SHP/NR0B2/Nuclear Receptor SHP Antibody

Images

 
Immunohistochemistry-Paraffin: SHP/NR0B2/Nuclear Receptor SHP Antibody [NLS5411] - Breast, carcinoma
Immunohistochemistry-Paraffin: SHP/NR0B2/Nuclear Receptor SHP Antibody [NLS5411] - Analysis of anti-NR0B2 antibody with human liver, hepatocytes.
Immunohistochemistry-Paraffin: SHP/NR0B2/Nuclear Receptor SHP Antibody [NLS5411] - Pancreas, carcinoma
Immunohistochemistry-Paraffin: SHP/NR0B2/Nuclear Receptor SHP Antibody [NLS5411] - Ovary, carcinoma

Product Details

Summary
Reactivity Hu, Mu, Rt, Ha, Pm, Pm, Rb, Bt, BvSpecies Glossary
Applications ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

SHP/NR0B2/Nuclear Receptor SHP Antibody Summary

Immunogen
Synthetic 16 amino acid peptide from ligand-binding domain of human NR0B2.
Specificity
Human NR0B2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Bat (94%), Bovine (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NR0B2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 4 ug/ml
Control
SHP/NR0B2/Nuclear Receptor SHP Overexpression Lysate
Publications
Read Publications using
NLS5411 in the following applications:

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 18586688). Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Equine (88%), Porcine (88%), Opossum (88%), Canine (81%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SHP/NR0B2/Nuclear Receptor SHP Antibody

  • FLJ17090
  • NR0B2
  • nuclear receptor subfamily 0 group B member 2
  • nuclear receptor subfamily 0, group B, member 2
  • Orphan nuclear receptor SHP
  • SHP
  • SHPSHP1
  • Small heterodimer partner

Background

SHP (short heterodimer partner) is a bile acid-dependent orphan NR0 Knirps-Like receptor with dimerization and ligand-binding domains but not the conventional DNA-binding domain. SHP has been shown to inhibit the transcriptional activity of other nuclear receptors, including thyroid hormone receptor, constitutive androstane receptor, and retinoic acid receptors. SHP affects hepatic cholesterol catabolism based on a two-step mechanism dependent on both coactivator competition and direct transcriptional repression by mediating the repression of CYP7A1, the rate-limiting enzyme for bile acid synthesis. Mutations in the SHP gene contribute to increased body weight, indicating a possible role of SHP in the development of early-onset diabetes (maturity-onset diabetes of the young, MODY). Loss of SHP in mice caused abnormal accumulation and increased synthesis of bile acids due to derepression of rate-limiting CYP7A1 and CYP8B1 hydroxylase enzymes in the biosynthetic pathway. SHP expression has been documented in human liver, adrenal, spleen, and pancreas. ESTs have been isolated from cancerous human kidney, lung, and stomach, as well as normal human heart, kidney, liver, and liver/spleen. Caution: The nuclear receptor SHP should not be confused with the tyrosine phosphatases SHP-1 and SHP-2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NB400-153
Species: Hu, Mu
Applications: WB, ICC/IF
MAB9120
Species: Hu
Applications: ICC
NBP2-67321
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
NBP2-27196
Species: Hu, Mu, Rt, Po, Bv, Ca, Ch, ChHa, Eq, Gp, Ma-Op, Pm, Rb, RM, Ze
Applications: WB, IHC, IHC-P, KD
NBP2-37454
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P, CyTOF-ready
NBP1-89319
Species: Hu
Applications: IHC, IHC-P
NBP2-61816
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF
AF2685
Species: Hu
Applications: WB, Simple Western, IHC
NBP1-89679
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
NBP2-34260
Species: Hu, Mu, Po, Bv, Rb
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
NBP1-82441
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
PP-N4111-00
Species: Hu
Applications: WB, IHC, IP
NBP1-52823
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
NBP1-80533
Species: Hu, Mu
Applications: WB
PP-H7431-00
Species: Hu
Applications: WB
NBP2-22106
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P, IP
NBP1-68884
Species: Hu
Applications: WB
NB600-582
Species: Hu, Mu, Rt, Ca, Ch, SyHa, Ha, Pm
Applications: WB, Simple Western, IHC, KO
PP-H6812-00
Species: Hu
Applications: WB, IHC, IP, DirELISA
NLS5411
Species: Hu, Mu, Rt, Ha, Pm, Pm, Rb, Bt, Bv
Applications: ICC/IF, IHC, IHC-P

Publications for SHP/NR0B2/Nuclear Receptor SHP Antibody (NLS5411)(2)

Reviews for SHP/NR0B2/Nuclear Receptor SHP Antibody (NLS5411) (0)

There are no reviews for SHP/NR0B2/Nuclear Receptor SHP Antibody (NLS5411). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

View specific protocols for SHP/NR0B2/Nuclear Receptor SHP Antibody (NLS5411): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for SHP/NR0B2/Nuclear Receptor SHP Antibody (NLS5411) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Additional SHP/NR0B2/Nuclear Receptor SHP Products

Bioinformatics Tool for SHP/NR0B2/Nuclear Receptor SHP Antibody (NLS5411)

Discover related pathways, diseases and genes to SHP/NR0B2/Nuclear Receptor SHP Antibody (NLS5411). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for SHP/NR0B2/Nuclear Receptor SHP Antibody (NLS5411)

Discover more about diseases related to SHP/NR0B2/Nuclear Receptor SHP Antibody (NLS5411).
 

Pathways for SHP/NR0B2/Nuclear Receptor SHP Antibody (NLS5411)

View related products by pathway.

PTMs for SHP/NR0B2/Nuclear Receptor SHP Antibody (NLS5411)

Learn more about PTMs related to SHP/NR0B2/Nuclear Receptor SHP Antibody (NLS5411).
 

Research Areas for SHP/NR0B2/Nuclear Receptor SHP Antibody (NLS5411)

Find related products by research area.

Blogs on SHP/NR0B2/Nuclear Receptor SHP

There are no specific blogs for SHP/NR0B2/Nuclear Receptor SHP, but you can read our latest blog posts.
Coronavirus Brochure

Customers Who Bought This Also Bought

Contact Information

Learn the difference between western blot and simple western

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our SHP/NR0B2/Nuclear Receptor SHP Antibody and receive a gift card or discount.

Bioinformatics

Gene Symbol NR0B2
Entrez
Uniprot