Caveolin-1 Antibody (7C8) [DyLight 488]

• Reactivity: Hu, Mu, Rt, Sh
• Applications: WB, Flow, ICC/IF, IHC, IP, WB
• Clone: 7C8
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 488

Caveolin-1 Antibody (7C8) [DyLight 488] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Intracellular membrane protein-containing vesicles (containing GLUT4) from rat adipocytes
• Localization: Cell Membrane
• Marker: Caveolae Marker, Endosome Marker
• Specificity: This is specific for caveolin alpha and beta proteins.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: CAV1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunoblotting
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NB100-615. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Caveolin-1 Antibody (7C8) [DyLight 488]

• CAV
• CAV1
• caveolae protein, 22kD
• caveolin 1, caveolae protein, 22kDa
• Caveolin1
• Caveolin-1
• cell growth-inhibiting protein 32
• MSTP085
• VIP21

Background

Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Caveolin-1 Antibody (NB100-615G)(1)

Publication using NB100-615G

• Liu C, Liu T, Yu X et al. A preliminary study on the interaction between Asn-Gly-Arg (NGR)-modified multifunctional nanoparticles and vascular epithelial cells Acta Pharm Sin B. 2017-04-01 [PMID: 28540174] (ICC/IF, FLOW, Human)
  
  Details:
  Citation used the DyLight 488 format of this antibody.

Bioinformatics

• Gene Symbol: CAV1