ZBP1/DLM-1/DAI Antibody

Images

 
Western Blot: ZBP1/DLM-1/DAI Antibody [NBP1-76854] - Mouse small intestine tissue lysate with Z DNA binding protein antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunohistochemistry-Paraffin: ZBP1/DLM-1/DAI Antibody [NBP1-76854] - Human small intestine tissue with Z DNA binding protein antibody at 2.5 ug/ml.
Immunofluorescence: ZBP1/DLM-1/DAI Antibody [NBP1-76854] - Immunofluorescence of ZBP1 in Human Small Intestine tissue with ZBP1 antibody at 20 ug/mL.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, ICC/IF, KD
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

ZBP1/DLM-1/DAI Antibody Summary

Immunogen
Antibody was raised against an 18 amino acid synthetic peptide from near the carboxy terminus of human ZBP1. The immunogen is located within the last 50 amino acids of ZBP1. Amino Acid Squence: TPSHSKLTPKLETMTLGN
Specificity
Multiple isoforms of ZBP1 are known to exist.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ZBP1
Purity
Peptide affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5-2 ug/ml
  • ELISA 1:100-1:2000
  • Immunohistochemistry 2.5 ug/ml
  • Immunohistochemistry-Paraffin 2.5 ug/ml
  • Immunofluorescence 20 ug/ml
  • Knockdown Validated
Theoretical MW
42 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
ZBP1/DLM-1/DAI Peptide (NBP1-76854PEP)
Publications
Read Publication using
NBP1-76854 in the following applications:

  • KD
    1 publication
  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified

Alternate Names for ZBP1/DLM-1/DAI Antibody

  • C20orf183
  • chromosome 20 open reading frame 183
  • DAI
  • DLM1
  • DLM-1
  • DLM1dJ718J7.3
  • DNA-dependent activator of interferon regulatory factors
  • DNA-dependent activator of IRFs
  • Tumor stroma and activated macrophage protein DLM-1
  • ZBP1 Z-DNA binding protein 1
  • ZBP1
  • Z-DNA binding protein 1
  • Z-DNA-binding protein 1

Background

Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for ZBP1/DLM-1/DAI Antibody (NBP1-76854)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: KD, WB.


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Bioinformatics

Gene Symbol ZBP1
Uniprot