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Altered expression of BCL2 in cancer

Similar to other cell processes, the balance between cell survival and cell death is an important equilibrium that when altered expression of genes can lead to a variety of disease.

KLF4 as a transcription factor in stem cell differentiation

Krüppel-like factors (KLFs) are evolutionarily conserved zinc finger transcription factors that play a role in cell differentiation, proliferation, and pluripotency.

IL-1 beta (interleukin 1 beta, lymphocyte activating factor (LAF))

IL-1 was originally identified and cloned as a lymphocyte mitogen and much later, was found to be comprised of two closely related but distinct proteins, interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta). Both these proteins bind to the same cell surface receptor. IL-1 is primarily released from stimulated macrophages, but is also released from several other cell types. Along with other IL-1 gene family members, IL-1 beta falls within a cytokine gene cluster on chromosome 2.

c-Myc. See Myc Run Transcription Regulation

Myc genes (L-Myc, N-Myc and C-Myc) are a family of transcription factors. c-Myc is involved in transcription regulation, apoptosis and cell growth. Mutations in c-Myc have been tied to several cancers.


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