STING/TMEM173 Products

Antibodies
STING/TMEM173 Antibody [Uncon ...
STING/TMEM173 Antibody [Unconjugated]
AF6516
Species: Hu
Applications: WB, Simple Western, KO
Host: Sheep Polyclonal
Formulation Catalog # Availability Price  
Lysates
STING/TMEM173 Overexpression ...
STING/TMEM173 Overexpression Lysate
NBL1-17038
Species: Hu
Applications: WB
Proteins
STING/TMEM173 Antibody Blocki ...
STING/TMEM173 Antibody Blocking Pe...
NBP2-24683PEP
Species: Hu
Applications: AC
STING/TMEM173 Recombinant Pro ...
STING/TMEM173 Recombinant Protein ...
NBP2-48684PEP
Species: Hu
Applications: AC
STING/TMEM173 Recombinant Pro ...
STING/TMEM173 Recombinant Protein ...
NBP2-38389PEP
Species: Hu
Applications: AC

Description

STING (stimulator of interferon genes) is encoded by the TMEM173 gene and is an adaptor molecule involved in the activation of innate immune responses to PAMPS (pathogen-associated molecular patterns) and DAMPS (damage-associated molecular patterns). STING specifically recognizes cytosolic DNA products derived from pathogens (e.g., cytomegalovirus, vaccinia virus, Listeria monocytogenes) or dead cells (1, 2). In the STING pathway, dsDNA derived from pathogens or damaged cells serves as a substrate for the enzyme cGAS (cyclic GMP-AMP synthase) which produces the second messenger cyclic GMP-AMP (cGAMP) from ATP and GTP (3, 4). Under steady-state conditions STING (theoretical molecular weight 42 kDa), a protein localizes to the ER membrane. Upon activation by dsDNA derived second messenger (cGAMP), STING translocates to the Golgi apparatus as a homodimer. Once STING has trafficked to the perinuclear region, it activates TANK binding kinase 1 (TBK1), interferon regulatory factor 3 (IRF3) and NF-B leading to the production of cytokines (e.g., type I interferon) (2, 4). Mutations in the TMEM173 gene affecting STING expression are associated with the development of the auto-inflammatory disease SAVI (STING-associated vasculopathy with onset in infancy) (2). A novel SAVI dominant mutation in the TMEM173 human gene (V155M) leads to increased localization of STING to the Golgi and perinuclear region, indicative of an activated state (1). Hallmarks of SAVI, a rare inflammatory disease, include severe vasculitis in extremities and lung inflammation (7).

References

1. Patel, S., & Jin, L. (2019). TMEM173 variants and potential importance to human biology and disease. Genes and Immunity. https://doi.org/10.1038/s41435-018-0029-9

2. Jounai, N., Kobiyama, K., Takeshita, F., & Ishii, K. J. (2013). Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2012.00168

3. Xiao, T. S., & Fitzgerald, K. A. (2013). The cGAS-STING Pathway for DNA Sensing. Molecular Cell. https://doi.org/10.1016/j.molcel.2013.07.004

4. Kato, K., Omura, H., Ishitani, R., & Nureki, O. (2017). Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA. Annual Review of Biochemistry. https://doi.org/10.1146/annurev-biochem-061516-044813

5. Crowl, J. T., Gray, E. E., Pestal, K., Volkman, H. E., & Stetson, D. B. (2017). Intracellular Nucleic Acid Detection in Autoimmunity. Annual Review of Immunology. https://doi.org/10.1146/annurev-immunol-051116-052331

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 340061
Alternate Names
  • hSTING
  • SAVI
  • stimulator of interferon protein
  • STING-beta
  • TMEM173
  • sting
  • MITA
  • N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
  • ERIS
  • mitochondrial mediator of IRF3 activation
  • Stimulator of interferon genes protein
  • endoplasmic reticulum IFN stimulator
  • Mediator of IRF3 activation
  • Endoplasmic reticulum interferon stimulator
  • NET23
  • MPYS
  • FLJ38577
  • hMITA
  • transmembrane protein 173

Diseases related to STING/TMEM173

Discover more about diseases related to STING/TMEM173.

Sting Injury
Infective Disorder
Innate Immune Response
Bacterial Infections
Systemic Infection
Listeriosis

Pathways for STING/TMEM173

View related products by pathway and learn more about each of the pathways below.

Innate Immune Response
Immune Response
Disease Resistance
Cytokine Production
Biofilm Formation
Virulence

Bioinformatics Tool for STING/TMEM173

Discover related pathways, diseases and genes to STING/TMEM173. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related STING/TMEM173 Blog Posts

Check out the latest blog posts on STING/TMEM173.
STING in Innate Immunity and Cancer: What’s the Buzz About?
STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also...    Read more.
Read more STING/TMEM173 related blogs.