Caveolin-1 Antibody (7C8) [FITC]

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Product Details

Summary
Reactivity Hu, Mu, Rt, ShSpecies Glossary
Applications Flow, ICC/IF, IHC-Fr, IHC-P
Clone
7C8
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

Caveolin-1 Antibody (7C8) [FITC] Summary

Immunogen
Intracellular membrane protein-containing vesicles (containing GLUT4) from rat adipocytes
Localization
Cell Membrane
Marker
Caveolae Marker, Endosome Marker
Specificity
This is specific for caveolin alpha and beta proteins.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
CAV1
Purity
Protein A purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
This Caveolin 1 antibody is useful for Flow Cytometry, Western blot, Immunocytochemistry/Immunofluorescence, Immunoprecipitation and Immunohistochemistry-paraffin embedded sections. In Western blot a band is observed ~23 kDa, representing the Caveolin 1 protein. A band at ~21 kDa may also be observed depending on the lysates used.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
23 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, rat, mouse and sheep.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Caveolin-1 Antibody (7C8) [FITC]

  • CAV
  • CAV1
  • caveolae protein, 22kD
  • caveolin 1, caveolae protein, 22kDa
  • Caveolin1
  • Caveolin-1
  • cell growth-inhibiting protein 32
  • MSTP085
  • VIP21

Background

Caveolin-1 (CAV1) belongs to caveolin family which encodes integral membrane proteins of 21kD-24 kD size and forms structural component of caveolar membrane in caveolae, the specialized domains of plasma membrane implicated in sequestration of lipids/proteins. Caveolin-1 as well as caveolin-2 are abundantly expressed in fibroblasts, differentiated adipocytes, smooth/skeletal muscle and in endothelial cells, whereas, caveolin-3 expression is limited to muscular tissues. Caveolin 1 interacts with a broad range of proteins that includes GLIPR2, NOSTRIN, SNAP25, syntaxin, rotavirus A NSP4, DPP4, CTNNB1, CDH1, JUP, BMX and BTK. It interacts directly with G-protein's alpha subunits for regulating their activity and is also implicated in costimulatory signal essential for TCR-mediated activation of T-cells. Caveolin 1 binding to DPP4 induces T-cell proliferation as well as activation of NFkB in TCR/CD3-dependent manner and also recruits CTNNB1 to caveolar membranes for regulating CTNNB1-mediated signal transduction via WNT pathway. Defects in caveolin-1 have been linked to congenital generalized lipodystrophy type 3 (CGL3), and it is also implicated in cardiovascular/pulmonary diseases and its role in carcinogensis is context/cancer dependent, wherein it suppresses genes that favor tumor development, and at the same time it promotes focal adhesion turnover as well as migration of metastatic cancer cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB100-615APC
Biotin Labeled NB100-615B
DyLight 350 Labeled NB100-615UV
DyLight 405 Labeled NB100-615V
DyLight 488 Labeled NB100-615G
DyLight 550 Labeled NB100-615R
DyLight 650 Labeled NB100-615C
DyLight 680 Labeled NB100-615FR
DyLight 755 Labeled NB100-615IR
HRP Labeled NB100-615H
PE Labeled NB100-615PE
PerCP Labeled NB100-615PCP

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Bioinformatics

Gene Symbol CAV1
Entrez