G0S2 Antibody

Images

 
Immunocytochemistry/ Immunofluorescence: G0S2 Antibody [NBP1-71690] - GOS2 antibody was tested at 1:50 in A431 cells with FITC (green). Nuclei were counterstained with Dapi (blue).

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.56 mg/ml

Order Details

G0S2 Antibody Summary

Immunogen
A genomic peptide made to the human G0S2 protein (residues 1-103). [Swiss-Prot P27469]
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
G0S2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:50-1:100
Application Notes
This G0S2 antibody is useful in ICC/IF.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, 0.1% BSA, and 50% Glycerol
Preservative
0.05% Sodium Azide
Concentration
0.56 mg/ml
Purity
Immunogen affinity purified

Notes

Manufactured by Genomic Antibody Technology™. GAT FAQs

Alternate Names for G0S2 Antibody

  • G0/G1 switch regulatory protein 2
  • G0/G1switch 2
  • RP1-28O10.2

Background

G0S2 (G0/G1 switch protein 2) was discovered in lectin activated lymphocytes during G0 to G1 transition favoring cell division and postulated to regulate G0/G1 phase either by releasing lymphocytes from quiescence (G0 to G1 transition) or via promoting proliferation (G1 to S phase transition). Subsequently, this multifaceted protein was documented to implicate in proliferation, metabolism, inflammation, and carcinogenesis. In mouse, G0S2 was shown to express in adipose tissue and its direct up-regulation by PPAR-gamma was associated with cell-cycle withdrawal, growth arrest and adipogenic differentiation of preadipocytes. G0S2 has been proposed to inhibit hematopoietic stem cell proliferation and to promote stem cell quiescence (G0 phase). G0S2 features a CpG-rich island that potentially allows for germ-line expression and its promoter region contains binding sites for transcription factors AP1, AP2, AP3, NFAT and sequence motifs which responds to transcriptional activation stimulated by lectin, retinoic acid, PPARs agonists, glucose and insulin. G0S2 is epigenetically silenced in head/neck and squamous lung cancer, and cisplatin-resistant cancer cells advocating for its role in tumorigenesis and chemoresistance. G0S2 expression is elevated in endometriosis, bronchial epithelial cells treated with retinoic acid, senescent dermal fibroblasts, BM cells from patients with rheumatoid arthritis, and peripheral mononuclear cells from patients with vasculitis and psoriasis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol G0S2
Entrez
Uniprot