STING/TMEM173 Antibody


Western Blot: STING/TMEM173 Antibody [NBP2-24548] - Analysis of STING in Rh30 lysate using STING antibody at 7 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this more

Product Details

Reactivity HuSpecies Glossary
Applications WB, ICC/IF
0.5 mg/ml

Order Details

STING/TMEM173 Antibody Summary

A portion of amino acids 50-100 of human STING was used as the immunogen.
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.2 ml PBS and 0.05% BSA
0.05% Sodium Azide
0.5 mg/ml
Immunogen affinity purified


  • Western Blot 5-10 ug/ml
  • Immunocytochemistry/Immunofluorescence
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NBP2-24548 in the following applications:

Reactivity Notes

The amino acid sequence used as immunogen is 100% homologous in human (isoform CRA_a), chimpanzee and rhesus monkey, 87% homologous in dog and cow, 81% homologous in horse, mouse and boar and 75% homologous in rat.

Alternate Names for STING/TMEM173 Antibody

  • endoplasmic reticulum IFN stimulator
  • Endoplasmic reticulum interferon stimulator
  • ERIS
  • FLJ38577
  • hMITA
  • Mediator of IRF3 activation
  • MITA
  • mitochondrial mediator of IRF3 activation
  • MPYS
  • NET23
  • N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
  • Stimulator of interferon genes protein
  • sting
  • TMEM173
  • transmembrane protein 173


STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA from bacteria/viruses or the self (intrinsic) and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING has been suggested to interact with DDX58/RIG-I, MAVS, SSR2, RNF5, TRIM56, TBK1, IFIT1 and IFIT2. It generally localize to the cytoplasm, and membranes of cell, ER and mitochondria but in response to DNA stimulation, it translocate to the perinuclear region for interaction with TBK1 kinase. The latter phosphorylates STING at Ser-358 residue which results in its activation. STING executes its role by spotting and binding cyclic di-GMP / c-di-GMP and cyclic GMP-AMP /cGAMP which follows the activation of NF-kappa B and IRF3 transcriptional signaling pathways leading to the induction of Type I interferon response. STING has also been suggested to involve in cell death signaling pathways through its association with MHC-II and the activation of ERK pathway. Besides immune response to bacterial/viral pathogens, innate immune gene transcription has been of great importance in the elucidation of the causes of auto-inflammatory disease involving the sensing of self-DNA and the generation of effective antitumor adaptive immunity. STING regulated innate signaling has offered critical insights and new opportunities into the development of novel immunization regimes and therapeutics for treatment of infection, autoimmune disorders, inflammation and cancer.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for STING/TMEM173 Antibody (NBP2-24548)(5)

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies


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Diseases for STING/TMEM173 Antibody (NBP2-24548)

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Blogs on STING/TMEM173.

STING in Innate Immunity and Cancer: What’s the Buzz About?
STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol TMEM173

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