NAIP Antibody

Images

 
Western Blot: NAIP Antibody [NBP1-77196] - Analysis of NAIP in human tonsil tissue lysate with NAIP antibody at 1 ug/mL.
Immunocytochemistry/ Immunofluorescence: NAIP Antibody [NBP1-77196] - Immunofluorescence of NAIP in A549 cells with NAIP antibody at 20 ug/mL.
Western Blot: NAIP Antibody [NBP1-77196] - Western blot analysis of NAIP in PC-3 cell lysate with anti-NAIP (CT) at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Western Blot: NAIP Antibody [NBP1-77196] - Analysis of NAIP in human tonsil tissue lysate with NAIP antibody at 1 ug/mL.
Immunocytochemistry/ Immunofluorescence: NAIP Antibody [NBP1-77196] - A549 cells with NAIP antibody at 10 ug/ml.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

NAIP Antibody Summary

Immunogen
Antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP. The immunogen is located within amino acids 1200 - 1250 of NAIP.
Specificity
Minor, lower molecular weight bands may represent alternately spliced forms.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NAIP
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
NAIP antibody can be used for the detection of NAIP by Western blot at 0.5 to 1 mg/ml. Minor, lower molecular weight bands may represent alternately spliced forms.
Theoretical MW
154 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
NAIP Peptide (NBP1-77196PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for NAIP Antibody

  • baculoviral IAP repeat-containing 1
  • BIRC1
  • BIRC1baculoviral IAP repeat-containing protein 1
  • FLJ18088
  • FLJ42520
  • FLJ58811
  • NAIP
  • Neuronal apoptosis inhibitory protein
  • NLR family, apoptosis inhibitory protein
  • NLR family, BIR domain containing 1
  • NLRB1
  • nucleotide-binding oligomerization domain, leucine rich repeat and BIR domaincontaining 1
  • psi neuronal apoptosis inhibitory protein
  • psiNAIP

Background

Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for NAIP Antibody (NBP1-77196)

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Blogs on NAIP.

Survivin - an inhibitor of apoptosis protein
Survivin is an anti-apoptotic protein which is the smallest protein within a large family of proteins including X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, NAIP, and Livin. Survivin is responsible for a wide range of basic cellula...  Read full blog post.

Survivin is thrivin'
The survivin anti-apoptotic protein is the smallest member of a large family of proteins such as X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates basic physiological events such as the cell cycle, tumor...  Read full blog post.

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Bioinformatics

Gene Symbol NAIP
Entrez
Uniprot