Recombinant Human EGF Protein, CF

Recombinant Human EGF (Catalog # 236‑EG) stimulates cell proliferation of the Balb/3T3 mouse embryonic fibroblast cell line. The ED50 for this effect is 20‑100 pg/mL.

1 µg/lane of Recombinant Human EGF was resolved with SDS-PAGE and visualized by silver staining under reducing (R) conditions, showing a single band at 6 kDa.

iPSC-derived human intestinal organoids were cultured using Cultrex™ UltiMatrix RGF Basement Membrane Extract (BME001-05) and intestinal organoid culture medium, which includes Recombinant Human EGF (Catalog # 236-EG), Recombinant Human Noggin (6057-NG), Recombinant Human R-Spondin 1 (4645-RS), and Recombinant Human Wnt-3a (5036-WN), along with the other reagents listed in the intestinal organoid culture medium recipe in the human intestinal organoid culture protocol. (A) Human intestinal organoids were stained using a Rat Anti-Human/Mouse/Rat Vimentin Monoclonal Antibody (MAB2105; green) and a Goat Anti-Human/Mouse Desmin Antigen Affinity-purified Polyclonal Antibody (AF3844; red) to visualize myofibroblast cells and counterstained with DAPI (5748; blue). (B) Human intestinal organoids were stained using a Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (AF748; green) and a Mouse Anti-Human MUC2 Monoclonal Antibody (Novus Biologicals, Catalog # NBP2-44431; red) and counterstained with DAPI (5748; blue).

Adult stem cells isolated from human descending colon were embedded in Cultrex UltiMatrix RGF Basement Membrane Extract (BME001-05) and cultured for 30 days in intestinal organoid culture medium, which includes Recombinant Human EGF (Catalog # 236-EG), Recombinant Human Noggin (6057-NG), Recombinant Human R-Spondin 1 (4645-RS), and Recombinant Human Wnt-3a (5036-WN), along with the other reagents listed in the intestinal organoid culture medium recipe in the human intestinal organoid culture protocol. (A) Organoids were fixed and stained with a Mouse Anti-Human MUC2 Monoclonal Antibody (Novus Biologicals; Catalog # NBP2-44431; green) to visualize intestinal goblet cells and counterstained with a Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (AF748; red) and DAPI (5748; blue). The image shown was taken at 10x magnification. (B) Organoids were fixed and stained with a Mouse Anti-Human Chromogranin A Monoclonal Antibody (MAB90981; green) to visualize enteroendocrine cells and counterstained with a Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (AF748; red) and DAPI (5748; blue). The image shown was taken at 20x magnification.

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human EGF Protein, CF Summary

• Details of Functionality: Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Rubin, J.S. et al. (1991) Proc. Natl. Acad. Sci. USA 88:415. The ED₅₀ for this effect is 20-100 pg/mL.
• Source: E. coli-derived human EGF protein
  Asn971-Arg1023, with an N-terminal Met
• Accession #: P01133
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: EGF
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 6 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 6 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 500 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human EGF Protein, CF

• beta-urogastrone
• EGF
• epidermal growth factor (beta-urogastrone)
• epidermal growth factor
• hEGF
• HOMG4
• pro-epidermal growth factor
• URG
• Urogastrone

Background

Epidermal growth factor (EGF) is a small, potent growth factor capable of inducing cell proliferation, differentiation, and survival. EGF is the founding member of the EGF family that also includes TGF-alpha, amphiregulin (AR), betacellulin (BTC), epiregulin (EPR), heparin‑binding EGF‑like growth factor (HB‑EGF), epigen, and the neuregulins (NRG)-1 through -6 (1). Members of The EGF family are characterized by a shared structural motif, the EGF‑like domain, which contains three intramolecular disulfide bonds that are formed by six similarly spaced, conserved cysteine residues (2). These disulfide bonds are essential for proper protein conformation and receptor binding. All EGF family members are synthesized as type I transmembrane precursor proteins that may contain several EGF domains in the extracellular region. The mature proteins are released from the cell surface by regulated proteolysis (1). The full length EGF protein is 1207 amino acids (aa) (EGF precursor) containing nine EGF domains and nine LDLR class B repeats. However, the mature protein is much smaller, only 53 aa, and is generated by proteolytic cleavage of the EGF domain proximal to the transmembrane region (3). EGF is well conserved across mammals with mature human EGF 70% identical to mature mouse and rat EGF. Physiologically, EGF is found in various body fluids, including blood, milk, urine, saliva, seminal fluid, pancreatic juice, cerebrospinal fluid, and amniotic fluid (4). EGF is a high affinity ligand of the EGF receptor (ErbB). Four ErbB (HER) family receptor tyrosine kinases including EGFR/ErbB1, ErbB2, ErbB3 and ErbB4, mediate responses to EGF family members (5). EGF binding induces dimerization of the EGF receptor resulting in activation of the protein tyrosine kinase signaling pathway. These receptors undergo a complex pattern of ligand-induced homo- or hetero-dimerization to transduce EGF family signals (6, 7). EGF binds ErbB1 and depending on the context, induces the formation of homodimers or heterodimers containing ErbB2. Dimerization results in autophosphorylation of the receptor at specific tyrosine residues to create docking sites for a variety of signaling molecules (5, 8). Biological activities ascribed to EGF include epithelial development, angiogenesis, inhibition of gastric acid secretion, fibroblast proliferation, and colony formation of epidermal cells in culture.

1. Harris, R.C. et al. (2003) Exp. Cell Res. 284:2.
2. Carpenter, G. and Cohen, S. (1990) J. Biol. Chem. 265:7709.
3. Bell, G.I. et al. (1986) Nucl. Acids Res. 14:8427.
4. Carpenter, G. and Zendegui, J.G. (1986) Exp. Cell Res. 164:1.
5. Jorissen, R.N. et al. (2003) Exp. Cell Res. 284:31.
6. Gamett, D.C. et al. (1997) J. Biol. Chem. 272:12052.
7. Qian, X. et al. (1994) Proc. Natl. Acad. Sci. 91:1500.
8. Qian, X. et al. (1999) J. Biol. Chem. 274:574.

Publications for EGF (236-EG)(734)

Publications using 236-EG	Applications	Species
Ai, Z;Niu, B;Yin, Y;Xiang, L;Shi, G;Duan, K;Wang, S;Hu, Y;Zhang, C;Zhang, C;Rong, L;Kong, R;Chen, T;Guo, Y;Liu, W;Li, N;Zhao, S;Zhu, X;Mai, X;Li, Y;Wu, Z;Zheng, Y;Fu, J;Ji, W;Li, T; Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids Cell research 2023-07-17 [PMID: 37460804] (Bioassay, Human)	Bioassay	Human
Erdem, C;Gross, SM;Heiser, LM;Birtwistle, MR; MOBILE pipeline enables identification of context-specific networks and regulatory mechanisms Nature communications 2023-07-06 [PMID: 37414767] (Bioassay, Human)	Bioassay	Human
Ankenbauer, KE;Rao, TC;Mattheyses, AL;Bellis, SL; Sialylation of EGFR by ST6GAL1 induces receptor activation and modulates trafficking dynamics bioRxiv : the preprint server for biology 2023-06-04 [PMID: 37398202] (Bioassay, Human)	Bioassay	Human
Fan, Y;Gao, Z;Xu, J;Wang, H;Guo, Q;Li, B;Li, M;Xu, H;Qi, Y;Zhao, S;Qiu, W;Pan, Z;Wang, Q;Xue, H;Zhao, R;Guo, X;Li, G; SPI1-mediated MIR222HG transcription promotes proneural-to-mesenchymal transition of glioma stem cells and immunosuppressive polarization of macrophages Theranostics 2023-05-27 [PMID: 37351164] (Bioassay, Human)	Bioassay	Human
Németh, Z;Debreczeni, ML;Kajdácsi, E;Dobó, J;Gál, P;Cervenak, L; Cooperation of Complement MASP-1 with Other Proinflammatory Factors to Enhance the Activation of Endothelial Cells International journal of molecular sciences 2023-05-24 [PMID: 37298134] (Bioassay, Human)	Bioassay	Human
Lucas, CH;Mirchia, K;Seo, K;Najem, H;Chen, W;Zakimi, N;Choudhury, A;Liu, SJ;Phillips, J;Magill, S;Horbinski, C;Solomon, D;Perry, A;Vasudevan, H;Heimberger, A;Raleigh, D; Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution Research square 2023-05-15 [PMID: 37292686] (Bioassay, Human)	Bioassay	Human
Martínez-Mármol, R;Giordano-Santini, R;Kaulich, E;Cho, AN;Przybyla, M;Riyadh, MA;Robinson, E;Chew, KY;Amor, R;Meunier, FA;Balistreri, G;Short, KR;Ke, YD;Ittner, LM;Hilliard, MA; SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity Science advances 2023-06-09 [PMID: 37285437] (Bioassay, Human)	Bioassay	Human
Mizuno, K;Ohnishi, H;Yoshimatsu, M;Zhao, C;Hayashi, Y;Kuwata, F;Kaba, S;Okuyama, H;Kawai, Y;Hiwatashi, N;Kishimoto, Y;Sakamoto, T;Ikeya, M;Omori, K; Laryngeal Cartilage Regeneration of Nude Rats by Transplantation of Mesenchymal Stem Cells Derived from Human-Induced Pluripotent Stem Cells Cell transplantation 2023-06-06 [PMID: 37278405] (Bioassay, Human)	Bioassay	Human
Gwon, K;Choi, D;de Hoyos-Vega, JM;Baskaran, H;Gonzalez-Suarez, AM;Lee, S;Hong, HJ;Nguyen, KM;Dharmesh, E;Sugahara, G;Ishida, Y;Saito, T;Stybayeva, G;Revzin, A; Function of hepatocyte spheroids in bioactive microcapsules is enhanced by endogenous and exogenous hepatocyte growth factor Bioactive materials 2023-10-01 [PMID: 37266448] (Bioassay, N/A)	Bioassay	N/A
Ito, R;Kimura, A;Hirose, Y;Hatano, Y;Mima, A;Mae, SI;Keidai, Y;Nakamura, T;Fujikura, J;Nishi, Y;Ohta, A;Toyoda, T;Inagaki, N;Osafune, K; Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model Scientific reports 2023-05-29 [PMID: 37248264] (Bioassay, Human)	Bioassay	Human
Bates, EA;Lovatt, C;Plein, AR;Davies, JA;Siebzehnrubl, FA;Parker, AL; Engineering Adenoviral Vectors with Improved GBM Selectivity Viruses 2023-04-28 [PMID: 37243172] (Bioassay, Human)	Bioassay	Human
Farahani, PE;Yang, X;Mesev, EV;Fomby, KA;Brumbaugh-Reed, EH;Bashor, CJ;Nelson, CM;Toettcher, JE; pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells eLife 2023-05-22 [PMID: 37212240] (Bioassay, Mouse, Human)	Bioassay	Mouse, Human
Frum, T;Hsu, PP;Hein, RFC;Conchola, AS;Zhang, CJ;Utter, OR;Anand, A;Zhang, Y;Clark, SG;Glass, I;Sexton, JZ;Spence, JR; Opposing roles for TGF?- and BMP-signaling during nascent alveolar differentiation in the developing human lung bioRxiv : the preprint server for biology 2023-05-05 [PMID: 37205521] (Bioassay, Human)	Bioassay	Human
Kuo, C;Choi, S;van Unen, V;Zhang, H;Rustagi, A;Alwahabi, S;Santos, A;Chan, J;Lam, B;Solis, D;Mah, J;R�ltgen, K;Trope, W;Guh-Siesel, A;Lin, Z;Beck, A;Edwards, C;Mallajosyula, V;Martin, B;Dunn, J;Shrager, J;Baric, R;Pinsky, B;Boyd, S;Blish, C;Davis, M; Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection Research square 2023-05-05 [PMID: 37205380] (Bioassay, Human)	Bioassay	Human
Yamakawa, K;Koyanagi-Aoi, M;Machinaga, A;Kakiuchi, N;Hirano, T;Kodama, Y;Aoi, T; Blockage of retinoic acid signaling via RAR? suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase Cancer cell international 2023-05-17 [PMID: 37198667] (Cell Culture, Human)	Cell Culture	Human
Yuan, H;Wu, X;Wu, Q;Chatoff, A;Megill, E;Gao, J;Huang, T;Duan, T;Yang, K;Jin, C;Yuan, F;Wang, S;Zhao, L;Zinn, PO;Abdullah, KG;Zhao, Y;Snyder, NW;Rich, JN; Lysine catabolism reprograms tumour immunity through histone crotonylation Nature 2023-05-17 [PMID: 37198486] (Bioassay, Human)	Bioassay	Human
Omar, FA;Brown, TC;Gillanders, WE;Fleming, TP;Smith, MA;Bremner, RM;Sankpal, NV; Cytosolic EpCAM cooperates with H-Ras to regulate epithelial to mesenchymal transition through ZEB1 PloS one 2023-05-16 [PMID: 37192201] (Bioassay, Human)	Bioassay	Human
Pedrosa, L;Bedia, C;Diao, D;Mosteiro, A;Ferr�s, A;Stanzani, E;Mart�nez-Soler, F;Tortosa, A;Pineda, E;Aldecoa, I;Centellas, M;Mu�oz-Tudur�, M;Sevilla, A;Sierra, �;Gonz�lez S�nchez, JJ; Preclinical Studies with Glioblastoma Brain Organoid Co-Cultures Show Efficient 5-ALA Photodynamic Therapy Cells 2023-04-10 [PMID: 37190034] (Bioassay, Human)	Bioassay	Human
Maylem, ERS;Spicer, LJ;Batalha, IM;Sch�tz, LF; Developmental and hormonal regulation of FBN1 and OR4M1 mRNA in bovine granulosa cells Domestic animal endocrinology 2023-04-25 [PMID: 37167929] (Bioassay, Bovine)	Bioassay	Bovine
Perez-Pepe, M;Desotell, AW;Li, H;Li, W;Han, B;Lin, Q;Klein, DE;Liu, Y;Goodarzi, H;Alarc�n, CR; 7SK methylation by METTL3 promotes transcriptional activity Science advances 2023-05-10 [PMID: 37163588] (Bioassay, Human)	Bioassay	Human
Huang, X;Zhou, Q; Generation of gastirc insulin-secreting organoids from human stomach sample Research square 2023-04-27 [PMID: 37163124] (Bioassay, Human)	Bioassay	Human
Mahr, RM;Jena, S;Nashif, SK;Nelson, AB;Rauckhorst, AJ;Rome, FI;Sheldon, RD;Hughey, CC;Puchalska, P;Gearhart, MD;Taylor, EB;Crawford, PA;Wernimont, SA; Mitochondrial citrate metabolism and efflux regulate BeWo differentiation Scientific reports 2023-05-06 [PMID: 37149697] (Bioassay, Human)	Bioassay	Human
Katabami, M;Kinoshita, I;Ariga, S;Shimizu, Y;Dosaka-Akita, H; Crystalline silica-exposed human lung epithelial cells presented enhanced anchorage-independent growth with upregulated expression of BRD4 and EZH2 in autocrine and paracrine manners PloS one 2023-05-05 [PMID: 37146018] (Bioassay, Human)	Bioassay	Human
SD Sharma, BK Reddy, R Pal, TE Ritakari, JD Cooper, BT Selvaraj, PC Kind, S Chandran, DJA Wyllie, S Chattarji Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons Cell Reports, 2023-04-04;42(4):112344. 2023-04-04 [PMID: 37018073] (Bioassay, Human)	Bioassay	Human
Y Liu, Y Zhang, S Chen, X Zhong, Q Liu Effect of LGR4/EGFR signaling on cell growth and cancer stem cell-like characteristics in liver cancer Cytokine, 2023-03-29;165(0):156185. 2023-03-29 [PMID: 37001327] (Bioassay, In Vivo, Human, Xenograft)	Bioassay, In Vivo	Human, Xenograft
J Vigna, D Sighel, EF Rosatti, A Defant, M Pancher, V Sidarovich, A Quattrone, I Mancini Expanding the Chemical Space of Arsenicin A-C Related Polyarsenicals and Evaluation of Some Analogs as Inhibitors of Glioblastoma Stem Cell Growth Marine Drugs, 2023-03-17;21(3):. 2023-03-17 [PMID: 36976235] (Bioassay, Human)	Bioassay	Human
W Lin, R Niu, SM Park, Y Zou, SS Kim, X Xia, S Xing, Q Yang, X Sun, Z Yuan, S Zhou, D Zhang, HJ Kwon, S Park, C Il Kim, H Koo, Y Liu, H Wu, M Zheng, H Yoo, B Shi, JB Park, J Yin IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis Nature Communications, 2023-03-22;14(1):1578. 2023-03-22 [PMID: 36949068] (Bioassay, Human)	Bioassay	Human
TT Lemmetyine, EW Viitala, L Wartiovaar, T Kaprio, J Hagström, C Haglund, P Katajisto, TC Wang, E Domènech-M, S Ollila Fibroblast-derived EGF ligand Neuregulin-1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth Disease Models & Mechanisms, 2023-04-03;0(0):. 2023-04-03 [PMID: 36912192] (Bioassay, Mouse)	Bioassay	Mouse
M Priedols, G Paidere, CB Santos, A Miscenko, RG Bergmanis, A Spule, B Bekere, G Mozolevski, A Abols, R Rimsa Bifurcated Asymmetric Field Flow Fractionation of Nanoparticles in PDMS-Free Microfluidic Devices for Applications in Label-Free Extracellular Vesicle Separation Polymers, 2023-02-04;15(4):. 2023-02-04 [PMID: 36850073] (Bioassay, Human)	Bioassay	Human
NB Campbell, Y Patel, TL Moore, M Medalla, E Zeldich Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome International Journal of Molecular Sciences, 2023-02-09;24(4):. 2023-02-09 [PMID: 36834891] (Bioassay, Human)	Bioassay	Human
M Shono, K Kishimoto, O Hikabe, M Hayashi, K Semi, Y Takashima, E Sasaki, K Kato, K Hayashi Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling Scientific Reports, 2023-02-23;13(1):3186. 2023-02-23 [PMID: 36823310] (Bioassay, Human)	Bioassay	Human
E Domènech-M, A Brandt, TT Lemmetyine, L Wartiovaar, TP Mäkelä, S Ollila Tellu: an object detector algorithm for automatic classification of intestinal organoids Disease Models & Mechanisms, 2023-03-13;0(0):. 2023-03-13 [PMID: 36804687] (Bioassay, Mouse)	Bioassay	Mouse
EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar Pervasive environmental chemicals impair oligodendrocyte development bioRxiv : the preprint server for biology, 2023-02-12;0(0):. 2023-02-12 [PMID: 36798415] (Bioassay, Human)	Bioassay	Human
MF Wells, J Nemesh, S Ghosh, JM Mitchell, MR Salick, CJ Mello, D Meyer, O Pietilaine, F Piccioni, EJ Guss, K Raghunatha, M Tegtmeyer, D Hawes, A Neumann, KA Worringer, D Ho, S Kommineni, K Chan, BK Peterson, JJ Raymond, JT Gold, MT Siekmann, E Zuccaro, R Nehme, A Kaykas, K Eggan, SA McCarroll Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages Cell Stem Cell, 2023-02-15;0(0):. 2023-02-15 [PMID: 36796362] (Bioassay, Human)	Bioassay	Human
L Pang, M Dunterman, W Xuan, A Gonzalez, Y Lin, WH Hsu, F Khan, RS Hagan, WA Muller, AB Heimberger, P Chen Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma Cell Reports, 2023-02-14;42(2):112127. 2023-02-14 [PMID: 36795563] (Bioassay, Human)	Bioassay	Human
RC Gimple, G Zhang, S Wang, T Huang, J Lee, S Taori, D Lv, D Dixit, ME Halbert, AR Morton, RL Kidwell, Z Dong, BC Prager, L Kim, Z Qiu, L Zhao, Q Xie, Q Wu, S Agnihotri, JN Rich Sorting-nexin-10 sustains platelet-derived growth factor receptor signaling in glioblastoma stem cells via endosomal protein sorting JCI Insight, 2023-03-22;0(0):. 2023-03-22 [PMID: 36795488] (Bioassay, Human)	Bioassay	Human
AH Ghobashi, TT Vuong, JW Kimani, HM O'Hagan Activation of AKT induces EZH2-mediated beta-catenin trimethylation in colorectal cancer bioRxiv : the preprint server for biology, 2023-02-04;0(0):. 2023-02-04 [PMID: 36778289] (Bioassay, Human)	Bioassay	Human
RH Purcell, E Sefik, E Werner, AT King, TJ Mosley, ME Merritt-Ga, P Chopra, ZT McEachin, S Karne, N Raj, K Tilahun, M Robinette, ST Warren, Z Wen, V Faundez, SA Sloan, GJ Bassell, JG Mulle Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion bioRxiv : the preprint server for biology, 2023-05-26;0(0):. 2023-05-26 [PMID: 36747819] (Bioassay, Human)	Bioassay	Human
J Tian, JH Chen, SX Chao, K Pelka, M Giannakis, J Hess, K Burke, V Jorgji, P Sindurakar, J Braverman, A Mehta, T Oka, M Huang, D Lieb, M Spurrell, JN Allen, TA Abrams, JW Clark, AC Enzinger, PC Enzinger, SJ Klempner, NJ McCleary, JA Meyerhardt, DP Ryan, MB Yurgelun, K Kanter, EE Van Sevent, I Baiev, G Chi, J Jarnagin, WB Bradford, E Wong, AG Michel, IJ Fetter, G Siravegna, AJ Gemma, A Sharpe, S Demehri, R Leary, CD Campbell, O Yilmaz, GA Getz, AR Parikh, N Hacohen, RB Corcoran Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial Nature Medicine, 2023-01-26;0(0):. 2023-01-26 [PMID: 36702949] (Bioassay, Human)	Bioassay	Human
P Kakni, B Jutten, D Teixeira O, J Penders, R Truckenmül, P Habibovic, S Giselbrech Hypoxia-tolerant apical-out intestinal organoids to model host-microbiome interactions Journal of tissue engineering, 2023-01-18;14(0):2041731422114. 2023-01-18 [PMID: 36699634] (Bioassay, Human)	Bioassay	Human
M Zhao, Y Li, C Lu, F Ding, M Xu, X Ge, M Li, Z Wang, J Yin, J Zhang, X Wang, Z Ge, H Xiao, Y Xiao, H Liu, W Liu, Y Cao, Q Wang, Y You, X Wang, K Yang, Z Shi, X Qian PGC-1alpha degradation suppresses mitochondrial biogenesis to confer radiation resistance in glioma Cancer Research, 2023-04-04;0(0):. 2023-04-04 [PMID: 36696363] (Bioassay, Human)	Bioassay	Human
V Zayat, Z Kuczynska, M Liput, E Metin, S Rzonca-Nie, M Smyk, T Mazurczak, A Goszczansk, P Leszczynsk, D Hoffman-Za, L Buzanska The Generation of Human iPSC Lines from Three Individuals with Dravet Syndrome and Characterization of Neural Differentiation Markers in iPSC-Derived Ventral Forebrain Organoid Model Cells, 2023-01-16;12(2):. 2023-01-16 [PMID: 36672274] (Bioassay, Human)	Bioassay	Human
T Fujimori, Y Shibayama, T Kanda, K Suzuki, D Ogawa, R Ishikawa, K Kadota, T Matsunaga, T Tamiya, A Nishiyama, K Miyake Effects of a monoclonal antibody against (pro)renin receptor on gliomagenesis Scientific Reports, 2023-01-16;13(1):808. 2023-01-16 [PMID: 36646875] (Cell Culture, Human)	Cell Culture	Human
J Sun, S Osenberg, A Irwin, LH Ma, N Lee, Y Xiang, F Li, YW Wan, IH Park, M Maletic-Sa, N Ballas Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation Cell Reports, 2023-01-05;42(1):111942. 2023-01-05 [PMID: 36640327] (Bioassay, Human)	Bioassay	Human
Y Sun, OY Revach, S Anderson, EA Kessler, CH Wolfe, A Jenney, CE Mills, EJ Robitschek, TGR Davis, S Kim, A Fu, X Ma, J Gwee, P Tiwari, PP Du, P Sindurakar, J Tian, A Mehta, AM Schneider, K Yizhak, M Sade-Feldm, T LaSalle, T Sharova, H Xie, S Liu, WA Michaud, R Saad-Beret, KB Yates, A Iracheta-V, JKE Spetz, X Qin, KA Sarosiek, G Zhang, JW Kim, MY Su, AM Cicerchia, MQ Rasmussen, SJ Klempner, D Juric, SI Pai, DM Miller, A Giobbie-Hu, JH Chen, K Pelka, DT Frederick, S Stinson, E Ivanova, AR Aref, CP Paweletz, DA Barbie, DR Sen, DE Fisher, RB Corcoran, N Hacohen, PK Sorger, KT Flaherty, GM Boland, RT Manguso, RW Jenkins Targeting TBK1 to overcome resistance to cancer immunotherapy Nature, 2023-01-12;0(0):. 2023-01-12 [PMID: 36634707] (Bioassay, Human)	Bioassay	Human
L Liu, S Han, X Xiao, X An, J Gladkich, U Hinz, S Hillmer, T Hoppe-Tich, Y Xu, M Schaefer, O Strobel, I Herr Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy Cell Death & Disease, 2022-12-19;13(12):1052. 2022-12-19 [PMID: 36535942] (Bioassay, Human)	Bioassay	Human
E Cuevas, A Guzman, SM Burks, A Ramirez-Le, SF Ali, SZ Imam Autophagy and protein aggregation as a mechanism of dopaminergic degeneration in a primary human dopaminergic neuronal model Toxicology reports, 2022-04-01;9(0):806-813. 2022-04-01 [PMID: 36518412] (Bioassay, Human)	Bioassay	Human
TM Triolo, JQ Matuschek, R Castro-Gut, AH Shilleh, SPM Williams, MS Hansen, K McDaniel, JM Barra, A Michels, HA Russ Stem-Cell-Derived beta-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity Cells, 2022-11-30;11(23):. 2022-11-30 [PMID: 36497105] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
D Sighel, G Battistini, EF Rosatti, J Vigna, M Pavan, R Belli, D Peroni, F Alessandri, S Longhi, M Pancher, J Rorbach, S Moro, A Quattrone, I Mancini Streptogramin A derivatives as mitochondrial translation inhibitors to suppress glioblastoma stem cell growth European Journal of Medicinal Chemistry, 2022-11-30;246(0):114979. 2022-11-30 [PMID: 36495628] (Bioassay, Human)	Bioassay	Human
C Degorre, IC Sutton, SL Lehman, UT Shankavara, K Camphausen, PJ Tofilon Glioblastoma cells have increased capacity to repair radiation-induced DNA damage after migration to the olfactory bulb Cancer Cell International, 2022-12-08;22(1):389. 2022-12-08 [PMID: 36482431] (Cell Culture, Human)	Cell Culture	Human
JE Kaserman, RB Werder, F Wang, T Matte, MI Higgins, M Dodge, J Lindstrom-, P Bawa, A Hinds, E Bullitt, IS Caballero, X Shi, RE Gerszten, N Brunetti-P, M Liesa, C Villacorta, AN Hollenberg, DN Kotton, AA Wilson Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity Cell Reports, 2022-12-06;41(10):111775. 2022-12-06 [PMID: 36476855] (Bioassay, Human)	Bioassay	Human
RE Thompson, MA Meyers, C Premananda, FK Hollinshea Generation and cryopreservation of feline oviductal organoids Theriogenology, 2022-11-17;196(0):167-173. 2022-11-17 [PMID: 36423511] (Bioassay, Feline)	Bioassay	Feline
EJ Kim, JY Kim, SO Kim, N Hong, SH Choi, MG Park, J Jang, SW Ham, S Seo, SY Lee, K Lee, HJ Jeong, SJ Kim, S Jeong, K Min, SC Kim, X Jin, SH Kim, SH Kim, H Kim The oncogenic JAG1 intracellular domain is a transcriptional cofactor that acts in concert with DDX17/SMAD3/TGIF2 Cell Reports, 2022-11-22;41(8):111626. 2022-11-22 [PMID: 36417870] (Bioassay, Human, Transgenic Mouse)	Bioassay	Human, Transgenic Mouse
HJ Kim, SS Suh, J Park, MJ Shin, MH Koo, SJ Lee, YJ Jeon, S Lee, UJ Youn, SH Kim 7beta-22 Dihydroxyhopane, Isolated from the Sub-Antarctic Lichen, Inhibits the Viability and Stemness in Glioma Stem Like Cells OncoTargets and Therapy, 2022-11-15;15(0):1375-1383. 2022-11-15 [PMID: 36411942] (Bioassay, Human)	Bioassay	Human
HC Wang, LY Haung, CJ Wang, YJ Chao, YC Hou, CJ Yen, YS Shan Tumor-associated macrophages promote resistance of hepatocellular carcinoma cells against sorafenib by activating CXCR2 signaling Journal of Biomedical Science, 2022-11-21;29(1):99. 2022-11-21 [PMID: 36411463] (Bioassay, Human)	Bioassay	Human
R Qureshi, M Picon-Ruiz, M Sho, D Van Booven, V Nunes de P, AB Diaz-Ruano, TA Ince, J Slingerlan Estrone, the major postmenopausal estrogen, binds ERa to induce SNAI2, epithelial-to-mesenchymal transition, and ER+ breast cancer metastasis Cell Reports, 2022-11-15;41(7):111672. 2022-11-15 [PMID: 36384125]
K Madden-Hen, D Gupta, AA Radecki, C Guild, A Rath, CD Heinen Loss of mismatch repair promotes a direct selective advantage in human stem cells Stem Cell Reports, 2022-11-10;0(0):. 2022-11-10 [PMID: 36368329] (Bioassay, Human)	Bioassay	Human
W Otsu, T Yako, E Sugisawa, S Nakamura, H Tsusaki, N Umigai, M Shimazawa, H Hara Crocetin protects against mitochondrial damage induced by UV-A irradiation in corneal epithelial cell line HCE-T cells Journal of pharmacological sciences, 2022-10-14;150(4):279-288. 2022-10-14 [PMID: 36344051] (Bioassay, Human)	Bioassay	Human
M Ishibane, H Hashimoto, M Kaneko, S Saito, S Pae, S Saito, Y Reien, Y Hirayama, N Higashi-Ku, H Mitsuya, N Anzai Effects of a novel hepatitis B anti-viral drug E-CFCP in renal organic acid transporters Journal of pharmacological sciences, 2022-09-16;150(4):201-203. 2022-09-16 [PMID: 36344041] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Z Li, F Fang, Y Long, Q Zhao, X Wang, Z Ye, T Meng, X Gu, W Xiang, C Xiong, H Li The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate Cell & bioscience, 2022-11-04;12(1):181. 2022-11-04 [PMID: 36333732] (Bioassay, Human)	Bioassay	Human
AN Cho, F Bright, N Morey, C Au, LM Ittner, YD Ke Efficient Gene Expression in Human Stem Cell Derived-Cortical Organoids Using Adeno Associated Virus Cells, 2022-10-11;11(20):. 2022-10-11 [PMID: 36291062] (Bioassay, Human)	Bioassay	Human
Z Tu, Y Hu, D Raizada, MA Bassal, DG Tenen, AE Karnoub Long noncoding RNA-mediated activation of PROTOR1/PRR5-AKT signaling shunt downstream of PI3K in�triple-negative breast cancer Proceedings of the National Academy of Sciences of the United States of America, 2022-10-21;119(43):e2203180119. 2022-10-21 [PMID: 36269860] (Bioassay, Human)	Bioassay	Human
W He, X Zhu, A Xin, H Zhang, Y Sun, H Xu, H Li, T Yang, D Zhou, H Yan, X Sun Long-term maintenance of human endometrial epithelial stem cells and their therapeutic effects on intrauterine adhesion Cell & bioscience, 2022-10-18;12(1):175. 2022-10-18 [PMID: 36258228] (Bioassay, Human)	Bioassay	Human
O Revah, F Gore, KW Kelley, J Andersen, N Sakai, X Chen, MY Li, F Birey, X Yang, NL Saw, SW Baker, ND Amin, S Kulkarni, R Mudipalli, B Cui, S Nishino, GA Grant, JK Knowles, M Shamloo, JR Huguenard, K Deisseroth, SP Pa?ca Maturation and circuit integration of transplanted human cortical organoids Nature, 2022-10-12;610(7931):319-326. 2022-10-12 [PMID: 36224417] (Bioassay, Human)	Bioassay	Human
DS Lee, YJ Song, HR Gug, JH Lee, HS Bae, JC Park Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cells Stem Cells International, 2022-09-27;2022(0):1092184. 2022-09-27 [PMID: 36213683] (Cell Culture, Mouse)	Cell Culture	Mouse
H Wang, B Keepers, Y Qian, Y Xie, M Colon, J Liu, L Qian Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes Cell Stem Cell, 2022-10-06;29(10):1491-1504.e9. 2022-10-06 [PMID: 36206732] (Bioassay, Mouse)	Bioassay	Mouse
A Beucher, I Miguel-Esc, D Balboa, MG De Vas, MA Maestro, J Garcia-Hur, A Bernal, R Gonzalez-F, P Vargiu, H Heyn, P Ravassard, S Ortega, J Ferrer The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A Nature Cell Biology, 2022-10-06;0(0):. 2022-10-06 [PMID: 36202974] (Bioassay, Human)	Bioassay	Human
PC Kinnunen, GD Luker, KE Luker, JJ Linderman Computational modeling implicates protein scaffolding in p38 regulation of Akt Journal of theoretical biology, 2022-10-01;555(0):111294. 2022-10-01 [PMID: 36195198] (Bioassay, Human)	Bioassay	Human
H Marei, WK Tsai, YS Kee, K Ruiz, J He, C Cox, T Sun, S Penikalapa, P Dwivedi, M Choi, D Kan, P Saenz-Lope, K Dorighi, P Zhang, YT Kschonsak, N Kljavin, D Amin, I Kim, AG Mancini, T Nguyen, C Wang, E Janezic, A Doan, E Mai, H Xi, C Gu, M Heinlein, B Biehs, J Wu, I Lehoux, S Harris, L Comps-Agra, D Seshasayee, FJ de Sauvage, M Grimmer, J Li, NJ Agard, F de Sousa E Antibody targeting of E3 ubiquitin ligases for receptor degradation Nature, 2022-09-21;610(7930):182-189. 2022-09-21 [PMID: 36131013] (Bioassay, Human)	Bioassay	Human
G Le-Bel, P Desjardins, C Gross, S Cortez Ghi, C Couture, L Germain, SL Guérin Influence of the Postmortem/Storage Time of Human Corneas on the Properties of Cultured Limbal Epithelial Cells Cells, 2022-08-31;11(17):. 2022-08-31 [PMID: 36078126] (Bioassay, Human)	Bioassay	Human
GM Jowett, E Read, LB Roberts, D Coman, M Vilà Gonzá, T Zabinski, U Niazi, R Reis, TJ Trieu, D Danovi, E Gentleman, L Vallier, MA Curtis, GM Lord, JF Neves Organoids capture tissue-specific innate lymphoid cell development in mice and humans Cell Reports, 2022-08-30;40(9):111281. 2022-08-30 [PMID: 36044863] (Bioassay, Mouse)	Bioassay	Mouse
I Jun, YJ Choi, BR Kim, KY Seo, TI Kim Activation of ADRB2/PKA Signaling Pathway Facilitates Lipid Synthesis in Meibocytes, and Beta-Blocker Glaucoma Drug Impedes PKA-Induced Lipid Synthesis by Inhibiting ADRB2 International Journal of Molecular Sciences, 2022-08-22;23(16):. 2022-08-22 [PMID: 36012741] (Cell Culture, Human)	Cell Culture	Human
Y Hattori, K Kurozumi, Y Otani, A Uneda, N Tsuboi, K Makino, S Hirano, K Fujii, Y Tomita, T Oka, Y Matsumoto, Y Shimazu, H Michiue, H Kumon, I Date Combination of Ad-SGE-REIC and bevacizumab modulates glioma progression by suppressing tumor invasion and angiogenesis PLoS ONE, 2022-08-25;17(8):e0273242. 2022-08-25 [PMID: 36006934] (Bioassay, Human)	Bioassay	Human
EJ Sohn Differentially expression and function of circular RNAs in ovarian cancer stem cells Journal of ovarian research, 2022-08-17;15(1):97. 2022-08-17 [PMID: 35978436] (Cell Culture, Human)	Cell Culture	Human
M Grouls, AWF Janssen, LPM Duivenvoor, GJEJ Hooiveld, H Bouwmeeste, M van der Za Differential gene expression in iPSC-derived human intestinal epithelial cell layers following exposure to two concentrations of butyrate, propionate and acetate Scientific Reports, 2022-08-17;12(1):13988. 2022-08-17 [PMID: 35977967] (Bioassay, Human)	Bioassay	Human
D Hao, L Lu, H Song, Y Duan, J Chen, R Carney, JJ Li, P Zhou, J Nolta, KS Lam, JK Leach, DL Farmer, A Panitch, A Wang Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair Theranostics, 2022-08-08;12(13):6021-6037. 2022-08-08 [PMID: 35966577] (Cell Culture, Human)	Cell Culture	Human
S Fan, K Boerner, CK Muraleedha, A Nusrat, M Quiros, CA Parkos Epithelial JAM-A is fundamental for intestinal wound repair in-vivo JCI Insight, 2022-09-08;0(0):. 2022-09-08 [PMID: 35943805] (Bioassay, Mouse)	Bioassay	Mouse
S Jeising, G Geerling, R Guthoff, D Hänggi, M Sabel, M Rapp, AC Nickel In-Vitro Use of Verteporfin for Photodynamic Therapy in Glioblastoma Photodiagnosis and photodynamic therapy, 2022-08-04;0(0):103049. 2022-08-04 [PMID: 35932958] (Bioassay, Human)	Bioassay	Human
K Wang, Z Li, Y Li, X Liu, Y Sun, J Hong, Y Ding, W Zheng, L Qian, D Xu Cardioprotection of Klotho against myocardial infarction-induced heart failure through inducing autophagy Mechanisms of Ageing and Development, 2022-08-03;207(0):111714. 2022-08-03 [PMID: 35931242] (In Vivo, Mouse)	In Vivo	Mouse
Y Wang, H Shu, J Liu, X Jin, L Wang, Y Qu, M Xia, P Peng, Y Feng, M Wei EGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association The Journal of Biological Chemistry, 2022-08-03;0(0):102340. 2022-08-03 [PMID: 35931120] (Bioassay, Human)	Bioassay	Human
CC Dibble, SA Barritt, GE Perry, EC Lien, RC Geck, SE DuBois-Coy, D Bartee, TT Zengeya, EB Cohen, M Yuan, BD Hopkins, JL Meier, JG Clohessy, JM Asara, LC Cantley, A Toker PI3K drives the de novo synthesis of coenzyme A from vitamin B5 Nature, 2022-07-27;608(7921):192-198. 2022-07-27 [PMID: 35896750] (Bioassay, Human)	Bioassay	Human
T Tabata, M Petitt, J Li, X Chi, W Chen, I Yurgelonis, S Wellnitz, S Bredl, T Vicente, X Yang, PR Dormitzer, L Pereira Neutralizing Antibodies to Human Cytomegalovirus Recombinant Proteins Reduce Infection in an Ex Vivo Model of Developing Human Placentas Vaccines, 2022-07-04;10(7):. 2022-07-04 [PMID: 35891239] (Bioassay, Human)	Bioassay	Human
D Sardar, HC Chen, A Reyes, S Varadharaj, A Jain, C Mohila, R Curry, B Lozzi, K Rajendran, A Cervantes, K Yu, A Jalali, G Rao, SC Mack, B Deneen Sox9 directs divergent epigenomic states in brain tumor subtypes Oncogene, 2022-07-15;119(29):e2202015119. 2022-07-15 [PMID: 35858326] (Bioassay, Mouse)	Bioassay	Mouse
M Cecchi, A Mannini, A Lapucci, A Silvano, M Lulli, C Luceri, M D'Ambrosio, A Chiarugi, AH Eid, A Parenti Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells via Tryptophan 2,3 Dioxygenase Frontiers in Pharmacology, 2022-06-30;13(0):911019. 2022-06-30 [PMID: 35847038] (Bioassay, Human)	Bioassay	Human
D Li, Q Zhang, L Li, K Chen, J Yang, D Dixit, RC Gimple, S Ci, C Lu, L Hu, J Gao, D Shan, Y Li, J Zhang, ZM Shi, D Gu, W Yuan, Q Wu, K Yang, L Zhao, Z Qiu, D Lv, W Gao, H Yang, F Lin, Q Wang, J Man, C Li, W Tao, S Agnihotri, X Qian, Y Shi, Y You, N Zhang, JN Rich, X Wang beta2-microglobulin maintains glioblastoma stem cells and induces M2-like polarization of tumor-associated macrophages Oncogene, 2022-09-16;0(0):. 2022-09-16 [PMID: 35841593] (Bioassay, Human)	Bioassay	Human
R Moser, J Annis, O Nikolova, CJ Whatcott, KE Gurley, E Mendez, K Moran-Jone, C Dorrell, RC Sears, CJ Kuo, H Han, AV Biankin, C Grandori, DD Von Hoff, CJ Kemp Pharmacological targeting of TFIIH suppresses KRAS mutant pancreatic ductal adenocarcinoma and synergizes with TRAIL Cancer Research, 2022-09-16;0(0):. 2022-09-16 [PMID: 35819261] (Bioassay, Human)	Bioassay	Human
CG Park, SH Choi, SY Lee, K Eun, MG Park, J Jang, HJ Jeong, SJ Kim, S Jeong, K Lee, H Kim Cytoplasmic LMO2-LDB1 Complex Activates STAT3 Signaling through Interaction with gp130-JAK in Glioma Stem Cells Cells, 2022-06-26;11(13):. 2022-06-26 [PMID: 35805116] (Bioassay, Human)	Bioassay	Human
JI Takahashi, S Nakamura, I Onuma, Y Zhou, S Yokoyama, H Sakurai Synchronous intracellular delivery of EGFR-targeted antibody-drug conjugates by p38-mediated non-canonical endocytosis Scientific Reports, 2022-07-07;12(1):11561. 2022-07-07 [PMID: 35798841] (Bioassay, Human)	Bioassay	Human
HY Chen, SJ Chan, X Liu, AC Wei, RI Jian, KW Huang, YD Lang, JH Shih, CC Liao, CL Luan, YT Kao, SY Chiang, PW Hsiao, YS Jou, Y Chen, RH Chen Long noncoding RNA Smyca coactivates TGF-beta/Smad and Myc pathways to drive tumor progression Journal of hematology & oncology, 2022-07-06;15(1):85. 2022-07-06 [PMID: 35794621] (Bioassay, Human)	Bioassay	Human
D Guo, J Xiao, J Liang, J Fan, P Hou, X Li, H Zhang, K Li, L Bu, P Li, M He, Y Zhong, L Guo, P Jia, Q Xiao, J Wu, H Peng, C Li, F Xing CDK4/6 inhibition enhances oncolytic virus efficacy by potentiating tumor-selective cell killing and T cell activation in refractory glioblastoma Cancer Research, 2022-09-16;0(0):. 2022-09-16 [PMID: 35792620] (Bioassay, Human)	Bioassay	Human
V Lungova, K Wendt, SL Thibeault Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling Oncogene, 2022-08-23;0(0):. 2022-08-23 [PMID: 35770504] (Bioassay, Human)	Bioassay	Human
EJ Sohn PIK3R3, a regulatory subunit of PI3K, modulates ovarian cancer stem cells and ovarian cancer development and progression by integrative analysis BMC Cancer, 2022-06-27;22(1):708. 2022-06-27 [PMID: 35761259] (Bioassay, Human)	Bioassay	Human
M Ratliff, H Kim, H Qi, M Kim, B Ku, DD Azorin, D Hausmann, RK Khajuria, A Patel, E Maier, L Cousin, A Ogier, F Sahm, N Etminan, L Bunse, F Winkler, V El-Khoury, M Platten, YJ Kwon Patient-Derived Tumor Organoids for Guidance of Personalized Drug Therapies in Recurrent Glioblastoma International Journal of Molecular Sciences, 2022-06-12;23(12):. 2022-06-12 [PMID: 35743016] (Bioassay, Human)	Bioassay	Human
MC Beer, H Kuhrt, L Kohen, P Wiedemann, A Bringmann, M Hollborn Kir4.2 Potassium Channels in Retinal Pigment Epithelial Cells In Vitro: Contribution to Cell Viability and Proliferation, and Down-Regulation by Vascular Endothelial Growth Factor Biomolecules, 2022-06-18;12(6):. 2022-06-18 [PMID: 35740973] (Bioassay, Human)	Bioassay	Human
RE Thompson, MA Meyers, DNR Veeramacha, BS Pukazhenth, FK Hollinshea Equine Oviductal Organoid Generation and Cryopreservation Methods and protocols, 2022-06-15;5(3):. 2022-06-15 [PMID: 35736552] (Bioassay, Equine)	Bioassay	Equine
Y Chen, J Mei, P Zhang, J Liu, L Chen, L Wu, Y Zhang IQGAP1 is positively correlated with PD-L1 and regulates its expression via mediating STAT proteins phosphorylation Oncogene, 2022-05-31;108(0):108897. 2022-05-31 [PMID: 35729832] (Bioassay, Human)	Bioassay	Human
U Mala, TK Baral, K Somasundar Integrative analysis of cell adhesion molecules in glioblastoma identified prostaglandin F2 receptor inhibitor (PTGFRN) as an essential gene BMC Cancer, 2022-06-11;22(1):642. 2022-06-11 [PMID: 35690717] (Bioassay, Human)	Bioassay	Human
M Wang, W Li, J Hao, A Gonzales, Z Zhao, RS Flores, X Kuang, X Mu, T Ching, G Tang, Z Luo, CE Garciamend, JK Sahoo, MF Wells, G Niu, P Agrawal, A Quiñones-H, K Eggan, YS Zhang Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues Nature Communications, 2022-06-09;13(1):3317. 2022-06-09 [PMID: 35680907] (Bioassay, Human)	Bioassay	Human
M Vicioso-Ma, R Fueyo, C Navarro, S Cruz-Molin, WFJ van Ijcken, E Rebollo, Á Rada-Igles, MA Martínez-B JMJD3 intrinsically disordered region links the 3D-genome structure to TGFbeta-dependent transcription activation Nature Communications, 2022-06-07;13(1):3263. 2022-06-07 [PMID: 35672304] (Bioassay, Mouse)	Bioassay	Mouse
AK Nair, M Traurig, JR Sutherland, YL Muller, ED Grellinger, L Saporito, RG Nelson, C Bogardus, LJ Baier Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians Cells, 2022-04-25;11(9):. 2022-04-25 [PMID: 35563754] (Bioassay, Human)	Bioassay	Human
V Semkova, S Haupt, M Segschneid, C Bell, M Ingelman-S, M Hajo, B Weykopf, P Muthukotti, A Till, O Brüstle Dynamics of Metabolic Pathways and Stress Response Patterns during Human Neural Stem Cell Proliferation and Differentiation Cells, 2022-04-20;11(9):. 2022-04-20 [PMID: 35563695] (Bioassay, Human)	Bioassay	Human
K Li, X Sun, R Zha, S Liu, Y Feng, T Sano, UK Aryal, A Sudo, BY Li, H Yokota Counterintuitive production of tumor-suppressive secretomes from Oct4- and c-Myc-overexpressing tumor cells and MSCs Theranostics, 2022-03-28;12(7):3084-3103. 2022-03-28 [PMID: 35547745] (Bioassay, Mouse)	Bioassay	Mouse
H Sun, J Zheng, J Xiao, J Yue, Z Shi, Z Xuan, C Chen, Y Zhao, W Tang, S Ye, J Li, Q Deng, L Zhang, F Zhu, C Shao TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC Cell Death & Disease, 2022-05-11;13(5):450. 2022-05-11 [PMID: 35546143] (Bioassay, Human)	Bioassay	Human
EQX Mulcahy, Y Zhang, RR Col?n, SR Cain, MK Gibert, CJ Dube, M Hafner, R Abounader MicroRNA 3928 Suppresses Glioblastoma through Downregulation of Several Oncogenes and Upregulation of p53 International Journal of Molecular Sciences, 2022-04-01;23(7):. 2022-04-01 [PMID: 35409289] (Bioassay, Human)	Bioassay	Human
D Bernareggi, Q Xie, BC Prager, J Yun, LS Cruz, TV Pham, W Kim, X Lee, M Coffey, C Zalfa, P Azmoon, H Zhu, P Tamayo, JN Rich, DS Kaufman CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity Nature Communications, 2022-04-07;13(1):1899. 2022-04-07 [PMID: 35393416] (Bioassay, Human)	Bioassay	Human
H Han, Y Wang, J Curto, S Gurrapu, S Laudato, A Rumandla, G Chakrabort, X Wang, H Chen, Y Jiang, D Kumar, EG Caggiano, M Capogiri, B Zhang, Y Ji, SN Maity, M Hu, S Bai, AM Aparicio, E Efstathiou, CJ Logothetis, N Navin, NM Navone, Y Chen, FG Giancotti Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis Cell Reports, 2022-04-05;39(1):110595. 2022-04-05 [PMID: 35385726] (Bioassay, Human)	Bioassay	Human
Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep, 2022-04-05;23(6):e54041. 2022-04-05 [PMID: 35384245] (Bioassay, Human)	Bioassay	Human
S Kim, S Min, YS Choi, SH Jo, JH Jung, K Han, J Kim, S An, YW Ji, YG Kim, SW Cho Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids Nature Communications, 2022-03-30;13(1):1692. 2022-03-30 [PMID: 35354790] (Bioassay, Human)	Bioassay	Human
R Suenaga, S Konagaya, J Yamaura, R Ito, S Tanaka, Y Ishizaki, T Toyoda Microwell bag culture for large-scale production of homogeneous islet-like clusters Scientific Reports, 2022-03-25;12(1):5221. 2022-03-25 [PMID: 35338209] (Bioassay, Human)	Bioassay	Human
V De Re, L Alessandri, G Brisotto, L Caggiari, M De Zorzi, M Casarotto, G Miolo, F Puglisi, SK Garattini, S Lonardi, R Cannizzaro, V Canzonieri, M Fassan, A Steffan HER2-CDH1 Interaction via Wnt/B-Catenin Is Associated with Patients' Survival in HER2-Positive Metastatic Gastric Adenocarcinoma Cancers, 2022-02-28;14(5):. 2022-02-28 [PMID: 35267574] (Cell Culture, Human)	Cell Culture	Human
K Uehara, M Koyanagi-A, T Koide, T Itoh, T Aoi Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids Stem Cell Reports, 2022-03-03;0(0):. 2022-03-03 [PMID: 35245440] (Bioassay, Human)	Bioassay	Human
K Pang, J Lee, J Kim, J Park, Y Park, E Hong, H An, A Ooshima, M Son, KS Park, JH Cho, C Lee, YS Song, KM Yang, SJ Kim Degradation of DRAK1 by CUL3/SPOP E3 Ubiquitin ligase promotes tumor growth of paclitaxel-resistant cervical cancer cells Cell Death & Disease, 2022-02-22;13(2):169. 2022-02-22 [PMID: 35194034] (Bioassay, Human)	Bioassay	Human
MM Capeling, S Huang, CJ Childs, JH Wu, YH Tsai, A Wu, N Garg, EM Holloway, N Sundaram, C Bouffi, M Helmrath, JR Spence Suspension culture promotes serosal mesothelial development in human intestinal organoids Cell Reports, 2022-02-15;38(7):110379. 2022-02-15 [PMID: 35172130] (Bioassay, Human)	Bioassay	Human
D Liu, G Rychkov, P Hurtado, HY Luo, T Zhang, L Bobrovskay, XF Zhou Conversion of Human Fibroblasts into Induced Neural Stem Cells by Small Molecules International Journal of Molecular Sciences, 2022-02-03;23(3):. 2022-02-03 [PMID: 35163660] (Cell Culture, Human, Mouse)	Cell Culture	Human, Mouse
SY Zhao, Z Wang, XB Wu, S Zhang, Q Chen, DD Wang, QF Tan CERS6-AS1 contributes to the malignant phenotypes of colorectal cancer cells by interacting with miR-15b-5p to regulate SPTBN2 The Kaohsiung journal of medical sciences, 2022-02-11;0(0):. 2022-02-11 [PMID: 35146902] (Bioassay, Human)	Bioassay	Human
C Hu, CA Leche, A Kiyatkin, Z Yu, SE Stayrook, KM Ferguson, MA Lemmon Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias Nature, 2022-02-09;602(7897):518-522. 2022-02-09 [PMID: 35140400] (Bioassay, Human)	Bioassay	Human
DA Eagles, NJ Saez, B Krishnarju, JJ Bradford, YK Chin, H Starobova, A Mueller, ME Reichelt, EAB Undheim, RS Norton, WG Thomas, I Vetter, GF King, SD Robinson A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals Proceedings of the National Academy of Sciences of the United States of America, 2022-02-15;119(7):. 2022-02-15 [PMID: 35131940] (Bioassay, Human)	Bioassay	Human
C Fu, A Arora, W Engl, M Sheetz, V Viasnoff Cooperative regulation of adherens junction expansion through Epidermal Growth Factor Receptor (EGFR) activation Journal of Cell Science, 2022-02-22;0(0):. 2022-02-22 [PMID: 35099018] (Bioassay, Mouse)	Bioassay	Mouse
A Hunziker, I Glas, MO Pohl, S Stertz Phosphoproteomic profiling of influenza virus entry reveals infection-triggered filopodia induction counteracted by dynamic cortactin phosphorylation Cell Reports, 2022-01-25;38(4):110306. 2022-01-25 [PMID: 35081340] (Bioassay, Human)	Bioassay	Human
L Yu, M Toriseva, S Afshan, M Cangiano, V Fey, A Erickson, H Seikkula, K Alanen, P Taimen, O Ettala, M Nurmi, PJ Boström, M Kallajoki, J Tuomela, T Mirtti, IJ Beumer, M Nees, P Härkönen Increased Expression and Altered Cellular Localization of Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) Are Associated with Prostate Cancer Progression Cancers, 2022-01-07;14(2):. 2022-01-07 [PMID: 35053442] (Bioassay, Human)	Bioassay	Human
Z Pan, R Zhao, B Li, Y Qi, W Qiu, Q Guo, S Zhang, S Zhao, H Xu, M Li, Z Gao, Y Fan, J Xu, H Wang, S Wang, J Qiu, Q Wang, X Guo, L Deng, P Zhang, H Xue, G Li EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3 Molecular Cancer, 2022-01-14;21(1):16. 2022-01-14 [PMID: 35031058] (Bioassay, Human)	Bioassay	Human
SH Gao, GZ Wang, LP Wang, L Feng, YC Zhou, XJ Yu, F Liang, FY Yang, Z Wang, BB Sun, D Wang, LJ Liang, DW Xie, S Zhao, HP Feng, X Li, KK Li, TS Tang, YC Huang, SQ Wang, GB Zhou Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer Cell Calcium, 2022-01-06;102(0):102527. 2022-01-06 [PMID: 35026540] (Bioassay, Human)	Bioassay	Human
Y Miura, MY Li, O Revah, SJ Yoon, G Narazaki, SP Pa?ca Engineering brain assembloids to interrogate human neural circuits Nature Protocols, 2022-01-06;17(1):15-35. 2022-01-06 [PMID: 34992269] (Bioassay, Human)	Bioassay	Human
PE Farahani, SB Lemke, E Dine, G Uribe, JE Toettcher, CM Nelson Substratum stiffness regulates Erk signaling dynamics through receptor-level control Cell Reports, 2021-12-28;37(13):110181. 2021-12-28 [PMID: 34965432] (Bioassay, Human)	Bioassay	Human
N Jalali Mot, C Wang, EG Kuellenber, GR Wojtkiewic, S Schmidt, JW Chen D-Mannose Slows Glioma Growth by Modulating Myeloperoxidase Activity Cancers, 2021-12-18;13(24):. 2021-12-18 [PMID: 34944979] (Bioassay, Human)	Bioassay	Human
K Dokladny, JK Crane, AJ Kassicieh, JB Kaper, O Kovbasnjuk Cross-Talk between Probiotic Nissle 1917 and Human Colonic Epithelium Affects the Metabolite Composition and Demonstrates Host Antibacterial Effect Metabolites, 2021-12-05;11(12):. 2021-12-05 [PMID: 34940599] (Bioassay, Human)	Bioassay	Human
V Chesnokova, S Zonis, A Apostolou, HQ Estrada, S Knott, K Wawrowsky, K Michelsen, A Ben-Shlomo, R Barrett, V Gorbunova, K Karalis, S Melmed Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage Cell Reports, 2021-12-14;37(11):110068. 2021-12-14 [PMID: 34910915] (Bioassay, Human)	Bioassay	Human
S Siddharth, S Parida, N Muniraj, S Hercules, D Lim, A Nagalingam, C Wang, B Gyorffy, JM Daniel, D Sharma Concomitant activation of GLI1 and Notch1 contributes to racial disparity of human triple negative breast cancer progression Elife, 2021-12-10;10(0):. 2021-12-10 [PMID: 34889737] (Bioassay, Human)	Bioassay	Human
AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells Cell Stem Cell, 2021-12-01;0(0):. 2021-12-01 [PMID: 34856121] (Bioassay, Human)	Bioassay	Human
AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients Cells, 2021-11-10;10(11):. 2021-11-10 [PMID: 34831322] (Bioassay, Human)	Bioassay	Human
KX Li, X Sun, BY Li, H Yokota Conversion of Osteoclasts into Bone-Protective, Tumor-Suppressing Cells Cancers, 2021-11-09;13(22):. 2021-11-09 [PMID: 34830748] (Bioassay, Human)	Bioassay	Human
Y Gu, Y Chen, L Wei, S Wu, K Shen, C Liu, Y Dong, Y Zhao, Y Zhang, C Zhang, W Zheng, J He, Y Wang, Y Li, X Zhao, H Wang, J Tan, L Wang, Q Zhou, G Xie, H Liang, J Ou ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation Nature Communications, 2021-11-18;12(1):6711. 2021-11-18 [PMID: 34795238] (Bioassay, Human)	Bioassay	Human
RJ Geusz, A Wang, DK Lam, NK Vinckier, KD Alysandrat, DA Roberts, J Wang, S Kefalopoul, A Ramirez, Y Qiu, J Chiou, KJ Gaulton, B Ren, DN Kotton, M Sander Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors Nature Communications, 2021-11-17;12(1):6636. 2021-11-17 [PMID: 34789735] (Bioassay, Human)	Bioassay	Human
RR Madsen, EC Erickson, OM Rueda, X Robin, C Caldas, A Toker, RK Semple, B Vanhaesebr Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype PloS Genetics, 2021-11-11;17(11):e1009876. 2021-11-11 [PMID: 34762647] (Bioassay, Human)	Bioassay	Human
T Gebregiwor, Y Kano, J St-Germain, N Radulovich, ML Udaskin, A Mentes, R Huang, BPK Poon, W He, I Valencia-S, CM Robinson, M Huestis, J Miao, JJ Yeh, ZY Zhang, MS Irwin, JE Lee, MS Tsao, B Raught, CB Marshall, M Ohh, M Ikura The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors Nature Communications, 2021-11-01;12(1):6274. 2021-11-01 [PMID: 34725361] (Bioassay, Human)	Bioassay	Human
A De Zutter, H Crijns, N Berghmans, M García-Cab, L Vanbrabant, N Pörtner, V Vanheule, P Verscheure, MM Siddiquei, AM Abu El-Asr, P Carmeliet, P Van Wielen, I De Meester, J Van Damme, P Proost, S Struyf The Chemokine-Based Peptide, CXCL9(74-103), Inhibits Angiogenesis by Blocking Heparan Sulfate Proteoglycan-Mediated Signaling of Multiple Endothelial Growth Factors Cancers, 2021-10-12;13(20):. 2021-10-12 [PMID: 34680238] (Cell Culture, Human)	Cell Culture	Human
X Morales, R Peláez, S Garasa, C Ortiz de S, A Rouzaut CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration Biomolecules, 2021-10-18;11(10):. 2021-10-18 [PMID: 34680167] (Bioassay, Human)	Bioassay	Human
T Kobayashi, A Castillo-V, CA Penfold, M Morgan, N Mizuno, WWC Tang, Y Osada, M Hirao, F Yoshida, H Sato, H Nakauchi, M Hirabayash, MA Surani Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells Cell Reports, 2021-10-12;37(2):109812. 2021-10-12 [PMID: 34644585] (Bioassay, Rabbit)	Bioassay	Rabbit
G Belthier, Z Homayed, F Grillet, C Duperray, J Vendrell, I Krol, S Bravo, JC Boyer, O Villeronce, J Vitre-Boub, D Heaug-Wane, F Macari-Fin, J Smith, M Merlot, G Lossaint, T Mazard, F Portales, J Solassol, M Ychou, N Aceto, E Mamessier, F Bertucci, JM Pascussi, E Samalin, F Hollande, J Pannequin CD44v6 Defines a New Population of Circulating Tumor Cells Not Expressing EpCAM Cancers, 2021-10-02;13(19):. 2021-10-02 [PMID: 34638450] (Cell Culture, Human)	Cell Culture	Human
M Niu, J Xu, Y Liu, Y Li, T He, L Ding, Y He, Y Yi, F Li, R Guo, Y Gao, R Li, L Li, M Fu, Q Hu, Y Luo, C Zhang, K Qin, J Yi, S Yu, J Yang, H Chen, L Wang, Z Li, B Dong, S Qi, L Ouyang, Y Zhang, Y Cao, ZJ Xiao FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth Nature Communications, 2021-10-11;12(1):5919. 2021-10-11 [PMID: 34635651] (Cell Culture, Human)	Cell Culture	Human
T Arad, N Fainstein, S Goldfarb, M Lachish, T Ganz, T Ben-Hur CD200 -dependent and -independent immune-modulatory functions of neural stem cells Stem Cell Research, 2021-10-07;56(0):102559. 2021-10-07 [PMID: 34634761] (Cell Culture, Mouse)	Cell Culture	Mouse
Kim Y, Kim H, Jung D, Kang D, Nam D, Nam H, Cho H Glioblastoma patient-derived cell-based phenotypic drug screening and identification of possible action mechanisms through proteomic analysis. STAR Protoc, 2021-09-24;2(4):100849. 2021-09-24 [PMID: 34611628] (Bioassay, Human)	Bioassay	Human
A Tarallo, C Damiano, S Strollo, N Minopoli, A Indrieri, E Polishchuk, F Zappa, E Nusco, S Fecarotta, C Porto, M Coletta, R Iacono, M Moracci, R Polishchuk, DL Medina, P Imbimbo, DM Monti, MA De Matteis, G Parenti Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease Embo Molecular Medicine, 2021-10-04;0(0):e14434. 2021-10-04 [PMID: 34606154] (Bioassay, Human)	Bioassay	Human
X Dolde, C Karreman, M Wiechers, S Schildknec, M Leist Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays International Journal of Molecular Sciences, 2021-09-18;22(18):. 2021-09-18 [PMID: 34576243] (Bioassay, Human)	Bioassay	Human
X Feng, A Cao, T Qin, Q Zhang, S Fan, B Wang, B Song, X Yu, L Li Abnormally elevated ubiquilin?1 expression in breast cancer regulates metastasis and stemness via AKT signaling Oncology reports, 2021-09-16;46(5):. 2021-09-16 [PMID: 34528694] (Bioassay, Human)	Bioassay	Human
Y Aghazadeh, F Poon, F Sarangi, FTM Wong, ST Khan, X Sun, R Hatkar, BJ Cox, SS Nunes, MC Nostro Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models Cell Stem Cell, 2021-09-03;0(0):. 2021-09-03 [PMID: 34480863] (Bioassay, Human)	Bioassay	Human
T Miyake, M Kuge, Y Matsumoto, M Shimada alpha-glucosyl-rutin activates immediate early genes in human induced pluripotent stem cells Stem Cell Research, 2021-08-20;56(0):102511. 2021-08-20 [PMID: 34455240] (Bioassay, Human)	Bioassay	Human
AV Parent, G Faleo, J Chavez, M Saxton, DI Berrios, NR Kerper, Q Tang, M Hebrok Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection Cell Reports, 2021-08-17;36(7):109538. 2021-08-17 [PMID: 34407395] (Bioassay, Human)	Bioassay	Human
C Lin, Å Ekblad-Nor, J Michaëlsso, C Götherströ, CC Hsu, H Ye, J Johansson, A Rising, E Sundström, E Åkesson In Vitro Study of Human Immune Responses to Hyaluronic Acid Hydrogels, Recombinant Spidroins and Human Neural Progenitor Cells of Relevance to Spinal Cord Injury Repair Cells, 2021-07-06;10(7):. 2021-07-06 [PMID: 34359882] (Bioassay, Human)	Bioassay	Human
A Ulman, M Kot, K Skrzypek, B Szewczyk, M Majka Myogenic Differentiation of iPS Cells Shows Different Efficiency in Simultaneous Comparison of Protocols Cells, 2021-07-02;10(7):. 2021-07-02 [PMID: 34359837] (Bioassay, Human)	Bioassay	Human
BM Larsen, M Kannan, LF Langer, BD Leibowitz, A Bentaieb, A Cancino, I Dolgalev, BE Drummond, JR Dry, CS Ho, G Khullar, BA Krantz, B Mapes, KE McKinnon, J Metti, JF Perera, TA Rand, V Sanchez-Fr, JM Shaxted, MM Stein, MA Streit, YC Tan, Y Zhang, E Zhao, J Venkataram, MC Stumpe, JA Borgia, A Masood, DVT Catenacci, JV Mathews, DB Gursel, JJ Wei, TH Welling, DM Simeone, KP White, AA Khan, C Igartua, AA Salahudeen A pan-cancer organoid platform for precision medicine Cell Reports, 2021-07-27;36(4):109429. 2021-07-27 [PMID: 34320344] (Bioassay, Human)	Bioassay	Human
IT Stancil, JE Michalski, D Davis-Hall, HW Chu, JA Park, CM Magin, IV Yang, BJ Smith, E Dobrinskik, DA Schwartz Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional Nature Communications, 2021-07-27;12(1):4566. 2021-07-27 [PMID: 34315881] (Bioassay, Human)	Bioassay	Human
MO Lee, SG Lee, CR Jung, YS Son, JW Ryu, KB Jung, JH Ahn, JH Oh, HA Lee, JH Lim, J Kim, I Jang, J Choi, J Jung, K Park, B Lee, DS Kim, MY Son, HS Cho Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells Nature Communications, 2021-07-23;12(1):4492. 2021-07-23 [PMID: 34301945] (Bioassay, Human)	Bioassay	Human
J Barra, J Cerda-Infa, L Sandoval, P Gajardo-Me, JF Henriquez, M Labarca, C Metz, J Venegas, C Retamal, C Oyanadel, J Cancino, A Soza, MA Cuello, JC Roa, VP Montecinos, A Gonzalez D-Propranolol Impairs EGFR Trafficking and Destabilizes Mutant p53 Counteracting AKT Signaling and Tumor Malignancy Cancers, 2021-07-20;13(14):. 2021-07-20 [PMID: 34298835] (Bioassay, Human)	Bioassay	Human
SM Dieter, C Siegl, PL Codó, M Huerta, AL Ostermann-, E Schulz, MK Zowada, S Martin, K Laaber, A Nowrouzi, M Blatter, S Kreth, F Westermann, A Benner, U Uhrig, K Putzker, J Lewis, A Haegebarth, D Mumberg, SJ Holton, J Weiske, LM Toepper, U Scheib, G Siemeister, CR Ball, B Kuster, G Stoehr, H Hahne, S Johannes, M Lange, F Herbst, H Glimm Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer Cell Reports, 2021-07-20;36(3):109394. 2021-07-20 [PMID: 34289372] (Bioassay, Human)	Bioassay	Human
K Jamal Jame, WJ Gallert, SD Yanik, S Panek, J Kronsbein, D Jungck, A Koch, J Knobloch Biomarkers for Comorbidities Modulate the Activity of T-Cells in COPD International Journal of Molecular Sciences, 2021-07-02;22(13):. 2021-07-02 [PMID: 34281240] (Bioassay, Human)	Bioassay	Human
S Deng, X Hu, L Luo, W Tang, Y Jiang, F Yin, C Hu, J Feng, X Li Anaphylatoxins orchestrate Th17 response via interactions between CD16+ monocytes and pleural mesothelial cells in tuberculous pleural effusion PloS Neglected Tropical Diseases, 2021-07-08;15(7):e0009508. 2021-07-08 [PMID: 34237073] (Bioassay, Human)	Bioassay	Human
Y Andersson, KG Fleten, TW Abrahamsen, W Reed, B Davidson, K Flatmark Anti-Angiogenic Treatment in Pseudomyxoma Peritonei-Still a Strong Preclinical Rationale Cancers, 2021-06-05;13(11):. 2021-06-05 [PMID: 34198773] (Bioassay, Human)	Bioassay	Human
J Dong, J Li, Y Li, Z Ma, Y Yu, CY Wang Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma Nature Communications, 2021-06-25;12(1):3974. 2021-06-25 [PMID: 34172737] (Bioassay, Human)	Bioassay	Human
R Wang, ST Wu, X Yang, Y Qian, JP Choi, R Gao, S Song, Y Wang, T Zhuang, JJ Wong, Y Zhang, Z Han, HA Lu, SI Alexander, R Liu, Y Xia, X Zheng Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting JCI Insight, 2021-06-22;6(12):. 2021-06-22 [PMID: 34156031] (Bioassay, Mouse)	Bioassay	Mouse
O Kwon, KB Jung, KR Lee, YS Son, H Lee, JJ Kim, K Kim, S Lee, YK Song, J Jung, K Park, DS Kim, MJ Son, MO Lee, TS Han, HS Cho, SJ Oh, H Chung, SH Kim, KS Chung, J Kim, CR Jung, MY Son The development of a functional human small intestinal epithelium model for drug absorption Science Advances, 2021-06-02;7(23):. 2021-06-02 [PMID: 34078609] (Bioassay, Human)	Bioassay	Human
S Mishra, J Taelman, YW Chang, A Boel, P De Sutter, B Heindryckx, SM Chuva De S Sex-Specific Isolation and Propagation of Human Premeiotic Fetal Germ Cells and Germ Cell-Like Cells Cells, 2021-05-16;10(5):. 2021-05-16 [PMID: 34065661] (Bioassay, Human)	Bioassay	Human
WZ Peng, J Zhao, X Liu, CF Li, S Si, R Ma hnRNPA2B1 regulates the alternative splicing of BIRC5 to promote gastric cancer progression Cancer Cell International, 2021-05-27;21(1):281. 2021-05-27 [PMID: 34044823] (Bioassay, Human)	Bioassay	Human
DG Kim, HJ Kim, SH Choi, SM Nam, HC Kim, H Rhim, IH Cho, MH Rhee, SY Nah Gintonin influences the morphology and motility of adult brain neurons via LPA receptors Journal of Ginseng Research, 2020-07-21;45(3):401-407. 2020-07-21 [PMID: 34025133] (Bioassay, Human)	Bioassay	Human
S Bahl, H Ling, NPN Acharige, I Santos-Bar, MKH Pflum, E Seto EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function Cell Death & Disease, 2021-05-11;12(5):469. 2021-05-11 [PMID: 33976119] (Bioassay, Human)	Bioassay	Human
C Wang, Y Li, L Jia, JK Kim, J Li, P Deng, W Zhang, PH Krebsbach, CY Wang CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance Cell Stem Cell, 2021-05-03;0(0):. 2021-05-03 [PMID: 33945793] (Bioassay, Human)	Bioassay	Human
M Kaneko, Y Reien, H Morio, T Fukuuchi, K Kaneko, Y Hirayama, H Hashimoto, N Kuwata, H Mitsuya, N Anzai Effects of islatravir (4'-ethynyl-2-fluoro-2'-deoxyadenosine or EFdA) on renal tubular cells and islatravir's interactions with organic anion transporters Journal of pharmacological sciences, 2021-03-19;146(2):82-87. 2021-03-19 [PMID: 33941324] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
H Lee, OB Kwon, JE Lee, YH Jeon, DS Lee, SH Min, JW Kim Repositioning Trimebutine Maleate as a Cancer Treatment Targeting Ovarian Cancer Stem Cells Cells, 2021-04-16;10(4):. 2021-04-16 [PMID: 33923707] (Bioassay, Human)	Bioassay	Human
M Ryding, M Gamre, MS Nissen, AC Nilsson, J Okarmus, AAE Poulsen, M Meyer, M Blaabjerg Neurodegeneration Induced by Anti-IgLON5 Antibodies Studied in Induced Pluripotent Stem Cell-Derived Human Neurons Cells, 2021-04-08;10(4):. 2021-04-08 [PMID: 33917676] (Bioassay, Human)	Bioassay	Human
D Sighel, M Notarangel, S Aibara, A Re, G Ricci, M Guida, A Soldano, V Adami, C Ambrosini, F Broso, EF Rosatti, S Longhi, M Buccarelli, QG D'Alessand, S Giannetti, S Pacioni, L Ricci-Viti, J Rorbach, R Pallini, S Roulland, A Amunts, I Mancini, A Modelska, A Quattrone Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth Cell Reports, 2021-04-27;35(4):109024. 2021-04-27 [PMID: 33910005] (Bioassay, Human)	Bioassay	Human
A Abdullah, C Herdenberg, H Hedman Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling Scientific Reports, 2021-04-21;11(1):8585. 2021-04-21 [PMID: 33883596] (Bioassay, Human)	Bioassay	Human
MDA Norman, SA Ferreira, GM Jowett, L Bozec, E Gentleman Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force microscopy Nature Protocols, 2021-04-14;0(0):. 2021-04-14 [PMID: 33854255] (Bioassay, Human)	Bioassay	Human
S Io, M Kabata, Y Iemura, K Semi, N Morone, A Minagawa, B Wang, I Okamoto, T Nakamura, Y Kojima, C Iwatani, H Tsuchiya, B Kaswandy, E Kondoh, S Kaneko, K Woltjen, M Saitou, T Yamamoto, M Mandai, Y Takashima Capturing human trophoblast development with naive pluripotent stem cells in�vitro Cell Stem Cell, 2021-04-07;28(6):1023-1039.e13. 2021-04-07 [PMID: 33831365] (Bioassay, Human)	Bioassay	Human
M Chiara Per, N Bellitto, ERS Maylem, F Caloni, LJ Spicer Effects of selected hormones and their combination on progesterone and estradiol production and proliferation of feline granulosa cells cultured in�vitro Theriogenology, 2021-03-28;168(0):1-12. 2021-03-28 [PMID: 33826978] (Bioassay, Feline)	Bioassay	Feline
S van der Po, GMH Birchenoug, JM Held NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation Cell Reports, 2021-04-06;35(1):108949. 2021-04-06 [PMID: 33826887] (Bioassay, Mouse)	Bioassay	Mouse
T Roebroek, W Vandenberg, F Sipieter, S Hugelier, C Stove, J Zhang, P Dedecker Simultaneous readout of multiple FRET pairs using photochromism Nature Communications, 2021-03-31;12(1):2005. 2021-03-31 [PMID: 33790271] (Bioassay, Human)	Bioassay	Human
RM Agoglia, D Sun, F Birey, SJ Yoon, Y Miura, K Sabatini, SP Pa?ca, HB Fraser Primate cell fusion disentangles gene regulatory divergence in neurodevelopment Nature, 2021-03-17;0(0):. 2021-03-17 [PMID: 33731928] (Bioassay, Human, Primate)	Bioassay	Human, Primate
L Preisler, A Habib, G Shapira, L Kuznitsov-, Y Mayshar, I Carmel-Gro, M Malcov, F Azem, N Shomron, R Kariv, D Hershkovit, D Ben-Yosef Heterozygous APC germline mutations impart predisposition to colorectal cancer Scientific Reports, 2021-03-04;11(1):5113. 2021-03-04 [PMID: 33664379] (Bioassay, Human)	Bioassay	Human
JA Sninsky, KS Bishnupuri, I González, NA Trikalinos, L Chen, BK Dieckgraef Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer Oncotarget, 2021-02-16;12(4):278-291. 2021-02-16 [PMID: 33659040] (Bioassay, Human)	Bioassay	Human
KA Lidberg, AJ Annalora, M Jozic, DJ Elson, L Wang, TK Bammler, S Ramm, MB Monteiro, J Himmelfarb, CB Marcus, PL Iversen, EJ Kelly Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease Scientific Reports, 2021-02-25;11(1):4722. 2021-02-25 [PMID: 33633318] (Bioassay, Human)	Bioassay	Human
A Gordon, SJ Yoon, SS Tran, CD Makinson, JY Park, J Andersen, AM Valencia, S Horvath, X Xiao, JR Huguenard, SP Pa?ca, DH Geschwind Long-term maturation of human cortical organoids matches key early postnatal transitions Nature Neuroscience, 2021-02-22;0(0):. 2021-02-22 [PMID: 33619405] (Bioassay, Human)	Bioassay	Human
C Tu, H Li, X Liu, Y Wang, W Li, L Meng, W Wang, Y Li, D Li, J Du, G Lu, G Lin, YQ Tan TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation Autophagy, 2021-03-03;0(0):. 2021-03-03 [PMID: 33618632] (Bioassay, Mouse)	Bioassay	Mouse
W Yuan, Z Yao, V Veerapandi, X Yang, X Wang, D Chen, L Ma, C Li, Y Zheng, F Luo, XY Zhao The histone demethylase KDM2B regulates human primordial germ cell-like cells specification International journal of biological sciences, 2021-01-01;17(2):527-538. 2021-01-01 [PMID: 33613110] (Bioassay, Human)	Bioassay	Human
M Yoshimatsu, H Ohnishi, C Zhao, Y Hayashi, F Kuwata, S Kaba, H Okuyama, Y Kawai, N Hiwatashi, Y Kishimoto, T Sakamoto, M Ikeya, K Omori In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells Stem Cell Research, 2021-02-11;52(0):102233. 2021-02-11 [PMID: 33607469] (Bioassay, Human)	Bioassay	Human
S Hao, X Zhu, Z Liu, X Wu, S Li, P Jiang, L Jiang Chronic intermittent hypoxia promoted lung cancer stem cell-like properties via enhancing Bach1 expression Respiratory Research, 2021-02-17;22(1):58. 2021-02-17 [PMID: 33596919] (Bioassay, Human)	Bioassay	Human
E Jung, M Osswald, M Ratliff, H Dogan, R Xie, S Weil, DC Hoffmann, FT Kurz, T Kessler, S Heiland, A von Deimli, F Sahm, W Wick, F Winkler Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma Nature Communications, 2021-02-12;12(1):1014. 2021-02-12 [PMID: 33579922] (Bioassay, Human)	Bioassay	Human
Q Zhu, F Sang, S Withey, W Tang, S Dietmann, D Klisch, P Ramos-Ibea, H Zhang, CE Requena, P Hajkova, M Loose, MA Surani, R Alberio Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage Cell Reports, 2021-02-09;34(6):108735. 2021-02-09 [PMID: 33567277] (Bioassay, Human)	Bioassay	Human
A Mischler, V Karakis, J Mahinthaku, CK Carberry, A San Miguel, JE Rager, RC Fry, BM Rao Two distinct trophectoderm lineage stem cells from human pluripotent stem cells The Journal of Biological Chemistry, 2021-02-05;0(0):100386. 2021-02-05 [PMID: 33556374] (Bioassay, Human)	Bioassay	Human
K Nomi, R Hayashi, Y Ishikawa, Y Kobayashi, T Katayama, AJ Quantock, K Nishida Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs Cell Reports, 2021-02-02;34(5):108715. 2021-02-02 [PMID: 33535050] (Bioassay, Human)	Bioassay	Human
C Phoomak, W Cui, TJ Hayman, SH Yu, P Zhao, L Wells, R Steet, JN Contessa The translocon-associated protein (TRAP) complex regulates quality control of N-linked glycosylation during ER stress Science Advances, 2021-01-15;7(3):. 2021-01-15 [PMID: 33523898] (Bioassay, Human)	Bioassay	Human
A Lita, A Pliss, A Kuzmin, T Yamasaki, L Zhang, T Dowdy, C Burks, N de Val, O Celiku, V Ruiz-Rodad, ER Nicoli, M Kruhlak, T Andresson, S Das, C Yang, R Schmitt, C Herold-Men, MR Gilbert, PN Prasad, M Larion IDH1 mutations induce organelle defects via dysregulated phospholipids Nature Communications, 2021-01-27;12(1):614. 2021-01-27 [PMID: 33504762] (Bioassay, Human)	Bioassay	Human
L Jerby-Arno, C Neftel, ME Shore, HR Weisman, ND Mathewson, MJ McBride, B Haas, B Izar, A Volorio, G Boulay, L Cironi, AR Richman, LC Broye, JM Gurski, CC Luo, R Mylvaganam, L Nguyen, S Mei, JC Melms, C Georgescu, O Cohen, JE Buendia-Bu, A Segerstolp, M Sud, MS Cuoco, D Labes, S Gritsch, DR Zollinger, N Ortogero, JM Beechem, G Petur Niel, I Chebib, T Nguyen-Ngo, M Montemurro, GM Cote, E Choy, I Letovanec, S Cherix, N Wagle, PK Sorger, AB Haynes, JT Mullen, I Stamenkovi, MN Rivera, C Kadoch, KW Wucherpfen, O Rozenblatt, ML Suvà, N Riggi, A Regev Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma Nature Medicine, 2021-01-25;0(0):. 2021-01-25 [PMID: 33495604] (Bioassay, Human)	Bioassay	Human
K Tanaka, T Sasayama, H Nagashima, Y Irino, M Takahashi, Y Izumi, T Uno, N Satoh, A Kitta, K Kyotani, Y Fujita, M Hashiguchi, T Nakai, M Kohta, Y Uozumi, M Shinohara, K Hosoda, T Bamba, E Kohmura Glioma cells require one-carbon metabolism to survive glutamine starvation Acta neuropathologica communications, 2021-01-19;9(1):16. 2021-01-19 [PMID: 33468252] (Bioassay, Human)	Bioassay	Human
S Ghatak, VC Hascall, RR Markwald, S Misra FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells International Journal of Molecular Sciences, 2021-01-13;22(2):. 2021-01-13 [PMID: 33451103] (Bioassay, Human)	Bioassay	Human
X Wu, S Xiao, M Zhang, L Yang, J Zhong, B Li, F Li, X Xia, X Li, H Zhou, D Liu, N Huang, X Yang, F Xiao, N Zhang A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity Genome Biology, 2021-01-14;22(1):33. 2021-01-14 [PMID: 33446260] (Bioassay, Human)	Bioassay	Human
J Kim, SW Lee, K Park CXCR4 Regulates Temporal Differentiation via PRC1 Complex in Organogenesis of Epithelial Glands International Journal of Molecular Sciences, 2021-01-10;22(2):. 2021-01-10 [PMID: 33435128] (Bioassay, Mouse)	Bioassay	Mouse
SK Sarvestani, S Signs, B Hu, Y Yeu, H Feng, Y Ni, DR Hill, RC Fisher, S Ferrandon, RK DeHaan, J Stiene, M Cruise, TH Hwang, X Shen, JR Spence, EH Huang Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity Nature Communications, 2021-01-11;12(1):262. 2021-01-11 [PMID: 33431859] (Bioassay, Human)	Bioassay	Human
Z Al-Bakri, M Ishige-Wad, N Fukuda, C Yoshida-No, N Nagoshi, H Okano, H Mugishima, T Matsumoto Isolation and characterization of neural crest-like progenitor cells in human umbilical cord blood Regenerative Therapy, 2020-07-18;15(0):53-63. 2020-07-18 [PMID: 33426202] (Bioassay, Human)	Bioassay	Human
MJ Workman, E Troisi, SR Targan, CN Svendsen, RJ Barrett Modeling Intestinal Epithelial Response to Interferon-&gamma in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids International Journal of Molecular Sciences, 2020-12-30;22(1):. 2020-12-30 [PMID: 33396621] (Bioassay, Human)	Bioassay	Human
LM Caballero, S Duchi, C Onofrillo, CD O'Connell, C Di Bella, SE Moulton Formation of alginate microspheres prepared by optimized microfluidics parameters for high encapsulation of bioactive molecules Journal of colloid and interface science, 2020-12-13;587(0):240-251. 2020-12-13 [PMID: 33360897] (Cell Culture, Human)	Cell Culture	Human
MMA Verstegen, FJM Roos, K Burka, H Gehart, M Jager, M de Wolf, MJC Bijvelds, HR de Jonge, AI Ardisasmit, NA van Huizen, HP Roest, J de Jonge, M Koch, F Pampaloni, SA Fuchs, IF Schene, TM Luider, HPJ van der Do, FAJA Bodewes, RHJ de Kleine, B Spee, GJ Kremers, H Clevers, JNM IJzermans, E Cuppen, LJW van der La Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease Scientific Reports, 2020-12-14;10(1):21900. 2020-12-14 [PMID: 33318612] (Bioassay, Human)	Bioassay	Human
M Li, G Li, J Kiyokawa, Z Tirmizi, LG Richardson, J Ning, S Das, RL Martuza, A Stemmer-Ra, SD Rabkin, H Wakimoto Characterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma Acta neuropathologica communications, 2020-12-11;8(1):221. 2020-12-11 [PMID: 33308315] (Cell Culture, Mouse)	Cell Culture	Mouse
C Zhong, P Li, S Argade, L Liu, A Chilla', W Liang, H Xin, B Eliceiri, B Choudhury, N Ferrara Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways Nature Communications, 2020-12-10;11(1):6330. 2020-12-10 [PMID: 33303737] (Cell Culture, Human)	Cell Culture	Human
Y Na, A Hall, K Choi, L Hu, J Rose, RA Coover, A Miller, RF Hennigan, E Dombi, MO Kim, S Subramania, N Ratner, J Wu MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK Oncogene, 2020-12-08;0(0):. 2020-12-08 [PMID: 33293695] (Bioassay, Mouse)	Bioassay	Mouse
EM Holloway, M Czerwinski, YH Tsai, JH Wu, A Wu, CJ Childs, KD Walton, CW Sweet, Q Yu, I Glass, B Treutlein, JG Camp, JR Spence Mapping Development of the Human Intestinal Niche at Single-Cell Resolution Cell Stem Cell, 2020-12-04;0(0):. 2020-12-04 [PMID: 33278341] (Bioassay, Human)	Bioassay	Human
T Chitiashvi, I Dror, R Kim, FM Hsu, R Chaudhari, E Pandolfi, D Chen, S Liebscher, K Schenke-La, K Plath, A Clark Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation Nature Cell Biology, 2020-11-30;22(12):1436-1446. 2020-11-30 [PMID: 33257808] (Bioassay, Human)	Bioassay	Human
C Arriagada, VA Cavieres, C Luchsinger, AE González, VC Muñoz, J Cancino, PV Burgos, GA Mardones GOLPH3 Regulates EGFR in T98G Glioblastoma Cells by Modulating Its Glycosylation and Ubiquitylation Int J Mol Sci, 2020-11-23;21(22):. 2020-11-23 [PMID: 33238647] (Cell Culture, Human)	Cell Culture	Human
F Rajabi, WY Liu-Bordes, M Pinskaya, F Dominika, G Kratassiou, G Pinna, S Nanni, A Farsetti, C Gespach, A Londoño-Va, I Groisman CPEB1 orchestrates a fine-tuning of miR-145-5p tumor-suppressive activity on TWIST1 translation in prostate cancer cells Oncotarget, 2020-11-10;11(45):4155-4168. 2020-11-10 [PMID: 33227047] (Bioassay, Human)	Bioassay	Human
G Newham, RK Mathew, H Wurdak, SD Evans, ZY Ong Polyelectrolyte complex templated synthesis of monodisperse, sub-100�nm porous silica nanoparticles for cancer targeted and stimuli-responsive drug delivery J Colloid Interface Sci, 2020-11-03;0(0):. 2020-11-03 [PMID: 33223243] (Cell Culture, Human)	Cell Culture	Human
L Song, Z Liu, HH Hu, Y Yang, TY Li, ZZ Lin, J Ye, J Chen, X Huang, DT Liu, J Zhou, Y Shi, H Zhao, C Xie, L Chen, E Song, SY Lin, SC Lin Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy Nat Commun, 2020-11-17;11(1):5842. 2020-11-17 [PMID: 33203880] (Cell Culture, Human)	Cell Culture	Human
YS Hwang, S Suzuki, Y Seita, J Ito, Y Sakata, H Aso, K Sato, BP Hermann, K Sasaki Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells Nat Commun, 2020-11-09;11(1):5656. 2020-11-09 [PMID: 33168808] (Cell Culture, Human)	Cell Culture	Human
N Jia, J Liu, G Zhu, Y Liang, Y Wang, W Wang, Y Chen, J Yang, W Zhang, J Zhang Polarization of ADAM17-driven EGFR signalling in electric field-guided collective migration of epidermal sheets J Cell Mol Med, 2020-11-08;0(0):. 2020-11-08 [PMID: 33164313] (Cell Culture, Human)	Cell Culture	Human
C Liang, J Niu, X Wang, ZS Zhang, RH Yang, X Yao, FY Liu, WQ Li, SH Pei, H Sun, CJ Wang, D Fang, SQ Xie P300-dependent acetylation of histone H3 is required for EGFR-mediated HMGA2 transcription in hepatocellular carcinoma Cancer Sci, 2020-12-15;0(0):. 2020-12-15 [PMID: 33164305] (Cell Culture, Human)	Cell Culture	Human
D Tabari, C Scholl, M Steffens, S Weickhardt, F Elgner, D Bender, ML Herrlein, C Sabino, V Semkova, M Peitz, A Till, O Brüstle, E Hildt, J Stingl Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures Viruses, 2020-10-27;12(11):. 2020-10-27 [PMID: 33121145] (Bioassay, Human)	Bioassay	Human
Linkous A, Fine H Generating Patient-Derived Gliomas within Cerebral Organoids. STAR Protoc, 2020-06-03;1(1):. 2020-06-03 [PMID: 33103125] (Bioassay, Human)	Bioassay	Human
A Di Grazia, I Marafini, G Pedini, D Di Fusco, F Laudisi, V Dinallo, E Rosina, C Stolfi, E Franzè, P Sileri, G Sica, G Monteleone, C Bagni, I Monteleone The Fragile X Mental Retardation Protein regulates RIP1K and colorectal cancer resistance to necroptosis Cell Mol Gastroenterol Hepatol, 2020-10-19;0(0):. 2020-10-19 [PMID: 33091622] (Bioassay, Human)	Bioassay	Human
KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function Cell Stem Cell, 2020-10-21;0(0):. 2020-10-21 [PMID: 33091368] (Bioassay, Human)	Bioassay	Human
CM Alexander, JA Martin, E Oxman, I Kasza, KA Senn, H Dvinge Alternative splicing and cleavage of GLUT8 Mol Cell Biol, 2020-12-21;0(0):. 2020-12-21 [PMID: 33077497] (Bioassay, Human)	Bioassay	Human
H Lee, JW Kim, DS Lee, SH Min Combined Poziotinib with Manidipine Treatment Suppresses Ovarian Cancer Stem-Cell Proliferation and Stemness Int J Mol Sci, 2020-10-06;21(19):. 2020-10-06 [PMID: 33036254] (Bioassay, Human)	Bioassay	Human
S Bammidi, P Bali, J Kalra, A Anand Transplantation Efficacy of Human Ciliary Epithelium Cells from Fetal Eye and Lin-ve Stem Cells from Umbilical Cord Blood in the Murine Retinal Degeneration Model of Laser Injury Cell Transplant, 2020-01-01;29(0):9636897209460. 2020-01-01 [PMID: 33023312] (Bioassay, Human)	Bioassay	Human
ST Magill, HN Vasudevan, K Seo, JE Villanueva, A Choudhury, S John Liu, M Pekmezci, S Findakly, S Hilz, S Lastella, B Demaree, SE Braunstein, NAO Bush, MK Aghi, PV Theodosopo, PK Sneed, AR Abate, MS Berger, MW McDermott, DA Lim, EM Ullian, JF Costello, DR Raleigh Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma Nat Commun, 2020-09-23;11(1):4803. 2020-09-23 [PMID: 32968068] (Bioassay, Human)	Bioassay	Human
SR Lin, YC Wen, HL Yeh, KC Jiang, WH Chen, N Mokgautsi, J Huang, WY Chen, YN Liu EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer Oncogene, 2020-09-22;0(0):. 2020-09-22 [PMID: 32963351] (Bioassay, Human)	Bioassay	Human
K Lloyd, S Papoutsopo, E Smith, P Stegmaier, F Bergey, L Morris, M Kittner, H England, D Spiller, MHR White, CA Duckworth, BJ Campbell, V Poroikov, VAP Martins Do, A Kel, W Muller, DM Pritchard, C Probert, MD Burkitt, SysmedIBD Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease Dis Model Mech, 2020-11-27;0(0):. 2020-11-27 [PMID: 32958515] (Bioassay, Human)	Bioassay	Human
EAA Obara, D Aguilar-Mo, RD Rasmussen, A Frias, K Vitting-Se, YC Lim, KJ Elbæk, H Pedersen, L Vardouli, KE Jensen, J Skjoth-Ras, J Brennum, L Tuckova, R Strauss, C Dinant, J Bartek, P Hamerlik SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells Nat Commun, 2020-09-18;11(1):4709. 2020-09-18 [PMID: 32948765] (Bioassay, Human)	Bioassay	Human
F Kolonics, E Kajdácsi, VJ Farkas, DS Veres, D Khamari, Á Kittel, ML Merchant, KR McLeish, ÁM L?rincz, E Ligeti Neutrophils produce proinflammatory or anti-inflammatory extracellular vesicles depending on the environmental conditions J. Leukoc. Biol., 2020-09-18;0(0):. 2020-09-18 [PMID: 32946637] (Cell Culture, Human)	Cell Culture	Human
F Rossi, B Josey, EC Sayitoglu, R Potens, T Sultu, AD Duru, V Beljanski Characterization of zika virus infection of human fetal cardiac mesenchymal stromal cells PLoS ONE, 2020-09-17;15(9):e0239238. 2020-09-17 [PMID: 32941515] (Bioassay, Human)	Bioassay	Human
S Liu, Y Wang, Y Han, W Xia, L Zhang, S Xu, H Ju, X Zhang, G Ren, L Liu, W Ye, Z Zhang, J Hu EREG-driven oncogenesis of Head and Neck Squamous Cell Carcinoma exhibits higher sensitivity to Erlotinib therapy Theranostics, 2020-08-25;10(23):10589-10605. 2020-08-25 [PMID: 32929368] (Bioassay, Human)	Bioassay	Human
HJ Lee, KJ Kim, JH Sung, M Nam, KJ Suh, JW Kim, SH Kim, JW Kim, YJ Kim, KW Lee, JS Lee, JH Kim PI3K p110&alpha Blockade Enhances Anti-Tumor Efficacy of Abemaciclib in Human Colorectal Cancer Cells Cancers, 2020-09-03;12(9):. 2020-09-03 [PMID: 32899250] (Bioassay, Human)	Bioassay	Human
JK Khalsa, N Cheng, J Keegan, A Chaudry, J Driver, WL Bi, J Lederer, K Shah Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types Nat Commun, 2020-08-06;11(1):3912. 2020-08-06 [PMID: 32764562] (Bioassay, Cell Culture, Mouse)	Bioassay, Cell Culture	Mouse
MH Hancock, J Mitchell, FD Goodrum, JA Nelson Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways mSphere, 2020-08-05;5(4):. 2020-08-05 [PMID: 32759334] (Bioassay, Human)	Bioassay	Human
SI Mae, M Ryosaka, S Sakamoto, K Matsuse, A Nozaki, M Igami, R Kabai, A Watanabe, K Osafune Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential Cell Rep, 2020-07-28;32(4):107963. 2020-07-28 [PMID: 32726627] (Bioassay, Human)	Bioassay	Human
S Findakly, A Choudhury, V Daggubati, M Pekmezci, UE Lang, DR Raleigh Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals Acta Neuropathol Commun, 2020-07-20;8(1):114. 2020-07-20 [PMID: 32690089] (Cell Culture, Human)	Cell Culture	Human
TF Dinger, O Chen, C Dittfeld, L Hetze, M Hüther, M Wondrak, S Löck, W Eicheler, G Breier, LA Kunz-Schug Microenvironmentally-driven Plasticity of CD44 isoform expression determines Engraftment and Stem-like Phenotype in CRC cell lines Theranostics, 2020-06-18;10(17):7599-7621. 2020-06-18 [PMID: 32685007] (Cell Culture, Human)	Cell Culture	Human
P Ahangar, SJ Mills, LE Smith, XL Strudwick, AE Ting, B Vaes, AJ Cowin Human multipotent adult progenitor cell-conditioned medium improves wound healing through modulating inflammation and angiogenesis in mice Stem Cell Res Ther, 2020-07-17;11(1):299. 2020-07-17 [PMID: 32680566] (Cell Culture, Human)	Cell Culture	Human
EB Cohen, RC Geck, A Toker Metabolic pathway alterations in microvascular endothelial cells in response to hypoxia PLoS ONE, 2020-07-09;15(7):e0232072. 2020-07-09 [PMID: 32645038] (Bioassay, Human)	Bioassay	Human
C Sieben, E Sezgin, C Eggeling, S Manley Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation PLoS Pathog., 2020-07-08;16(7):e1008656. 2020-07-08 [PMID: 32639985] (Cell Culture, Human)	Cell Culture	Human
E Gronseth, A Gupta, C Koceja, S Kumar, RG Kutty, K Rarick, L Wang, R Ramchandra Astrocytes influence medulloblastoma phenotypes and CD133 surface expression PLoS ONE, 2020-07-06;15(7):e0235852. 2020-07-06 [PMID: 32628717] (Cell Culture, Zebrafish)	Cell Culture	Zebrafish
S Sun, L Yuan, Z An, D Shi, J Xin, J Jiang, K Ren, J Chen, B Guo, X Zhou, Q Zhou, X Jin, S Ruan, T Cheng, N Xia, J Li DLL4 restores damaged liver by enhancing hBMSC differentiation into cholangiocytes Stem Cell Res, 2020-06-29;47(0):101900. 2020-06-29 [PMID: 32622343] (Bioassay, Human)	Bioassay	Human
PL Hsieh, YW Liao, CW Hsieh, PN Chen, CC Yu Soy Isoflavone Genistein Impedes Cancer Stemness and Mesenchymal Transition in Head and Neck Cancer through Activating miR-34a/RTCB Axis Nutrients, 2020-06-29;12(7):. 2020-06-29 [PMID: 32610494] (Bioassay, Human)	Bioassay	Human
H Dokduang, W Jamnongkar, B Promraksa, M Suksawat, S Padthaison, M Thanee, J Phetcharab, N Namwat, S Sangkhaman, A Titapun, N Khuntikeo, P Klanrit, W Loilome In vitro and in vivo Anti-Tumor Effects of Pan-HER Inhibitor Varlitinib on Cholangiocarcinoma Cell Lines Drug Des Devel Ther, 2020-06-11;14(0):2319-2334. 2020-06-11 [PMID: 32606601] (Bioassay, Human)	Bioassay	Human
L Liu, W Saitz-Roja, R Smith, L Gonyar, JG In, O Kovbasnjuk, NC Zachos, M Donowitz, JP Nataro, F Ruiz-Perez Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli Sci Rep, 2020-06-29;10(1):10533. 2020-06-29 [PMID: 32601325] (Cell Culture, Human)	Cell Culture	Human
L Wang, H Zi, Y Luo, T Liu, H Zheng, C Xie, X Wang, X Huang Inhibition of Notch pathway enhances the anti-tumor effect of docetaxel in prostate cancer stem-like cells Stem Cell Res Ther, 2020-06-26;11(1):258. 2020-06-26 [PMID: 32586404] (Bioassay, Human)	Bioassay	Human
A Fischer, T Koopmans, P Ramesh, S Christ, M Strunz, J Wannemache, M Aichler, A Feuchtinge, A Walch, M Ansari, FJ Theis, K Schorpp, K Hadian, PA Neumann, HB Schiller, Y Rinkevich Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces Nat Commun, 2020-06-17;11(1):3068. 2020-06-17 [PMID: 32555155] (Bioassay, Human)	Bioassay	Human
F Li, Q Hu, T He, J Xu, Y Yi, S Xie, L Ding, M Fu, R Guo, ZJ Xiao, M Niu The Deubiquitinase USP4 Stabilizes Twist1 Protein to Promote Lung Cancer Cell Stemness Cancers (Basel), 2020-06-15;12(6):. 2020-06-15 [PMID: 32549341] (Bioassay, Human)	Bioassay	Human
BN Sheikh, S Guhathakur, TH Tsang, M Schwabenla, G Renschler, B Herquel, V Bhardwaj, H Holz, T Stehle, O Bondareva, N Aizarani, O Mossad, O Kretz, W Reichardt, A Chatterjee, LJ Braun, J Thevenon, H Sartelet, T Blank, D Grün, D von Elverf, TB Huber, D Vestweber, S Avilov, M Prinz, JM Buescher, A Akhtar Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature Nat. Cell Biol., 2020-06-15;0(0):. 2020-06-15 [PMID: 32541879] (Bioassay, Mouse)	Bioassay	Mouse
BA Humphries, AC Cutter, JM Buschhaus, YC Chen, T Qyli, DSW Palagama, S Eckley, TH Robison, A Bevoor, B Chiang, HR Haley, S Sahoo, PC Spinosa, DB Neale, J Boppisetti, D Sahoo, P Ghosh, J Lahann, BD Ross, E Yoon, KE Luker, GD Luker Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer Breast Cancer Res., 2020-06-05;22(1):60. 2020-06-05 [PMID: 32503622] (Bioassay, Human)	Bioassay	Human
K Wei, I Korsunsky, JL Marshall, A Gao, GFM Watts, T Major, AP Croft, J Watts, PE Blazar, JK Lange, TS Thornhill, A Filer, K Raza, LT Donlin, CW Siebel, CD Buckley, S Raychaudhu, MB Brenner Notch signalling drives synovial fibroblast identity and arthritis pathology Nature, 2020-04-22;582(7811):259-264. 2020-04-22 [PMID: 32499639] (Bioassay, Human)	Bioassay	Human
K Takeishi, A Collin de, Y Wang, K Handa, J Guzman-Lep, K Matsubara, K Morita, S Jang, N Haep, RM Florentino, F Yuan, K Fukumitsu, K Tobita, W Sun, J Franks, ER Delgado, EM Shapiro, NA Fraunhoffe, AW Duncan, H Yagi, T Mashimo, IJ Fox, A Soto-Gutie Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells Cell Rep, 2020-06-02;31(9):107711. 2020-06-02 [PMID: 32492423] (Human)		Human
M Huo, Y Zhao, X Liu, Y Gao, D Zhang, M Chang, M Liu, N Xu, H Zhu EGFR targeting enhances the efficiency of chemotherapy through inhibiting IRE1alpha-XBP1s pathway in colorectal cancer cells J Cancer, 2020-05-18;11(15):4464-4473. 2020-05-18 [PMID: 32489465] (Bioassay, Human)	Bioassay	Human
G Meinhardt, S Haider, V Kunihs, L Saleh, J Pollheimer, C Fiala, S Hetey, Z Feher, A Szilagyi, NG Than, M Knöfler Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta Proc. Natl. Acad. Sci. U.S.A., 2020-06-01;0(0):. 2020-06-01 [PMID: 32482863] (Bioassay, Human)	Bioassay	Human
J Pan, LX Zhao Epithelial-mesenchymal transition suppresses ERas to activate autophagy in retinal pigment epithelial cells in proliferative vitreoretinopathy Eur Rev Med Pharmacol Sci, 2020-05-01;24(9):4627-4634. 2020-05-01 [PMID: 32432726] (Cell Culture, Human)	Cell Culture	Human
T Verheyen, T Fang, D Lindenhofe, Y Wang, K Akopyan, A Lindqvist, B Högberg, AI Teixeira Spatial�organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers Nucleic Acids Res., 2020-06-04;0(0):. 2020-06-04 [PMID: 32352518] (Bioassay, Human)	Bioassay	Human
NK Vinckier, NA Patel, RJ Geusz, A Wang, J Wang, I Matta, AR Harrington, M Wortham, N Wetton, J Wang, US Jhala, MG Rosenfeld, CW Benner, HP Shih, M Sander LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development Nat Commun, 2020-04-29;11(1):2082. 2020-04-29 [PMID: 32350257] (Bioassay, Human)	Bioassay	Human
M Nair, M Khosla, Y Otani, M Yeh, F Park, T Shimizu, JM Kang, C Bolyard, JG Yu, Y Kumar Bana, G Lopez, B Kaur, RE Pollock, TJ Lee, M Old, JY Yoo Enhancing Antitumor Efficacy of Heavily Vascularized Tumors by RAMBO Virus through Decreased Tumor Endothelial Cell Activation Cancers (Basel), 2020-04-23;12(4):. 2020-04-23 [PMID: 32340193] (Bioassay, Human)	Bioassay	Human
V Licursi, S Anzellotti, J Favaro, S Sineri, N Carucci, E Cundari, M Fiore, G Guarguagli, S Pippa, PS Nisi, F Vernì, S Biagioni, E Cacci, R Amendola, G Lupo, R Negri X-ray irradiated cultures of mouse cortical neural stem/progenitor cells recover cell viability and proliferation with dose-dependent kinetics Sci Rep, 2020-04-16;10(1):6562. 2020-04-16 [PMID: 32300147] (Bioassay, Mouse)	Bioassay	Mouse
S Yoshida, H Miwa, T Kawachi, S Kume, K Takahashi Generation of intestinal organoids derived from human pluripotent stem cells for drug testing Sci Rep, 2020-04-06;10(1):5989. 2020-04-06 [PMID: 32249832] (Bioassay, Human)	Bioassay	Human
C Yamashiro, K Sasaki, S Yokobayash, Y Kojima, M Saitou Generation of human oogonia from induced pluripotent stem cells in culture Nat Protoc, 2020-03-30;15(4):1560-1583. 2020-03-30 [PMID: 32231324] (Bioassay, Human)	Bioassay	Human
H Lee, JW Kim, DK Kim, DK Choi, S Lee, JH Yu, OB Kwon, J Lee, DS Lee, JH Kim, SH Min Calcium Channels as Novel Therapeutic Targets for Ovarian Cancer Stem Cells Int J Mol Sci, 2020-03-27;21(7):. 2020-03-27 [PMID: 32230901] (Bioassay, Human)	Bioassay	Human
SK Ryan, MV Gonzalez, JP Garifallou, FC Bennett, KS Williams, NP Sotuyo, E Mironets, K Cook, H Hakonarson, SA Anderson, KL Jordan-Sci Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection Stem Cell Reports, 2020-03-26;0(0):. 2020-03-26 [PMID: 32220329] (Bioassay, Human)	Bioassay	Human
R Malik, FA Darche, R Rivinius, A Seckinger, U Krause, M Koenen, D Thomas, HA Katus, PA Schweizer Quantitative Efficacy and Fate of Mesenchymal Stromal Cells Targeted to Cardiac Sites by Radiofrequency Catheter Ablation Cell Transplant, 2020-01-01;29(0):9636897209142. 2020-01-01 [PMID: 32207339] (Cell Culture, Human)	Cell Culture	Human
DJH Shih, N Nayyar, I Bihun, I Dagogo-Jac, CM Gill, E Aquilanti, M Bertalan, A Kaplan, MR D'Andrea, U Chukwueke, FM Ippen, C Alvarez-Br, ND Camarda, M Lastrapes, D McCabe, B Kuter, B Kaufman, MR Strickland, JC Martinez-G, D Nagabhusha, M De Sauvage, MD White, BA Castro, K Hoang, A Kaneb, ED Batchelor, SH Paek, SH Park, M Martinez-L, AS Berghoff, P Merrill, ER Gerstner, TT Batchelor, MP Frosch, RP Frazier, DR Borger, AJ Iafrate, BE Johnson, S Santagata, M Preusser, DP Cahill, SL Carter, PK Brastianos Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma Nat. Genet., 2020-03-23;0(0):. 2020-03-23 [PMID: 32203465] (Cell Culture, Human)	Cell Culture	Human
SL Boddy, R Romero-Gue, AR Ji, C Unger, L Corns, W Marcotti, MN Rivolta Generation of Otic Lineages from Integration-Free Human-Induced Pluripotent Stem Cells Reprogrammed by mRNAs Stem Cells Int, 2020-03-01;2020(0):3692937. 2020-03-01 [PMID: 32190057] (Bioassay, Human)	Bioassay	Human
H Xie, Y Ma, J Li, H Chen, Y Xie, M Chen, X Zhao, S Tang, S Zhao, Y Zhang, J Du, F Zhang, L Gu WNT7A Promotes EGF-Induced Migration of Oral Squamous Cell Carcinoma Cells by Activating &beta-Catenin/MMP9-Mediated Signaling Front Pharmacol, 2020-02-26;11(0):98. 2020-02-26 [PMID: 32174831] (Cell Culture, Human)	Cell Culture	Human
R Bergès, A Tchoghandj, A Sergé, S Honoré, D Figarella-, F Bachmann, HA Lane, D Braguer EB1-dependent long survival of glioblastoma-grafted mice with the oral tubulin-binder BAL101553 is associated with inhibition of tumor angiogenesis Oncotarget, 2020-02-25;11(8):759-774. 2020-02-25 [PMID: 32165998] (Cell Culture, Human)	Cell Culture	Human
S Pradhan, SS Karve, AA Weiss, J Hawkins, HM Poling, MA Helmrath, JM Wells, HA McCauley Tissue Responses to Shiga Toxin in Human Intestinal Organoids Cell Mol Gastroenterol Hepatol, 2020-03-05;0(0):. 2020-03-05 [PMID: 32145469] (Cell Culture, Human)	Cell Culture	Human
Z Chen, J Zhang, H Xue, M Qian, X Guo, X Gao, J Xu, Y Qi, X Sun, G Li Nitidine Chloride Is a Potential Alternative Therapy for Glioma Through Inducing Endoplasmic Reticulum Stress and Alleviating Epithelial-Mesenchymal Transition Integr Cancer Ther, 2020-01-01;19(0):1534735419900. 2020-01-01 [PMID: 32129091] (Bioassay, Human)	Bioassay	Human
F Fang, Z Li, Q Zhao, C Xiong, K Ni Analysis of multi-lineage gene expression dynamics during primordial germ cell induction from human induced pluripotent stem cells Stem Cell Res Ther, 2020-03-04;11(1):100. 2020-03-04 [PMID: 32127035] (Cell Culture, Human)	Cell Culture	Human
H Pedersen, E Anne Adanm, KJ Elbæk, K Vitting-Se, P Hamerlik Replication Protein A (RPA) Mediates Radio-Resistance of Glioblastoma Cancer Stem-Like Cells Int J Mol Sci, 2020-02-26;21(5):. 2020-02-26 [PMID: 32111042] (Cell Culture, Human)	Cell Culture	Human
A Schulte, F Ewald, M Spyra, DJ Smit, W Jiang, J Salamon, M Jücker, VF Mautner Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo Int J Mol Sci, 2020-02-24;21(4):. 2020-02-24 [PMID: 32102484] (Cell Culture, Human)	Cell Culture	Human
NJ Hogrebe, P Augsornwor, KG Maxwell, L Velazco-Cr, JR Millman Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells Nat. Biotechnol., 2020-02-24;0(0):. 2020-02-24 [PMID: 32094658] (Cell Culture, Human)	Cell Culture	Human
ML Debreczeni, I Szekacs, B Kovacs, A Saftics, S Kurunczi, P Gál, J Dobó, L Cervenak, R Horvath Human primary endothelial label-free biochip assay reveals unpredicted functions of plasma serine proteases Sci Rep, 2020-02-24;10(1):3303. 2020-02-24 [PMID: 32094469] (Cell Culture, Human)	Cell Culture	Human
Y Yuan, L Li, Q Cheng, F Diao, Q Zeng, X Yang, Y Wu, H Zhang, M Huang, J Chen, Q Zhou, Y Zhu, R Hua, J Tian, X Wang, Z Zhou, J Hao, J Yu, D Hua, J Liu, X Guo, Q Zhou, J Sha In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids Cell Res., 2020-02-21;0(0):. 2020-02-21 [PMID: 32086476] (Bioassay, Human)	Bioassay	Human
R Lucero, V Zappulli, A Sammarco, OD Murillo, PS Cheah, S Srinivasan, E Tai, DT Ting, Z Wei, ME Roth, LC Laurent, AM Krichevsky, XO Breakefiel, A Milosavlje Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells Cell Rep, 2020-02-18;30(7):2065-2074.e4. 2020-02-18 [PMID: 32075753] (Cell Culture, Human)	Cell Culture	Human
Y Wang, L Lifshitz, K Gellatly, CL Vinton, K Busman-Sah, S McCauley, P Vangala, K Kim, A Derr, S Jaiswal, A Kucukural, P McDonel, PW Hunt, T Greenough, J Houghton, M Somsouk, JD Estes, JM Brenchley, M Garber, SG Deeks, J Luban HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells Nat. Immunol., 2020-02-17;21(3):274-286. 2020-02-17 [PMID: 32066947] (Cell Culture, Human)	Cell Culture	Human
C Ding, Q Zou, Y Wu, J Lu, C Qian, H Li, B Huang EGF released from human placental mesenchymal stem cells improves premature ovarian insufficiency via NRF2/HO-1 activation Aging (Albany NY), 2020-02-10;12(3):2992-3009. 2020-02-10 [PMID: 32040445] (Cell Culture, Human)	Cell Culture	Human
T Okubo, R Hayashi, S Shibata, Y Kudo, Y Ishikawa, S Inoue, Y Kobayashi, A Honda, Y Honma, S Kawasaki, K Nishida Generation and validation of a PITX2-EGFP reporter line of human induced pluripotent stem cells enables isolation of periocular mesenchymal cells J. Biol. Chem., 2020-02-07;295(11):3456-3465. 2020-02-07 [PMID: 32034090] (Bioassay, Human)	Bioassay	Human
SJ Liu, ST Magill, HN Vasudevan, S Hilz, JE Villanueva, S Lastella, V Daggubati, J Spatz, A Choudhury, BA Orr, B Demaree, K Seo, SP Ferris, AR Abate, NA Oberheim B, AW Bollen, MW McDermott, JF Costello, DR Raleigh Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma Cell Rep, 2020-02-04;30(5):1300-1309.e5. 2020-02-04 [PMID: 32023450] (Bioassay, Human)	Bioassay	Human
AR Nickolls, MM Lee, DF Espinoza, M Szczot, RM Lam, Q Wang, J Beers, J Zou, MQ Nguyen, HJ Solinski, AA AlJanahi, KR Johnson, ME Ward, AT Chesler, CG Bönnemann Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells Cell Rep, 2020-01-21;30(3):932-946.e7. 2020-01-21 [PMID: 31968264] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
S Yomtoubian, SB Lee, A Verma, F Izzo, G Markowitz, H Choi, L Cerchietti, L Vahdat, KA Brown, E Andreopoul, O Elemento, J Chang, G Inghirami, D Gao, S Ryu, V Mittal Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer Cell Rep, 2020-01-21;30(3):755-770.e6. 2020-01-21 [PMID: 31968251] (Cell Culture, Mouse)	Cell Culture	Mouse
L Cai, SV Kirchleitn, D Zhao, M Li, JC Tonn, R Glass, RE Kälin Glioblastoma Exhibits Inter-Individual Heterogeneity of TSPO and LAT1 Expression in Neoplastic and Parenchymal Cells Int J Mol Sci, 2020-01-17;21(2):. 2020-01-17 [PMID: 31963507] (Bioassay, Human)	Bioassay	Human
H Ramos, J Calheiros, J Almeida, V Barcherini, S Santos, ATP Carvalho, MMM Santos, L Saraiva SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner Int J Mol Sci, 2020-01-17;21(2):. 2020-01-17 [PMID: 31963392] (Cell Culture, Human)	Cell Culture	Human
C Peng, Y Li, L Lu, J Zhu, H Li, J Hu Efficient One-Step Induction of Human Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs) Produces MSC-Derived Neurospheres (MSC-NS) with Unique Transcriptional Profile and Enhanced Neurogenic and Angiogenic Secretomes Stem Cells Int, 2019-12-17;2019(0):9208173. 2019-12-17 [PMID: 31933651] (Cell Culture, Human)	Cell Culture	Human
M Lundberg, S Curbo, H Bohman, I Agartz, SO Ögren, C Patrone, S Mansouri Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy Biosci. Rep., 2020-01-31;0(0):. 2020-01-31 [PMID: 31919522] (Cell Culture, Mouse)	Cell Culture	Mouse
É Dóka, T Ida, M Dagnell, Y Abiko, NC Luong, N Balog, T Takata, B Espinosa, A Nishimura, Q Cheng, Y Funato, H Miki, JM Fukuto, JR Prigge, EE Schmidt, ESJ Arnér, Y Kumagai, T Akaike, P Nagy Control of protein function through oxidation and reduction of persulfidated states Sci Adv, 2020-01-01;6(1):eaax8358. 2020-01-01 [PMID: 31911946] (Cell Culture, Human)	Cell Culture	Human
K Kawai, R Negoro, M Ichikawa, T Yamashita, S Deguchi, K Harada, K Hirata, K Takayama, H Mizuguchi Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies Mol Ther Methods Clin Dev, 2019-11-21;17(0):49-57. 2019-11-21 [PMID: 31890740] (Cell Culture, Human)	Cell Culture	Human
B You, F Mercier, E Assenat, C Langlois-J, O Glehen, J Soulé, L Payen, V Kepenekian, M Dupuy, F Belouin, E Morency, V Saywell, M Flacelière, P Elies, P Liaud, T Mazard, D Maucort-Bo, W Tan, B Vire, L Villeneuve, M Ychou, M Kohli, D Joubert, A Prieur The oncogenic and druggable hPG80 (Progastrin) is overexpressed in multiple cancers and detected in the blood of patients EBioMedicine, 2019-12-24;51(0):102574. 2019-12-24 [PMID: 31877416] (Bioassay, Human)	Bioassay	Human
D Chen, N Sun, L Hou, R Kim, J Faith, M Aslanyan, Y Tao, Y Zheng, J Fu, W Liu, M Kellis, A Clark Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors Cell Rep, 2019-12-24;29(13):4568-4582.e5. 2019-12-24 [PMID: 31875561] (Cell Culture, Human)	Cell Culture	Human
D Parashar, A Geethadevi, MR Aure, J Mishra, J George, C Chen, MK Mishra, A Tahiri, W Zhao, B Nair, Y Lu, LS Mangala, C Rodriguez-, G Lopez-Bere, AKS Camara, M Liang, JS Rader, R Ramchandra, M You, AK Sood, VN Kristensen, GB Mills, S Pradeep, P Chaluvally miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer Cell Rep, 2019-12-24;29(13):4389-4406.e10. 2019-12-24 [PMID: 31875548] (Cell Culture, Human)	Cell Culture	Human
GH Son, Y Kim, JJ Lee, KY Lee, H Ham, JE Song, ST Park, YH Kim MicroRNA-548 regulates high mobility group box 1 expression in patients with preterm birth and chorioamnionitis Sci Rep, 2019-12-24;9(1):19746. 2019-12-24 [PMID: 31875024] (Bioassay, Human)	Bioassay	Human
D De Silva, Z Zhang, Y Liu, JS Parker, C Xu, L Cai, GG Wang, HS Earp, YE Whang Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen Sci Rep, 2019-12-09;9(1):18637. 2019-12-09 [PMID: 31819114] (Cell Culture, Human)	Cell Culture	Human
C Peng, L Lu, Y Li, J Hu Neurospheres induced from human adipose-derived stem cells as a new source of neural progenitor cells Cell Transplant, 2019-12-08;0(0):9636897198886. 2019-12-08 [PMID: 31813268] (Bioassay, Human)	Bioassay	Human
KH Grinnemo, M Löfling, L Nathanson, R Baumgartne, DFJ Ketelhuth, V Beljanski, LC Davies, C Österholm Immunomodulatory effects of interferon-gamma on human fetal cardiac mesenchymal stromal cells Stem Cell Res Ther, 2019-12-04;10(1):371. 2019-12-04 [PMID: 31801632] (Bioassay, Human)	Bioassay	Human
S Weber, SE Koschade, CM Hoffmann, TD Dubash, KM Giessler, SM Dieter, F Herbst, H Glimm, CR Ball The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo BMC Cancer, 2019-12-03;19(1):1181. 2019-12-03 [PMID: 31796022] (Bioassay, Human)	Bioassay	Human
L Zhu, Y Li, X Xie, X Zhou, M Gu, Z Jie, CJ Ko, T Gao, BE Hernandez, X Cheng, SC Sun TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis Nat. Cell Biol., 2019-12-02;21(12):1604-1614. 2019-12-02 [PMID: 31792381] (Cell Culture, Mouse)	Cell Culture	Mouse
C Bueno, M Martínez-M, S Martínez Non-proliferative neurogenesis in human periodontal ligament stem cells Sci Rep, 2019-12-02;9(1):18038. 2019-12-02 [PMID: 31792338] (Cell Culture, Human)	Cell Culture	Human
D Hao, C He, B Ma, L Lankford, L Reynaga, DL Farmer, F Guo, A Wang Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering Stem Cells Int, 2019-11-12;2019(0):9695239. 2019-11-12 [PMID: 31781252] (Tissue Culture, Human)	Tissue Culture	Human
JK Sa, JR Hwang, YJ Cho, JY Ryu, JJ Choi, SY Jeong, J Kim, MS Kim, ES Paik, YY Lee, CH Choi, TJ Kim, BG Kim, DS Bae, Y Lee, NG Her, YJ Shin, HJ Cho, JY Kim, YJ Seo, H Koo, JW Oh, T Lee, HS Kim, SY Song, JS Bae, WY Park, HD Han, HJ Ahn, AK Sood, R Rabadan, JK Lee, DH Nam, JW Lee Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers Genome Biol., 2019-11-26;20(1):253. 2019-11-26 [PMID: 31771620] (Cell Culture, Human)	Cell Culture	Human
V Costa, V Carina, L Raimondi, A De Luca, D Bellavia, A Conigliaro, F Salamanna, R Alessandro, M Fini, G Giavaresi MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation Cells, 2019-11-22;8(12):. 2019-11-22 [PMID: 31771093] (Cell Culture, Human)	Cell Culture	Human
AP Singh, YH Hung, MT Shanahan, M Kanke, A Bonfini, MK Dame, M Biraud, BCE Peck, OO Oyesola, JM Freund, RL Cubitt, EG Curry, LM Gonzalez, GA Bewick, ED Tait-Wojno, NA Kurpios, S Ding, JR Spence, CM Dekaney, N Buchon, P Sethupathy Enteroendocrine progenitor cell enriched miR-7 regulates intestinal epithelial proliferation in an Xiap-dependent manner Cell Mol Gastroenterol Hepatol, 2019-11-19;0(0):. 2019-11-19 [PMID: 31756561] (Tissue Culture, Human, Porcine)	Tissue Culture	Human, Porcine
L Hu, Y Sun, J Luo, X He, M Ye, G Li, Y Zhang, J Bai, D Zhang, C Chang Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression Oncogene, 2019-11-20;0(0):. 2019-11-20 [PMID: 31748715] (Bioassay, Human)	Bioassay	Human
Z Li, F Fang, Q Zhao, H Li, C Xiong Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells Stem Cell Res Ther, 2019-11-15;10(1):324. 2019-11-15 [PMID: 31730021] (Cell Culture, Human)	Cell Culture	Human
L Yammine, A Zablocki, W Baron, F Terzi, M Gallazzini Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking Cell Rep, 2019-11-12;29(7):2067-2077.e6. 2019-11-12 [PMID: 31722218] (Cell Culture, Human)	Cell Culture	Human
AA Qayyum, AB Mathiasen, ND Mygind, NG Vejlstrup, J Kastrup Cardiac Magnetic Resonance Imaging used for Evaluation of Adipose-Derived Stromal Cell Therapy in Patients with Chronic Ischemic Heart Disease Cell Transplant, 2019-11-08;0(0):9636897198835. 2019-11-08 [PMID: 31698917] (Stimulation, Human)	Stimulation	Human
M Reed, AC Luissint, V Azcutia, S Fan, MN O'Leary, M Quiros, J Brazil, A Nusrat, CA Parkos Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo Nat Commun, 2019-11-01;10(1):5004. 2019-11-01 [PMID: 31676794] (Cell Culture, Mouse)	Cell Culture	Mouse
Y Koutmani, IA Gampieraki, A Polissidis, M Ximerakis, PN Koutsoudak, A Polyzos, G Agrogianni, S Karaliota, D Thomaidou, LL Rubin, PK Politis, KP Karalis CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus Cell Rep, 2019-10-22;29(4):932-945.e7. 2019-10-22 [PMID: 31644914] (Bioassay, Mouse)	Bioassay	Mouse
J Chen, B Ananthanar, KS Springer, KJ Wolf, SM Sheyman, VD Tran, S Kumar Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion Cancer Res., 2019-10-22;0(0):. 2019-10-22 [PMID: 31641031] (Bioassay, Human)	Bioassay	Human
T Yung, F Poon, M Liang, S Coquenlorg, EC McGaugh, CC Hui, MD Wilson, MC Nostro, TH Kim Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals Nat Commun, 2019-10-11;10(1):4647. 2019-10-11 [PMID: 31604927] (Bioassay, Human)	Bioassay	Human
YH Lee, HT Lee, CL Chen, CH Chang, CY Hsu, WC Shyu Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrPC signaling Theranostics, 2019-08-15;9(22):6443-6465. 2019-08-15 [PMID: 31588228] (Cell Culture, Human)	Cell Culture	Human
S Mukherjee, I Akbar, R Bhagat, B Hazra, A Bhattachar, P Seth, D Roy, A Basu Identification and Classification of Hubs in microRNA Target Gene Networks in Human Neural Stem/Progenitor Cells following Japanese Encephalitis Virus Infection mSphere, 2019-10-02;4(5):. 2019-10-02 [PMID: 31578247] (Cell Culture, Human)	Cell Culture	Human
T Tabata, M Petitt, J Fang-Hoove, DC Freed, F Li, Z An, D Wang, TM Fu, L Pereira Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas Vaccines (Basel), 2019-09-29;7(4):. 2019-09-29 [PMID: 31569508] (Bioassay, Human)	Bioassay	Human
CY Su, RL Yan, WH Hsu, CT Chu, HC Chang, CC Lai, HP Hsu, HC Chen Phosphorylation of adducin-1 by cyclin-dependent kinase 5 is important for epidermal growth factor-induced cell migration Sci Rep, 2019-09-23;9(1):13703. 2019-09-23 [PMID: 31548578] (Bioassay, Human)	Bioassay	Human
CY Lee, TJ Huang, MH Wu, YY Li, KD Lee High Expression of Acid-Sensing Ion Channel 2 (ASIC2) in Bone Cells in Osteoporotic Vertebral Fractures Biomed Res Int, 2019-08-19;2019(0):4714279. 2019-08-19 [PMID: 31531354] (Bioassay, Human)	Bioassay	Human
Y Shen, K Pu, K Zheng, X Ma, J Qin, L Jiang, J Li Differentially Expressed microRNAs in MIA PaCa-2 and PANC-1 Pancreas Ductal Adenocarcinoma Cell Lines are Involved in Cancer Stem Cell Regulation Int J Mol Sci, 2019-09-10;20(18):. 2019-09-10 [PMID: 31510100] (Bioassay, Human)	Bioassay	Human
H Kim, K Chong, BK Ryu, KJ Park, MO Yu, J Lee, S Chung, S Choi, MJ Park, YG Chung, SH Kang Repurposing Penfluridol in Combination with Temozolomide for the Treatment of Glioblastoma Cancers (Basel), 2019-09-05;11(9):. 2019-09-05 [PMID: 31492002] (Bioassay, Human)	Bioassay	Human
V Ravi, AB Madhankuma, T Abraham, B Slagle-Web, JR Connor Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms PLoS ONE, 2019-09-06;14(9):e0221952. 2019-09-06 [PMID: 31491006] (Bioassay, Human)	Bioassay	Human
L Jin, H Tao, A Karachi, Y Long, AY Hou, M Na, KA Dyson, AJ Grippin, LP Deleyrolle, W Zhang, DA Rajon, QJ Wang, JC Yang, JL Kresak, EJ Sayour, M Rahman, FJ Bova, Z Lin, DA Mitchell, J Huang CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors Nat Commun, 2019-09-05;10(1):4016. 2019-09-05 [PMID: 31488817] (Cell Culture, Human)	Cell Culture	Human
J Tiihonen, M Koskuvi, M Lähteenvuo, PLJ Virtanen, I Ojansuu, O Vaurio, Y Gao, I Hyötyläine, KA Puttonen, E Repo-Tiiho, T Paunio, MR Rautiainen, S Tyni, J Koistinaho, Š Lehtonen Neurobiological roots of psychopathy Mol. Psychiatry, 2019-08-27;0(0):. 2019-08-27 [PMID: 31455857] (Bioassay, Human)	Bioassay	Human
L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation Mol. Vis., 2019-06-30;25(0):329-344. 2019-06-30 [PMID: 31341381] (Bioassay, Human)	Bioassay	Human
K Shik Mun, K Arora, Y Huang, F Yang, S Yarlagadda, Y Ramananda, M Abu-El-Hai, JJ Palermo, BN Appakalai, JD Nathan, AP Naren Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders Nat Commun, 2019-07-16;10(1):3124. 2019-07-16 [PMID: 31311920] (Cell Culture, Human)	Cell Culture	Human
G Xiong, W Tang, D Zhang, D He, G Wei, A Atala, XJ Liang, AJ Bleyer, ME Bleyer, J Yu, JA Aloi, JX Ma, CM Furdui, Y Zhang Impaired Regeneration Potential in Urinary Stem Cells Diagnosed from the Patients with Diabetic Nephropathy Theranostics, 2019-05-31;9(14):4221-4232. 2019-05-31 [PMID: 31281543] (Bioassay, Human)	Bioassay	Human
F Du, C Qiao, X Li, Z Chen, H Liu, S Wu, S Hu, Z Qiu, M Qian, D Tian, K Wu, D Fan, Y Nie, L Xia Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR Theranostics, 2019-05-31;9(13):3879-3902. 2019-05-31 [PMID: 31281520] (Bioassay, Human)	Bioassay	Human
KB Jung, O Kwon, MO Lee, H Lee, YS Son, O Habib, JH Oh, HS Cho, CR Jung, J Kim, MY Son Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells J Clin Med, 2019-07-04;8(7):. 2019-07-04 [PMID: 31277507] (Bioassay, Human)	Bioassay	Human
MR Wu, L Nissim, D Stupp, E Pery, A Binder-Nis, K Weisinger, C Enghuus, SR Palacios, M Humphrey, Z Zhang, E Maria Novo, M Kellis, R Weiss, SD Rabkin, Y Tabach, TK Lu A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS) Nat Commun, 2019-06-28;10(1):2880. 2019-06-28 [PMID: 31253799] (Cell Culture, Human)	Cell Culture	Human
E Skaga, E Kulesskiy, A Fayzullin, CJ Sandberg, S Potdar, A Kyttälä, IA Langmoen, A Laakso, E Gaál-Paavo, M Perola, K Wennerberg, EO Vik-Mo Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-na�ve glioblastoma BMC Cancer, 2019-06-25;19(1):628. 2019-06-25 [PMID: 31238897] (Cell Culture, Human)	Cell Culture	Human
OC Tysoe, AW Justin, T Brevini, SE Chen, KT Mahbubani, AK Frank, H Zedira, E Melum, K Saeb-Parsy, AE Markaki, L Vallier, F Sampazioti Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue Nat Protoc, 2019-05-20;14(6):1884-1925. 2019-05-20 [PMID: 31110298] (Bioassay, Human)	Bioassay	Human
WY Teo, K Sekar, P Seshachala, J Shen, WY Chow, CC Lau, H Yang, J Park, SG Kang, X Li, DH Nam, KM Hui Relevance of a TCGA-derived Glioblastoma Subtype Gene-Classifier among Patient Populations Sci Rep, 2019-05-15;9(1):7442. 2019-05-15 [PMID: 31092847] (Bioassay, Human)	Bioassay	Human
N Kawai, Y Hirohashi, Y Ebihara, T Saito, A Murai, T Saito, T Shirosaki, T Kubo, M Nakatsugaw, T Kanaseki, T Tsukahara, T Shichinohe, L Li, S Hirano, T Torigoe ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD PLoS ONE, 2019-05-13;14(5):e0216503. 2019-05-13 [PMID: 31083682] (Bioassay, Human)	Bioassay	Human
ML Shiao, C Yuan, AT Crane, JP Voth, M Juliano, LLH Stone, Z Nan, Y Zhang, N Kuzmin-Nic, PR Sanberg, AW Grande, WC Low Immunomodulation with Human Umbilical Cord Blood Stem Cells Ameliorates Ischemic Brain Injury - A Brain Transcriptome Profiling Analysis Cell Transplant, 2019-05-08;0(0):9636897198367. 2019-05-08 [PMID: 31066288] (Bioassay, Human)	Bioassay	Human
YB Pang, J He, BY Cui, S Xu, XL Li, MY Wu, R Liang, Y Feng, X Guo, XH Zhang, XL Luo A Potential Antitumor Effect of Dendritic Cells Fused with Cancer Stem Cells in Hepatocellular Carcinoma Stem Cells Int, 2019-04-01;2019(0):5680327. 2019-04-01 [PMID: 31065274] (Bioassay, Human)	Bioassay	Human
P Min, S Zhao, L Liu, Y Zhang, Y Ma, X Zhao, Y Wang, Y Song, C Zhu, H Jiang, L Gu, J Du MICAL-L2 potentiates Cdc42-dependent EGFR stability and promotes gastric cancer cell migration J. Cell. Mol. Med., 2019-04-29;0(0):. 2019-04-29 [PMID: 31034158] (Bioassay, Human)	Bioassay	Human
A Hall, K Choi, W Liu, J Rose, C Zhao, Y Yu, Y Na, Y Cai, RA Coover, Y Lin, E Dombi, M Kim, D Levanon, Y Groner, E Boscolo, D Pan, PP Liu, QR Lu, N Ratner, G Huang, J Wu RUNX represses Pmp22 to drive neurofibromagenesis Sci Adv, 2019-04-24;5(4):eaau8389. 2019-04-24 [PMID: 31032403] (Bioassay, Mouse)	Bioassay	Mouse
EE Mulkearns-, LA Torre-Heal, DJ Silver, JT Eurich, D Bayik, E Serbinowsk, M Hitomi, J Zhou, B Przychodze, R Zhang, SA Sprowls, JS Hale, TJ Alban, A Berezovsky, BA Bell, PR Lockman, BK Jha, JD Lathia Development of a Cx46 Targeting Strategy for Cancer Stem Cells Cell Rep, 2019-04-23;27(4):1062-1072.e5. 2019-04-23 [PMID: 31018124] (Bioassay, Xenograft)	Bioassay	Xenograft
L Sun, F Wang, H Chen, D Liu, T Qu, X Li, D Xu, F Liu, Z Yin, Y Chen Co-Transplantation of Human Umbilical Cord Mesenchymal Stem Cells and Human Neural Stem Cells Improves the Outcome in Rats with Spinal Cord Injury Cell Transplant, 2019-04-23;0(0):9636897198445. 2019-04-23 [PMID: 31012325] (Bioassay, Human)	Bioassay	Human
JA Bernatchez, M Coste, S Beck, GA Wells, LA Luna, AE Clark, Z Zhu, D Hecht, JN Rich, CD Sohl, BW Purse, JL Siqueira-N Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells Viruses, 2019-04-20;11(4):. 2019-04-20 [PMID: 31010044] (Bioassay, Human)	Bioassay	Human
M Urbischek, H Rannikmae, T Foets, K Ravn, M Hyvönen, M de la Roch Organoid culture media formulated with growth factors of defined cellular activity Sci Rep, 2019-04-17;9(1):6193. 2019-04-17 [PMID: 30996238] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
T Hirose, A Cabrera-So, D Chitayat, T Lemonnier, O Féraud, C Cifuentes-, N Gervasi, C Mombereau, T Ghosh, L Stoica, JDA Bacha, H Yamada, MA Lauterbach, M Guillon, K Kaneko, JW Norris, K Siriwarden, S Blasér, J Teillon, R Mendoza-Lo, M Russeau, J Hadoux, S Ito, P Corvol, MG Matheus, KR Holden, K Takei, V Emiliani, A Bennaceur-, CE Schwartz, G Nguyen, M Groszer ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration J. Clin. Invest., 2019-04-15;130(0):. 2019-04-15 [PMID: 30985297] (Bioassay, Human)	Bioassay	Human
S Beck, Z Zhu, MF Oliveira, DM Smith, JN Rich, JA Bernatchez, JL Siqueira-N Mechanism of Action of Methotrexate Against Zika Virus Viruses, 2019-04-10;11(4):. 2019-04-10 [PMID: 30974762] (Cell Culture, Human)	Cell Culture	Human
SFB Fadhlullah, NBA Halim, JYT Yeo, RLY Ho, P Um, BT Ang, C Tang, WH Ng, DM Virshup, IAW Ho Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness Oncogene, 2019-04-09;38(27):5367-5380. 2019-04-09 [PMID: 30967630] (Bioassay, Human)	Bioassay	Human
S An, I Raju, B Surenkhuu, JE Kwon, S Gulati, M Karaman, A Pradeep, S Sinha, C Mun, S Jain Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies Ocul Surf, 2019-04-06;0(0):. 2019-04-06 [PMID: 30965123] (Bioassay, Human)	Bioassay	Human
S Li, KW Fong, G Gritsina, A Zhang, JC Zhao, J Kim, A Sharp, W Yuan, C Aversa, XJ Yang, PS Nelson, FY Feng, AM Chinnaiyan, JS de Bono, C Morrissey, MB Rettig, J Yu Activation of MAPK signaling by CXCR7 leads to enzalutamide resistance in prostate cancer Cancer Res., 2019-04-05;0(0):. 2019-04-05 [PMID: 30952632] (Bioassay, Human)	Bioassay	Human
M Matsushita, Y Mori, K Uchiumi, T Ogata, M Nakamura, H Yoda, H Soda, N Takiguchi, Y Nabeya, O Shimozato, T Ozaki PTPRK suppresses progression and chemo-resistance of colon cancer cells via direct inhibition of pro-oncogenic CD133 FEBS Open Bio, 2019-04-18;0(0):. 2019-04-18 [PMID: 30947381] (Bioassay, Human)	Bioassay	Human
HL Zhang, P Wang, MZ Lu, SD Zhang, L Zheng c-Myc maintains the self-renewal and chemoresistance properties of colon cancer stem cells Oncol Lett, 2019-02-28;17(5):4487-4493. 2019-02-28 [PMID: 30944638] (Bioassay, Human)	Bioassay	Human
EM Kim, YM Bae, MH Choi, ST Hong Connexin 43 plays an important role in the transformation of cholangiocytes with Clonochis sinensis excretory-secretory protein and N-nitrosodimethylamine PLoS Negl Trop Dis, 2019-04-03;13(4):e0006843. 2019-04-03 [PMID: 30943209] (Bioassay, Human)	Bioassay	Human
Z Shen, C Zhang, L Qu, C Lu, M Xiao, R Ni, J Liu MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway Cancer Cell Int., 2019-03-18;19(0):61. 2019-03-18 [PMID: 30923463] (Bioassay, Human)	Bioassay	Human
Z Wang, L Kang, H Zhang, Y Huang, L Fang, M Li, PJ Brown, CH Arrowsmith, J Li, J Wong AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation Oncogene, 2019-03-20;0(0):. 2019-03-20 [PMID: 30894683] (Bioassay, Human)	Bioassay	Human
A Linkous, D Balamatsia, M Snuderl, L Edwards, K Miyaguchi, T Milner, B Reich, L Cohen-Goul, A Storaska, Y Nakayama, E Schenkein, R Singhania, S Cirigliano, T Magdeldin, Y Lin, G Nanjangud, K Chadalavad, D Pisapia, C Liston, HA Fine Modeling Patient-Derived Glioblastoma with Cerebral Organoids Cell Rep, 2019-03-19;26(12):3203-3211.e5. 2019-03-19 [PMID: 30893594] (Bioassay, Human)	Bioassay	Human
MA Ajmone-Cat, A Onori, C Toselli, E Stronati, M Morlando, I Bozzoni, E Monni, Z Kokaia, G Lupo, L Minghetti, S Biagioni, E Cacci Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death Sci Rep, 2019-03-14;9(1):4572. 2019-03-14 [PMID: 30872738] (Bioassay, Human)	Bioassay	Human
N Naldaiz-Ga, M Goicoechea, IM Aragón, V Pérez-Lópe, S Fuertes-Al, B Herrera-Im, A López de M, R de Luna-Di, PM Baptista, MA Fernández, MF Lara, A Izeta Isolation and characterization of myogenic precursor cells from human cremaster muscle Sci Rep, 2019-03-05;9(1):3454. 2019-03-05 [PMID: 30837559] (Bioassay, Human)	Bioassay	Human
YP Xu, Y Qiu, B Zhang, G Chen, Q Chen, M Wang, F Mo, J Xu, J Wu, RR Zhang, ML Cheng, NN Zhang, B Lyu, WL Zhu, MH Wu, Q Ye, D Zhang, JH Man, XF Li, J Cui, Z Xu, B Hu, X Zhou, CF Qin Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids Cell Res., 2019-02-27;0(0):. 2019-02-27 [PMID: 30814679] (Bioassay, Human)	Bioassay	Human
J Klose, S Trefz, T Wagner, L Steffen, A Prei beta endör, P Radhakrish, C Volz, T Schmidt, A Ulrich, SM Dieter, C Ball, H Glimm, M Schneider Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model PLoS ONE, 2019-02-14;14(2):e0211916. 2019-02-14 [PMID: 30763370] (Bioassay, Human)	Bioassay	Human
M Inoue, K Kajiwara, A Yamaguchi, T Kiyono, O Samura, H Akutsu, H Sago, A Okamoto, A Umezawa Autonomous trisomic rescue of Down syndrome cells Lab. Invest., 2019-02-13;0(0):. 2019-02-13 [PMID: 30760866] (Bioassay, Human)	Bioassay	Human
JH Wang, ST Huang, L Zhang, ZG Liu, RX Liang, SW Jiang, YN Jiang, XJ Yu, YC Jiang, XZ Li, PF Zhang, ZS Wen, M Zheng Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma Cancer Med, 2019-02-11;0(0):. 2019-02-11 [PMID: 30741466] (Bioassay, Human)	Bioassay	Human
S Bunda, P Heir, J Metcalf, ASC Li, S Agnihotri, S Pusch, M Yasin, M Li, K Burrell, S Mansouri, O Singh, M Wilson, A Alamsahebp, R Nejad, B Choi, D Kim, A von Deimli, G Zadeh, K Aldape CIC protein instability contributes to tumorigenesis in glioblastoma Nat Commun, 2019-02-08;10(1):661. 2019-02-08 [PMID: 30737375] (Bioassay, Human)	Bioassay	Human
S Matsui, M Ochiai, K Yasuda, SI Mae, M Kotaka, T Toyoda, T Yamamoto, K Osafune Differentiation and isolation of iPSC-derived remodeling ductal plate-like cells by use of an AQP1-GFP reporter human iPSC line Stem Cell Res, 2019-01-31;35(0):101400. 2019-01-31 [PMID: 30735882] (Bioassay, Human)	Bioassay	Human
S Mandal, F Arfuso, G Sethi, A Dharmaraja, S Warrier Encapsulated human mesenchymal stem cells (eMSCs) as a novel anti-cancer agent targeting breast cancer stem cells: development of 3D primed therapeutic MSCs Int. J. Biochem. Cell Biol., 2019-02-06;0(0):. 2019-02-06 [PMID: 30735730] (Bioassay, Human)	Bioassay	Human
V Chesnokova, S Zonis, R Barrett, H Kameda, K Wawrowsky, A Ben-Shlomo, M Yamamoto, J Gleeson, C Bresee, V Gorbunova, S Melmed Excess growth hormone suppresses DNA damage repair in epithelial cells JCI Insight, 2019-02-07;4(3):. 2019-02-07 [PMID: 30728323] (Bioassay, Human)	Bioassay	Human
G Mastrella, M Hou, M Li, VM Stoecklein, N Zdouc, MNM Volmar, H Miletic, S Reinhard, CC Herold-Men, S Kleber, K Eisenhut, G Gargiulo, M Synowitz, AL Vescovi, PN Harter, JM Penninger, E Wagner, M Mittelbron, R Bjerkvig, D Hambardzum, U Schüller, JC Tonn, J Radke, R Glass, RE Kälin Targeting APLN/APLNR improves anti-angiogenic efficiency and blunts pro-invasive side effects of VEGFA/VEGFR2-blockade in glioblastoma Cancer Res., 2019-02-04;0(0):. 2019-02-04 [PMID: 30718358] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
CY Yang, PW Chang, WH Hsu, HC Chang, CL Chen, CC Lai, WT Chiu, HC Chen Src and SHP2 coordinately regulate the dynamics and organization of vimentin filaments during cell migration Oncogene, 2019-01-29;0(0):. 2019-01-29 [PMID: 30696956] (Bioassay, Human)	Bioassay	Human
JH Jo, SB Park, S Park, HS Lee, C Kim, DE Jung, SY Song Novel Gastric Cancer Stem Cell-Related Marker LINGO2 Is Associated with Cancer Cell Phenotype and Patient Outcome Int J Mol Sci, 2019-01-28;20(3):. 2019-01-28 [PMID: 30696080] (Bioassay, Human)	Bioassay	Human
RM Marton, Y Miura, SA Sloan, Q Li, O Revah, RJ Levy, JR Huguenard, SP Pa?ca Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures Nat. Neurosci., 2019-01-28;0(0):. 2019-01-28 [PMID: 30692691] (Bioassay, Human)	Bioassay	Human
G Wang, J Long, Y Gao, W Zhang, F Han, C Xu, L Sun, SC Yang, J Lan, Z Hou, Z Cai, G Jin, CC Hsu, YH Wang, J Hu, TY Chen, H Li, MG Lee, HK Lin SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis Nat. Cell Biol., 2019-01-28;0(0):. 2019-01-28 [PMID: 30692626] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
X Feng, Y Jia, Y Zhang, F Ma, Y Zhu, X Hong, Q Zhou, R He, H Zhang, J Jin, D Piao, H Huang, Q Li, X Qiu, Z Zhang Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth Autophagy, 2019-01-27;0(0):1-20. 2019-01-27 [PMID: 30686098] (Bioassay, Human)	Bioassay	Human
D Ramchandan, SK Lee, S Yomtoubian, MS Han, CH Tung, V Mittal Nanoparticle delivery of miR-708 mimetic impairs breast cancer metastasis Mol. Cancer Ther., 2019-01-24;0(0):. 2019-01-24 [PMID: 30679387] (Bioassay, Human)	Bioassay	Human
X Ma, L Zhang, J Song, E Nguyen, RS Lee, SJ Rodgers, F Li, C Huang, RB Schittenhe, H Chan, C Chheang, J Wu, KK Brown, CA Mitchell, KJ Simpson, RJ Daly Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation Nat Commun, 2019-01-17;10(1):296. 2019-01-17 [PMID: 30655532] (Bioassay, Human)	Bioassay	Human
Y Kano, T Gebregiwor, CB Marshall, N Radulovich, BPK Poon, J St-Germain, JD Cook, I Valencia-S, BMM Grant, SG Herrera, J Miao, B Raught, MS Irwin, JE Lee, JJ Yeh, ZY Zhang, MS Tsao, M Ikura, M Ohh Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation Nat Commun, 2019-01-15;10(1):224. 2019-01-15 [PMID: 30644389] (Bioassay, Human)	Bioassay	Human
X Wang, T Liao, C Wan, X Yang, J Zhao, R Fu, Z Yao, Y Huang, Y Shi, G Chang, Y Zheng, F Luo, Z Liu, Y Wang, X Mao, XY Zhao Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale PeerJ, 2019-01-09;6(0):e6143. 2019-01-09 [PMID: 30643676] (Bioassay, Human)	Bioassay	Human
S Ranganatha, M Doucet, CL Grassel, B Delaine-El, NC Zachos, EM Barry Evaluating S. flexneri pathogenesis in the human enteroid model Infect. Immun., 2019-03-25;0(0):. 2019-03-25 [PMID: 30642900] (Bioassay, Human)	Bioassay	Human
SZ Kuo, CO Honda, WT Li, TK Honda, E Kim, X Altuna, E Abhold, J Wang-Rodri, WM Ongkeko Metformin Results in Diametrically Opposed Effects by Targeting Non-Stem Cancer Cells but Protecting Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma Int J Mol Sci, 2019-01-07;20(1):. 2019-01-07 [PMID: 30621095] (Bioassay, Human)	Bioassay	Human
D Chen, W Liu, J Zimmerman, WA Pastor, R Kim, L Hosohama, J Ho, M Aslanyan, JJ Gell, SE Jacobsen, AT Clark The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation Cell Rep, 2018-12-26;25(13):3591-3602.e5. 2018-12-26 [PMID: 30590035] (Bioassay, Human)	Bioassay	Human
C Bonamy, E Sechet, A Amiot, A Alam, M Mourez, L Fraisse, PJ Sansonetti, B Sperandio Expression of the human antimicrobial peptide ?-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells Sci Rep, 2018-12-21;8(1):18043. 2018-12-21 [PMID: 30575780] (Bioassay, Human)	Bioassay	Human
SJ Yoon, LS Elahi, AM Pa?ca, RM Marton, A Gordon, O Revah, Y Miura, EM Walczak, GM Holdgate, HC Fan, JR Huguenard, DH Geschwind, SP Pa?ca Reliability of human cortical organoid generation Nat. Methods, 2018-12-20;16(1):75-78. 2018-12-20 [PMID: 30573846] (Bioassay, Human)	Bioassay	Human
T Kijima, H Nakagawa, M Shimonoson, PM Chandramou, T Hara, V Sahu, Y Kasagi, O Kikuchi, K Tanaka, V Giroux, AB Muir, KA Whelan, S Ohashi, S Naganuma, AJ Klein-Szan, Y Shinden, K Sasaki, I Omoto, Y Kita, M Muto, AJ Bass, JA Diehl, GG Ginsberg, Y Doki, M Mori, Y Uchikado, T Arigami, NG Avadhani, D Basu, AK Rustgi, S Natsugoe Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells Cell Mol Gastroenterol Hepatol, 2018-09-14;7(1):73-91. 2018-09-14 [PMID: 30510992] (Bioassay, Human)	Bioassay	Human
S Ma, R Viola, L Sui, V Cherubini, F Barbetti, D Egli ? Cell Replacement after Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus Stem Cell Reports, 2018-11-29;0(0):. 2018-11-29 [PMID: 30503261] (Bioassay, Human)	Bioassay	Human
YQ Guan, CS Zhao, HQ Zou, XM Yan, LL Luo, JL Wu, X Li, YA Zhang Aging, rather than Parkinson's disease, affects the responsiveness of PBMCs to the immunosuppression of bone marrow mesenchymal stem cells Mol Med Rep, 2018-11-19;19(1):165-176. 2018-11-19 [PMID: 30483752] (Bioassay, Human)	Bioassay	Human
R Negoro, K Takayama, K Kawai, K Harada, F Sakurai, K Hirata, H Mizuguchi Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies Stem Cell Reports, 2018-11-21;0(0):. 2018-11-21 [PMID: 30472010] (Bioassay, Human)	Bioassay	Human
TR Broda, KW McCracken, JM Wells Generation of human antral and fundic gastric organoids from pluripotent stem cells Nat Protoc, 2019-01-01;14(1):28-50. 2019-01-01 [PMID: 30470820] (Bioassay, Human)	Bioassay	Human
H Takahashi, H Ashikawa, H Nakamura, T Murayama Phosphorylation and inhibition of ceramide kinase by protein kinase C-?: Their changes by serine residue mutations Cell. Signal., 2018-11-15;0(0):. 2018-11-15 [PMID: 30448345] (Cell Culture, Human)	Cell Culture	Human
C Choi, N Thi Thao T, T Van Ngu, SW Park, MS Song, SH Kim, YU Bae, PDN Ayudthaya, J Munir, E Kim, MJ Baek, S Song, S Ryu, KH Nam Promotion of tumor progression and cancer stemness by MUC15 in thyroid cancer via the GPCR/ERK and integrin-FAK signaling pathways Oncogenesis, 2018-11-12;7(11):85. 2018-11-12 [PMID: 30420637] (Bioassay, Human)	Bioassay	Human
M Ferrandis, MP Trudeau, YT Hung, Z Zeng, PE Urriola, GC Shurson, M Saqui-Salc Dietary fiber sources and non-starch polysaccharide-degrading enzymes modify mucin expression and the immune profile of the swine ileum PLoS ONE, 2018-11-08;13(11):e0207196. 2018-11-08 [PMID: 30408134] (Bioassay, Mouse)	Bioassay	Mouse
SL Kloet, ID Karemaker, L van Voorth, RGH Lindeboom, MP Baltissen, RR Edupuganti, DW Poramba-Li, PWTC Jansen, M Vermeulen NuRD-interacting protein ZFP296 regulates genome-wide NuRD localization and differentiation of mouse embryonic stem cells Nat Commun, 2018-11-02;9(1):4588. 2018-11-02 [PMID: 30389936] (Bioassay, Mouse)	Bioassay	Mouse
JY Yeon, JY Hwang, HW Lee, HJ Pyeon, JS Won, YJ Noh, H Nam, KM Joo Optimized Clump Culture Methods for Adult Human Multipotent Neural Cells Int J Mol Sci, 2018-10-29;19(11):. 2018-10-29 [PMID: 30380605] (Bioassay, Human)	Bioassay	Human
Y Wang, X Xu, D Maglic, MT Dill, K Mojumdar, PK Ng, KJ Jeong, YH Tsang, D Moreno, VH Bhavana, X Peng, Z Ge, H Chen, J Li, Z Chen, H Zhang, L Han, D Du, CJ Creighton, GB Mills, F Camargo, H Liang Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer Cell Rep, 2018-10-30;25(5):1304-1317.e5. 2018-10-30 [PMID: 30380420] (Bioassay, Human)	Bioassay	Human
D Saengwimol, D Rojanaporn, V Chaitankar, P Chittavani, R Aroonroch, T Boontawon, W Thammachot, N Jinawath, S Hongeng, R Kaewkhaw A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma Sci Rep, 2018-10-23;8(1):15664. 2018-10-23 [PMID: 30353124] (Organoid Culture, Human)	Organoid Culture	Human
E Sechet, E Telford, C Bonamy, PJ Sansonetti, B Sperandio Natural molecules induce and synergize to boost expression of the human antimicrobial peptide ?-defensin-3 Proc. Natl. Acad. Sci. U.S.A., 2018-10-01;0(0):. 2018-10-01 [PMID: 30275324] (Bioassay, Human)	Bioassay	Human
Q Chen, J Wu, Q Ye, F Ma, Q Zhu, Y Wu, C Shan, X Xie, D Li, X Zhan, C Li, XF Li, X Qin, T Zhao, H Wu, PY Shi, J Man, CF Qin Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate MBio, 2018-09-18;9(5):. 2018-09-18 [PMID: 30228241] (Bioassay, Human)	Bioassay	Human
SA Sloan, J Andersen, AM Pa?ca, F Birey, SP Pa?ca Generation and assembly of human brain region-specific three-dimensional cultures Nat Protoc, 2018-09-01;0(0):. 2018-09-01 [PMID: 30202107] (Cell Culture, Human)	Cell Culture	Human
E Lång, A Po?e?, A Lång, M Valk, P Blicher, AD Rowe, KA Tønseth, CJ Jackson, TP Utheim, LMC Janssen, J Eriksson, SO Bøe Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding Nat Commun, 2018-09-10;9(1):3665. 2018-09-10 [PMID: 30202009] (Cell Culture, Human)	Cell Culture	Human
R Cruz-Acuña, M Quirós, S Huang, D Siuda, JR Spence, A Nusrat, AJ García PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery Nat Protoc, 2018-09-01;0(0):. 2018-09-01 [PMID: 30190557] (Bioassay, Human)	Bioassay	Human
K Kirino, T Nakahata, T Taguchi, MK Saito Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition Sci Rep, 2018-08-27;8(1):12865. 2018-08-27 [PMID: 30150715] (Bioassay, Human)	Bioassay	Human
JD Blair, D Hockemeyer, HS Bateup Genetically engineered human cortical spheroid models of tuberous sclerosis Nat. Med., 2018-08-20;0(0):. 2018-08-20 [PMID: 30127391] (Bioassay, Human)	Bioassay	Human
Z Liu, Y Wei, L Zhang, PP Yee, M Johnson, X Zhang, M Gulley, JM Atkinson, M Trebak, HG Wang, W Li Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ Oncogene, 2018-08-06;38(1):120-139. 2018-08-06 [PMID: 30082911] (Bioassay, Human)	Bioassay	Human
S Haider, G Meinhardt, L Saleh, V Kunihs, M Gamperl, U Kaindl, A Ellinger, TR Burkard, C Fiala, J Pollheimer, S Mendjan, PA Latos, M Knöfler Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta Stem Cell Reports, 2018-08-02;0(0):. 2018-08-02 [PMID: 30078556] (Bioassay, Human)	Bioassay	Human
KH Lee, HJ Pyeon, H Nam, JS Won, JY Hwang, KA Lee, JY Yeon, SC Hong, DH Nam, K Lee, SH Lee, KM Joo Significant therapeutic effects of adult human multipotent neural cells on spinal cord injury Stem Cell Res, 2018-07-19;31(0):71-78. 2018-07-19 [PMID: 30031233] (Bioassay, Human)	Bioassay	Human
E Porcù, F Maule, D Boso, E Rampazzo, V Barbieri, G Zuccolotto, A Rosato, C Frasson, G Viola, AD Puppa, G Basso, L Persano BMP9 counteracts the tumorigenic and pro-angiogenic potential of glioblastoma Cell Death Differ., 2018-07-05;0(0):. 2018-07-05 [PMID: 29977042] (Bioassay, Human)	Bioassay	Human
CH Peng, LC Woung, KH Lu, CY Tsai, SD Lee, CS Huang, TC Lin, KH Chien, DK Hwang Acoustic waves improves retroviral transduction in human retinal stem cells J Chin Med Assoc, 2018-06-22;0(0):. 2018-06-22 [PMID: 29941298] (Bioassay, Human)	Bioassay	Human
Michael J Workman, John P Gleeson, Elissa J Troisi, Hannah Q Estrada, S Jordan Kerns, Christopher D Hinojosa, Geraldine A Hamilton, Stephan R Targan, Clive N Svendsen, Robert J Barrett Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cellular and Molecular Gastroenterology and Hepatology, 2017-12-29;0(0):2352-345X. 2017-12-29 [PMID: 29930984] (Bioassay, Human)	Bioassay	Human
H Lahlou, A Lopez-Juar, A Fontbonne, E Nivet, A Zine Modeling human early otic sensory cell development with induced pluripotent stem cells PLoS ONE, 2018-06-14;13(6):e0198954. 2018-06-14 [PMID: 29902227] (Bioassay, Human)	Bioassay	Human
M Li, X Zhao, W Wang, H Shi, Q Pan, Z Lu, SP Perez, R Suganthan, C He, M Bjørås, A Klungland Ythdf2-mediated m6A mRNA clearance modulates neural development in mice Genome Biol., 2018-05-31;19(1):69. 2018-05-31 [PMID: 29855337] (Bioassay, Mouse)	Bioassay	Mouse
D Garnier, R Li, F Delbos, A Fourrier, C Collet, C Guguen-Gui, C Chesné, TH Nguyen Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system Sci Rep, 2018-05-29;8(1):8222. 2018-05-29 [PMID: 29844473] (Bioassay, Human)	Bioassay	Human
K Skrzypek, A Kusienicka, E Trzyna, B Szewczyk, A Ulman, P Konieczny, T Adamus, B Badyra, M Kortylewsk, M Majka SNAIL is a key regulator of alveolar rhabdomyosarcoma tumor growth and differentiation through repression of MYF5 and MYOD function Cell Death Dis, 2018-05-29;9(6):643. 2018-05-29 [PMID: 29844345] (Bioassay, Human)	Bioassay	Human
MH Choe, Y Yoon, J Kim, SG Hwang, YH Han, JS Kim miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor resistance through the direct targeting of YAP Cell Death Dis, 2018-05-29;9(6):640. 2018-05-29 [PMID: 29844307] (Bioassay, Human)	Bioassay	Human
GS Wong, J Zhou, JB Liu, Z Wu, X Xu, T Li, D Xu, SE Schumacher, J Puschhof, J McFarland, C Zou, A Dulak, L Henderson, P Xu, E O'Day, R Rendak, WL Liao, F Cecchi, T Hembrough, S Schwartz, C Szeto, AK Rustgi, KK Wong, JA Diehl, K Jensen, F Graziano, A Ruzzo, S Fereshetia, P Mertins, SA Carr, R Beroukhim, K Nakamura, E Oki, M Watanabe, H Baba, Y Imamura, D Catenacci, AJ Bass Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition Nat. Med., 2018-05-28;0(0):. 2018-05-28 [PMID: 29808010] (Bioassay, Human)	Bioassay	Human
H Yang, C Wang, H Chen, L Li, S Ma, H Wang, Y Fu, T Qu Neural Stem Cell-Conditioned Medium Ameliorated Cerebral Ischemia-Reperfusion Injury in Rats Stem Cells Int, 2018-04-03;2018(0):4659159. 2018-04-03 [PMID: 29765412] (Bioassay, Human)	Bioassay	Human
JM Kim, S Choi, SW Lee, K Park Voltage-dependent Ca2+ channels promote branching morphogenesis of salivary glands by patterning differential growth Sci Rep, 2018-05-15;8(1):7566. 2018-05-15 [PMID: 29765108] (Bioassay, Mouse)	Bioassay	Mouse
B Roy, S Venkatacha, P Ratna, Y Wang, DS Jokhun, M Nagarajan, GV Shivashank Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors Proc. Natl. Acad. Sci. U.S.A., 2018-05-07;0(0):. 2018-05-07 [PMID: 29735717] (Bioassay, Human)	Bioassay	Human
IG Ryoo, BH Choi, SK Ku, MK Kwak High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance Redox Biol, 2018-04-26;17(0):246-258. 2018-04-26 [PMID: 29729523] (Bioassay, Human)	Bioassay	Human
JR Fan, HT Lee, W Lee, CH Lin, CY Hsu, CH Hsieh, WC Shyu Potential role of CBX7 in regulating pluripotency of adult human pluripotent-like olfactory stem cells in stroke model Cell Death Dis, 2018-05-01;9(5):502. 2018-05-01 [PMID: 29717132] (Bioassay, Human)	Bioassay	Human
Y Zhang, Q Zhang, Z Cao, Y Huang, S Cheng, D Pang HOXD3 Plays a Critical Role in Breast Cancer Stemness and Drug Resistance Cell. Physiol. Biochem., 2018-04-23;46(4):1737-1747. 2018-04-23 [PMID: 29698974] (Bioassay, Human)	Bioassay	Human
F Ihler, R Gratz, HA Wolff, BG Weiss, M Bertlich, J Kitz, G Salinas, M Rave-Fränk, M Canis Epithelial-Mesenchymal Transition during Metastasis of HPV-Negative Pharyngeal Squamous Cell Carcinoma Biomed Res Int, 2018-03-06;2018(0):7929104. 2018-03-06 [PMID: 29693014] (Bioassay, Human)	Bioassay	Human
I Pop?na, A ?bols, L Saul?te, K Pleiko, E Zandberga, K J?kabsons, E Endzeli?š, A Llorente, A Lin?, U Rieksti?a Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages Cell Commun. Signal, 2018-04-24;16(1):17. 2018-04-24 [PMID: 29690889] (Cell Culture, Human)	Cell Culture	Human
MR Rovere, P Rousselle, M Haftek, B Charleux, V Kocaba, C Auxenfans, S Nataf, O Damour Preserving Basement Membranes during Detachment of Cultivated Oral Mucosal Epithelial Cell Sheets for the Treatment of Total Bilateral Limbal Stem Cell Deficiency Cell Transplant, 2018-02-01;27(2):264-274. 2018-02-01 [PMID: 29637812] (Bioassay, Human)	Bioassay	Human
D Saha, H Wakimoto, CW Peters, SJ Antoszczyk, SD Rabkin, RL Martuza Combinatorial effects of VEGFR kinase inhibitor axitinib and oncolytic virotherapy in mouse and human glioblastoma stem-like cell models Clin. Cancer Res., 2018-03-29;0(0):. 2018-03-29 [PMID: 29599413] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
PD Leiphrakpa, MG Brattain, JD Black, JJ Wang TGF? and IGF1R signaling activate protein kinase A through differential regulation of ezrin phosphorylation in colon cancer�cells J. Biol. Chem., 2018-03-29;0(0):. 2018-03-29 [PMID: 29599290] (Bioassay, Human)	Bioassay	Human
D Poppe, J Doerr, M Schneider, R Wilkens, JA Steinbeck, J Ladewig, A Tam, DE Paschon, PD Gregory, A Reik, CE Müller, P Koch, O Brüstle Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity Stem Cells Transl Med, 2018-03-28;0(0):. 2018-03-28 [PMID: 29589874] (Bioassay, Human)	Bioassay	Human
FN Vögtle, B Brändl, A Larson, M Pendziwiat, MW Friederich, SM White, A Basinger, C Kücükköse, H Muhle, JA Jähn, O Keminer, KL Helbig, CF Delto, L Myketin, D Mossmann, N Burger, N Miyake, A Burnett, A van Baalen, MA Lovell, N Matsumoto, M Walsh, HC Yu, DN Shinde, U Stephani, JLK Van Hove, FJ Müller, I Helbig Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood Am. J. Hum. Genet., 2018-03-22;0(0):. 2018-03-22 [PMID: 29576218] (Bioassay, Human)	Bioassay	Human
J Lee, GK Geiss, G Demirkan, CP Vellano, B Filanoski, Y Lu, Z Ju, S Yu, H Guo, LY Bogatzki, WE Carter, RK Meredith, S Krishnamur, Z Ding, JM Beechem, G Mills Implementation of a Multiplex and Quantitative Proteomics Platform for Assessing Protein Lysates Using DNA-Barcoded Antibodies Mol. Cell Proteomics, 2018-03-12;0(0):. 2018-03-12 [PMID: 29531020] (Bioassay, Human)	Bioassay	Human
C Ding, Q Zou, F Wang, H Wu, R Chen, J Lv, M Ling, J Sun, W Wang, H Li, B Huang Human amniotic mesenchymal stem cells improve ovarian function in natural aging through secreting hepatocyte growth factor and epidermal growth factor Stem Cell Res Ther, 2018-03-09;9(1):55. 2018-03-09 [PMID: 29523193] (Bioassay, Human)	Bioassay	Human
M Telechea-F, L Rodríguez-, C García, R Zaragozá, J Viña, A Cervantes, ER García-Tre New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status Oncotarget, 2018-01-03;9(10):9100-9113. 2018-01-03 [PMID: 29507677] (Bioassay, Human)	Bioassay	Human
EM André, N Daviaud, L Sindji, J Cayon, R Perrot, CN Montero-Me A novel ex vivo Huntington's disease model for studying GABAergic neurons and cell grafts by laser microdissection PLoS ONE, 2018-03-05;13(3):e0193409. 2018-03-05 [PMID: 29505597] (Bioassay, Human)	Bioassay	Human
W Wang, D Chen, K Zhu SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition J. Exp. Clin. Cancer Res., 2018-02-23;37(1):37. 2018-02-23 [PMID: 29475441] (Bioassay, Human)	Bioassay	Human
YG Kim, YN Yoon, HS Choi, JH Kim, H Seol, JK Lee, MK Seong, IC Park, KI Kim, HA Kim, JS Kim, WC Noh Breast cancer stem cells in HER2-negative breast cancer cells contribute to HER2-mediated radioresistance and molecular subtype conversion: clinical implications for serum HER2 in recurrent HER2-negative breast cancer Oncotarget, 2017-12-20;9(5):5811-5822. 2017-12-20 [PMID: 29464036] (Bioassay, Human)	Bioassay	Human
EE Alexeev, JM Lanis, DJ Kao, EL Campbell, CJ Kelly, KD Battista, ME Gerich, BR Jenkins, ST Walk, DJ Kominsky, SP Colgan Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor Am. J. Pathol., 2018-02-16;0(0):. 2018-02-16 [PMID: 29454749] (Bioassay, Human)	Bioassay	Human
R Fueyo, S Iacobucci, S Pappa, C Estarás, S Lois, M Vicioso-Ma, C Navarro, S Cruz-Molin, JC Reyes, Á Rada-Igles, X de la Cruz, MA Martínez-B Lineage specific transcription factors and epigenetic regulators mediate TGF?-dependent enhancer activation Nucleic Acids Res., 2018-04-20;0(0):. 2018-04-20 [PMID: 29438503] (Bioassay, Mouse)	Bioassay	Mouse
T Speck, JP Heidbueche, R Veinalde, D Jaeger, C von Kalle, CR Ball, G Ungerechts, CE Engeland Targeted BiTE expression by an oncolytic vector augments therapeutic efficacy against solid tumors Clin. Cancer Res., 2018-02-06;0(0):. 2018-02-06 [PMID: 29437789] (Bioassay, Human)	Bioassay	Human
M Meng, Y Liu, W Wang, C Wei, F Liu, Z Du, Y Xie, W Tang, Z Hou, Q Li Umbilical cord mesenchymal stem cell transplantation in the treatment of multiple sclerosis Am J Transl Res, 2018-01-15;10(1):212-223. 2018-01-15 [PMID: 29423006] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
VNS Garikipati, SP Singh, Y Mohanram, AK Gupta, D Kapoor, S Nityanand Isolation and characterization of mesenchymal stem cells from human fetus heart PLoS ONE, 2018-02-08;13(2):e0192244. 2018-02-08 [PMID: 29420637] (Bioassay, Human)	Bioassay	Human
A Wahba, MC Ryan, UT Shankavara, K Camphausen, PJ Tofilon Radiation-induced alternative transcripts as detected in total and polysome-bound mRNA Oncotarget, 2017-10-09;9(1):691-705. 2017-10-09 [PMID: 29416646] (Bioassay, Human)	Bioassay	Human
C Laterza, N Uoshima, D Tornero, U Wilhelmsso, A Stokowska, R Ge, M Pekny, O Lindvall, Z Kokaia Attenuation of reactive gliosis in stroke-injured mouse brain does not affect neurogenesis from grafted human iPSC-derived neural progenitors PLoS ONE, 2018-02-05;13(2):e0192118. 2018-02-05 [PMID: 29401502] (Bioassay, Human)	Bioassay	Human
M Stromecki, N Tatari, LC Morrison, R Kaur, J Zagozewski, G Palidwor, V Ramaswamy, P Skowron, M Wölfl, T Milde, MR Del Bigio, MD Taylor, TE Werbowetsk Characterization of a novel OTX2-driven stem cell program in Group 3 and Group 4 medulloblastoma Mol Oncol, 2018-03-01;12(4):495-513. 2018-03-01 [PMID: 29377567] (Bioassay, Human)	Bioassay	Human
S Miyamoto, V Kochin, T Kanaseki, A Hongo, S Tokita, Y Kikuchi, A Takaya, Y Hirohashi, T Tsukahara, T Terui, K Ishitani, F Hata, I Takemasa, A Miyazaki, H Hiratsuka, N Sato, T Torigoe The antigen ASB4 on cancer stem cells serves as a target for CTL immunotherapy of colorectal cancer Cancer Immunol Res, 2018-01-25;0(0):. 2018-01-25 [PMID: 29371260] (Bioassay, Human)	Bioassay	Human
C Bessa, J Soares, L Raimundo, JB Loureiro, C Gomes, F Reis, ML Soares, D Santos, C Dureja, SR Chaudhuri, C Lopez-Habe, MG Kazanietz, J Gonçalves, MF Simões, P Rijo, L Saraiva Discovery of a small-molecule protein kinase C?-selective activator with promising application in colon cancer therapy Cell Death Dis, 2018-01-18;9(2):23. 2018-01-18 [PMID: 29348560] (Bioassay, Human)	Bioassay	Human
N Dreyer-And, AS Almeida, P Jensen, M Kamand, J Okarmus, T Rosenberg, SD Friis, A Martínez S, M Blaabjerg, BW Kristensen, T Skrydstrup, JB Gramsberge, HLA Vieira, M Meyer Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells PLoS ONE, 2018-01-16;13(1):e0191207. 2018-01-16 [PMID: 29338033] (Bioassay, Human)	Bioassay	Human
V Sobrino, P González-R, V Annese, J López-Barn, R Pardal Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia EMBO Rep., 2018-01-15;0(0):. 2018-01-15 [PMID: 29335248] (Cell Culture, Human)	Cell Culture	Human
ML Schulte, A Fu, P Zhao, J Li, L Geng, ST Smith, J Kondo, RJ Coffey, MO Johnson, JC Rathmell, JT Sharick, MC Skala, JA Smith, J Berlin, MK Washington, ML Nickels, HC Manning Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models Nat. Med., 2018-01-15;0(0):. 2018-01-15 [PMID: 29334372] (Bioassay, Human)	Bioassay	Human
JJ Gell, J Zhao, D Chen, TJ Hunt, AT Clark PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation Stem Cell Res, 2018-01-04;27(0):46-56. 2018-01-04 [PMID: 29324254] (Bioassay, Human)	Bioassay	Human
CJ Drummond, JA Hanna, MR Garcia, DJ Devine, AJ Heyrana, D Finkelstei, JE Rehg, ME Hatley Hedgehog Pathway Drives Fusion-Negative Rhabdomyosarcoma Initiated From Non-myogenic Endothelial Progenitors Cancer Cell, 2018-01-08;33(1):108-124.e5. 2018-01-08 [PMID: 29316425] (Bioassay, Mouse)	Bioassay	Mouse
HY Lin, YS Chen, K Wang, HW Chien, YH Hsieh, SF Yang Fisetin inhibits epidermal growth factor-induced migration of ARPE-19 cells by suppression of AKT activation and Sp1-dependent MMP-9 expression Mol. Vis., 2017-12-10;23(0):900-910. 2017-12-10 [PMID: 29296070] (Bioassay, Human)	Bioassay	Human
T Tanaka, Y Zhou, T Ozawa, R Okizono, A Banba, T Yamamura, E Oga, A Muraguchi, H Sakurai Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation J. Biol. Chem., 2017-12-18;0(0):. 2017-12-18 [PMID: 29255092] (Bioassay, Human)	Bioassay	Human
JJ Song, SM Oh, OC Kwon, N Wulnansari, HS Lee, MY Chang, E Lee, W Sun, SE Lee, S Chang, H An, CJ Lee, SH Lee Cografting astrocytes improves cell therapeutic outcomes in a Parkinson's disease model J. Clin. Invest., 2017-12-11;0(0):. 2017-12-11 [PMID: 29227284] (Bioassay, Mouse)	Bioassay	Mouse
J Dietrich, N Baryawno, N Nayyar, YK Valtis, B Yang, I Ly, A Besnard, N Severe, KU Gustafsson, OC Andronesi, TT Batchelor, A Sahay, DT Scadden Bone marrow drives central nervous system regeneration after radiation injury J. Clin. Invest., 2017-12-04;0(0):. 2017-12-04 [PMID: 29202481] (Bioassay, Mouse)	Bioassay	Mouse
T Johansen, C Krabbe, SI Schmidt, AM Serrano, M Meyer Comparative Analysis of Spontaneous and Stimulus-Evoked Calcium Transients in Proliferating and Differentiating Human Midbrain-Derived Stem Cells Stem Cells Int, 2017-10-22;2017(0):9605432. 2017-10-22 [PMID: 29201062] (Bioassay, Human)	Bioassay	Human
Jun-Hung Cho, Bhaumik Patel, Santosh Bonala, Sasikanth Manne, Yan Zhou, Surya K Vadrevu, Jalpa Patel, Marco Peronaci, Shanawaz Ghouse, Elizabeth P Henske, Fabrice Roegiers, Krinio Giannikou, David J Kwiatkows, Hossein Mansouri, Maciej M Markiewsk, Brandon White, Magdalena Karbownic Notch transactivates Rheb to maintain the multipotency of TSC-null cells. Nature Communications, 2017-11-29;0(0):2041-1723. 2017-11-29 [PMID: 29184052] (Bioassay, Human)	Bioassay	Human
SG Wohl, NL Jorstad, EM Levine, TA Reh M�ller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture Nat Commun, 2017-11-17;8(1):1603. 2017-11-17 [PMID: 29150673] (Bioassay, Mouse)	Bioassay	Mouse
O Patel, MDW Griffin, S Panjikar, W Dai, X Ma, H Chan, C Zheng, A Kropp, JM Murphy, RJ Daly, IS Lucet Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association Nat Commun, 2017-10-27;8(1):1157. 2017-10-27 [PMID: 29079850] (Bioassay, Human)	Bioassay	Human
Z Wei, AO Batagov, S Schinelli, J Wang, Y Wang, R El Fatimy, R Rabinovsky, L Balaj, CC Chen, F Hochberg, B Carter, XO Breakefiel, AM Krichevsky Coding and noncoding landscape of extracellular RNA released by human glioma stem cells Nat Commun, 2017-10-26;8(1):1145. 2017-10-26 [PMID: 29074968] (Bioassay, Human)	Bioassay	Human
JX Wang, JF Zhou, FK Huang, L Zhang, QL He, HY Qian, HL Lai GLI2 induces PDGFRB expression and modulates cancer stem cell properties of gastric cancer Eur Rev Med Pharmacol Sci, 2017-10-01;21(17):3857-3865. 2017-10-01 [PMID: 28975979] (Bioassay, Human)	Bioassay	Human
L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis Autophagy, 2017-01-01;0(0):0. 2017-01-01 [PMID: 28933598] (Bioassay, Human)	Bioassay	Human
KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors Nat Commun, 2017-08-24;8(1):331. 2017-08-24 [PMID: 28835709] (Bioassay, Human)	Bioassay	Human
KJ Yoon, G Song, X Qian, J Pan, D Xu, HS Rho, NS Kim, C Habela, L Zheng, F Jacob, F Zhang, EM Lee, WK Huang, FR Ringeling, C Vissers, C Li, L Yuan, K Kang, S Kim, J Yeo, Y Cheng, S Liu, Z Wen, CF Qin, Q Wu, KM Christian, H Tang, P Jin, Z Xu, J Qian, H Zhu, H Song, GL Ming Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins Cell Stem Cell, 2017-08-17;0(0):. 2017-08-17 [PMID: 28826723] (Bioassay, Mouse)	Bioassay	Mouse
FM Khan, S Marquardt, SK Gupta, S Knoll, U Schmitz, A Spitschak, D Engelmann, J Vera, O Wolkenhaue, BM Pützer Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures Nat Commun, 2017-08-04;8(1):198. 2017-08-04 [PMID: 28775339] (Bioassay, Human)	Bioassay	Human
E Zanini, LS Louis, J Antony, E Karali, IS Okon, AB McKie, S Vaughan, M El-Bahrawy, J Stebbing, C Recchi, H Gabra The tumor suppressor protein OPCML potentiates anti-EGFR and anti-HER2 targeted therapy in HER2-positive ovarian and breast cancer Mol. Cancer Ther., 2017-08-03;0(0):. 2017-08-03 [PMID: 28775148] (Bioassay, Human)	Bioassay	Human
K Hino, K Horigome, M Nishio, S Komura, S Nagata, C Zhao, Y Jin, K Kawakami, Y Yamada, A Ohta, J Toguchida, M Ikeya Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva J. Clin. Invest., 2017-07-31;0(0):. 2017-07-31 [PMID: 28758906] (Bioassay, Human)	Bioassay	Human
J Yin, YT Oh, JY Kim, SS Kim, E Choi, TH Kim, JH Hong, N Chang, HJ Cho, JK Sa, JC Kim, HJ Kwon, S Park, W Lin, I Nakano, HS Gwak, H Yoo, SH Lee, J Lee, JH Kim, SY Kim, DH Nam, MJ Park, JB Park Transglutaminase 2 inhibition reverses mesenchymal transdifferentiation of glioma stem cells by regulating C/EBP? signaling Cancer Res., 2017-07-28;0(0):. 2017-07-28 [PMID: 28754668] (Bioassay, Human)	Bioassay	Human
E Martínez-S, S Montori, C Gil-Recio, R Núñez-Told, D Costamagna, A Rotini, M Atari, A Luttun, M Sampaolesi Human dental pulp pluripotent-like stem cells promote wound healing and muscle regeneration Stem Cell Res Ther, 2017-07-27;8(1):175. 2017-07-27 [PMID: 28750661] (Bioassay, Human)	Bioassay	Human
X Wang, Z Huang, Q Wu, BC Prager, SC Mack, K Yang, LJY Kim, RC Gimple, Y Shi, S Lai, Q Xie, TE Miller, CG Hubert, A Song, Z Dong, W Zhou, X Fang, Z Zhu, V Mahadev, S Bao, JN Rich MYC-regulated Mevalonate Metabolism Maintains Brain Tumor Initiating Cells Cancer Res., 2017-07-20;0(0):. 2017-07-20 [PMID: 28729418] (Bioassay, Human)	Bioassay	Human
EK Kim, JH Cho, E Kim, YJ Kim Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth PLoS ONE, 2017-07-14;12(7):e0181183. 2017-07-14 [PMID: 28708871] (Bioassay, Human)	Bioassay	Human
D Yu, OF Khan, ML Suvà, B Dong, WK Panek, T Xiao, M Wu, Y Han, AU Ahmed, IV Balyasniko, HF Zhang, C Sun, R Langer, DG Anderson, MS Lesniak Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression Proc. Natl. Acad. Sci. U.S.A., 2017-07-10;0(0):. 2017-07-10 [PMID: 28696296] (Bioassay, Human)	Bioassay	Human
M Morrison J, MM Williams, DJ Hicks, B Jones, V Sanchez, CD Young, DD Sarbassov, WJ Muller, D Brantley-S, RS Cook Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis Breast Cancer Res., 2017-06-30;19(1):74. 2017-06-30 [PMID: 28666462] (Bioassay, Human)	Bioassay	Human
CT Kuo, JY Wang, YF Lin, AM Wo, BPC Chen, H Lee Three-dimensional spheroid culture targeting versatile tissue bioassays using a PDMS-based hanging drop array Sci Rep, 2017-06-29;7(1):4363. 2017-06-29 [PMID: 28663555] (Bioassay, Human)	Bioassay	Human
S Mahati, D Bolati, Y Yang, R Mao, H Zhang, Y Bao TMPRSS4 promotes cancer stem cell traits by regulating CLDN1 in hepatocellular carcinoma Biochem. Biophys. Res. Commun., 2017-06-23;0(0):. 2017-06-23 [PMID: 28651932] (Bioassay, Human)	Bioassay	Human
JO Múnera, N Sundaram, SA Rankin, D Hill, C Watson, M Mahe, JE Vallance, NF Shroyer, KL Sinagoga, A Zarzoso-La, JR Hudson, JC Howell, P Chatuvedi, JR Spence, JM Shannon, AM Zorn, MA Helmrath, JM Wells Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling Cell Stem Cell, 2017-06-22;0(0):. 2017-06-22 [PMID: 28648364] (Bioassay, Human)	Bioassay	Human
CN Im Combination Treatment with PPAR? Ligand and Its Specific Inhibitor GW9662 Downregulates BIS and 14-3-3 Gamma, Inhibiting Stem-Like Properties in Glioblastoma Cells Biomed Res Int, 2017-05-31;2017(0):5832824. 2017-05-31 [PMID: 28642874] (Bioassay, Human)	Bioassay	Human
Y Hao, J Lyu, R Qu, D Sun, Z Zhao, Z Chen, J Ding, H Xie, Y Xu, H Li Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors Sci Rep, 2017-06-19;7(1):3830. 2017-06-19 [PMID: 28630494] (Bioassay, Human)	Bioassay	Human
M Crespo, E Vilar, SY Tsai, K Chang, S Amin, T Srinivasan, T Zhang, NH Pipalia, HJ Chen, M Witherspoo, M Gordillo, JZ Xiang, FR Maxfield, S Lipkin, T Evans, S Chen Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing Nat. Med., 2017-06-19;0(0):. 2017-06-19 [PMID: 28628110] (Bioassay, Human)	Bioassay	Human
AI Sagredo, EA Sagredo, C Cappelli, P Báez, AM Rodrigo, C Blanco, JC Tapia, C Echeverría, O Cerda, A Stutzin, F Simon, K Marcelain, R Armisén TRPM4 regulates Akt/GSK3-? activity and enhances ?-catenin signaling and cell proliferation in prostate cancer cells Mol Oncol, 2017-12-30;0(0):. 2017-12-30 [PMID: 28614631] (Bioassay, Human)	Bioassay	Human
SS Karve, S Pradhan, DV Ward, AA Weiss Intestinal organoids model human responses to infection by commensal and Shiga toxin producing Escherichia coli PLoS ONE, 2017-06-14;12(6):e0178966. 2017-06-14 [PMID: 28614372] (Bioassay, Human)	Bioassay	Human
R Chijimatsu, M Ikeya, Y Yasui, Y Ikeda, K Ebina, Y Moriguchi, K Shimomura, DA Hart, Y Hideki, N Norimasa Characterization of Mesenchymal Stem Cell-Like Cells Derived From Human iPSCs via Neural Crest Development and Their Application for Osteochondral Repair Stem Cells Int, 2017-05-10;2017(0):1960965. 2017-05-10 [PMID: 28607560] (Bioassay, Human)	Bioassay	Human
E Jung, M Osswald, J Blaes, B Wiestler, F Sahm, T Schmenger, G Solecki, K Deumelandt, FT Kurz, R Xie, S Weil, O Heil, C Thomé, M Gömmel, M Syed, P Häring, PE Huber, S Heiland, M Platten, A von Deimli, W Wick, F Winkler Tweety-homologue 1 drives brain colonization of gliomas J. Neurosci., 2017-06-12;0(0):. 2017-06-12 [PMID: 28607172] (Bioassay, Human)	Bioassay	Human
MJ Son, JS Ryu, JY Kim, Y Kwon, KS Chung, SJ Mun, YS Cho Upregulation of mitochondrial NAD(+) levels impairs the clonogenicity of SSEA1(+) glioblastoma tumor-initiating cells Exp. Mol. Med., 2017-06-09;49(6):e344. 2017-06-09 [PMID: 28604662] (Bioassay, Human)	Bioassay	Human
D Jung, J Xiong, M Ye, X Qin, L Li, S Cheng, M Luo, J Peng, J Dong, F Tang, W Shen, MM Matzuk, K Kee In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells Nat Commun, 2017-06-12;8(0):15680. 2017-06-12 [PMID: 28604658] (Bioassay, Human)	Bioassay	Human
A Prieur, M Cappellini, G Habif, MP Lefranc, T Mazard, E Morency, JM Pascussi, M Flaceliere, N Cahuzac, B Vire, B Dubuc, A Durochat, P Liaud, J Ollier, C Pfeiffer, S Poupeau, V Saywell, C Planque, E Assenat, F Bibeau, JF Bourgaux, P Pujol, A Sézeur, M Ychou, D Joubert Targeting the Wnt pathway and cancer stem cells with anti-progastrin humanized antibodies: a major breakthrough for K-RAS mutated colorectal cancer treatment Clin. Cancer Res., 2017-06-09;0(0):. 2017-06-09 [PMID: 28600477] (Bioassay, Human)	Bioassay	Human
K Kajiwara, T Tanemoto, S Wada, J Karibe, N Ihara, Y Ikemoto, T Kawasaki, Y Oishi, O Samura, K Okamura, S Takada, H Akutsu, H Sago, A Okamoto, A Umezawa Fetal Therapy Model of Myelomeningocele with Three-Dimensional Skin Using Amniotic Fluid Cell-Derived Induced Pluripotent Stem Cells Stem Cell Reports, 2017-06-06;8(6):1701-1713. 2017-06-06 [PMID: 28591652] (Bioassay, Human)	Bioassay	Human
J Trott, EK Tan, S Ong, DM Titmarsh, SLIJ Denil, M Giam, CK Wong, J Wang, M Shboul, M Eio, J Cooper-Whi, SM Cool, G Rancati, LW Stanton, B Reversade, NR Dunn Long-Term Culture of Self-renewing Pancreatic Progenitors Derived from Human Pluripotent Stem Cells Stem Cell Reports, 2017-06-06;8(6):1675-1688. 2017-06-06 [PMID: 28591650] (Bioassay, Human)	Bioassay	Human
M Yoshihara, Y Sasamoto, R Hayashi, Y Ishikawa, M Tsujikawa, Y Hayashizak, M Itoh, H Kawaji, K Nishida High-resolution promoter map of human limbal epithelial cells cultured with keratinocyte growth factor and rho kinase inhibitor Sci Rep, 2017-06-06;7(1):2845. 2017-06-06 [PMID: 28588247] (Bioassay, Human)	Bioassay	Human
C Zou, Y Lu, X Teng, S Wang, X Sun, F Huang, G Shu, X Huang, H Guo, Z Chen, J Zhang, YA Zhang MRI tracking of autologous pancreatic progenitor-derived insulin-producing cells in monkeys Sci Rep, 2017-05-31;7(1):2505. 2017-05-31 [PMID: 28566744] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))	Bioassay	Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
H Isshiki, Y Arimura, K Nagaishi, K Kawakami, K Onodera, K Yamashita, Y Naishiro, M Fujimiya, K Imai, Y Shinomura Establishment of a refined culture method for rat colon organoids Biochem. Biophys. Res. Commun., 2017-05-27;0(0):. 2017-05-27 [PMID: 28559141] (Bioassay, Rat)	Bioassay	Rat
DA Casolari, T Nguyen, CM Butcher, DG Iarossi, CN Hahn, SC Bray, P Neufing, WT Parker, J Feng, KZY Maung, A Wee, L Vidovic, CH Kok, PG Bardy, S Branford, ID Lewis, SW Lane, HS Scott, DM Ross, RJ D'Andrea A novel, somatic, transforming mutation in the extracellular domain of Epidermal Growth Factor Receptor identified in myeloproliferative neoplasm Sci Rep, 2017-05-26;7(1):2467. 2017-05-26 [PMID: 28550306] (Bioassay, Mouse)	Bioassay	Mouse
LJ Fulcher, LD Hutchinson, TJ Macartney, C Turnbull, GP Sapkota Targeting endogenous proteins for degradation through the affinity-directed protein missile system Open Biol, 2017-05-01;7(5):. 2017-05-01 [PMID: 28490657] (Bioassay, Human)	Bioassay	Human
J Zhou, C Zhang, J Pan, L Chen, ST Qi Interleukin?6 induces an epithelial?mesenchymal transition phenotype in human adamantinomatous craniopharyngioma cells and promotes tumor cell migration Mol Med Rep, 2017-05-02;15(6):4123-4131. 2017-05-02 [PMID: 28487953] (Bioassay, Human)	Bioassay	Human
N Sahoo, M Gu, X Zhang, N Raval, J Yang, M Bekier, R Calvo, S Patnaik, W Wang, G King, M Samie, Q Gao, S Sahoo, S Sundaresan, TM Keeley, Y Wang, J Marugan, M Ferrer, LC Samuelson, JL Merchant, H Xu Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca(2+) Efflux Channel in the Tubulovesicle Dev. Cell, 2017-05-08;41(3):262-273.e6. 2017-05-08 [PMID: 28486130] (Bioassay, Mouse)	Bioassay	Mouse
YJ Chen, L Lankford, S Kabagambe, Z Saenz, P Kumar, D Farmer, A Wang Effect of 2-octylcyanoacrylate on placenta derived mesenchymal stromal cells on extracellular matrix Placenta, 2017-04-02;0(0):. 2017-04-02 [PMID: 28465002] (Bioassay, Human)	Bioassay	Human
R Chen, G Jin, TM McIntyre The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-EGF to active high molecular weight EGF J. Biol. Chem., 2017-04-28;0(0):. 2017-04-28 [PMID: 28455445] (Bioassay, Human)	Bioassay	Human
F Birey, J Andersen, CD Makinson, S Islam, W Wei, N Huber, HC Fan, KRC Metzler, G Panagiotak, N Thom, NA O'Rourke, LM Steinmetz, JA Bernstein, J Hallmayer, JR Huguenard, SP Pa?ca Assembly of functionally integrated human forebrain spheroids Nature, 2017-04-26;545(7652):54-59. 2017-04-26 [PMID: 28445465] (Bioassay, Human)	Bioassay	Human
S Lugert, T Kremer, R Jagasia, A Herrmann, S Aigner, C Giachino, I Mendez-Dav, AM Gardier, JP Carralot, H Meisterman, A Augustin, MD Saxe, J Lamerz, G Duran-Pach, A Ducret, V Taylor, DJ David, C Czech Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis Sci Rep, 2017-04-25;7(0):46543. 2017-04-25 [PMID: 28440309] (Bioassay, Human)	Bioassay	Human
J Li, B Yu, P Deng, Y Cheng, Y Yu, K Kevork, S Ramadoss, X Ding, X Li, CY Wang KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/?-catenin signalling Nat Commun, 2017-04-25;8(0):15146. 2017-04-25 [PMID: 28440295] (Bioassay, Human)	Bioassay	Human
JRW Conway, SC Warren, P Timpson Context-dependent intravital imaging of therapeutic response using intramolecular FRET biosensors Methods, 2017-04-19;0(0):. 2017-04-19 [PMID: 28435000] (Bioassay, Human)	Bioassay	Human
R Núñez-Told, E Martínez-S, C Gil-Recio, MÁ Carrasco, A Al Madhoun, S Montori, M Atari Dental pulp pluripotent-like stem cells (DPPSC), a new stem cell population with chromosomal stability and osteogenic capacity for biomaterials evaluation BMC Cell Biol., 2017-04-21;18(1):21. 2017-04-21 [PMID: 28427322] (Bioassay, Human)	Bioassay	Human
DH Lee, S Cheul Oh, AJ Giles, J Jung, MR Gilbert, DM Park Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF-1? in human glioma stem cells Oncotarget, 2017-06-20;8(25):40233-40245. 2017-06-20 [PMID: 28410215] (Bioassay, Human)	Bioassay	Human
YC Xu, X Wang, Y Chen, SM Chen, XY Yang, YM Sun, MY Geng, J Ding, LH Meng Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3K?-selective Inhibitors in Breast Cancer Theranostics, 2017-02-23;7(4):974-986. 2017-02-23 [PMID: 28382169] (Bioassay, Human)	Bioassay	Human
Y Wan, X Fei, Z Wang, D Jiang, H Chen, M Wang, S Zhou miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway Tumour Biol., 2017-04-01;39(4):1010428317695. 2017-04-01 [PMID: 28381178] (Bioassay, Human)	Bioassay	Human
NA Guadagno, C Moriconi, V Licursi, E D'Acunto, PS Nisi, N Carucci, A De Jaco, E Cacci, R Negri, G Lupo, E Miranda Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB Neurobiol. Dis., 2017-03-28;103(0):32-44. 2017-03-28 [PMID: 28363799] (Bioassay, Human)	Bioassay	Human
PH Vincent, E Benedikz, P Uhlen, O Hovatta, E Sundström Expression of Pluripotency Markers in Non-pluripotent Human Neural Stem and Progenitor Cells Stem Cells Dev., 2017-03-27;0(0):. 2017-03-27 [PMID: 28351210] (Bioassay, Human)	Bioassay	Human
X Wang, K Yang, Q Xie, Q Wu, SC Mack, Y Shi, LJ Kim, BC Prager, WA Flavahan, X Liu, M Singer, CG Hubert, TE Miller, W Zhou, Z Huang, X Fang, A Regev, ML Suvà, TH Hwang, JW Locasale, S Bao, JN Rich Purine synthesis promotes maintenance of brain tumor initiating cells in glioma Nat. Neurosci, 2017-03-27;0(0):. 2017-03-27 [PMID: 28346452] (Bioassay, Human)	Bioassay	Human
L Xue, Y Li, J Chen Duration of simulated microgravity affects the differentiation of mesenchymal stem cells Mol Med Rep, 2017-03-22;15(5):3011-3018. 2017-03-22 [PMID: 28339035] (Bioassay, Rat)	Bioassay	Rat
F Sampazioti, MC de Brito, I Geti, A Bertero, NR Hannan, L Vallier Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells Nat Protoc, 2017-03-23;12(4):814-827. 2017-03-23 [PMID: 28333915] (Bioassay, Human)	Bioassay	Human
K Eun, HM Jeon, SO Kim, SH Choi, SY Lee, X Jin, SC Kim, H Kim A cell-autonomous positive-signaling circuit associated with the PDGF-NO-ID4-regulatory axis in glioblastoma cells Biochem. Biophys. Res. Commun, 2017-03-19;0(0):. 2017-03-19 [PMID: 28327358] (Bioassay, Human)	Bioassay	Human
M Imaizumi, NY Li-Jessen, Y Sato, DT Yang, SL Thibeault Retention of Human-Induced Pluripotent Stem Cells (hiPS) With Injectable HA Hydrogels for Vocal Fold Engineering Ann. Otol. Rhinol. Laryngol., 2017-02-12;126(4):304-314. 2017-02-12 [PMID: 28290232]
D Chen, M Wu, Y Li, I Chang, Q Yuan, M Ekimyan-Sa, P Deng, B Yu, Y Yu, J Dong, JM Szymanski, S Ramadoss, J Li, CY Wang Targeting BMI1(+) Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma Cell Stem Cell, 2017-03-09;0(0):. 2017-03-09 [PMID: 28285905] (Bioassay, Human)	Bioassay	Human
G Riddick, S Kotliarova, V Rodriguez, HS Kim, A Linkous, AJ Storaska, S Ahn, J Walling, G Belova, HA Fine A Core Regulatory Circuit in Glioblastoma Stem Cells Links MAPK Activation to a Transcriptional Program of Neural Stem Cell Identity Sci Rep, 2017-03-03;7(0):43605. 2017-03-03 [PMID: 28256619] (Bioassay, Human)	Bioassay	Human
S Fu, H Xu, M Gu, C Liu, Q Wang, X Wan, Y Chen, Q Chen, Y Peng, Z Cai, J Zhou, Z Wang Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity Sci Rep, 2017-03-03;7(0):43771. 2017-03-03 [PMID: 28256562] (Bioassay, Human)	Bioassay	Human
H He, AE Kuriyan, CW Su, M Mahabole, Y Zhang, YT Zhu, HW Flynn, JM Parel, SC Tseng Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3 Sci Rep, 2017-03-02;7(0):43736. 2017-03-02 [PMID: 28252047] (Bioassay, Human)	Bioassay	Human
R Horibe, Y Hirohashi, T Asano, T Mariya, T Suzuki, A Takaya, H Saijo, Y Shionoya, T Kubo, M Nakatsugaw, T Kanaseki, T Tsukahara, K Watanabe, E Atsuyama, S Toji, H Hirano, T Hasegawa, H Takahashi, N Sato, T Torigoe Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy PLoS ONE, 2017-03-01;12(3):e0171460. 2017-03-01 [PMID: 28248963] (Bioassay, Human)	Bioassay	Human
J Liao, PP Liu, G Hou, J Shao, J Yang, K Liu, W Lu, S Wen, Y Hu, P Huang Regulation of stem-like cancer cells by glutamine through ?-catenin pathway mediated by redox signaling Mol. Cancer, 2017-02-28;16(1):51. 2017-02-28 [PMID: 28245869] (Bioassay, Human)	Bioassay	Human
A Almazán-Mo, P Zarzosa, I Vidal, C Molist, I Giralt, N Navarro, A Soriano, MF Segura, A Alfranca, J Garcia-Cas, J Sánchez de, J Roma, S Gallego Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma Stem Cells Int, 2017-01-24;2017(0):7507380. 2017-01-24 [PMID: 28243259] (Bioassay, Human)	Bioassay	Human
CN Im, HH Yun, JH Lee Heat Shock Factor 1 Depletion Sensitizes A172 Glioblastoma Cells to Temozolomide via Suppression of Cancer Stem Cell-Like Properties Int J Mol Sci, 2017-02-22;18(2):. 2017-02-22 [PMID: 28241425] (Bioassay, Human)	Bioassay	Human
L Wang, Y Hirohashi, T Ogawa, M Shen, R Takeda, A Murai, E Yamamoto, T Kubo, M Nakatsugaw, T Kanaseki, T Tsukahara, T Nishidate, K Okita, G Kutomi, N Sato, I Takemasa, T Torigoe LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells Biochem. Biophys. Res. Commun, 2017-02-24;0(0):. 2017-02-24 [PMID: 28238780] (Bioassay, Human)	Bioassay	Human
CA Valle Oseg, JV Spencer Human cytomegalovirus interleukin-10 enhances matrigel invasion of MDA-MB-231 breast cancer cells Cancer Cell Int, 2017-02-13;17(0):24. 2017-02-13 [PMID: 28228690] (Bioassay, Human)	Bioassay	Human
R Takeda, Y Hirohashi, M Shen, L Wang, T Ogawa, A Murai, E Yamamoto, T Kubo, M Nakatsugaw, T Kanaseki, T Tsukahara, T Nishidate, K Okita, G Kutomi, N Sato, I Takemasa, T Torigoe Identification and functional analysis of variants of a cancer/testis antigen LEMD1 in colorectal cancer stem-like cells Biochem. Biophys. Res. Commun, 2017-02-20;0(0):. 2017-02-20 [PMID: 28219643] (Bioassay, Human)	Bioassay	Human
E Kassianido, CA Brand, US Schwarz, S Kumar Geometry and network connectivity govern the mechanics of stress fibers Proc. Natl. Acad. Sci. U.S.A, 2017-02-17;0(0):. 2017-02-17 [PMID: 28213499] (Bioassay, Human)	Bioassay	Human
PH Lakner, MG Monaghan, Y Möller, MA Olayioye, K Schenke-La Applying phasor approach analysis of multiphoton FLIM measurements to probe the metabolic activity of three-dimensional in vitro cell culture models Sci Rep, 2017-02-13;7(0):42730. 2017-02-13 [PMID: 28211922] (Bioassay, Human)	Bioassay	Human
JC Niclis, C Turner, J Durnall, S McDougal, JA Kauhausen, B Leaw, M Dottori, CL Parish, LH Thompson Long-Distance Axonal Growth and Protracted Functional Maturation of Neurons Derived From Human Induced Pluripotent Stem Cells After Intracerebral Transplantation Stem Cells Transl Med, 2017-02-15;0(0):. 2017-02-15 [PMID: 28198124] (Bioassay, Human)	Bioassay	Human
NV Sankpal, TP Fleming, PK Sharma, HJ Wiedner, WE Gillanders A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial-mesenchymal transition in cancer Oncogene, 2017-02-13;0(0):. 2017-02-13 [PMID: 28192403] (Bioassay, Human)	Bioassay	Human
N Arora, J Imran Also, JW Guggenheim, M Mak, J Munera, JM Wells, RD Kamm, HH Asada, SY Shvartsman, LG Griffith A process engineering approach to increase organoid yield Development, 2017-02-07;144(6):1128-1136. 2017-02-07 [PMID: 28174251] (Bioassay, Human)	Bioassay	Human
J Worthingto, G Spain, JF Timms Effects of ErbB2 Overexpression on the Proteome and ErbB Ligand-specific Phosphosignaling in Mammary Luminal Epithelial Cells Mol. Cell Proteomics, 2017-02-07;16(4):608-621. 2017-02-07 [PMID: 28174229] (Bioassay, Human)	Bioassay	Human
J Wang, K Nikhil, K Viccaro, L Chang, M Jacobsen, G Sandusky, K Shah Aurora A-Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma J. Cell. Sci, 2017-02-06;0(0):. 2017-02-06 [PMID: 28167680] (Bioassay, Human)	Bioassay	Human
HO King, T Brend, HL Payne, A Wright, TA Ward, K Patel, T Egnuni, LF Stead, A Patel, H Wurdak, SC Short RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells Stem Cell Reports, 2017-01-10;8(1):125-139. 2017-01-10 [PMID: 28076755] (Bioassay, Human)	Bioassay	Human
DH Heiland, R Ferrarese, R Claus, F Dai, AP Masilamani, E Kling, A Weyerbrock, T Kling, S Nelander, MS Carro c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas Oncotarget, 2017-01-24;0(0):. 2017-01-24 [PMID: 28036297] (Bioassay, Human)	Bioassay	Human
Xinfang Yu Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production Mol. Carcinog, 2017-05-01;0(0):. 2017-05-01 [PMID: 27996164] (Bioassay, Human)	Bioassay	Human
Young Dong Yoo Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition EMBO Rep, 2016-12-19;0(0):. 2016-12-19 [PMID: 27993939] (Bioassay, Human)	Bioassay	Human
Brain tissue banking for stem cells for our future Sci Rep, 2016-12-19;6(0):39394. 2016-12-19 [PMID: 27991551] (Bioassay, Human)	Bioassay	Human
SW Lee, JU Chong, SO Min, SY Bak, KS Kim Are Adipose-Derived Stem Cells From Liver Falciform Ligaments Another Possible Source of Mesenchymal Stem Cells? Cell Transplant, 2016-11-24;26(5):855-866. 2016-11-24 [PMID: 27938473] (Bioassay, Human)	Bioassay	Human
Xiaoguang Fang Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination J. Exp. Med, 2016-12-06;0(0):. 2016-12-06 [PMID: 27923907] (Bioassay, Human)	Bioassay	Human
Kristen M Bullard-Fe The FDA-approved drug sofosbuvir inhibits Zika virus infection Antiviral Res, 2016-11-27;137(0):134-140. 2016-11-27 [PMID: 27902933] (Bioassay, Human)	Bioassay	Human
Sachdev S Sidhu A Highly Diverse and Functional Na�ve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents J. Mol. Biol., 2016-11-22;0(0):. 2016-11-22 [PMID: 27887869] (Bioassay, Human)	Bioassay	Human
Xiu Li Ju Angiopoietin-1 Modified Human Umbilical Cord Mesenchymal Stem Cell Therapy for Endotoxin-Induced Acute Lung Injury in Rats Yonsei Med. J., 2017-01-01;58(1):206-216. 2017-01-01 [PMID: 27873515] (Bioassay, Human)	Bioassay	Human
Jong Seok Lee EGF Induced RET Inhibitor Resistance in CCDC6-RET Lung Cancer Cells Yonsei Med. J., 2017-01-01;58(1):9-18. 2017-01-01 [PMID: 27873490] (Bioassay, Human)	Bioassay	Human
Lucie Germain Improved Methods to Produce Tissue-Engineered Skin Substitutes Suitable for the Permanent Closure of Full-Thickness Skin Injuries Biores Open Access, 2016-11-01;5(1):320-329. 2016-11-01 [PMID: 27872793] (Bioassay, Human)	Bioassay	Human
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking Nat. Genet., 2016-11-21;0(0):. 2016-11-21 [PMID: 27869826] (Bioassay, Human)	Bioassay	Human
Defined three-dimensional culture conditions mediate efficient induction of definitive endoderm lineage from human umbilical cord Wharton's jelly mesenchymal stem cells Stem Cell Res Ther, 2016-11-16;7(1):165. 2016-11-16 [PMID: 27852316] (Bioassay, Human)	Bioassay	Human
ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer Oncotarget, 2016-12-13;0(0):. 2016-12-13 [PMID: 27829216] (Bioassay, Human)	Bioassay	Human
L Zhu, A Gomez-Dura, G Saretzki, S Jin, K Tilgner, D Melguizo-S, G Anyfantis, J Al-Aama, L Vallier, P Chinnery, M Lako, L Armstrong The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages J. Cell Biol., 2016-10-17;215(2):187-202. 2016-10-17 [PMID: 27810911] (Bioassay, Human)	Bioassay	Human
Maria Rossing A new NFIA:RAF1 fusion activating the MAPK pathway in pilocytic astrocytoma Cancer Genet, 2016-09-16;209(10):440-444. 2016-09-16 [PMID: 27810072] (Bioassay, Human)	Bioassay	Human
Characterization of Neurogenic Potential of Dental Pulp Stem Cells Cultured in Xeno/Serum-Free Condition: In Vitro and In Vivo Assessment Stem Cells Int, 2016-09-05;2016(0):6921097. 2016-09-05 [PMID: 27688776] (Bioassay, Human)	Bioassay	Human
SPINK6 promotes metastasis of nasopharyngeal carcinoma via binding and activation of epithelial growth factor receptor Cancer Res, 2016-09-26;0(0):. 2016-09-26 [PMID: 27671677] (Bioassay, Human)	Bioassay	Human
LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer Oncotarget, 2016-12-13;0(0):. 2016-12-13 [PMID: 27626181] (Bioassay, Human)	Bioassay	Human
The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling J Cell Sci, 2016-08-05;0(0):. 2016-08-05 [PMID: 27505894] (Bioassay, Human)	Bioassay	Human
Barquilla A, Lamberto I, Heynen-Genel S, Brill L, Pasquale E Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. Mol Biol Cell, 2016-07-06;27(17):2757-70. 2016-07-06 [PMID: 27385333] (Bioassay, Human)	Bioassay	Human
Shiva Mansouri Pituitary Adenlylate Cyclase Activating Peptide Protects Adult Neural Stem Cells from a Hypoglycaemic milieu PLoS ONE, 2016-06-15;11(6):e0156867. 2016-06-15 [PMID: 27305000] (Bioassay, Mouse)	Bioassay	Mouse
Growth hormone is permissive for neoplastic colon growth Proc Natl Acad Sci USA, 2016-05-25;0(0):. 2016-05-25 [PMID: 27226307] (Bioassay, Human)	Bioassay	Human
Cancer stem cell-secreted macrophage migration inhibitory factor stimulates myeloid derived suppressor cell function and facilitates glioblastoma immune evasion Stem Cells, 2016-05-27;0(0):. 2016-05-27 [PMID: 27145382] (Bioassay, Human)	Bioassay	Human
Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma Genome Biol, 2016-04-29;17(1):80. 2016-04-29 [PMID: 27139883] (Bioassay, Human)	Bioassay	Human
Glucocorticoids Suppress Mitochondrial Oxidant Production via Upregulation of Uncoupling Protein 2 in Hyperglycemic Endothelial Cells PLoS ONE, 2016-04-29;11(4):e0154813. 2016-04-29 [PMID: 27128320] (Bioassay, Human)	Bioassay	Human