Stabilin-1 Antibody [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: WB, Flow, CyTOF-ready
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 594

Stabilin-1 Antibody [Alexa Fluor® 594] Summary

• Immunogen: E. coli-derived recombinant human Stabilin-1
  Gly2208-Val2305 (Val2282Ile)
  Accession # Q9NY15
• Specificity: Detects human Stabilin-1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human Stabilin-2 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Stabilin-1 Antibody [Alexa Fluor® 594]

• CLEVER-1
• fasciclin egf-like, laminin-type egf-like, and link domain-containing scavengerreceptor-1
• Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavengerreceptor 1
• FEEL1
• FEEL-1
• FEEL-1MS-1 antigen
• FELE-1
• FEX1
• KIAA0246common lymphatic endothelial and vascular endothelial receptor-1
• MS-1 Antigen
• STAB1
• STAB-1
• stabilin 1
• Stabilin1
• Stabilin-1

Background

Stabilin-1, also known as FEEL-1 (fasciclin, EGF-like, laminin type EGF-like, and link domain containing scavenger receptor 1) and CLEVER-1 (common lymphatic endothelial and vascular endothelial receptor 1), was originally identified as the MS-1 antigen. It is a type I transmembrane multi-domain protein with a large extracellular domain that contains 7 fasciclin, multiple EGF-like and laminin type EGF-like, and a link domain. The short cytoplasmic tail interacts with CGAs which are cargo adaptors that link cargo into the clathrin-coated pits. Stabilin-1 is expressed by tissue macrophages and sinusoidal endothelial cells, which are scavenging cells. Stabilin-1 is involved in intracellular trafficking pathways and binds multiple ligands including acetylated LDL, SPARC, AGE, and SI-CLP. By alternative splicing, a soluble Stabilin-1 containing a 58 residue substitution between amino acid residues 746 and 803, followed by truncation, has been identified. Within the region used as immunogen, human Stabilin-1 shares 83% and 84% amino acid sequence homology with mouse and canine Stabilin-1, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.