CD68/SR-D1 Antibody (KP1)


Immunohistochemistry-Paraffin: CD68/SR-D1 Antibody (KP1) [NB100-683] - Analysis of a formalin fixed paraffin embedded human spleen tissue section using 1:10 dilution of CD68/SR-D1 antibody (clone KP1) with HRP-DAB more

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP

Order Details

CD68/SR-D1 Antibody (KP1) Summary

Subcellular fraction of human alveolar macrophages.
Cell membrane
Macrophage Marker
This is specific to macrophages in a wide variety of human tissues. It reacts with myeloid precursors and peripheral blood granulocytes. It also stains a cell population known as Plasmacytoid T cells.
IgG1 Kappa
Tissue culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 1:100
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry 1:10-1:200
  • Immunohistochemistry-Frozen 1:10-1:200
  • Immunohistochemistry-Paraffin 1:10-1:200
  • Immunoprecipitation
Application Notes
This CD68 Antibody (KP1) is useful for Immunohistochemistry on frozen fixed and paraffin-emdedded sections, Immunoprecipitation, Western blot and ICC/IF. IHC: For an ABC system, dilute 1:20 and incubate for 30-60 minutes at RT. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Use in Flow Cytometry reported in scientific literature (PMID 18405323)
CD68/SR-D1 Lysate (NBL1-08962)
CD68/SR-D1 Lysate (NBP2-64803)
Read Publications using
NB100-683 in the following applications:

  • 2 publications
  • 4 publications
  • IHC
    14 publications
  • 6 publications
  • WB
    2 publications

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 25058444)

Packaging, Storage & Formulations

Store at 4C. Do not freeze.
Tissue culture supernatant
0.1% Sodium Azide
Tissue culture supernatant

Alternate Names for CD68/SR-D1 Antibody (KP1)

  • CD68 antigenmacrophage antigen CD68
  • CD68 molecule
  • CD68
  • DKFZp686M18236
  • gp110
  • Macrosialin
  • SCARD1
  • scavenger receptor class D, member 1
  • SRD1
  • SR-D1


CD68, also known as GP110, LAMP4, and SCARD1, encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissues. CD68 is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family and favors binding to lectins through its heavily glycosylated extracellular domain. Furthermore, CD68 has also been found to be a member of the scavenger receptor family, whose main purpose is to clear cellular debris and regulate phagocytosis and macrophage recruitment. Recent studies have investigated the role of tumor related macrophages using CD68 as a probe (PMID: 22931216), as well as their involvement in the progression of other cancers (PMID: 21113139).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu
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Species: Hu, Mu, Rt, Bv
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Species: Hu, Mu
Applications: IHC
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Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, Single Cell Western

Publications for CD68/SR-D1 Antibody (NB100-683)(34)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 5 applications: FLOW, ICC/IF, IHC, IHC-P, WB.

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Showing Publications 1 - 10 of 34. Show All 34 Publications.
Publications using NB100-683 Applications Species
Ao JY, Zhu XD, Chai ZT et al. Colony-stimulating factor 1 receptor blockade inhibits tumor growth by altering the polarization of tumor-associated macrophages in hepatocellular carcinoma. Mol. Cancer Ther. 2017 Jun 01 [PMID: 28572167] (IHC-P, Mouse) IHC-P Mouse
Ayari H, Legedz L, Lantelme P et al. Auto-amplification of cortisol actions in human carotid atheroma is linked to arterial remodeling and stroke Fundamental & Clinical Pharmacology 2012 Jul 20 (IHC, Human) IHC Human
Liu X, Guo X, Li J et al. Interferon-gamma Aggravated L-Arginine-Induced Acute Pancreatitis in Sprague-Dawley Rats and Its Possible Mechanism: Trypsinogen Activation and Autophagy Up-regulation. Pancreas. Apr 4 2017 [PMID: 28375949] (Rat) Rat
Feng X, Weng D, Zhou F et al. Activation of PPARgamma by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization. EBioMedicine Jun 15 2016 [PMID: 27374313] (IHC, Mouse) IHC Mouse
Miao H, Ou J, Peng Y et al. Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM. Nat Commun. May 18 2016 [PMID: 27189574] (IHC-P, Human) IHC-P Human
Koh MY, Gagea M, Sargis T et al. A new HIF-1alpha/RANTES driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF. Hepatology. 2016 Jan 22 [PMID: 26799785]
Pandurangan AK, Ismail S, Saadatdoust Z. Allicin Alleviates Dextran Sodium Sulfate-(DSS-) Induced Ulcerative Colitis in BALB/c Mice. Oxidative Medicine and Cellular Longevity. 2015 [PMID: 26075036] (IHC-P, Mouse) IHC-P Mouse
Lin FY, Hsiao FP, Huang CY et al. Porphyromonas gingivalis GroEL Induces Osteoclastogenesis of Periodontal Ligament Cells and Enhances Alveolar Bone Resorption in Rats. PLoS ONE 2014 Jul 25 [PMID: 25058444] (IHC-P, Rat)

CD68 antibody used in IHC-P for detecting the inflammatory infiltration of the gingival connective tissue of Rats inoculated or not with Porphyromonas gingivalis GroEL (inoculated into rat gingiva). Figure 5D - GroEL induced macrophages infiltration in rat gingival as marked by CD68 expression.
Joshi-Barr S, Bett C, Chiang WC et al. De novo prion aggregates trigger autophagy in skeletal muscle. J Virol 2013 Dec 4 [PMID: 24307586] (IHC-P, Mouse) IHC-P Mouse
Herwig MC, Bergstrom C, Wells JR et al. M2/M1 ratio of tumor associated macrophages and PPAR-gamma expression in uveal melanomas with class 1 and class 2 molecular profiles Exp Eye Res 2012 Nov 30 [PMID: 23206928] (IHC, Human) IHC Human
Show All 34 Publications.

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Control Lysate(s)

Secondary Antibodies


Isotype Controls

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Blogs on CD68/SR-D1.

CD68 (Cluster of differentiation 68, GP110, LAMP4, SCARD1)
CD68 belongs to a growing family of hematopoietic mucin-like molecules known as lysosomal/endosomal-associated membrane glycoproteins (LAMPs). Other LAMP family members included leukosialin, stem cell antigen CD34, and GlyCAM-1. CD68 encodes a 110-kD...  Read full blog post.

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Gene Symbol CD68