Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
Immunogen affinity purified
Alternate Names for MAVS Antibody
CARD adapter inducing interferon beta
CARD adapter inducing interferon-beta
CARD adaptor inducing IFN-beta
IFN-B promoter stimulator 1
Interferon beta promoter stimulator protein 1
interferon-beta promoter stimulator protein 1
mitochondrial antiviral signaling protein
mitochondrial antiviral-signaling protein
mitochondrial viral signaling protein
Putative NF-kappa-B-activating protein 031N
virus-induced signaling adapter variant 1b
virus-induced signaling adaptor variant 1a
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappaB. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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