This antibody is stable for greater than six months when held at -20 °C in a
manual defrost freezer or at -70 °C. Upon thawing, the antibody can be
stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid
repeated freeze-thaw cycles.
A liquid formulation in
physiologic saline with
0.1% Sodium Azide
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for FXR/NR1H4 Antibody (A9033A) [Unconjugated]
bile acid receptor
farnesoid X receptor
Farnesoid X-activated receptor
Farnesol receptor HRR-1
Nuclear receptor subfamily 1 group H member 4
nuclear receptor subfamily 1, group H, member 4
Retinoid X receptor-interacting protein 14
RIP14RXR-interacting protein 14
Farnesoid X-activated Receptor (FXR, HRR-1, BAR, RIP14; NR1H4) is a
member of the Orphan Nuclear Receptor family. FXR is expressed in the liver,
intestinal villi, renal tubes and adrenal cortex. FXR is a global regulator of bile
acid metabolism. Two genes, cholesterol 7a-hydroxylase (CYP7A1) and
IBABP (Ileal Bile Acid Binding Protein), which are implicated in bile acid
biosynthesis and recycling, respectively, are target genes of FXR. FXR is
shown to be transcriptionally activated by farnesol metabolites such as
farnesol itself and juvenile hormone III. FXR binds to DNA only as a
heterodimer with Retinoid X Receptor (RXR).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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