IRF3 Products

Antibodies
IRF3 Antibody (2G3)
IRF3 Antibody (2G3)
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
IRF3 Antibody
IRF3 Antibody
NBP1-76597
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
IRF3 Antibody Pair
IRF3 Antibody Pair
H00003661-AP21
Species: Hu
Applications: S-ELISA
IRF3 Antibody Pair
IRF3 Antibody Pair
H00003661-PW2
Species: Hu
Applications: WB, IP
IRF3 Antibody Pair
IRF3 Antibody Pair
H00003661-AP11
Species: Hu
Applications: S-ELISA
Lysates
IRF3 Overexpression Lysate (N ...
IRF3 Overexpression Lysate (Native)
NBL1-12032
Applications: WB
IRF3 Overexpression Lysate (D ...
IRF3 Overexpression Lysate (Denatu...
H00003661-T01
Species: Hu
Applications: WB
Proteins
Recombinant Human IRF3 Protei ...
Recombinant Human IRF3 Protein
H00003661-P02
Species: Hu
Applications: WB, ELISA, PA
IRF3 Recombinant Protein Anti ...
IRF3 Recombinant Protein Antigen
NBP1-92028PEP
Species: Hu
Applications: AC
Recombinant Human IRF3 Protei ...
Recombinant Human IRF3 Protein
NBC1-18469
Species: Hu
Applications: PAGE
RNAi
IRF3 RNAi
IRF3 RNAi
H00003661-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

IRF3 is a family of interferon (IFN) regulatory factors (IRFs) have been shown to play a role in transcription of IFN genes as well as IFN-stimulated genes. The IRF-3 gene encodes a 50-kDa protein that binds specifically to the IFN-stimulated response element (ISRE) but not to the IRF-1 binding site PRD-I. Overexpression of IRF-3 stimulates expression of the IFN-stimulated gene 15 (ISG15) promoter, an ISRE-containing promoter. he high amino acid homology between IRF-3 and ISG factor 3 gamma polypeptide (ISGF3 gamma) and their similar binding properties indicate that, like ISGF3 gamma, IRF-3 may activate transcription by complex formation with other transcriptional factors, possibly members of the Stat family (1). IRF-3 is expressed constitutively in a variety of tissues, and the relative levels of IRF-3 mRNA do not change in virus-infected or IFN-treated cells. (2). In uninfected cells, the IRF-3 component of DRAF1 resides in the cytoplasm. The cytoplasmic localization of IRF-3 is dependent on a nuclear export signal, and IRF-3 is recognized by the chromosome region maintenance 1 (CRM1) (also known as exportin 1) shuttling receptor. Following infection and specific phosphorylation, IRF-3 accumulates in the nucleus where it associates with CBP and p300 (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Mouse
Product By Gene ID 3661
Alternate Names
  • IRF-3
  • interferon regulatory factor 3

Research Areas for IRF3

Find related products by research area and learn more about each of the different research areas below.

Immunology
Innate Immunity
Phospho-Specific
Transcription Factors and Regulators

Bioinformatics Tool for IRF3

Discover related pathways, diseases and genes to IRF3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related IRF3 Blog Posts

Check out the latest blog posts on IRF3.
TRIF/TICAM1 and mitochondrial dynamics in the innate immune response
TRIF, also known as toll like receptor adaptor molecule 1 or TICAM1, is known for its role in invading foreign pathogens as part of our innate immune response. TRIF/TICAM1 is a TIR-domain adaptor protein (toll/interleukin-1 receptor) that interacts...    Read more.
STING in Innate Immunity and Cancer: What’s the Buzz About?
STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also...    Read more.
Read more IRF3 related blogs.