FXR/NR1H4 Products

Antibodies
Lysates
FXR/NR1H4 Overexpression Lysa ...
FXR/NR1H4 Overexpression Lysate
NBL1-13769
Species: Hu
Applications: WB
Proteins
FXR/NR1H4 Antibody Blocking P ...
FXR/NR1H4 Antibody Blocking Peptide
NB400-153PEP
Species: Hu
Applications: AC
Recombinant Human FXR/NR1H4 G ...
Recombinant Human FXR/NR1H4 GST (N...
H00009971-Q01
Species: Hu
Applications: WB, ELISA, MA, AP

Description

FXR and LXR fall into a category of proteins termed orphan receptors; because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid. The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, as well as several novel receptors including LXR (also referred to as RLD-1) and FXR.

Bioinformatics

Entrez Mouse
Human
Uniprot Human
Human
Human
Human
Mouse
Human
Product By Gene ID 9971
Alternate Names
  • bile acid receptor
  • farnesoid X receptor
  • Farnesoid X-activated receptor
  • Farnesol receptor HRR-1
  • FXRBAR
  • HRR-1
  • HRR1MGC163445
  • Nuclear receptor subfamily 1 group H member 4
  • nuclear receptor subfamily 1, group H, member 4
  • Retinoid X receptor-interacting protein 14
  • RIP14RXR-interacting protein 14

Research Areas for FXR/NR1H4

Find related products by research area and learn more about each of the different research areas below.

Cancer
Chromatin Research
Lipid and Metabolism
Signal Transduction

PTMs for FXR/NR1H4

Learn more about PTMs related to FXR/NR1H4.

Phosphorylation
Amidation
Oxidation

Bioinformatics Tool for FXR/NR1H4

Discover related pathways, diseases and genes to FXR/NR1H4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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