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KLF4

Breast cancer stem cells survive chemotherapy through S100A10-ANXA2-SPT6 interaction that epigenetically promotes OCT4-mediated stemness

Deriving neural precursor cells from human induced pluripotent stem cells

Application Focus: New Methods for iPSC Differentiation, Inducing a Mammary Fate

KLF4 as a transcription factor in stem cell differentiation

Krüppel-like factors (KLFs) are evolutionarily conserved zinc finger transcription factors that play a role in cell differentiation, proliferation, and pluripotency.

KLF4 opens the door for stem cell research

KLF4 (Kruppel-like factor 4, Epithelial zinc finger protein EZF) is a zinc finger transcription factor thought to be involved in developmental differentiation and proliferation. It is considered a pluripotency reprogramming factor (PRF) due to its ability to change cell fate via gene expression conversion. Other PRFs including Sox2, Oct4 and KLF4, as well as a discussion about their capabilities, are reviewed by Jauch et al in hopes of enabling the engineering and optimization of PRFs1.