FXR/NR1H4 Products

Description

FXR and LXR fall into a category of proteins termed orphan receptors; because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid. The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, as well as several novel receptors including LXR (also referred to as RLD-1) and FXR.

Bioinformatics

Entrez	20186 Mouse 9971 Human
Uniprot	B6ZGS9 Human NM_005123 Human NP_005114 Human NP_005114.1 Human Q60641 Mouse Q96RI1 Human
Product By Gene ID	9971
Alternate Names	bile acid receptor farnesoid X receptor Farnesoid X-activated receptor Farnesol receptor HRR-1 FXRBAR HRR-1 HRR1MGC163445 Nuclear receptor subfamily 1 group H member 4 nuclear receptor subfamily 1, group H, member 4 Retinoid X receptor-interacting protein 14 RIP14RXR-interacting protein 14

Diseases related to FXR/NR1H4

Discover more about diseases related to FXR/NR1H4.

Inflammation
Obesity
Liver Carcinoma
Cholestasis
Liver Diseases
Insulin Resistance
Cholecystolithiasis
Carcinoma
Malignant Neoplasms
Neoplasms
Fatty Liver
Intrahepatic Cholestasis
Diabetes Mellitus
Atherosclerosis
Cholangiocarcinoma
Dyslipidemias
Neoplasm Metastasis
Drug-induced Liver Injury
Injury To Liver
Hepatotoxicity

Pathways for FXR/NR1H4

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Transport
Lipid Homeostasis
Pathogenesis
Cholesterol Homeostasis
Secretion
Glucose Homeostasis
Cell Proliferation
Energy Homeostasis
Regeneration
Excretion
Intestinal Absorption
Reverse Transcription
Cell Cycle
Cholesterol Transport
Insulin Secretion
Dna Repair
Cell Death
Reverse Cholesterol Transport
Cell Activation
Cell Migration

Research Areas for FXR/NR1H4

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Cancer
Chromatin Research
Lipid and Metabolism
Signal Transduction

PTMs for FXR/NR1H4

Learn more about PTMs related to FXR/NR1H4.

Phosphorylation
Amidation
Oxidation

Bioinformatics Tool for FXR/NR1H4

Discover related pathways, diseases and genes to FXR/NR1H4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.