LYVE-1 Antibody [Unconjugated]


LYVE‑1 was detected in perfusion fixed frozen sections of mouse liver using 15 µg/mL Goat Anti-Mouse LYVE‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2125) overnight at 4 °C. Tissue was stained more
Western blot shows lysates of mouse liver tissue and bEnd.3 mouse brain endothelial cell line. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse LYVE‑1 Antigen Affinity-purified Polyclonal Antibody more

Product Details

Reactivity MuSpecies Glossary
Applications WB, IHC

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LYVE-1 Antibody [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant mouse LYVE-1
Accession # Q8BHC0
Detects mouse LYVE-1 in direct ELISAs and Western blots.
Purity Statement
Antigen Affinity-purified
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Immunohistochemistry 5-15 ug/mL
  • Western Blot 0.25 ug/mL
Reviewed Applications
Read 1 Review rated 4
AF2125 in the following applications:

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AF2125 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LYVE-1 Antibody [Unconjugated]

  • cell surface retention sequence binding protein-1
  • Cell surface retention sequence-binding protein 1
  • CRSBP1
  • CRSBP-1
  • extracellular link domain containing 1
  • extracellular link domain-containing 1
  • Extracellular link domain-containing protein 1
  • HAR
  • Hyaluronic acid receptor
  • lymphatic vessel endothelial hyaluronan receptor 1
  • lymphatic vessel endothelial hyaluronic acid receptor 1
  • LYVE1
  • LYVE-1
  • UNQ230/PRO263
  • XLKD1


Lymphatic vessel endothelial hyaluronan (HA) receptor-1 (LYVE-1) is a recently identified receptor of HA, a linear high molecular weight polymer composed of alternating units of D-glucuronic acid and N-acetyl-D-glucosamine. HA is found in the extracellular matrix of most animal tissues and in body fluids. It modulates cell behavior and functions during tissue remodeling, development, homeostasis, and disease. The turnover of HA (several grams/day in humans) occurs primarily in the lymphatics and liver, the two major clearance systems that catabolize approximately 85% and 15% of HA, respectively. LYVE-1 shares 41% homology with the other known HA receptor, CD44. The homology between the two proteins increases to 61% within the HA binding domain. The HA binding domain, known as the link module, is a common structural motif found in other HA binding proteins such as link protein, aggrecan and versican. Human and mouse LYVE-1 share 69% amino acid sequence identity.

LYVE-1 is primarily expressed on both the luminal and abluminal surfaces of lymphatic vessels. In addition, LYVE-1 is also present in normal hepatic blood sinusoidal endothelial cells. LYVE-1 mediates the endocytosis of HA and may transport HA from tissue to lymph by transcytosis, delivering HA to lymphatic capillaries for removal and degradation in the regional lymph nodes. Because of its restricted expression patterns, LYVE-1, along with other lymphatic proteins such as VEGF R3, podoplanin and the homeobox protein propero-related (Prox-1), constitute a set of markers useful for distinguishing between lymphatic and blood microvasculature.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for LYVE-1 Antibody (AF2125)(71)

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

We have publications tested in 10 applications: Cell Selection, Flow Cytometry, ICC, ICC/IF, IF, IHC, IHC-Fr, IHC-P, Immunoprecipitation, Western Blot.

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Flow Cytometry
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Showing Publications 1 - 10 of 71. Show All 71 Publications.
Publications using AF2125 Applications Species
J Li, D Huang, B Lei, J Huang, L Yang, M Nie, S Su, Q Zhao, Y Wang VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis Elife, 2022;11(0):. 2022 [PMID: 36484779] (IHC, Mouse) IHC Mouse
A Axelsson R, H Wakimoto, DM DeLaughter, D Reichart, J Gorham, DA Conner, M Lun, CK Probst, N Sakai, RS Knipe, SB Montesi, B Shea, LP Adam, LA Leinwand, W Wan, ES Choi, EL Lindberg, G Patone, M Noseda, N Hübner, CE Seidman, AM Tager, JG Seidman, CY Ho Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model Proceedings of the National Academy of Sciences of the United States of America, 2022;119(28):e2204174119. 2022 [PMID: 35787042] (IHC, Mouse) IHC Mouse
W Xu, NP Nelson-Man, L Bálint, HB Kwon, RB Davis, DCM Dy, JM Dunleavey, B St Croix, KM Caron Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development International Journal of Molecular Sciences, 2022;23(10):. 2022 [PMID: 35628521] (IHC, Mouse) IHC Mouse
O Meçe, D Houbaert, ML Sassano, T Durré, H Maes, M Schaaf, S More, M Ganne, M García-Cab, M Borri, J Verhoeven, M Agrawal, K Jacobs, G Bergers, S Blacher, B Ghesquière, M Dewerchin, JV Swinnen, S Vinckier, MS Soengas, P Carmeliet, A Noël, P Agostinis Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis Nature Communications, 2022;13(1):2760. 2022 [PMID: 35589749] (IHC, Mouse) IHC Mouse
Y Yang, S Shen, Y Cao, D Wang, Z Kang, P Wang, X Wang Remodeling lymphatic vessels in intrinsically aged skin on SKH-1 mouse using low dose 5-aminolevulinic acid photodynamic therapy via VEGF-C/VEGFR3 pathway Photodiagnosis and photodynamic therapy, 2022;0(0):102851. 2022 [PMID: 35398260] (IHC, Mouse) IHC Mouse
L Dupont, L Joannes, F Morfoisse, S Blacher, C Monseur, CF Deroanne, A Noël, AC Colige ADAMTS2 and ADAMTS14 substitute ADAMTS3 in adults for proVEGFC activation and lymphatic homeostasis JCI Insight, 2022;0(0):. 2022 [PMID: 35316211] (IHC, Human) IHC Human
SA Wohlfeil, V Häfele, B Dietsch, C Weller, C Sticht, AS Jauch, M Winkler, CD Schmid, AL Irkens, A Olsavszky, K Schledzews, PS Reiners-Ko, S Goerdt, C Géraud Angiogenic and molecular diversity determine hepatic melanoma metastasis and response to anti-angiogenic treatment Journal of Translational Medicine, 2022;20(1):62. 2022 [PMID: 35109875] (ICC/IF, Mouse) ICC/IF Mouse
RJ Torphy, Y Sun, R Lin, A Caffrey-Ca, Y Fujiwara, F Ho, EN Miller, MD McCarter, TR Lyons, RD Schulick, RM Kedl, Y Zhu GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models Nature Communications, 2022;13(1):97. 2022 [PMID: 35013216] (IHC, Mouse) IHC Mouse
J Heil, V Olsavszky, K Busch, K Klapproth, C de la Torr, C Sticht, K Sandorski, J Hoffmann, H Schönhaber, J Zierow, M Winkler, CD Schmid, T Staniczek, DE Daniels, J Frayne, G Metzgeroth, D Nowak, S Schneider, M Neumaier, V Weyer, C Groden, HJ Gröne, K Richter, C Mogler, MM Taketo, K Schledzews, C Géraud, S Goerdt, PS Koch Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation Nature Communications, 2021;12(1):6963. 2021 [PMID: 34845225] (IHC, Mouse) IHC Mouse
C Sogawa-Fuj, Y Fujiwara, A Hanagata, Q Yang, T Mihara, N Kaji, T Kunieda, M Hori Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery Bmc Research Notes, 2021;14(1):438. 2021 [PMID: 34838130] (IHC, Mouse) IHC Mouse
Show All 71 Publications.

Review for LYVE-1 Antibody (AF2125) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Mouse.

Reviews using AF2125:
Filter by Applications
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Images Ratings Applications Species Date Details
reviewed by:
Anonymous -
Flow Mouse 01/06/2015


ApplicationFlow Cytometry
Sample TestedSee PMID 22287283

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Blogs on LYVE-1.

Meningeal lymphatics: recent discovery defying the concept of central nervous system 'immune privilege'
By Jennifer Sokolowski, MD, PhD. Identification and characterization of meningeal lymphaticsThe recent discovery of a lymphatic system in the meninges surrounding the brain and spinal cord has spurred a surge of int...  Read full blog post.

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Recent Reviews


Anonymous -
Application: Flow
Species: Mouse


Gene Symbol LYVE1