SMN Antibody (2B1) [FITC]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Pm, XpSpecies Glossary
Applications ELISA, ICC/IF, IHC, IHC-P
Clone
2B1
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

SMN Antibody (2B1) [FITC] Summary

Immunogen
Purified recombinant His6-tagged human SMN protein. [Swiss-Prot# Q16637]
Localization
Cytoplasm. Nucleus > gem. Note: Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems).
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
SMN1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This SMN Antibody (2B1) is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections, Flow Cytometry, Immunoprecipitation and Western blot where a band can be seen at ~ 35 kDa. Use in ELISA reported in scientific literature (PMID 23973875)

Reactivity Notes

Human, mouse, rat, monkey and Xenopus. Other species not tested.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SMN Antibody (2B1) [FITC]

  • Gemin-1
  • Kugelberg-Welander disease)
  • SMNC
  • survival of motor neuron 1, telomeric

Background

Spinal muscular atrophy (SMA) is a common fatal autosomal recessive disorder characterized by the degeneration of motor neurons and muscular atrophy. A gene called Survival of Motor Neurons (SMN) has been identified as the determining gene in SMA and is deleted or mutated in greater than 98% of SMA patients. The SMN protein localizes to both the cytoplasm and the nucleus. In the nucleus, SMN has been found to localize in a nuclear structure termed gems for Gemini of coiled bodies, which contain high levels of small ribonucleoproteins (snRNPs). SMN forms complexes with proteins including SIP1, Gemin 2-7 and several others known to be involved in the biogenesis of snRNPs. SMN antibodies may serve as a useful research tool to study SMN complexes and gems, and their role in pre-RNA processing and RNA metabolism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

FAQs for SMN Antibody (NB100-1936F). (Showing 1 - 1 of 1 FAQ).

  1. Could you recommond the Human specific SMN antibody? It will only recognize human SMN, without cross reaction with mouse smn.
    • We do not have an SMN antibody that has been validated NOT to work in mouse samples. When an antibody is found to not react with a certain species, we mark the data sheet with a (-) next to the species' name. Unfortunately, the SMN antibodies that do not list mouse have not been tested in mouse, and may react.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

DyLight 350 Labeled NB100-1936UV
DyLight 405 Labeled NB100-1936V
DyLight 488 Labeled NB100-1936G
DyLight 680 Labeled NB100-1936FR
DyLight 755 Labeled NB100-1936IR

Additional SMN Products

SMN NB100-1936F

Bioinformatics Tool for SMN Antibody (NB100-1936F)

Discover related pathways, diseases and genes to SMN Antibody (NB100-1936F). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for SMN Antibody (NB100-1936F)

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Pathways for SMN Antibody (NB100-1936F)

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PTMs for SMN Antibody (NB100-1936F)

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Research Areas for SMN Antibody (NB100-1936F)

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Blogs on SMN

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Contact Information

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Calculators

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Bioinformatics

Gene Symbol SMN1