Abhd5 Products

Description

Abhydrolase domain containing 5 (ABHD5) belongs to a very large protein family which contains an alpha/beta hydrolase fold. ABHD5 also contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. Abhd 5 is distinct from other members of this subfamily because the putative catalytic triad contains an asparagine rather than a serine residue.

ABHD5 is a lysophosphatidic acid acyltransferase with a role in phosphatidic acid biosynthesis. ABHD5 may also help regulate cellular storage of triacylglycerol by activating the phospholipase PNPLA2. Additionaly, the ABHD5 protein is thought to play a role in keratinocyte differentiation.

Mutations in this gene are associated with Chanarin-Dorfman syndrome, a triglyceride storage disease characterized by impaired oxidation of long-chain fatty acids. Abhd5 is expressed in many tissues, including brain, liver, skin, skeletal muscle and lymphocytes.

Bioinformatics

Product By Gene ID	51099
Alternate Names	abhydrolase domain containing 5 Abhydrolase domain-containing protein 5,1-acylglycerol-3-phosphate O-acyltransferase ABHD5 CDS CGI58 EC 2.3.1.51 IECN2 Lipid droplet-binding protein CGI-58 MGC8731 NCIE2CGI-58

Research Areas for Abhd5

Find related products by research area and learn more about each of the different research areas below.

Cancer
Lipid and Metabolism
Lipid Droplets
Signal Transduction