Western Blot: Abhd5 Antibody [NB110-41576] - Abhd5 overexpression lysates (NBL1-07199).
Western Blot: Abhd5 Antibody [NB110-41576] - MCF7 cell lysates.
Simple Western: Abhd5 Antibody [NB110-41576] - Image shows a specific band for Abhd5 in 0.5 mg/mL of MCF-7 lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
Mouse reactivity reported in scientific literature (PMID:23878361)
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
Alternate Names for Abhd5 Antibody
abhydrolase domain containing 5
Abhydrolase domain-containing protein 5,1-acylglycerol-3-phosphate O-acyltransferase ABHD5
Lipid droplet-binding protein CGI-58
ABHD5 (abhydrolase domain containing protein 5; or lipid droplet-binding protein CGI-58) belongs to peptidase S33 family and it is a ubiquitously expressed enzyme which is critical to triacylglycerol (TAG) metabolism. Localized in the cytoplasm and lipid droplets, ABHD5 colocalized with PLIN/ADRP on lipid droplets surfaces. It is widely expressed in various tissues including lymphocytes, liver, skeletal muscle and brain. Biochemically, ABHD5 is a lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis and regulate the cellular storage of TAG through activation of phospholipase PNPLA2. ABHD5 mutations have been linked to neutral lipid storage disorder called Chanarin-Dorfman syndrome which is characterized by ichthyosis, hepatic steatosis, and excessive storage of TAG in multiple cells and tissues. ABHD5 lacks TAG hydrolase activity, but increases the lipase activity of ATGL through a poorly understood mechanism. In vitro and in vivo studies established that modulating expression of ABHD5 significantly alters lipolysis and levels of TAG, and endogenous ABHD5 expression are limiting in murine adipose tissue.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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