African Green Monkey)
Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases. Mol Endocrinol, 2013;27(1):106-15. 2013 [PMID: 23211525] (ChIP,, Human) ChIP Human
Mebis L, Eerdekens A, Guiza F, Princen L, Derde S, Vanwijngaerden YM, Vanhorebeek I, Darras VM, Van den Berghe G, Langouche L Contribution of nutritional deficit to the pathogenesis of the nonthyroidal illness syndrome in critical illness: a rabbit model study. Endocrinology, 2012;153(2):973-84. 2012 [PMID: 22166982] (IHC Paraffin-embedded,, Rabbit) IHC Paraffin-embedded Rabbit
Sueyoshi T, Green WD, Vinal K, Woodrum TS, Moore R, Negishi M Garlic Extract Diallyl Sulfide (DAS) Activates Nuclear Receptor CAR to Induce the Sult1e1 Gene in Mouse Liver. PLoS ONE, 2011;6(6):e21229. 2011 [PMID: 21698271] (WB,, Mouse) WB Mouse
Surapureddi S, Rana R, Reddy JK, Goldstein JA Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha. Mol. Pharmacol., 2008;74(3):913-23. 2008 [PMID: 18552123] (ChIP,, Human) ChIP Human

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for CAR/NR1I3 Antibody (PP-N4111-00) (0)

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Secondary Antibodies

 

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Diseases for CAR/NR1I3 Antibody (PP-N4111-00)

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PTMs for CAR/NR1I3 Antibody (PP-N4111-00)

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Bioinformatics

Gene Symbol NR1I3