Human FGF-19 Quantikine ELISA Kit



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Reactivity HuSpecies Glossary
Applications ELISA

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Human FGF-19 Quantikine ELISA Kit Summary

The Quantikine Human FGF-19 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human FGF-19 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human FGF-19 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human FGF-19 showed linear curves that were parallel to the standard curves obt...ained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human FGF-19.
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Natural and recombinant human FGF-19
Assay Type
Solid Phase Sandwich ELISA
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details


Application Notes
No significant interference observed with available related molecules.
Read Publications using DF1900.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human FGF-19 Quantikine ELISA Kit

  • FGF19
  • FGF-19
  • fibroblast growth factor 19


The Fibroblast Growth Factor (FGF) family consists of at least 22 highly conserved proteins and are found in many species ranging from C. elegans and Drosophila to humans (1). FGFs are heparin-binding growth factors with a core 120 amino acid (aa) FGF domain that allows for a common tertiary structure. In general, FGFs are expressed during embryonic development and in restricted adult tissues. They act on cells of mesodermal and neuroectodermal origin to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, metabolic regulation, cell migration, neurotrophic effects, and tissue repair (2). The activities of the FGF family are mediated by four receptors, FGF R1 through FGF R4 (2). The receptors are transmembrane proteins with a tyrosine kinase domain and are thought to act as classical receptor tyrosine kinases. FGF R5/FGF RL1 has also been described, but lacks the kinase domain and signaling capability (3). 
Human FGF-19 cDNA predicts a 251 aa precursor protein with a 22 aa signal peptide and a 229 aa secreted mature protein with no potential N-linked glycosylation sites (4, 5). It shares approximately 50% aa sequence identity with mouse and rat FGF-15 and 62% aa sequence identity with chicken FGF-19 (4-6). Unlike most FGFs, which bind to and activate more than one FGF receptor, FGF-19 appears to bind only FGF R4 (5). Receptor binding is capable of activating MAP Kinase and inducing the Prolactin promoter (7). FGF-19 has two putative disulfide bonds, one of which is conserved in the FGF family (8). Uniquely, it also has an extended loop structure that may affect heparan sulfate binding (8). 
The functional roles of FGF-19 continue to be elucidated and include developmental, metabolic, and tumorigenic activities. During chick embryogenesis, FGF-19 has been shown to act synergistically with Wnt-8c to initiate inner ear development (6). However, the mouse FGF-19 ortholog, FGF-15, is not required for this activity (9). FGF-19 is also expressed in the embryonic chicken eye where it may play a role in lens development (10). Questions regarding the functions of human FGF-19 have been addressed using ectopic expression. Transgenic over-expression of human FGF-19 in mice results in tumor formation, increased energy expenditure, decreased adiposity, and a resistance to weight gain in response to a high fat diet (11, 12). Similar affects have been observed in mice treated intravenously with recombinant FGF-19 (13).

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to

Publications for FGF-19 (DF1900)(33)

We have publications tested in 1 confirmed species: Human.

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Showing Publications 1 - 10 of 33. Show All 33 Publications.
Publications using DF1900 Applications Species
Goralska, J;Razny, U;Gruca, A;Zdzienicka, A;Micek, A;Dembinska-Kiec, A;Solnica, B;Malczewska-Malec, M; Plasma Cytokeratin-18 Fragment Level Reflects the Metabolic Phenotype in Obesity Biomolecules 2023-04-14 [PMID: 37189422] (Human) Human
RO Ali, GM Quinn, R Umarova, JA Haddad, GY Zhang, EC Townsend, L Scheuing, KL Hill, M Gewirtz, S Rampertaap, SD Rosenzweig, AT Remaley, JM Han, V Periwal, H Cai, PJ Walter, C Koh, EB Levy, DE Kleiner, O Etzion, T Heller Longitudinal multi-omics analyses of the gut-liver axis reveals metabolic dysregulation in hepatitis C infection and cirrhosis Nature Microbiology, 2022-12-15;0(0):. 2022-12-15 [PMID: 36522461] (Human) Human
X Yuan, R Wang, B Han, C Sun, R Chen, H Wei, L Chen, H Du, G Li, Y Yang, X Chen, L Cui, Z Xu, J Fu, J Wu, W Gu, Z Chen, X Fang, H Yang, Z Su, J Wu, Q Li, M Zhang, Y Zhou, L Zhang, G Ji, F Luo Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes Nature Communications, 2022-10-26;13(1):6356. 2022-10-26 [PMID: 36289225] (Human) Human
S Sydor, C Dandyk, J Schwerdt, P Manka, D Benndorf, T Lehmann, K Schallert, M Wolf, U Reichl, A Canbay, LP Bechmann, R Heyer Discovering Biomarkers for Non-Alcoholic Steatohepatitis Patients with and without Hepatocellular Carcinoma Using Fecal Metaproteomics International Journal of Molecular Sciences, 2022-08-09;23(16):. 2022-08-09 [PMID: 36012106] (Human) Human
JY Guo, HH Chen, WJ Lee, SC Chen, SD Lee, CY Chen Fibroblast Growth Factor 19 and Fibroblast Growth Factor 21 Regulation in Obese Diabetics, and Non-Alcoholic Fatty Liver Disease after Gastric Bypass Nutrients, 2022-02-02;14(3):. 2022-02-02 [PMID: 35277004] (Human) Human
N Memon, CW Lee, A Herdt, BI Weinberger, T Hegyi, MO Carayannop, LM Aleksunes, GL Guo, IJ Griffin Suppression of Bile Acid Synthesis in a Preterm Infant Receiving Prolonged Parenteral Nutrition Journal of clinical and experimental hepatology, 2021-04-13;12(1):200-203. 2021-04-13 [PMID: 35068799] (Human) Human
J Wang, H Zhao, L Zheng, Y Zhou, L Wu, Y Xu, X Zhang, G Yan, H Sheng, R Xin, L Jiang, J Lei, J Zhang, Y Chen, J Peng, Q Chen, S Yang, K Yu, D Li, Q Xie, Y Li FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells Theranostics, 2021-03-05;11(10):5045-5060. 2021-03-05 [PMID: 33754043] (Human) Human
F Mao, MX Wang, X Hou, Z Zhou, YY Yan, LJ Fang, Z Tan, WY Fang, T Liu, W He, C Li, XB Xie, SQ Lu, J Sui, F Wang, L Han, JS Wang, W Li NTCP Deficiency Causes Gallbladder Abnormalities in Mouse and Human Beings Cell Mol Gastroenterol Hepatol, 2020-09-09;0(0):. 2020-09-09 [PMID: 32919083] (Human) Human
A Wilson, Q Wang, AA Almousa, LE Jansen, YH Choi, UI Schwarz, RB Kim Genetic variation in the farnesoid X-receptor predicts Crohn's disease severity in female patients Sci Rep, 2020-07-16;10(1):11725. 2020-07-16 [PMID: 32678214] (Human) Human
WS Liu, MJ Tang, TL Xu, JB Su, XQ Wang, F Xu, DM Zhang, Q Zhu, J Cao, H Wang Association of serum fibroblast growth factor 19 levels with arteriosclerosis parameters assessed by arterial stiffness and atherogenic index of plasma in patients with type 2 diabetes Diabetol Metab Syndr, 2020-05-20;12(0):44. 2020-05-20 [PMID: 32477430] (Human) Human
Show All 33 Publications.

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Gene Symbol FGF19