Human Total Adiponectin/Acrp30 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human Total Adiponectin/Acrp30 Quantikine ELISA Kit Summary

• Background: The Quantikine Human Total Adiponectin Immunoassay is a 4.5 hour solid-phase ELISA designed to measure total (low, middle, and high molecular weight) human Adiponectin in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human Adiponectin and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human Adiponectin showed... linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring Adiponectin.
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• Specificity: Natural and recombinant human total Adiponectin (low, middle, and high molecular weight)
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: ADIPOQ

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Total Adiponectin/Acrp30 Quantikine ELISA Kit

• ACDC
• Acrp30
• ACRP30ADPN
• adipocyte, C1Q and collagen domain containing
• Adiponectin
• adiponectin, C1Q and collagen domain containing
• AdipoQ
• ADIPQTL1
• ApM1
• apM-1
• APM1APM-1
• C1q and collagen domain-containing protein
• GBP28
• GBP28apM1
• Gelatin-binding protein

Background

Adiponectin, alternately named Adipocyte complement-related protein of 30 kDa (Acrp30), adipoQ, adipose most abundant gene transcript 1 (apM1), and gelatin-binding protein of 28 kDa (GBP28), is an adipocyte-specific, secreted protein with potential roles in glucose and lipid homeostasis. Circulating Adiponectin levels are high, accounting for approximately 0.01% of total plasma protein (1-4). Adiponectin contains a modular structure that includes an N-terminal collagen-like domain followed by a C-terminal globular domain with significant sequence and structural resemblance to the complement factor C1q (1, 5, 6). Although they share little sequence identity, similar threedimensional structure and certain conserved amino acid residues suggest an evolutionary link between the C1q-like domain of Adiponectin and members of the TNF superfamily (7). Adiponectin assembles into different complexes including trimers (low molecular weight), hexamers (middle molecular weight), and higher order oligomeric structures (high molecular weight) that may affect biological activity (1, 7, 8). Adiponectin is induced during adipocyte differentiation and its secretion is stimulated by insulin (1, 9). Two receptors for Adiponectin, termed AdipoR1 and AdipoR2, have been cloned (10). Although functionally distinct from G-protein-coupled receptors, the genes encode predicted proteins containing 7 transmembrane domains. AdipoR1 is highly expressed in skeletal muscle, while AdipoR2 is primarily found in hepatic tissues. 

Injection of Adiponectin into non-obese diabetic mice leads to an insulin-independent decrease in glucose levels (11). This is likely due to insulin-sensitizing effects involving Adiponectin regulation of triglyceride metabolism (11). A truncated form of Adiponectin (gAdiponectin) containing only the C-terminal globular domain has been identified in the blood, and recombinant gAdiponectin has been shown to regulate weight reduction as well as free fatty acid oxidation in mouse muscle and liver (2, 12). The full-length recombinant Adiponectin protein is apparently less potent at mediating these effects (2, 12). The mechanism underlying the role of Adiponectin in lipid oxidation may involve the regulation of expression or activity of proteins associated with triglyceride metabolism including CD36, acyl CoA oxidase, AMPK, and PPAR gamma (12-14). 

Although Adiponectin-regulation of glucose and lipid metabolism in humans is less clear, similar mechanisms may also be in place (15). A negative correlation between obesity and circulating Adiponectin has been well established (6, 16, 17), and Adiponectin levels increase concomitantly with weight loss (18). Decreased Adiponectin levels are associated with insulin resistance and hyperinsulinemia, and patients with type-2 diabetes are reported to exhibit decreased circulating Adiponectin (19, 20). Thiazolidinediones, a class of insulin-sensitizing, anti-diabetic drugs, elevate Adiponectin in insulin-resistant patients (21). In addition, high Adiponectin levels are associated with a reduced risk of type-2 diabetes (22). Using magnetic resonance spectroscopy it has been demonstrated that intracellular lipid content in human muscle negatively correlates with Adiponectin levels, potentially due to Adiponectin-induced fatty acid oxidation (15). 

Adiponectin may also play anti-atherogenic and anti-inflammatory roles. Adiponectin plasma levels are decreased in patients with coronary artery disease (20). Furthermore, neointimal thickening of damaged arteries is exacerbated in Adiponectin-deficient mice and is inhibited by exogenous Adiponectin (23). Adiponectin inhibits endothelial cell expression of adhesion molecules in vitro, suppressing the attachment of monocytes (24). In addition, Adiponectin negatively regulates myelomonocytic progenitor cell growth and TNF-alpha production in macrophages (25, 26).

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Adiponectin/Acrp30 (DRP300)(165)

Publications using DRP300

• G Leodori, C Pellicano, V Basile, A Colalillo, L Navarini, A Gigante, F Gulli, M Marino, U Basile, E Rosato Serum Adiponectin, a Novel Biomarker Correlates with Skin Thickness in Systemic Sclerosis Journal of personalized medicine, 2022;12(10):. 2022 [PMID: 36294874] (Human)
• AD Ruggiero, R Vemuri, M Block, D DeStephani, M Davis, J Chou, A Williams, A Brock, SK Das, K Kavanagh Macrophage Phenotypes and Gene Expression Patterns Are Unique in Naturally Occurring Metabolically Healthy Obesity International Journal of Molecular Sciences, 2022;23(20):. 2022 [PMID: 36293536] (Primate - Chlorocebus aethiops (African Green Monkey))
• B Geidl-Flue, M Hochuli, GA Spinas, PA Gerber Do Sugar-Sweetened Beverages Increase Fasting FGF21 Irrespective of the Type of Added Sugar? A Secondary Exploratory Analysis of a Randomized Controlled Trial Nutrients, 2022;14(19):. 2022 [PMID: 36235821] (Human)
• S Park, Z Vargas, A Zhao, PI Baltazar, JF Friedman, EA McDonald Cord blood adiponectin and leptin are associated with a lower risk of stunting during infancy Scientific Reports, 2022;12(1):15122. 2022 [PMID: 36068284] (Human)
• E Vuong, S Mhlongo, E Chirwa, C Lombard, N Peer, SM Hemmings, N Abrahams, S Seedat Serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women Neurobiology of stress, 2022;20(0):100477. 2022 [PMID: 35982731] (Human)
• D de Luis Ro, D Primo, O Izaola, R Aller Association of the APOA-5 Genetic Variant rs662799 with Metabolic Changes after an Intervention for 9 Months with a Low-Calorie Diet with a Mediterranean Profile Nutrients, 2022;14(12):. 2022 [PMID: 35745158] (Human)
• JS Pedersen, MO Rygg, K Chrøis, EG Sustarsic, Z Gerhart-Hi, NJ Wever Albr, RR Serizawa, VB Kristianse, AL Basse, AEB Boilesen, BH Olsen, T Hansen, LL Gluud, S Madsbad, S Larsen, F Bendtsen, F Dela Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration Nature Communications, 2022;13(1):2931. 2022 [PMID: 35614135] (Human)
• B Forseth, M Polfuss, M Brondino, SD Hunter, MW Lawlor, MJ Beatka, MJ Prom, J Eells, JA Lyons Adherence to and changes in mental and physiological health during an 8-week yoga intervention: A pilot study Journal of bodywork and movement therapies, 2022;30(0):203-209. 2022 [PMID: 35500972] (Human)
• E Herbers, M Patrikoski, A Wagner, R Jokinen, A Hassinen, S Heinonen, S Miettinen, H Peltoniemi, E Pirinen, KH Pietiläine Preventing White Adipocyte Browning during Differentiation In Vitro: The Effect of Differentiation Protocols on Metabolic and Mitochondrial Phenotypes Stem Cells International, 2022;2022(0):3308194. 2022 [PMID: 35422865] (Human)
• H Ko, H Choi, Y Han, S An, D Min, WS Park, SH Jin, HJ Kim, M Noh 3,4,5-Trimethoxycinnamate thymol ester inhibits melanogenesis in normal human melanocytes and 3D human epidermal equivalents via the PGC-1alpha-independent PPARgamma partial agonism Journal of dermatological science, 2022;0(0):. 2022 [PMID: 35260321] (Human)
• OV Gruzdeva, YA Dyleva, EV Belik, MY Sinitsky, AN Stasev, AN Kokov, NK Brel, EO Krivkina, EE Bychkova, RS Tarasov, OL Barbarash Relationship between Epicardial and Coronary Adipose Tissue and the Expression of Adiponectin, Leptin, and Interleukin 6 in Patients with Coronary Artery Disease Journal of personalized medicine, 2022;12(2):. 2022 [PMID: 35207618] (Human)
• N Šebunova, J Štšepetova, T Kullisaar, K Suija, A Rätsep, I Junkin, H Soeorg, M Lember, T Sillakivi, R Mändar Changes in adipokine levels and metabolic profiles following bariatric surgery BMC endocrine disorders, 2022;22(1):33. 2022 [PMID: 35114975] (Human)
• YH Joo, MW Lee, YD Son, KA Chang, M Yaqub, HK Kim, P Cumming, JH Kim In Vivo Cerebral Translocator Protein (TSPO) Binding and Its Relationship with Blood Adiponectin Levels in Treatment-Na�ve Young Adults with Major Depression: A [11C]PK11195 PET Study Biomedicines, 2021;10(1):. 2021 [PMID: 35052718] (Human)
• C Gar, B Thorand, C Herder, C Sujana, M Heier, C Meisinger, A Peters, W Koenig, W Rathmann, M Roden, M Stumvoll, H Maalmi, T Meitinger, H Then, J Seissler, C Then Association of circulating MR-proADM with all-cause and cardiovascular mortality in the general population: Results from the KORA F4 cohort study PLoS ONE, 2022;17(1):e0262330. 2022 [PMID: 34990470] (Human)
• K Micielska, M Flis, JA Kortas, E Rodziewicz, J Antosiewic, K Wochna, G Lombardi, E Ziemann Nordic Walking Rather Than High Intensity Interval Training Reduced Myostatin Concentration More Effectively in Elderly Subjects and the Range of This Drop Was Modified by Metabolites of Vitamin D Nutrients, 2021;13(12):. 2021 [PMID: 34959945] (Human)
• C Then, C Herder, B Thorand, C Sujana, M Heier, C Meisinger, A Peters, W Koenig, W Rathmann, M Roden, M Stumvoll, H Maalmi, H Then, U Ferrari, J Scherberic, J Seissler, KORA-Study Association of serum uromodulin with adipokines in dependence of type 2 diabetes Cytokine, 2021;150(0):155786. 2021 [PMID: 34920231] (Human)
• N Pérez-Hern, R Posadas-Sá, G Vargas-Ala, LP Hernández-, VM Borgonio-C, JM Rodríguez- Osteopontin Gene Polymorphisms Are Associated with Cardiovascular Risk Factors in Patients with Premature Coronary Artery Disease Biomedicines, 2021;9(11):. 2021 [PMID: 34829826] (Human)
• JJ Joseph, B Kluwe, JB Echouffo-T, S Zhao, G Brock, D Kline, JB Odei, RR Kalyani, DP Bradley, WA Hsueh, M Sims, SH Golden Association of Adiposity With Incident Diabetes Among Black Adults in the Jackson Heart Study Journal of the American Heart Association, 2021;0(0):e020716. 2021 [PMID: 34493073] (Human)
• D de Luis, O Izaola, D Primo APOA-5 Genetic Variant rs662799: Role in Lipid Changes and Insulin Resistance after a Mediterranean Diet in Caucasian Obese Subjects Disease Markers, 2021;2021(0):1257145. 2021 [PMID: 34422134] (Human)
• EM Cody, MR Bennett, G Gulati, Q Ma, M Altaye, P Devarajan, HI Brunner Successful Urine Multiplex Bead Assay to Measure Lupus Nephritis Activity Kidney international reports, 2021;6(7):1949-1960. 2021 [PMID: 34307989] (Human)
• E Fragopoulo, C Argyrou, M Detopoulou, S Tsitsou, S Seremeti, M Yannakouli, S Antonopoul, G Kolovou, P Kalogeropo The effect of moderate wine consumption on cytokine secretion by peripheral blood mononuclear cells: A randomized clinical study in coronary heart disease patients Cytokine, 2021;146(0):155629. 2021 [PMID: 34247040] (Human)
• A Stochmal, A Wa?kiel-Bu, S Chrostowsk, M Zaremba, A Rakowska, J Czuwara, L Rudnicka Adiponectin as a novel biomarker of disease severity in alopecia areata Scientific Reports, 2021;11(1):13809. 2021 [PMID: 34226603] (Human)
• Y Yang, M Xie, S Yuan, Y Zeng, Y Dong, Z Wang, Q Xiao, B Dong, J Ma, J Hu Sex differences in the associations between adiposity distribution and cardiometabolic risk factors in overweight or obese individuals: a cross-sectional study BMC Public Health, 2021;21(1):1232. 2021 [PMID: 34174845] (Human)
• I Olejniczak, J Narbutt, J Ceryn, M Skibi?ska, I Bednarski, A Wo?niacka, J Sieniawska, M Kraska-Gac, M Ci??y?ska, J ?migielski, M Noweta, M Waszczykow, W Owczarek, A Reich, A Lesiak AntiTNF-alpha therapy normalizes levels of lipids and adipokines in psoriatic patients in the real-life settings Scientific Reports, 2021;11(1):9289. 2021 [PMID: 33927259] (Human)
• J Jarecki, T Ma?ecka-Ma, I Polkowska, B Potoczniak, E Kosior-Jar, I Szerb, E Tomaszewsk, M Gutbier, M Dobrzy?ski, T Blicharski Level of Adiponectin, Leptin and Selected Matrix Metalloproteinases in Female Overweight Patients with Primary Gonarthrosis Journal of Clinical Medicine, 2021;10(6):. 2021 [PMID: 33803785] (Human)
• B Forseth, M Polfuss, M Brondino, MW Lawlor, MJ Beatka, MJ Prom, J Eells, JA Lyons Association between yoga, physiologic and psychologic health: A cross sectional study Complementary therapies in clinical practice, 2021;43(0):101350. 2021 [PMID: 33770740] (Human)
• OV Gruzdeva, EV Belik, YA Dyleva, DA Borodkina, MY Sinitsky, DY Naumov, EE Bychkova, EV Fanaskova, EI Palicheva, AA Kuzmina, VN Karetnikov, OL Barbarash Expression of adipocytokines in heart fat depots depending on the degree of coronary artery atherosclerosis in patients with coronary artery disease PLoS ONE, 2021;16(3):e0248716. 2021 [PMID: 33735200] (Human)
• T P?atek, A Polus, J Góralska, U Ra?ny, A Dziewo?ska, A Micek, A Dembi?ska-, B Solnica, M Malczewska Epigenetic Regulation of Processes Related to High Level of Fibroblast Growth Factor 21 in Obese Subjects Genes, 2021;12(2):. 2021 [PMID: 33670024] (Human)
• GK Vasileiadi, AC Lundell, Y Zhang, K Andersson, I Gjertsson, A Rudin, C Maglio Adipocytokines in Untreated Newly Diagnosed Rheumatoid Arthritis: Association with Circulating Chemokines and Markers of Inflammation Biomolecules, 2021;11(2):. 2021 [PMID: 33669910] (Human)
• S Kurose, K Onishi, N Takao, T Miyauchi, K Takahashi, Y Kimura Association of serum adiponectin and myostatin levels with skeletal muscle in patients with obesity: A cross-sectional study PLoS ONE, 2021;16(1):e0245678. 2021 [PMID: 33465151] (Human)
• D Jo, Y Son, G Yoon, J Song, OY Kim Role of Adiponectin and Brain Derived Neurotrophic Factor in Metabolic Regulation Involved in Adiposity and Body Fat Browning Journal of Clinical Medicine, 2020;10(1):. 2020 [PMID: 33375318] (Human)
• O Hakim, O Bello, M Ladwa, JL Peacock, AM Umpleby, G Charles-Ed, SA Amiel, LM Goff The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity Nutrients, 2020;12(12):. 2020 [PMID: 33322261] (Human)
• S Mariani, MR Di Giorgio, E Rossi, R Tozzi, S Contini, L Bauleo, F Cipriani, R Toscano, S Basciani, G Barbaro, M Watanabe, A Valenti, A Cotugno, C Ancona, C Lubrano, L Gnessi Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa Nutrients, 2020;12(11):. 2020 [PMID: 33202604] (Human)
• JP Mole, F Fasano, J Evans, R Sims, E Kidd, JP Aggleton, C Metzler-Ba APOE-&epsilon4-related differences in left thalamic microstructure in cognitively healthy adults Sci Rep, 2020;10(1):19787. 2020 [PMID: 33188215] (Human)
• PT Williams Quantile-dependent expressivity of plasma adiponectin concentrations may explain its sex-specific heritability, gene-environment interactions, and genotype-specific response to postprandial lipemia PeerJ, 2020;8(0):e10099. 2020 [PMID: 33088620] (Human)
• M Mietus-Sny, N Narayanan, RM Krauss, K Laine-Grav, JC McCann, MK Shigenaga, TH McHugh, BN Ames, JH Suh Randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk PLoS ONE, 2020;15(10):e0240437. 2020 [PMID: 33079935] (Human)
• M Pierard, A Tassin, A Legrand, A Legrand Chronic hypoxaemia and gender status modulate adiponectin plasmatic level and its multimer proportion in severe COPD patients: new endotypic presentation? BMC Pulm Med, 2020;20(1):255. 2020 [PMID: 32998721] (Human)
• KM Terlikowsk, B Dobrzycka, R Terlikowsk, A Sienkiewic, M Kinalski, SJ Terlikowsk Clinical value of selected markers of angiogenesis, inflammation, insulin resistance and obesity in type 1 endometrial cancer BMC Cancer, 2020;20(1):921. 2020 [PMID: 32977765] (Human)
• S Iwanaga, R Hashida, Y Takano, M Bekki, D Nakano, M Omoto, T Nago, T Kawaguchi, H Matsuse, T Torimura, N Shiba Hybrid Training System Improves Insulin Resistance in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Pilot Study Tohoku J. Exp. Med., 2020;252(1):23-32. 2020 [PMID: 32863329] (Human)
• H Wang, YX Gao, YN Wu, C Li, J Duan Association between plasma adiponectin levels and left ventricular systolic dysfunction in sepsis patients J Crit Care, 2020;60(0):195-201. 2020 [PMID: 32854089] (Human)
• D Luo, P Chen, Z Yang, Y Fu, Y Huang, H Li, J Chen, J Zhuang, C Zhang High plasma adiponectin is associated with increased pulmonary blood flow and reduced right ventricular function in patients with pulmonary hypertension BMC Pulm Med, 2020;20(1):204. 2020 [PMID: 32731857] (Human)
• K Oluwagbemi, A Anesi, M Ulaszewska, G Clarke, U Alexy, M Schmid, M Roden, C Herder, F Mattivi, U Nöthlings Longitudinal relationship of amino acids and indole metabolites with long-term body mass index and cardiometabolic risk markers in young individuals Sci Rep, 2020;10(1):6399. 2020 [PMID: 32286421] (Human)
• J Gorwood, T Ejlalmanes, C Bourgeois, M Mantecon, C Rose, M Atlan, D Desjardins, R Le Grand, B Fève, O Lambotte, J Capeau, V Béréziat, C Lagathu SIV Infection and the HIV Proteins Tat and Nef Induce Senescence in Adipose Tissue and Human Adipose Stem Cells, Resulting in Adipocyte Dysfunction Cells, 2020;9(4):. 2020 [PMID: 32244726] (Human)
• S Sindhu, S Kochumon, R Thomas, A Bennakhi, F Al-Mulla, R Ahmad Enhanced Adipose Expression of Interferon Regulatory Factor (IRF)-5 Associates with the Signatures of Metabolic Inflammation in Diabetic Obese Patients Cells, 2020;9(3):. 2020 [PMID: 32188105] (Human)
• K Oniki, T Kawakami, A Nakashima, K Miyata, T Watanabe, H Fujikawa, R Nakashima, A Nasu, Y Eto, N Takahashi, H Nohara, MA Suico, S Kotani, Y Obata, Y Sakamoto, Y Seguchi, J Saruwatari, T Imafuku, H Watanabe, T Maruyama, H Kai, T Shuto Melinjo seed extract increases adiponectin multimerization in physiological and pathological conditions Sci Rep, 2020;10(1):4313. 2020 [PMID: 32152335] (Human)
• NM Varda, M Medved, L Ojsteršek The associations between some biological markers, obesity, and cardiovascular risk in Slovenian children and adolescents BMC Pediatr, 2020;20(1):81. 2020 [PMID: 32085704] (Human)
• S Ahn, DM Jang, SC Park, S An, J Shin, BW Han, M Noh Cyclin-Dependent Kinase 5 Inhibitor Butyrolactone I Elicits a Partial Agonist Activity of Peroxisome Proliferator-Activated Receptor &gamma Biomolecules, 2020;10(2):. 2020 [PMID: 32054125] (Human)
• YZ Chen, SQ Zhou, YQ Chen, H Peng, YG Zhuang Plasma Adipokines in Patients Resuscitated from Cardiac Arrest: Difference of Visfatin between Survivors and Nonsurvivors Dis. Markers, 2020;2020(0):9608276. 2020 [PMID: 32015774] (Human)
• S Lucht, F Hennig, S Moebus, S Ohlwein, C Herder, B Kowall, KH Jöckel, B Hoffmann All-source and source-specific air pollution and 10-year diabetes Incidence: Total effect and mediation analyses in the Heinz Nixdorf recall study Environ Int, 2020;136(0):105493. 2020 [PMID: 31991234] (Human)
• AE O'Mara, JW Johnson, JD Linderman, RJ Brychta, S McGehee, LA Fletcher, YA Fink, D Kapuria, TM Cassimatis, N Kelsey, C Cero, Z Abdul-Sate, F Piccinini, AS Baskin, BP Leitner, H Cai, CM Millo, W Dieckmann, M Walter, NB Javitt, Y Rotman, PJ Walter, M Ader, RN Bergman, P Herscovitc, KY Chen, AM Cypess Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity J. Clin. Invest., 2020;0(0):. 2020 [PMID: 31961826] (Human)
• S Sindhu, R Thomas, S Kochumon, A Wilson, M Abu-Farha, A Bennakhi, F Al-Mulla, R Ahmad Increased Adipose Tissue Expression of Interferon Regulatory Factor (IRF)-5 in Obesity: Association with Metabolic Inflammation Cells, 2019;8(11):. 2019 [PMID: 31718015] (Human)
• T Sawaguchi, T Nakajima, A Haruyama, T Hasegawa, I Shibasaki, T Nakajima, H Kaneda, T Arikawa, S Obi, M Sakuma, H Ogawa, Y Takei, S Toyoda, F Nakamura, S Abe, H Fukuda, T Inoue Association of serum leptin and adiponectin concentrations with echocardiographic parameters and pathophysiological states in patients with cardiovascular disease receiving cardiovascular surgery PLoS ONE, 2019;14(11):e0225008. 2019 [PMID: 31703113] (Human)
• MJ Valente, S Rocha, S Coimbra, C Catarino, P Rocha-Pere, E Bronze-da-, JG Oliveira, J Madureira, JC Fernandes, M do Sameiro, V Miranda, L Belo, A Santos-Sil Long Pentraxin 3 as a Broader Biomarker for Multiple Risk Factors in End-Stage Renal Disease: Association with All-Cause Mortality Mediators Inflamm., 2019;2019(0):3295725. 2019 [PMID: 31316299] (Human)
• S Chauhan, K Dunlap, LK Duffy Effects of Methylmercury and Theaflavin Digallate on Adipokines in Mature 3T3-L1 Adipocytes Int J Mol Sci, 2019;20(11):. 2019 [PMID: 31195622] (Mouse)
• S Gariballa, J Alkaabi, J Yasin, A Al Essa Total adiponectin in overweight and obese subjects and its response to visceral fat loss BMC Endocr Disord, 2019;19(1):55. 2019 [PMID: 31159801] (Human)
• AMB Menezes, PD Oliveira, FC Wehrmeiste, MCF Assunção, IO Oliveira, L Tovo-Rodri, GD Ferreira, H Gonçalves Association of modifiable risk factors and IL-6, CRP, and adiponectin: Findings from the 1993 Birth Cohort, Southern Brazil PLoS ONE, 2019;14(5):e0216202. 2019 [PMID: 31071114] (Human)
• HJ Hwang, Y Liu, HS Kim, H Lee, Y Lim, H Park Daily walnut intake improves metabolic syndrome status and increases circulating adiponectin levels: randomized controlled crossover trial Nutr Res Pract, 2019;13(2):105-114. 2019 [PMID: 30984354] (Human)
• AK Ziegler, SM Jensen, P Schjerling, AL Mackey, JL Andersen, M Kjaer The effect of resistance exercise upon age-related systemic and local skeletal muscle inflammation Exp. Gerontol., 2019;121(0):19-32. 2019 [PMID: 30905721] (Human)
• T Nakajima, T Yokota, Y Shingu, A Yamada, Y Iba, K Ujihira, S Wakasa, T Ooka, S Takada, R Shirakawa, T Katayama, T Furihata, A Fukushima, R Matsuoka, H Nishihara, F Dela, K Nakanishi, Y Matsui, S Kinugawa Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis Sci Rep, 2019;9(1):3535. 2019 [PMID: 30837669] (Human)
• FC Sasso, PC Pafundi, R Marfella, P Calabrò, F Piscione, F Furbatto, G Esposito, R Galiero, F Gragnano, L Rinaldi, T Salvatore, M D'Amico, LE Adinolfi, C Sardu Adiponectin and insulin resistance are related to restenosis and overall new PCI in subjects with normal glucose tolerance: the prospective AIRE Study Cardiovasc Diabetol, 2019;18(1):24. 2019 [PMID: 30832662] (Human)
• YD Yang, CJ Zheng, YH Dong, ZY Zou, Y Lv, ZH Wang, ZG Yang, S Wang, B Dong, J Ma Sex difference in the mediation roles of an inflammatory factor (hsCRP) and adipokines on the relationship between adiposity and blood pressure Hypertens. Res., 2019;0(0):. 2019 [PMID: 30816318] (Human)
• SR Chaudhry, IS Lendvai, S Muhammad, P Westhofen, J Kruppenbac, L Scheef, H Boecker, D Scheele, R Hurlemann, TM Kinfe Inter-ictal assay of peripheral circulating inflammatory mediators in migraine patients under adjunctive cervical non-invasive vagus nerve stimulation (nVNS): A proof-of-concept study Brain Stimul, 2019;0(0):. 2019 [PMID: 30745260] (Human)
• C Metzler-Ba, JP Mole, E Leonaviciu, R Sims, EJ Kidd, B Ertefai, A Kelso-Mitc, F Gidney, F Fasano, J Evans, DK Jones, RJ Baddeley Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure Neuroimage, 2019;189(0):793-803. 2019 [PMID: 30735826] (Human)
• R Posadas-Sá, B Roque-Ramí, JM Rodríguez-, N Pérez-Hern, JM Fragoso, T Villarreal, R Coral-Vázq, ME Tejero-Bar, C Posadas-Ro, G Vargas-Ala Raet1e Polymorphisms Are Associated with Increased Risk of Developing Premature Coronary Artery Disease and with Some Cardiometabolic Parameters: The GEA Mexican Study Mediators Inflamm., 2018;2018(0):1847696. 2018 [PMID: 30662365] (Human)
• K Oluwagbemi, AE Buyken, U Alexy, M Schmid, C Herder, U Nöthlings Developmental trajectories of body mass index from childhood into late adolescence and subsequent late adolescence-young adulthood cardiometabolic risk markers Cardiovasc Diabetol, 2019;18(1):9. 2019 [PMID: 30660185] (Human)
• EH Aburawi, S Al Hamad, J Yasin, LA Almekhaini, AK Souid Dyslipidemia, subclinical inflammation, hepatic cholestasis and endothelial dysfunction in schoolchildren with excess fat: A study from the United Arab Emirates PLoS ONE, 2019;14(1):e0210316. 2019 [PMID: 30625218] (Human)
• AMB Menezes, PD Oliveira, H Gonçalves, IO Oliveira, MCF Assunção, L Tovo-Rodri, GD Ferreira, FC Wehrmeiste Are cytokines (IL-6, CRP and adiponectin) associated with bone mineral density in a young adult birth cohort? BMC Musculoskelet Disord, 2018;19(1):427. 2018 [PMID: 30501623] (Human)
• S Kalyan, A Goshtesabi, S Sarray, A Joannou, WY Almawi Assessing C reactive protein/albumin ratio as a new biomarker for polycystic ovary syndrome: a case-control study of women from Bahraini medical clinics BMJ Open, 2018;8(10):e021860. 2018 [PMID: 30368447] (Human)
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• Qurashi S, Mynarcik DC, McNurlan MA, Ahn H, Ferris R, Gelato MC Importance of the high-molecular-mass isoform of adiponectin in improved insulin sensitivity with rosiglitazone treatment in HIV disease. Clin. Sci., 2008;115(6):197-202. 2008 [PMID: 18254722] (Human)
• Savvidou MD, Sotiriadis A, Kaihura C, Nicolaides KH, Sattar N Circulating levels of adiponectin and leptin at 23-25 weeks of pregnancy in women with impaired placentation and in those with established fetal growth restriction. Clin. Sci., 2008;115(7):219-24. 2008 [PMID: 18211260] (Human)
• Musso G, Gambino R, De Michieli F, Biroli G, Premoli A, Pagano G, Bo S, Durazzo M, Cassader M Nitrosative stress predicts the presence and severity of nonalcoholic fatty liver at different stages of the development of insulin resistance and metabolic syndrome: possible role of vitamin A intake. Am. J. Clin. Nutr., 2007;86(3):661-71. 2007 [PMID: 17823431] (Human)
• Ruano J, Lopez-Miranda J, de la Torre R, Delgado-Lista J, Fernandez J, Caballero J, Covas MI, Jimenez Y, Perez-Martinez P, Marin C, Fuentes F, Perez-Jimenez F Intake of phenol-rich virgin olive oil improves the postprandial prothrombotic profile in hypercholesterolemic patients. Am. J. Clin. Nutr., 2007;86(2):341-6. 2007 [PMID: 17684203] (Human)
• Wannamethee SG, Whincup PH, Lennon L, Sattar N Circulating adiponectin levels and mortality in elderly men with and without cardiovascular disease and heart failure. Arch. Intern. Med., 2007;167(14):1510-7. 2007 [PMID: 17646605] (Human)
• Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower WR, Nimal S, Choi CS, Kim S, Shulman GI, Kahn CR, Braun U, Leitges M Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J. Clin. Invest., 2007;117(8):2289-301. 2007 [PMID: 17641777] (Human)
• Wang TD, Chen WJ, Cheng WC, Lin JW, Chen MF, Lee YT Relation of improvement in endothelium-dependent flow-mediated vasodilation after rosiglitazone to changes in asymmetric dimethylarginine, endothelin-1, and C-reactive protein in nondiabetic patients with the metabolic syndrome. Am. J. Cardiol., 2006;98(8):1057-62. 2006 [PMID: 17027571] (Human)
• Weyermann M, Beermann C, Brenner H, Rothenbacher D Adiponectin and leptin in maternal serum, cord blood, and breast milk. Clin. Chem., 2006;52(11):2095-102. 2006 [PMID: 16990422] (Human)
• Koh KK, Quon MJ, Han SH, Chung WJ, Ahn JY, Kim JA, Lee Y, Shin EK Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hypertriglyceridemic hypertensive patients. Diabetes Care, 2006;29(2):195-201. 2006 [PMID: 16443859] (Human)
• Lemoine M, Barbu V, Girard PM, Kim M, Bastard JP, Wendum D, Paye F, Housset C, Capeau J, Serfaty L Altered hepatic expression of SREBP-1 and PPARgamma is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients. AIDS, 2006;20(3):387-95. 2006 [PMID: 16439872] (Human)
• Holt HB, Wild SH, Wood PJ, Zhang J, Darekar AA, Dewbury K, Poole RB, Holt RI, Phillips DI, Byrne CD Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects. Diabetologia, 2006;49(1):141-8. 2006 [PMID: 16323001] (Human)
• Iversen PO, Wiig H Tumor necrosis factor alpha and adiponectin in bone marrow interstitial fluid from patients with acute myeloid leukemia inhibit normal hematopoiesis. Clin. Cancer Res., 2005;11(19):6793-9. 2005 [PMID: 16203766] (Human)
• Chan DC, Watts GF, Ng TW, Uchida Y, Sakai N, Yamashita S, Barrett PH Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism. Clin. Chem., 2005;51(3):578-85. 2005 [PMID: 15650029] (Human)

Bioinformatics

• Gene Symbol: ADIPOQ