SMN Antibody (2B1) [DyLight 405]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Pm, XpSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P, IP
Clone
2B1
Clonality
Monoclonal
Host
Mouse

SMN Antibody (2B1) [DyLight 405] Summary

Immunogen
Purified recombinant His6-tagged human SMN protein. [Swiss-Prot# Q16637]
Localization
Cytoplasm. Nucleus > gem. Note: Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems).
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
SMN1
Purity
Protein G purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Conjugate
DyLight 405
Format
DyLight 405 (A=400, E=420)
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Applications/Dilutions

Dilutions
  • Western Blot 2 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:50-100
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:200
  • Immunoprecipitation 1:10-1:500
Application Notes
This SMN Antibody (2B1) is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections, Flow Cytometry, Immunoprecipitation and Western blot where a band can be seen at ~ 35 kDa. Use in ELISA reported in scientific literature (PMID 23973875)

Reactivity Notes

Human, mouse, rat, monkey and Xenopus. Other species not tested.

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for SMN Antibody (2B1) [DyLight 405]

  • Gemin-1
  • Kugelberg-Welander disease)
  • SMNC
  • survival of motor neuron 1, telomeric

Background

Spinal muscular atrophy (SMA) is a common fatal autosomal recessive disorder characterized by the degeneration of motor neurons and muscular atrophy. A gene called Survival of Motor Neurons (SMN) has been identified as the determining gene in SMA and is deleted or mutated in greater than 98% of SMA patients. The SMN protein localizes to both the cytoplasm and the nucleus. In the nucleus, SMN has been found to localize in a nuclear structure termed gems for Gemini of coiled bodies, which contain high levels of small ribonucleoproteins (snRNPs). SMN forms complexes with proteins including SIP1, Gemin 2-7 and several others known to be involved in the biogenesis of snRNPs. SMN antibodies may serve as a useful research tool to study SMN complexes and gems, and their role in pre-RNA processing and RNA metabolism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for SMN Antibody (NB100-1936V). (Showing 1 - 1 of 1 FAQ).

  1. Could you recommond the Human specific SMN antibody? It will only recognize human SMN, without cross reaction with mouse smn.
    • We do not have an SMN antibody that has been validated NOT to work in mouse samples. When an antibody is found to not react with a certain species, we mark the data sheet with a (-) next to the species' name. Unfortunately, the SMN antibodies that do not list mouse have not been tested in mouse, and may react.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB100-1936APC
DyLight 350 Labeled NB100-1936UV
DyLight 405LS Labeled NB100-1936V3
DyLight 488 Labeled NB100-1936G
DyLight 680 Labeled NB100-1936FR
DyLight 755 Labeled NB100-1936IR
FITC Labeled NB100-1936F
PE Labeled NB100-1936PE
PerCP Labeled NB100-1936PCP

Additional SMN Antibody (2B1) [DyLight 405] Products

SMN NB100-1936V

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Bioinformatics Tool for SMN Antibody (NB100-1936V)

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Diseases for SMN Antibody (NB100-1936V)

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Pathways for SMN Antibody (NB100-1936V)

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PTMs for SMN Antibody (NB100-1936V)

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Research Areas for SMN Antibody (NB100-1936V)

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Blogs on SMN

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol SMN1

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