LYVE-1 Antibody [Unconjugated]

LYVE‑1 was detected in perfusion fixed frozen sections of mouse liver using 15 µg/mL Goat Anti-Mouse LYVE‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2125) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of endothelial cells in sinusoids. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Western blot shows lysates of mouse liver tissue and bEnd.3 mouse brain endothelial cell line. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse LYVE‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2125) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for LYVE‑1 at approximately 60-65 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

• Reactivity: Mu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

LYVE-1 Antibody [Unconjugated] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse LYVE-1
  Ala24-Thr234
  Accession # Q8BHC0
• Specificity: Detects mouse LYVE-1 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: LYVE1
• Purity Statement: Antigen Affinity-purified
• Endotoxin Note: <0.10 EU per 1 μg of the antibody by the LAL method.

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 5-15 ug/mL
  • Western Blot 0.25 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LYVE-1 Antibody [Unconjugated]

• cell surface retention sequence binding protein-1
• Cell surface retention sequence-binding protein 1
• CRSBP1
• CRSBP-1
• extracellular link domain containing 1
• extracellular link domain-containing 1
• Extracellular link domain-containing protein 1
• HAR
• Hyaluronic acid receptor
• lymphatic vessel endothelial hyaluronan receptor 1
• lymphatic vessel endothelial hyaluronic acid receptor 1
• LYVE1
• LYVE-1
• UNQ230/PRO263
• XLKD1

Background

Lymphatic vessel endothelial hyaluronan (HA) receptor-1 (LYVE-1) is a recently identified receptor of HA, a linear high molecular weight polymer composed of alternating units of D-glucuronic acid and N-acetyl-D-glucosamine. HA is found in the extracellular matrix of most animal tissues and in body fluids. It modulates cell behavior and functions during tissue remodeling, development, homeostasis, and disease. The turnover of HA (several grams/day in humans) occurs primarily in the lymphatics and liver, the two major clearance systems that catabolize approximately 85% and 15% of HA, respectively. LYVE-1 shares 41% homology with the other known HA receptor, CD44. The homology between the two proteins increases to 61% within the HA binding domain. The HA binding domain, known as the link module, is a common structural motif found in other HA binding proteins such as link protein, aggrecan and versican. Human and mouse LYVE-1 share 69% amino acid sequence identity.

LYVE-1 is primarily expressed on both the luminal and abluminal surfaces of lymphatic vessels. In addition, LYVE-1 is also present in normal hepatic blood sinusoidal endothelial cells. LYVE-1 mediates the endocytosis of HA and may transport HA from tissue to lymph by transcytosis, delivering HA to lymphatic capillaries for removal and degradation in the regional lymph nodes. Because of its restricted expression patterns, LYVE-1, along with other lymphatic proteins such as VEGF R3, podoplanin and the homeobox protein propero-related (Prox-1), constitute a set of markers useful for distinguishing between lymphatic and blood microvasculature.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for LYVE-1 Antibody (AF2125)(71)

Publications using AF2125

• J Li, D Huang, B Lei, J Huang, L Yang, M Nie, S Su, Q Zhao, Y Wang VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis Elife, 2022;11(0):. 2022 [PMID: 36484779] (IHC, Mouse)
• A Axelsson R, H Wakimoto, DM DeLaughter, D Reichart, J Gorham, DA Conner, M Lun, CK Probst, N Sakai, RS Knipe, SB Montesi, B Shea, LP Adam, LA Leinwand, W Wan, ES Choi, EL Lindberg, G Patone, M Noseda, N Hübner, CE Seidman, AM Tager, JG Seidman, CY Ho Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model Proceedings of the National Academy of Sciences of the United States of America, 2022;119(28):e2204174119. 2022 [PMID: 35787042] (IHC, Mouse)
• W Xu, NP Nelson-Man, L Bálint, HB Kwon, RB Davis, DCM Dy, JM Dunleavey, B St Croix, KM Caron Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development International Journal of Molecular Sciences, 2022;23(10):. 2022 [PMID: 35628521] (IHC, Mouse)
• O Meçe, D Houbaert, ML Sassano, T Durré, H Maes, M Schaaf, S More, M Ganne, M García-Cab, M Borri, J Verhoeven, M Agrawal, K Jacobs, G Bergers, S Blacher, B Ghesquière, M Dewerchin, JV Swinnen, S Vinckier, MS Soengas, P Carmeliet, A Noël, P Agostinis Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis Nature Communications, 2022;13(1):2760. 2022 [PMID: 35589749] (IHC, Mouse)
• Y Yang, S Shen, Y Cao, D Wang, Z Kang, P Wang, X Wang Remodeling lymphatic vessels in intrinsically aged skin on SKH-1 mouse using low dose 5-aminolevulinic acid photodynamic therapy via VEGF-C/VEGFR3 pathway Photodiagnosis and photodynamic therapy, 2022;0(0):102851. 2022 [PMID: 35398260] (IHC, Mouse)
• L Dupont, L Joannes, F Morfoisse, S Blacher, C Monseur, CF Deroanne, A Noël, AC Colige ADAMTS2 and ADAMTS14 substitute ADAMTS3 in adults for proVEGFC activation and lymphatic homeostasis JCI Insight, 2022;0(0):. 2022 [PMID: 35316211] (IHC, Human)
• SA Wohlfeil, V Häfele, B Dietsch, C Weller, C Sticht, AS Jauch, M Winkler, CD Schmid, AL Irkens, A Olsavszky, K Schledzews, PS Reiners-Ko, S Goerdt, C Géraud Angiogenic and molecular diversity determine hepatic melanoma metastasis and response to anti-angiogenic treatment Journal of Translational Medicine, 2022;20(1):62. 2022 [PMID: 35109875] (ICC/IF, Mouse)
• RJ Torphy, Y Sun, R Lin, A Caffrey-Ca, Y Fujiwara, F Ho, EN Miller, MD McCarter, TR Lyons, RD Schulick, RM Kedl, Y Zhu GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models Nature Communications, 2022;13(1):97. 2022 [PMID: 35013216] (IHC, Mouse)
• J Heil, V Olsavszky, K Busch, K Klapproth, C de la Torr, C Sticht, K Sandorski, J Hoffmann, H Schönhaber, J Zierow, M Winkler, CD Schmid, T Staniczek, DE Daniels, J Frayne, G Metzgeroth, D Nowak, S Schneider, M Neumaier, V Weyer, C Groden, HJ Gröne, K Richter, C Mogler, MM Taketo, K Schledzews, C Géraud, S Goerdt, PS Koch Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation Nature Communications, 2021;12(1):6963. 2021 [PMID: 34845225] (IHC, Mouse)
• C Sogawa-Fuj, Y Fujiwara, A Hanagata, Q Yang, T Mihara, N Kaji, T Kunieda, M Hori Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery Bmc Research Notes, 2021;14(1):438. 2021 [PMID: 34838130] (IHC, Mouse)
• G Baranwal, HA Creed, LM Black, A Auger, AM Quach, R Vegiraju, HE Eckenrode, A Agarwal, JM Rutkowski Expanded renal lymphatics improve recovery following kidney injury Physiological Reports, 2021;9(22):e15094. 2021 [PMID: 34806312] (IHC, Mouse)
• E Redder, N Kirschnick, S Bobe, R Hägerling, NR Hansmeier, F Kiefer Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities PLoS ONE, 2021;16(9):e0249256. 2021 [PMID: 34543279] (IHC, Mouse)
• CC Clement, A D'Alessand, S Thangaswam, S Chalmers, R Furtado, S Spada, G Mondanelli, F Ianni, S Gehrke, M Gargaro, G Manni, LCL Cara, P Runge, WL Tsai, S Karaman, J Arasa, R Fernandez-, A Beck, A Macchiarul, M Gadina, C Halin, F Fallarino, M Skobe, M Veldhoen, S Moretti, S Formenti, S Demaria, RK Soni, R Galarini, R Sardella, G Lauvau, C Putterman, K Alitalo, U Grohmann, L Santambrog 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine Nature Communications, 2021;12(1):4447. 2021 [PMID: 34290243] (IHC, Mouse)
• E Sibler, Y He, L Ducoli, N Keller, N Fujimoto, LC Dieterich, M Detmar Single-Cell Transcriptional Heterogeneity of Lymphatic Endothelial Cells in Normal and Inflamed Murine Lymph Nodes Cells, 2021;10(6):. 2021 [PMID: 34199492] (IHC, Mouse)
• N Homayun Se, AL McCarter, R Helaers, C Galant, LM Boon, P Brouillard, M Vikkula, MT Dellinger KRAS-driven model of Gorham-Stout disease effectively treated with trametinib JCI Insight, 2021;0(0):. 2021 [PMID: 34156985] (IHC, Mouse)
• D Sz?ke, G Kovács, É Kemecsei, L Bálint, K Szoták-Ajt, P Aradi, A Styevkóné, BL Mui, YK Tam, TD Madden, K Karikó, RP Kataru, MJ Hope, D Weissman, BJ Mehrara, N Pardi, Z Jakus Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema Nature Communications, 2021;12(1):3460. 2021 [PMID: 34103491] (IHC, Mouse)
• J Zhu, T Inomata, K Fujimoto, K Uchida, K Fujio, K Nagino, M Miura, N Negishi, Y Okumura, Y Akasaki, K Hirosawa, M Kuwahara, A Eguchi, H Shokirova, A Yanagawa, A Midorikawa, A Murakami Ex Vivo-Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice Investigative Ophthalmology & Visual Science, 2021;62(7):3. 2021 [PMID: 34061951] (IHC, Mouse)
• FW Meng, JT Yu, JY Chen, PF Yang New lymphatic cell formation is associated with damaged brain tissue clearance after penetrating traumatic brain injury Scientific Reports, 2021;11(1):10193. 2021 [PMID: 33986371] (IHC, Mouse)
• T Naito, R Yuge, Y Kitadai, H Takigawa, Y Higashi, T Kuwai, K Kuraoka, S Tanaka, K Chayama Mesenchymal stem cells induce tumor stroma formation and epithelial?mesenchymal transition through SPARC expression in colorectal cancer Oncology reports, 2021;45(6):. 2021 [PMID: 33907853] (ICC, Human)
• H Shokirova, T Inomata, T Saitoh, J Zhu, K Fujio, Y Okumura, A Yanagawa, K Fujimoto, J Sung, A Eguchi, M Miura, K Nagino, K Hirosawa, M Kuwahara, Y Akasaki, H Nagase, A Murakami Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation Scientific Reports, 2021;11(1):8647. 2021 [PMID: 33883646] (IHC, Mouse)
• R Luo, Y Cheng, D Chang, T Liu, L Liu, G Pei, N Zhang, Z Wang, K Guo, W Chen, M Li, L Fan, C Zhang, Y Li, W Dai, M Zuo, Y Xu, Y Yao, S Ge, G Xu Tertiary lymphoid organs are associated with the progression of kidney damage and regulated by interleukin-17A Theranostics, 2021;11(1):117-131. 2021 [PMID: 33391465] (IHC, Human)
• I Tai-Nagara, Y Hasumi, D Kusumoto, H Hasumi, K Okabe, T Ando, F Matsuzaki, F Itoh, H Saya, C Liu, W Li, YS Mukouyama, W Marston Li, X Liu, M Hirashima, Y Suzuki, S Funasaki, Y Satou, M Furuya, M Baba, Y Kubota Blood and lymphatic systems are segregated by the FLCN tumor suppressor Nature Communications, 2020;11(1):6314. 2020 [PMID: 33298956] (IHC, Mouse)
• T Inomata, K Fujimoto, Y Okumura, J Zhu, K Fujio, H Shokirova, M Miura, M Okano, T Funaki, J Sung, N Negishi, A Murakami Novel immunotherapeutic effects of topically administered ripasudil (K-115) on corneal allograft survival Sci Rep, 2020;10(1):19817. 2020 [PMID: 33188243] (IHC, Mouse)
• M Subileau, N Acar, A Carret, L Bretillon, I Vilgrain, S Bailly, D Vittet Eye lymphatic defects induced by bone morphogenetic protein 9 deficiency have no functional consequences on intraocular pressure Sci Rep, 2020;10(1):16040. 2020 [PMID: 32994463] (IHC, Mouse)
• C Sogawa-Fuj, A Hanagata, Y Fujiwara, Y Ishida, H Tomiyasu, T Kunieda, H Nakatomi, M Hori Defective development and microcirculation of intestine in Npr2 mutant mice Sci Rep, 2020;10(1):14761. 2020 [PMID: 32901096]
• M Honda, Y Ito, K Hattori, K Hosono, K Sekiguchi, K Tsujikawa, N Unno, M Majima Inhibition of receptor activity-modifying protein 1 suppresses the development of endometriosis and the formation of blood and lymphatic vessels J. Cell. Mol. Med., 2020;0(0):. 2020 [PMID: 32869443] (IHC, Mouse)
• X Geng, K Yanagida, RG Akwii, D Choi, L Chen, Y Ho, B Cha, MR Mahamud, K Berman de, H Ichise, H Chen, J Wythe, CM Mikelis, T Hla, RS Srinivasan S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling JCI Insight, 2020;0(0):. 2020 [PMID: 32544090] (IHC, Transgenic Mouse)
• A Chakrabort, CK Scogin, K Rizwan, TS Morley, JM Rutkowski Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D Front Physiol, 2020;11(0):363. 2020 [PMID: 32390866] (IHC-P, Mouse)
• CJ Park, PC Lin, S Zhou, R Barakat, ST Bashir, JM Choi, JA Cacioppo, OR Oakley, DM Duffy, JP Lydon, CJ Ko Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation Cell Rep, 2020;31(2):107496. 2020 [PMID: 32294429] (IHC, Mouse)
• E Song, T Mao, H Dong, LSB Boisserand, S Antila, M Bosenberg, K Alitalo, JL Thomas, A Iwasaki VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours Nature, 2020;577(7792):689-694. 2020 [PMID: 31942068] (IF, Mouse)
• G Zhu, Q Du, X Chen, X Wang, N Tang, F She, Y Chen Receptor?interacting serine/threonine?protein kinase 1 promotes the progress and lymph metastasis of gallbladder cancer Oncol. Rep., 2019;0(0):. 2019 [PMID: 31545498] (IHC-P, Mouse)
• SY Yoon, LC Dieterich, S Karaman, ST Proulx, SB Bachmann, C Sciaroni, M Detmar An important role of cutaneous lymphatic vessels in coordinating and promoting anagen hair follicle growth PLoS ONE, 2019;14(7):e0220341. 2019 [PMID: 31344105] (IHC, Mouse)
• KM Lee, GJ Wilson, M Pingen, A Fukuoka, CAH Hansell, R Bartolini, L Medina-Rui, GJ Graham Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism PLoS Biol., 2019;17(5):e3000287. 2019 [PMID: 31141500] (Flow Cytometry, Mouse)
• D Esterházy, MCC Canesso, L Mesin, PA Muller, TBR de Castro, A Lockhart, M ElJalby, AMC Faria, D Mucida Compartmentalized gut lymph node drainage dictates adaptive immune responses Nature, 2019;0(0):. 2019 [PMID: 30988509] (IHC, Mouse)
• HO Reed, L Wang, J Sonett, M Chen, J Yang, L Li, P Aradi, Z Jakus, J D'Armiento, WW Hancock, ML Kahn Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage J. Clin. Invest., 2019;129(6):2514-2526. 2019 [PMID: 30946031] (IHC-P, Mouse)
• A Dili, V Lebrun, C Bertrand, IA Leclercq Associating liver partition and portal vein ligation for staged hepatectomy: establishment of an animal model with insufficient liver remnant Lab. Invest., 2019;0(0):. 2019 [PMID: 30666050] (ICC, Mouse)
• M Subileau, G Merdzhanov, D Ciais, V Collin-Fau, JJ Feige, S Bailly, D Vittet Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation Stem Cell Reports, 2018;0(0):. 2018 [PMID: 30595547] (Flow Cytometry, Mouse)
• E Gucciardo, S Loukovaara, P Salven, K Lehti Lymphatic Vascular Structures: A New Aspect in Proliferative Diabetic Retinopathy Int J Mol Sci, 2018;19(12):. 2018 [PMID: 30551619] (IHC, Mouse)
• T Durré, F Morfoisse, C Erpicum, M Ebroin, S Blacher, M García-Cab, C Deroanne, T Louis, C Balsat, M Van de Vel, S Kaijalaine, F Kridelka, L Engelholm, I Struman, K Alitalo, N Behrendt, J Paupert, A Noel uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis Nat Commun, 2018;9(1):5178. 2018 [PMID: 30518756] (IHC, Mouse)
• CZ Li, XJ Jiang, B Lin, HJ Hong, SY Zhu, L Jiang, XQ Wang, NH Tang, FF She, YL Chen RIP1 regulates TNF-?-mediated lymphangiogenesis and lymphatic metastasis in gallbladder cancer by modulating the NF-?B-VEGF-C pathway Onco Targets Ther, 2018;11(0):2875-2890. 2018 [PMID: 29844685] (IHC, Mouse)
• GD García Nor, CL Ly, DA Cuzzone, RP Kataru, GE Hespe, JS Torrisi, JJ Huang, JC Gardenier, IL Savetsky, MD Nitti, JZ Yu, S Rehal, BJ Mehrara CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema Nat Commun, 2018;9(1):1970. 2018 [PMID: 29773802] (IHC, Mouse)
• D Hominick, A Silva, N Khurana, Y Liu, PC Dechow, JQ Feng, B Pytowski, JM Rutkowski, K Alitalo, MT Dellinger VEGF-C promotes the development of lymphatics in bone and bone loss Elife, 2018;7(0):. 2018 [PMID: 29620526] (IHC-P, Mouse)
• Z Kontarakis, A Rossi, S Ramas, MT Dellinger, DYR Stainier Mir-126 is a conserved modulator of lymphatic development Dev. Biol., 2018;0(0):. 2018 [PMID: 29550364] (Western Blot, Mouse)
• LKM Lam, AM Watson, KD Ryman, WB Klimstra Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204 Npj Vaccines, 2018;3(0):5. 2018 [PMID: 29387474] (IHC-Fr, Mouse)
• BF Westendorp, NVJA Büller, ON Karpus, WA van Dop, J Koster, R Versteeg, PJ Koelink, CY Snel, S Meisner, JJTH Roelofs, A Uhmann, E Ver Loren, J Heijmans, H Hahn, V Muncan, ME Wildenberg, GR van den Br Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response Cell Mol Gastroenterol Hepatol, 2018;5(1):67-82.e1. 2018 [PMID: 29276753] (IHC-P, Mouse)
• M García-Cab, J Paupert, S Blacher, M Van de Vel, AR Quesada, MA Medina, A Noël Targeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases J Hematol Oncol, 2017;10(1):122. 2017 [PMID: 28629427] (IHC, Mouse)
• X Jiang, C Li, B Lin, H Hong, L Jiang, S Zhu, X Wang, N Tang, X Li, F She, Y Chen cIAP2 promotes gallbladder cancer invasion and lymphangiogenesis by activating the NF-?B pathway Cancer Sci., 2017;108(6):1144-1156. 2017 [PMID: 28295868] (IHC, Mouse)
• Boksik Cha Mechanotransduction activates canonical Wnt/?-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves Genes Dev, 2016;30(12):1454-69. 2016 [PMID: 27313318]
• Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD J Clin Invest, 2016;0(0):. 2016 [PMID: 27159393] (IHC-P, Mouse)
• Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation Proc Natl Acad Sci USA, 2016;113(20):E2842-51. 2016 [PMID: 27140620] (IHC, Mouse)
• CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity J Clin Invest, 2016;0(0):. 2016 [PMID: 27140400] (Immunoprecipitation, Mouse)
• Zhou Y, Williams J, Smallwood P, Nathans J Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina. PLoS ONE, 2015;10(12):e0143650. 2015 [PMID: 26630461] (IHC-Fr, Mouse)
• Geng X, Cha B, Mahamud M, Lim K, Silasi-Mansat R, Uddin M, Miura N, Xia L, Simon A, Engel J, Chen H, Lupu F, Srinivasan R Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development. Dev Biol, 2016;409(1):218-33. 2016 [PMID: 26542011] (IHC, Mouse)
• Sweet D, Jimenez J, Chang J, Hess P, Mericko-Ishizuka P, Fu J, Xia L, Davies P, Kahn M Lymph flow regulates collecting lymphatic vessel maturation in vivo. J Clin Invest, 2015;125(8):2995-3007. 2015 [PMID: 26214523] (IHC-P, Mouse)
• Bianchi R, Teijeira A, Proulx S, Christiansen A, Seidel C, Rulicke T, Makinen T, Hagerling R, Halin C, Detmar M A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research. PLoS ONE, 2015;10(4):e0122976. 2015 [PMID: 25849579] (IHC-Fr, Mouse)
• Maertens L, Erpicum C, Detry B, Blacher S, Lenoir B, Carnet O, Pequeux C, Cataldo D, Lecomte J, Paupert J, Noel A Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis. PLoS ONE, 2014;9(9):e106976. 2014 [PMID: 25222747] (IHC, Mouse)
• D'Alessio S, Correale C, Tacconi C, Gandelli A, Pietrogrande G, Vetrano S, Genua M, Arena V, Spinelli A, Peyrin-Biroulet L, Fiocchi C, Danese S VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease. J Clin Invest, 2014;124(9):3863-78. 2014 [PMID: 25105363] (IHC, Human)
• Kizhatil , Krishnak, Ryan , Margaret, Marchant , Jeffrey, Henrich , Stephen, John , Simon W Schlemm&#039;s canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process. PLoS Biol, 2014;12(7):e1001912. 2014 [PMID: 25051267] (IHC, Mouse)
• Jakus Z, Gleghorn J, Enis D, Sen A, Chia S, Liu X, Rawnsley D, Yang Y, Hess P, Zou Z, Yang J, Guttentag S, Nelson C, Kahn M Lymphatic function is required prenatally for lung inflation at birth. J Exp Med, 2014;211(5):815-26. 2014 [PMID: 24733830]
• Iwasaki T, Takeda Y, Maruyama K, Yokosaki Y, Tsujino K, Tetsumoto S, Kuhara H, Nakanishi K, Otani Y, Jin Y, Kohmo S, Hirata H, Takahashi R, Suzuki M, Inoue K, Nagatomo I, Goya S, Kijima T, Kumagai T, Tachibana I, Kawase I, Kumanogoh A Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro. J Biol Chem, 2013;288(4):2118-31. 2013 [PMID: 23223239] (Cell Selection, Mouse)
• Luckashenak N, Wahe A, Breit K, Brakebusch C, Brocker T Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo. J Immunol, 2013;190(1):27-35. 2013 [PMID: 23209325] (IHC, Mouse)
• Jeansson M, Gawlik A, Anderson G Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J. Clin. Invest., 2011;121(6):2278-89. 2011 [PMID: 21606590] (IHC-Fr, Mouse)
• Ocana-Morgner C, Reichardt P, Chopin M, Braungart S, Wahren C, Gunzer M, Jessberger R Sphingosine 1-Phosphate-Induced Motility and Endocytosis of Dendritic Cells Is Regulated by SWAP-70 through RhoA. J. Immunol., 2011;186(9):5345-55. 2011 [PMID: 21421853] (IHC-Fr, Mouse)
• Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivee B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. J. Cell Biol., 2010;188(1):115-30. 2010 [PMID: 20065093] (ICC, Mouse)
• Niessen K, Zhang G, Ridgway JB, Chen H, Yan M ALK1 signaling regulates early postnatal lymphatic vessel development. Blood, 2010;115(8):1654-61. 2010 [PMID: 19903896] (IHC, Mouse)
• Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth. Proc. Natl. Acad. Sci. U.S.A., 2009;106(17):7137-42. 2009 [PMID: 19359485] (ICC, Mouse)
• Katagiri K, Katakai T, Ebisuno Y, Ueda Y, Okada T, Kinashi T Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes. EMBO J., 2009;28(9):1319-31. 2009 [PMID: 19339990] (IHC-Fr, Mouse)
• Katakai T, Suto H, Sugai M, Gonda H, Togawa A, Suematsu S, Ebisuno Y, Katagiri K, Kinashi T, Shimizu A Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J. Immunol., 2008;181(9):6189-200. 2008 [PMID: 18941209] (ICC, Mouse)
• Zhang J, Dong H, Wang B, Zhu S, Croy BA Dynamic changes occur in patterns of endometrial EFNB2/EPHB4 expression during the period of spiral arterial modification in mice. Biol. Reprod., 2008;79(3):450-8. 2008 [PMID: 18463357] (IHC-P, Mouse)
• Kowalewska J, Muhlfeld AS, Hudkins KL, Yeh MM, Farr AG, Ravetch JV, Alpers CE Thymic stromal lymphopoietin transgenic mice develop cryoglobulinemia and hepatitis with similarities to human hepatitis C liver disease. Am. J. Pathol., 2007;170(3):981-9. 2007 [PMID: 17322382] (IHC, Mouse)
• Bagley RG, Weber W, Rouleau C, Teicher BA Pericytes and endothelial precursor cells: cellular interactions and contributions to malignancy. Cancer Res., 2005;65(21):9741-50. 2005 [PMID: 16266995] (IHC, Mouse)

Review for LYVE-1 Antibody (AF2125) (1)

Average Rating: 4

(Based on 1 review)

We have 1 review tested in 1 species: Mouse.

reviewed by: Anonymous - Flow Mouse 01/06/2015

Summary

• Application: Flow Cytometry
• Sample Tested: See PMID 22287283
• Species: Mouse

Bioinformatics

• Gene Symbol: LYVE1
• Uniprot:
  • Q8BHC0()