Orthogonal Strategies: Immunohistochemistry-Paraffin: ABCB11 Antibody [NBP1-89319] - Staining in human liver and skeletal muscle tissues . Corresponding ABCB11 RNA-seq data are presented for the same tissues.
Immunohistochemistry: ABCB11 Antibody [NBP1-89319] - Histopathology of ABCB11 disease. (a) Giant-cell hepatitis (arrows) with hepatocanalicular cholestasis and (b) complete absence of ABCB11/BSEP protein are typical ...read more
Immunohistochemistry-Paraffin: ABCB11 Antibody [NBP1-89319] - Staining of human liver shows moderate to strong membranous positivity in bile canaliculi.
Immunohistochemistry-Paraffin: ABCB11 Antibody [NBP1-89319] - Staining of human skeletal muscle shows no membranous positivity in myocytes as expected.
Immunohistochemistry-Paraffin: ABCB11 Antibody [NBP1-89319] - Staining of human endometrium shows no positivity in glandular cells as expected.
Immunohistochemistry-Paraffin: ABCB11 Antibody [NBP1-89319] - Staining of human prostate shows no positivity in glandular cells as expected.
This antibody was developed against Recombinant Protein corresponding to amino acids: RLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILK
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Reactivity reported in scientific literature (PMID: 24614073)
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.2) and 40% Glycerol
0.02% Sodium Azide
Immunogen affinity purified
Alternate Names for ABCB11 Antibody
ABC member 16, MDR/TAP subfamily
ATP-binding cassette sub-family B member 11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
bile salt export pump
progressive familial intrahepatic cholestasis 2
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. (provided by RefSeq)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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