TBK1 Products

Antibodies
TBK1 Antibody
TBK1 Antibody
NB100-421
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
TBK1 Antibody
TBK1 Antibody
NBP2-13416
Species: Hu, Mouse, Rat
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
TBK1 Overexpression Lysate (N ...
TBK1 Overexpression Lysate (Native)
NBP2-10346
Applications: WB
TBK1 Overexpression Lysate (D ...
TBK1 Overexpression Lysate (Denatu...
H00029110-T02
Species: Hu
Applications: WB
Proteins
TBK1 Recombinant Protein
TBK1 Recombinant Protein
H00029110-P01
Species: Hu
Applications: WB, ELISA, PA
TBK1 Partial Recombinant Prot ...
TBK1 Partial Recombinant Protein
H00029110-Q01
Species: Hu
Applications: WB, ELISA, PA
TBK1 Recombinant Protein Anti ...
TBK1 Recombinant Protein Antigen
NBP2-13416PEP
Species: Hu
Applications: AC
RNAi
TBK1 RNAi
TBK1 RNAi
H00029110-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

NFkappaB-activating kinase (NAK) also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor associated factor 2-associated kinase (T2K) is a serine/threonine protein that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta (2), NAK induces IkB degradation and NF-kB activity. NAK is activated by phorbol ester tumour promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4).

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Product By Gene ID 29110
Alternate Names
  • TBK 1
  • NAK serine/threonine-protein kinase TBK 1
  • FLJ11330
  • EC 2.7.11
  • NF-kappa-B-activating kinase
  • EC 2.7.11.1
  • T2K
  • NAKserine/threonine-protein kinase TBK1
  • TANK-binding kinase 1NF-kB-activating kinase

Research Areas for TBK1

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction

Bioinformatics Tool for TBK1

Discover related pathways, diseases and genes to TBK1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related TBK1 Blog Posts

Check out the latest blog posts on TBK1.
STING in Innate Immunity and Cancer: What’s the Buzz About?
STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also...    Read more.
Read more TBK1 related blogs.