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HAF109). Specific bands were detected for Caveolin-1 at approximately 21 to 24 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
CTS013). Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; (CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to endothelial cells in bile canaliculi. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections." class="big_lightbox" target="_blank">
HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system." class="big_lightbox" target="_blank">
HAF017). A specific band was detected for Caveolin-1 at approximately 25 kDa (as indicated) in the parental HeLa cell line, but is not detectable in knockout HeLa cell line. GAPDH (AF5718) is shown as a loading control. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.
![Western Blot Caveolin-1 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/Caveolin-1_AF5736_Western_Blot_9443.jpg)
![Immunohistochemistry Caveolin-1 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/Caveolin-1_AF5736_Immunohistochemistry_10304.jpg)
![Simple Western Caveolin-1 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/Caveolin1_AF5736_Simple_Western_17064.jpg)
![Knockout Validated Caveolin-1 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/Caveolin1_AF5736_Knockout_Validated_22481.jpg)
![Knockout Validated Caveolin-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af5736_human-caveolin-1-affinity-purified-polyclonal-ab-knockout-validated-2882025152051.png)
