IRF3 Products

IRF3 Antibody [Unconjugated]
IRF3 Antibody [Unconjugated]
Species: Hu
Applications: WB, Simple Western, CyTOF-ready, Flow, ICC/IF, KO
Host: Goat Polyclonal
Formulation Catalog # Availability Price  
IRF3 Overexpression Lysate
IRF3 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human IRF3 Protei ...
Recombinant Human IRF3 Protein
Species: Hu
Applications: PAGE
IRF3 Recombinant Protein Anti ...
IRF3 Recombinant Protein Antigen
Species: Hu
Applications: AC
IRF3 Antibody Blocking Peptid ...
IRF3 Antibody Blocking Peptide
Species: Hu
Applications: AC


IRF3 is a family of interferon (IFN) regulatory factors (IRFs) have been shown to play a role in transcription of IFN genes as well as IFN-stimulated genes. The IRF-3 gene encodes a 50-kDa protein that binds specifically to the IFN-stimulated response element (ISRE) but not to the IRF-1 binding site PRD-I. Overexpression of IRF-3 stimulates expression of the IFN-stimulated gene 15 (ISG15) promoter, an ISRE-containing promoter. he high amino acid homology between IRF-3 and ISG factor 3 gamma polypeptide (ISGF3 gamma) and their similar binding properties indicate that, like ISGF3 gamma, IRF-3 may activate transcription by complex formation with other transcriptional factors, possibly members of the Stat family (1). IRF-3 is expressed constitutively in a variety of tissues, and the relative levels of IRF-3 mRNA do not change in virus-infected or IFN-treated cells. (2). In uninfected cells, the IRF-3 component of DRAF1 resides in the cytoplasm. The cytoplasmic localization of IRF-3 is dependent on a nuclear export signal, and IRF-3 is recognized by the chromosome region maintenance 1 (CRM1) (also known as exportin 1) shuttling receptor. Following infection and specific phosphorylation, IRF-3 accumulates in the nucleus where it associates with CBP and p300 (3).


Entrez Rat
Uniprot Human
Product By Gene ID 3661
Alternate Names
  • interferon regulatory factor 3
  • IRF-3

Research Areas for IRF3

Find related products by research area and learn more about each of the different research areas below.

Innate Immunity
Transcription Factors and Regulators

Bioinformatics Tool for IRF3

Discover related pathways, diseases and genes to IRF3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related IRF3 Blog Posts

Check out the latest blog posts on IRF3.
STING in Innate Immunity and Cancer: What’s the Buzz About?
STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also ...    Read more.
TRIF/TICAM1 and mitochondrial dynamics in the innate immune response
TRIF, also known as toll like receptor adaptor molecule 1 or TICAM1, is known for its role in invading foreign pathogens as part of our innate immune response. TRIF/TICAM1 is a TIR-domain adaptor protein (toll/interleukin-1 receptor) that interacts...    Read more.
Read more IRF3 related blogs.