WB, IHC, IP, DirELISAHost:
WB, ELISA, ICC/IF, S-ELISAHost:
Applications: WB, ELISA, PA
FXR and LXR fall into a category of proteins termed orphan receptors; because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid. The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, as well as several novel receptors including LXR (also referred to as RLD-1) and FXR.
|Product By Gene ID
- Nuclear receptor subfamily 1 group H member 4
- Farnesol receptor HRR-1
- farnesoid X receptor
- Farnesoid X-activated receptor
- bile acid receptor
- RIP14RXR-interacting protein 14
- Retinoid X receptor-interacting protein 14
- nuclear receptor subfamily 1, group H, member 4
Bioinformatics Tool for FXR/NR1H4
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