Myeloperoxidase/MPO Antibody [Unconjugated]

Western blot shows lysates of HL-60 human acute promyelocytic leukemia cell line, human neutrophil cells, and mouse spleen tissue. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Human/Mouse Myeloperoxidase/MPO Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3667) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF019). A specific band was detected for Myeloperoxidase/MPO at approximately 60 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2.

Myeloperoxidase/MPO was detected in immersion fixed mouse splenocytes using Goat Anti-Human/Mouse Myeloperoxidase/MPO Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3667) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.For human Immunocytochemistry samples, we recommend Mouse Anti-Human Myeloperoxidase/ MPO Monoclonal Antibody (MAB3174).

Myeloperoxidase/MPO was detected in immersion fixed paraffin-embedded sections of mouse spleen tissue using Goat Anti-Human/Mouse Myeloperoxidase/MPO Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3667) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to lymphocytes. Staining was performed using our IHC Staining with VisUCyte HRP Polymer Detection Reagents.For human Immunohistochemistry samples, we recommend Mouse Anti-Human Myeloperoxidase/ MPO Monoclonal Antibody (MAB3174).

Simple Western lane view shows lysates of mouse spleen tissue, loaded at 0.2 mg/mL. A specific band was detected for Myeloperoxidase/MPO at approximately 67 kDa (as indicated) using 5 µg/mL of Goat Anti-Human/Mouse Myeloperoxidase/MPO Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3667) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the12-230 kDa separation system.

SAA levels positively correlate with tumour-associated neutrophil infiltration. (A) Representative images of MPO-positive neutrophils in a lung adenocarcinoma tumour section (original magnification ×200). (B) Neutrophils are significantly elevated in tumours compared to control tissue biopsies, which was confirmed by (C) paired analysis of tumour and adjacent control lung tissue. (D) Circulating SAA levels were elevated in lung adenocarcinoma patients as determined by ELISA. (E) SAA transcript levels were not increased in tumours as measured by RTqPCR and confirmed by (F) sub-analysis of the paired from the tumour and adjacent control tissue samples. (G) Tissue sections were stained for SAA, which identified positive staining within seromucinous glands and tumour-associated macrophages (original magnification ×200). (H) Spearman correlation was used to assess associations between SAA transcript levels and tumour infiltrating neutrophil density (r = 0.51, *** p AF3667) at 1ug/mL with overnight incubation at 4 degrees Celsius followed by incubation with anti-goat IgG VisUCyte HRP Polymer Antibody (Catalog # VC004) and DAB chromogen (yellow-brown). Tissue was counterstained with hematoxylin (blue). Specific staining was localized to cell surface.

Immunofluorescence staining reveals that flagellum-deficiency abolishes P. aeruginosa-induced NET formation.Human PMNs were exposed to wild-type (WT) or flagellum-deficient strains of P. aeruginosa PAK flgC and PAO1 fliC, and NET release was documented. (A) Immunofluorescence staining of myeloperoxidase (MPO, green), citrullinated histone H4 (citH4, red), extracellular DNA (DAPI, blue) and their merged images are shown. Representative results, n = 3. (B) Quantitation of immunofluorescence images shown in panel (A). Based on nuclear morphology and co-staining with MPO and citH4, NET-forming PMNs were identified and their numbers quantitated compared to the total cell population (expressed as percentage of total). Mean+/-S.E.M., n = 3. One-way ANOVA, Tukey’s post hoc test. *, p<0.05; **, p<0.01. Nonstim., nonstimulated; WT, wild-type. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27855208), licensed under a CC-BY license. Not internally tested by R&D Systems.

Postoperative AIC stimulates NETs release both in peripheral blood and abdominal infectious site.A Left panel: representative immunofluorescence co-staining of DNA (Hochest and Sytox), Cit-H3 (citrullinated histone-3) and MPO (myeloperoxidase) to assess NETs formation in the neutrophils isolated from peripheral blood of control, Non-AIC, AIC and AIC + DNase I groups; Right panel: plasma and serum levels of MPO–DNA in GC patients with control, Non-AIC and AIC; B Preoperative and postoperative serum MPO–DNA levels between Non-AIC and AIC groups; C Representative SEM (scan electron microscopy) of neutrophils isolated from preoperative and postoperative ascites fluid between Non-AIC and AIC groups. Green arrows point to extracellular meshes of NETs and white arrows point to neutrophils; D Preoperative and postoperative ascites fluid MPO–DNA levels between Non-AIC and AIC groups; E Representative images of HE and immunofluorescence staining of DNA, Cit-H3, and MPO in omental tissues among AIC, Non-AIC, and control groups; F Quantification of NETs in omental tissues among AIC, Non-AIC, and control groups. Data represent the mean ± S.D. in A, F (n = 10 per group); one-way ANOVA with Tukey test was used in A, F; paired and unpaired Student’s t-tests were used in B, D (n = 10 per group). Source data are provided as a Source Data file. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/35197446), licensed under a CC-BY license. Not internally tested by R&D Systems.

Postoperative AIC stimulates NETs release both in peripheral blood and abdominal infectious site.A Left panel: representative immunofluorescence co-staining of DNA (Hochest and Sytox), Cit-H3 (citrullinated histone-3) and MPO (myeloperoxidase) to assess NETs formation in the neutrophils isolated from peripheral blood of control, Non-AIC, AIC and AIC + DNase I groups; Right panel: plasma and serum levels of MPO–DNA in GC patients with control, Non-AIC and AIC; B Preoperative and postoperative serum MPO–DNA levels between Non-AIC and AIC groups; C Representative SEM (scan electron microscopy) of neutrophils isolated from preoperative and postoperative ascites fluid between Non-AIC and AIC groups. Green arrows point to extracellular meshes of NETs and white arrows point to neutrophils; D Preoperative and postoperative ascites fluid MPO–DNA levels between Non-AIC and AIC groups; E Representative images of HE and immunofluorescence staining of DNA, Cit-H3, and MPO in omental tissues among AIC, Non-AIC, and control groups; F Quantification of NETs in omental tissues among AIC, Non-AIC, and control groups. Data represent the mean ± S.D. in A, F (n = 10 per group); one-way ANOVA with Tukey test was used in A, F; paired and unpaired Student’s t-tests were used in B, D (n = 10 per group). Source data are provided as a Source Data file. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/35197446), licensed under a CC-BY license. Not internally tested by R&D Systems.

CXCR4 expressed at neutrophils mediates NET formation in rats. (D) Representative images of immunolabeling with CitH3, MPO,&DAPI at 20 mm distal to the injury site 12 h after injury. Dashed lines indicate the border of the epineurium&the parenchyma. * are high-magnification images of boxed areas in the epineurium. Arrows indicate triple immunolabeled NETs. Scale bar: 10 μm. Image collected & cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/35961782), licensed under a CC-BY license. Not internally tested by R&D Systems.

Migration inhibitory factor (MIF) secreted from neutrophils promotes NET formation in rats. (D) Representative images of immunolabeling with CitH3, MPO,&DAPI at 20 mm distal to the injury site 12 h after injury. Dashed lines indicate the border of the epineurium&the parenchyma. Images marked with * are high-magnification images of boxed areas in the epineurium. Arrows indicate triple immunolabeled NETs. Treatment with iso-1 dramatically inhibited NET formation. Scale bar: 10 μm. Image collected & cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/35961782), licensed under a CC-BY license. Not internally tested by R&D Systems.

Inhibition of NET formation promotes the macrophage infiltration from the epineurium into the parenchyma in rats. (C) Representative images of immunolabeling with CitH3, MPO,&DAPI at 20 mm distal to the injury site. Dashed lines indicate the border of the epineurium&the parenchyma. Images marked with * are high-magnification views of the boxed areas at the epineurium. Arrows indicate neutrophils releasing NETs. Treatment with Cl-amidine or DNase I inhibited NET formation. Scale bars: 100&10 μm in low-&high-magnification images, respectively. Image collected & cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/35961782), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: Hu, Mu
• Applications: WB, Simple Western, IHC, Dual ISH-IHC, ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

Myeloperoxidase/MPO Antibody [Unconjugated] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse MPO
  Met16-Thr718
  Accession # P11247
• Specificity: Detects human and mouse Myeloperoxidase/MPO in Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant mouse EPPO is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: MPO
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Dual RNAscope ISH-IHC 5-15 ug/mL
  • Immunocytochemistry 5-15 ug/mL
  • Immunohistochemistry 1-15 ug/mL
  • Simple Western 5 ug/mL
  • Western Blot 0.5 ug/mL
• Application Notes: In Simple Western only 10-15 uL of the recommended dilution is used per data point.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
  *Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Myeloperoxidase/MPO Antibody [Unconjugated]

• EC 1.11.1
• EC 1.11.1.7
• MPO
• Myeloperoxidase

Background

Myeloperoxidase (MPO) is a hemeprotein that belongs to the XPO subfamily of the heme peroxidase superfamily. MPO is synthesized as a preproprotein that undergoes proteolytic processing to generate a disulfide-linked heterodimer of the N-terminal beta -subunit (12 kDa) and C-terminal alpha subunit (60 kDa). Active MPO is a tetramer of two beta -subunits and two alpha -subunits that are also disulfide-linked through the two alpha -subunits. MPO is stored in granules and is an abundant protein in neutrophils and monocytes. MPO is released upon activation to catalyze the formation of powerful oxidants such as hypochlorous acid, which kills microbes. Unprocessed pro-MPO can also be released. Mouse MPO shares 87% amino acid sequence identity with that of human MPO.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Myeloperoxidase/MPO Antibody (AF3667)(185)

Publications using AF3667

• De Volder, J;Bontinck, A;Haelterman, V;Boon, L;Joos, GF;Brusselle, GG;Maes, T; Anti-IL-5 treatment, but not neutrophil interference, attenuates inflammation in a mixed granulocytic asthma mouse model, elicited by air pollution Respiratory research 2025-01-28 [PMID: 39875874] (Immunohistochemistry, Mouse)
• Li, Z;Li, Z;Hu, Y;Xie, Y;Shi, Y;Chen, G;Huang, J;Xiao, Z;Zhu, W;Huang, H;Wang, M;Chen, J;Chen, X;Liang, D; Neutrophil extracellular traps potentiate effector T cells via endothelial senescence in uveitis JCI insight 2025-01-23 [PMID: 39846254] (ELISA, Immunocytochemistry, Human)
• Dai, SZ;Wu, RH;Chen, H;Chen, MH;Xie, W;Zheng, WP;Tan, GH;Huang, FY; Progesterone suppresses rhinovirus-induced airway inflammation by inhibiting neutrophil infiltration and extracellular traps formation International immunopharmacology 2025-01-10 [PMID: 39626540] (Immunohistochemistry, Immunocytochemistry, Human, Mouse)
• Miranda, S;Lassnig, C;Schmidhofer, K;Kjartansdottir, H;Vogl, C;Tangermann, S;Tsymala, I;Babl, V;Müller, M;Kuchler, K;Strobl, B; Lack of TYK2 signaling enhances host resistance to Candida albicans skin infection Nature communications 2024-12-03 [PMID: 39622833] (Immunohistochemistry, Transgenic Mouse)
• Kikuchi, K;Kazuma, S;Yamakage, M; Recombinant thrombomodulin and recombinant antithrombin attenuate pulmonary endothelial glycocalyx degradation and neutrophil extracellular trap formation in ventilator-induced lung injury in the context of endotoxemia Respiratory research 2024-09-03 [PMID: 39227918] (Immunohistochemistry, Mouse)
• Nishibata, Y;Arai, S;Taniguchi, M;Nakade, I;Ogawa, H;Kitano, S;Hosoi, Y;Shindo, A;Nishiyama, R;Masuda, S;Nakazawa, D;Tomaru, U;Shimizu, T;Sinko, W;Nagakura, T;Terada, Y;Ishizu, A; Cathepsin C inhibition reduces neutrophil serine protease activity and improves activated neutrophil-mediated disorders Nature communications 2024-08-22 [PMID: 39174512] (Immunohistochemistry, Rat)
• Turkkahraman, H;Flanagan, S;Zhu, T;Akel, N;Marino, S;Ortega-Gonzalez, D;Yuan, X;Bellido, T; Sclerostin antibody corrects periodontal disease in type 2 diabetic mice JCI insight 2024-07-18 [PMID: 39171525] (Immunohistochemistry, Mouse)
• Wang, L;Huang, FY;Dai, SZ;Fu, Y;Zhou, X;Wang, CC;Tan, GH;Li, Q; Progesterone modulates the immune microenvironment to suppress ovalbumin-induced airway inflammation by inhibiting NETosis Scientific reports 2024-07-26 [PMID: 39060348] (Immunohistochemistry, Mouse)
• Rosenzweig, N;Kleemann, KL;Rust, T;Carpenter, M;Grucci, M;Aronchik, M;Brouwer, N;Valenbreder, I;Cooper-Hohn, J;Iyer, M;Krishnan, RK;Sivanathan, KN;Brandão, W;Yahya, T;Durao, A;Yin, Z;Chadarevian, JP;Properzi, MJ;Nowarski, R;Davtyan, H;Weiner, HL;Blurton-Jones, M;Yang, HS;Eggen, BJL;Sperling, RA;Butovsky, O; Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease Nature medicine 2024-07-03 [PMID: 38961225] (Flow Cytometry, Human, Mouse)
• Donahue, KL;Watkoske, HR;Kadiyala, P;Du, W;Brown, K;Scales, MK;Elhossiny, AM;Espinoza, CE;Lasse Opsahl, EL;Griffith, BD;Wen, Y;Sun, L;Velez-Delgado, A;Renollet, NM;Morales, J;Nedzesky, NM;Baliira, RK;Menjivar, RE;Medina-Cabrera, PI;Rao, A;Allen, B;Shi, J;Frankel, TL;Carpenter, ES;Bednar, F;Zhang, Y;Pasca di Magliano, M; Oncogenic KRAS-dependent stromal interleukin-33 directs the pancreatic microenvironment to promote tumor growth Cancer discovery 2024-07-03 [PMID: 38958646] (Immunohistochemistry, Transgenic Mouse)
• Barbu, E;Mihaila, AC;Gan, AM;Ciortan, L;Macarie, RD;Tucureanu, MM;Filippi, A;Stoenescu, AI;Petrea, SV;Simionescu, M;Balanescu, SM;Butoi, E; The Elevated Inflammatory Status of Neutrophils Is Related to In-Hospital Complications in Patients with Acute Coronary Syndrome and Has Important Prognosis Value for Diabetic Patients International journal of molecular sciences 2024-05-08 [PMID: 38791147] (Western Blot, Immunocytochemistry, Human)
• Shad, A;Rewell, SSJ;Macowan, M;Gandasasmita, N;Wang, J;Chen, K;Marsland, B;O'Brien, TJ;Li, J;Semple, BD; Modelling lung infection with Klebsiella pneumoniae after murine traumatic brain injury Journal of neuroinflammation 2024-05-08 [PMID: 38720343] (Immunohistochemistry, Mouse)
• Su, Q;Su, C;Zhang, Y;Guo, Y;Liu, Y;Liu, Y;Yong, VW;Xue, M; Adjudin protects blood-brain barrier integrity and attenuates neuroinflammation following intracerebral hemorrhage in mice International immunopharmacology 2024-04-01 [PMID: 38565042] (Immunohistochemistry, Mouse)
• Abraham, MJ;Goncalves, C;McCallum, P;Gupta, V;Preston, SEJ;Huang, F;Chou, H;Gagnon, N;Johnson, NA;Miller, WH;Mann, KK;Del Rincon, SV; Tunable PhenoCycler imaging of the murine pre-clinical tumour microenvironments Cell & bioscience 2024-02-04 [PMID: 38311785] (Immunohistochemistry, Mouse)
• Krishnan, A;Ozturk, NB;Cutshaw, KA;Guicciardi, ME;Kitagataya, T;Olson, KE;Pavelko, KD;Sherman, W;Wixom, AQ;Jalan-Sakrikar, N;Baez-Faria, M;Gutierrez, F;Gores, GJ; Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) deletion in myeloid cells augments cholestatic liver injury Scientific reports 2024-01-25 [PMID: 38273071] (Immunohistochemistry, Mouse, Transgenic Mouse)
• Wilkening, RV;Langouët-Astrié, C;Severn, MM;Federle, MJ;Horswill, AR; Identifying genetic determinants of Streptococcus pyogenes-host interactions in a murine intact skin infection model Cell reports 2023-10-26 [PMID: 37889753] (IHC, Mouse)
• Hutka, B;Várallyay, A;László, SB;Tóth, AS;Scheich, B;Paku, S;Vörös, I;Pós, Z;Varga, ZV;Norman, DD;Balogh, A;Benyó, Z;Tigyi, G;Gyires, K;Zádori, ZS; A dual role of lysophosphatidic acid type 2 receptor (LPAR2) in nonsteroidal anti-inflammatory drug-induced mouse enteropathy Acta pharmacologica Sinica 2023-10-10 [PMID: 37816857] (Western Blot, IHC, Mouse)
• Shi, G;Liu, L;Cao, Y;Ma, G;Zhu, Y;Xu, J;Zhang, X;Li, T;Mi, L;Jia, H;Zhang, Y;Liu, X;Zhou, Y;Li, S;Yang, G;Liu, X;Chen, F;Wang, B;Deng, Q;Zhang, S;Zhang, J; Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1?/ASK1/JNK signaling pathway in mice with traumatic brain injury Journal of neuroinflammation 2023-09-30 [PMID: 37777772] (IHC, Mouse)
• Cao, L;Ma, L;Zhao, J;Wang, X;Fang, X;Li, W;Qi, Y;Tang, Y;Liu, J;Peng, S;Yang, L;Zhou, L;Li, L;Hu, X;Ji, Y;Hou, Y;Zhao, Y;Zhang, X;Zhao, YY;Zhao, Y;Wei, Y;Malik, AB;Saiyin, H;Xu, J; An unexpected role of neutrophils in clearing apoptotic hepatocytes in vivo eLife 2023-09-20 [PMID: 37728612] (IHC, Human)
• Hao Zhang, Dan Wu, Yanghanzhao Wang, Kefang Guo, Charles B. Spencer, Lilibeth Ortoga et al. METTL3-mediated N6-methyladenosine exacerbates ferroptosis via m6A-IGF2BP2-dependent mitochondrial metabolic reprogramming in sepsis-induced acute lung injury Clin Transl Med 9/15/2023 [PMID: 37715457]
• Hernandez Pichardo, A;Wilm, B;Liptrott, NJ;Murray, P; Intravenous Administration of Human Umbilical Cord Mesenchymal Stromal Cells Leads to an Inflammatory Response in the Lung Stem cells international 2023-09-05 [PMID: 37705699] (IHC, Human)
• Mei Yang, Xinmiao Zhou, Stuart W.A. Pearce, Zhisheng Yang, Qishan Chen, Kaiyuan Niu et al. Causal Role for Neutrophil Elastase in Thoracic Aortic Dissection in Mice Arteriosclerosis, Thrombosis, and Vascular Biology 8/17/2023 [PMID: 37589142]
• Ma T, Tang Y, Wang T et al. Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCII(hi) neutrophils Signal Transduction and Targeted Therapy 2023-08-11 [PMID: 37563136]
• Ma T, Tang Y, Wang T et al. Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCII(hi) neutrophils Signal Transduction and Targeted Therapy 8/11/2023 [PMID: 37563136]
• Wu, H;Guo, C;Liu, Z;Cai, J;Wang, C;Yi, H;Sanyal, A;Puri, P;Zhou, H;Wang, XY; Neutrophils exacerbate acetaminophen-induced liver injury by producing cytotoxic interferon-? International immunopharmacology 2023-08-02 [PMID: 37541108] (IHC, Mouse)
• Le, PM;Pal-Ghosh, S;Menko, AS;Stepp, MA; Immune Cells Localize to Sites of Corneal Erosions in C57BL/6 Mice Biomolecules 2023-06-29 [PMID: 37509096] (IHC, Mouse)
• Perico, L;Morigi, M;Pezzotta, A;Locatelli, M;Imberti, B;Corna, D;Cerullo, D;Benigni, A;Remuzzi, G; SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling Scientific reports 2023-07-14 [PMID: 37452090] (IHC, Transgenic Mouse)
• Ana Raquel Maceiras, Diogo Silvério, Rute Gonçalves, Marcos S. Cardoso, Margarida Saraiva Infection with hypervirulent Mycobacterium tuberculosis triggers emergency myelopoiesis but not trained immunity Frontiers in Immunology 6/13/2023 [PMID: 37383236]
• Shiratori-Aso, S;Nakazawa, D;Kudo, T;Kanda, M;Ueda, Y;Watanabe-Kusunoki, K;Nishio, S;Iwasaki, S;Tsuji, T;Masuda, S;Tomaru, U;Ishizu, A;Atsumi, T; CD47 blockade ameliorates autoimmune vasculitis via efferocytosis of neutrophil extracellular traps JCI insight 2023-08-08 [PMID: 37368493] (IHC, Mouse)
• Chen Li, Tianli Chen, Jialiang Liu, Yue Wang, Chunhuan Zhang, Lu Guo et al. FGF19‐Induced Inflammatory CAF Promoted Neutrophil Extracellular Trap Formation in the Liver Metastasis of Colorectal Cancer Advanced Science 8/1/2023 [PMID: 37345586]
• Huerga Encabo, H;Aramburu, IV;Garcia-Albornoz, M;Piganeau, M;Wood, H;Song, A;Ferrelli, A;Sharma, A;Minutti, CM;Domart, MC;Papazoglou, D;Gurashi, K;Llorian Sopena, M;Goldstone, R;Fallesen, T;Wang, Q;Ariza-McNaughton, L;Wiseman, DH;Batta, K;Gupta, R;Papayannopoulos, V;Bonnet, D; Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils Cell stem cell 2023-06-01 [PMID: 37267914] (ICC, IHC, Mouse)
• Sung, PS;Sun, CP;Tao, MH;Hsieh, SL; Inhibition of SARS-CoV-2-mediated thromboinflammation by CLEC2.Fc EMBO molecular medicine 2023-05-22 [PMID: 37211986] (Immunohistochemistry, Immunocytochemistry, Human, Mouse)
• Yiyao Cao, Mingming Shi, Liang Liu, Yan Zuo, Haoran Jia, Xiaobin Min et al. Inhibition of neutrophil extracellular trap formation attenuates NLRP1-dependent neuronal pyroptosis via STING/IRE1 alpha pathway after traumatic brain injury in mice Frontiers in Immunology 4/14/2023 [PMID: 37143681]
• Yiyao Cao, Mingming Shi, Liang Liu, Yan Zuo, Haoran Jia, Xiaobin Min et al. Inhibition of neutrophil extracellular trap formation attenuates NLRP1-dependent neuronal pyroptosis via STING/IRE1 alpha pathway after traumatic brain injury in mice Frontiers in Immunology 2023-04-14 [PMID: 37143681] (Immunohistochemistry, Mouse)
• Bruna M. Silva, Giovanni F. Gomes, Flavio P. Veras, Seppe Cambier, Gabriel V.L. Silva, Andreza U. Quadros et al. C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps Journal of Clinical Investigation 6/15/2023 [PMID: 37104043]
• N Boonpraman, S Yoon, CY Kim, JS Moon, SS Yi NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease Redox Biology, 2023-04-10;62(0):102698. 2023-04-10 [PMID: 37058998] (ICC, Western Blot, Mouse)
• FP Veras, GF Gomes, BMS Silva, DB Caetité, CJLR Almeida, CMS Silva, AH Schneider, ES Corneo, CS Bonilha, SS Batah, R Martins, E Arruda, AT Fabro, JC Alves-Filh, TM Cunha, FQ Cunha Targeting neutrophils extracellular traps (NETs) reduces multiple organ injury in a COVID-19 mouse model Respiratory Research, 2023-03-02;24(1):66. 3/2/2023 [PMID: 36864506]
• X Peng, Y Li, W Zhao, S Yang, J Huang, Y Chen, Y Wang, Z Gong, X Chen, C Yu, S Cai, H Zhao Blockade of neutrophil extracellular traps ameliorates toluene diisocyanate-induced steroid-resistant asthma International immunopharmacology, 2023-02-22;117(0):109719. 2023-02-22 [PMID: 36827917] (IHC, Mouse)
• Julia Elrod, Moritz Lenz, Antonia Kiwit, Lina Armbrust, Lavinia Schönfeld, Konrad Reinshagen et al. Murine scald models characterize the role of neutrophils and neutrophil extracellular traps in severe burns Frontiers in Immunology 2/7/2023 [PMID: 36825027]
• K Sivaraman, S Wrenger, B Liu, D Schaudien, C Hesse, G Gomez-Mari, S Perez-Luz, K Sewald, D DeLuca, MJ Wurm, P Pino, T Welte, B Martinez-D, S Janciauski Mice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin Journal of leukocyte biology, 2023-01-10;113(1):58-70. 2023-01-10 [PMID: 36822165] (IHC, Mouse)
• Tracy W Liu, Seth T Gammon, Ping Yang, Wencai Ma, Jing Wang, David Piwnica-Worms Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma Journal for ImmunoTherapy of Cancer 2/17/2023 [PMID: 36805920]
• Min Kook Lee, Hyo Dam Kim, Suk Hee Lee, Jin Hyup Lee Curcumin Ameliorates Particulate Matter-Induced Pulmonary Injury through Bimodal Regulation of Macrophage Inflammation via NF-kappa B and Nrf2 International Journal of Molecular Sciences 1/17/2023 [PMID: 36768180]
• Briana N. James, Cynthia Weigel, Christopher D. Green, Ryan D. R. Brown, Elisa N. D. Palladino, Anuj Tharakan et al. Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice The FASEB Journal 3/1/2023 [PMID: 36753412]
• D Kucsera, VE Tóth, NV Sayour, T Kovács, TG Gergely, M Ruppert, T Radovits, A Fábián, A Kovács, B Merkely, P Ferdinandy, ZV Varga IL-1beta neutralization prevents diastolic dysfunction development, but lacks hepatoprotective effect in an aged mouse model of NASH Scientific Reports, 2023-01-07;13(1):356. 2023-01-07 [PMID: 36611037] (IHC, Mouse)
• Ali A. Zarban, Hiba Chaudhry, Davide Maselli, Xenia Kodji, Joao de Sousa Valente, Justin Joachim et al. Enhancing Techniques for Determining Inflammatory Edema Formation and Neutrophil Accumulation in Murine Skin JID Innovations 1/1/2023 [PMID: 36561914]
• Michael T. Bounajem, Frederik Denorme, John L. Rustad, Robert A. Campbell, Ramesh Grandhi Investigation of Neutrophil Extracellular Traps as Potential Mediators in the Pathogenesis of Non-Acute Subdural Hematomas: A Pilot Study Diagnostics (Basel) 11/24/2022 [PMID: 36552941]
• Morten F. Gjerstorff, Sofie Traynor, Odd L. Gammelgaard, Simone Johansen, Christina B. Pedersen, Henrik J. Ditzel et al. PDX Models: A Versatile Tool for Studying the Role of Myeloid-Derived Suppressor Cells in Breast Cancer Cancers (Basel) 12/13/2022 [PMID: 36551639]
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• J Huang, H Tao, PG Yancey, Z Leuthner, LS May-Zhang, JY Jung, Y Zhang, L Ding, V Amarnath, D Liu, S Collins, SS Davies, MF Linton Scavenging dicarbonyls with 5&#039;-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance Molecular Metabolism, 2022-12-05;67(0):101651. 2022-12-05 [PMID: 36481344] (IHC, Mouse)
• J Zeller, KS Cheung Tun, TL Nero, JD McFadyen, G Krippner, B Bogner, S Kreuzaler, J Kiefer, VK Horner, D Braig, H Danish, S Baratchi, M Fricke, X Wang, MG Kather, B Kammerer, KJ Woollard, P Sharma, CJ Morton, G Pietersz, MW Parker, K Peter, SU Eisenhardt A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein Embo Molecular Medicine, 2022-12-05;0(0):e16236. 2022-12-05 [PMID: 36468184] (ICC, Human)
• Yin Li, Qinyi Jiang, Xiaohua Zhou, Mengyuan Wu, Jian Chen, Hao Liu et al. A prospective marker for the prediction of postoperative deep venous thrombosis: Neutrophil extracellular traps Frontiers in Cell and Developmental Biology 2022-11-16 [PMID: 36467414] (Immunocytochemistry, Human)
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• GJ Pir, A Parray, R Ayadathil, SV Pananchikk, FA Mir, I Muhammad, A Abubakar, N Amir, S Hussain, KH Haroon, A Muhammad, Y Imam, SN Patro, N Akhtar, A Zakaria, S Kamran Platelet-Neutrophil Association in NETs-Rich Areas in the Retrieved AIS Patient Thrombi International Journal of Molecular Sciences, 2022-11-21;23(22):. 2022-11-21 [PMID: 36430952] (IHC, Human)
• Kentaro Nakata, Mikio Okazaki, Tomohisa Sakaue, Rie Kinoshita, Yuhei Komoda, Dai Shimizu et al. Functional Blockage of S100A8/A9 Ameliorates Ischemia–Reperfusion Injury in the Lung Bioengineering (Basel) 11/10/2022 [PMID: 36354584]
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• Lifei Hou, Richard A. Voit, Miho Shibamura-Fujiogi, Sophia Koutsogiannaki, Yunan Li, Yue Chen et al. CD11c regulates neutrophil maturation Blood Advances 4/11/2023 [PMID: 36306384]
• Hsuan-An Chen, Yu-Jui Ho, Riccardo Mezzadra, Jose M. Adrover, Ryan Smolkin, Changyu Zhu et al. Senescence rewires microenvironment sensing to facilitate anti-tumor immunity Cancer Discovery 2/6/2023 [PMID: 36302222]
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• PS Sung, YC Peng, SP Yang, CH Chiu, SL Hsieh CLEC5A is critical in Pseudomonas aeruginosa-induced acute lung injury JCI Insight, 2022-09-01;0(0):. 2022-09-01 [PMID: 36048544] (IHC, Mouse)
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• Pierre Janssen, Irene Tosi, Alexandre Hego, Pauline Maréchal, Thomas Marichal, Coraline Radermecker Neutrophil Extracellular Traps Are Found in Bronchoalveolar Lavage Fluids of Horses With Severe Asthma and Correlate With Asthma Severity Frontiers in Immunology 7/13/2022 [PMID: 35911691]
• A Gupta, K Singh, S Fatima, S Ambreen, S Zimmermann, R Younis, S Krishnan, R Rana, I Gadi, C Schwab, R Biemann, K Shahzad, V Rani, S Ali, PR Mertens, S Kohli, B Isermann Neutrophil Extracellular Traps Promote NLRP3 Inflammasome Activation and Glomerular Endothelial Dysfunction in Diabetic Kidney Disease Nutrients, 2022-07-20;14(14):. 2022-07-20 [PMID: 35889923] (IHC, Mouse)
• W Chen, B Li, F Jia, J Li, H Huang, C Ni, W Xia High PANX1 Expression Leads to Neutrophil Recruitment and the Formation of a High Adenosine Immunosuppressive Tumor Microenvironment in Basal-like Breast Cancer Cancers, 2022-07-11;14(14):. 2022-07-11 [PMID: 35884429] (IHC, Human)
• N Caporarell, J Lee, TX Pham, DL Jones, J Guan, PA Link, JA Meridew, G Marden, T Yamashita, CA Osborne, AV Bhagwate, SK Huang, RF Nicosia, DJ Tschumperl, M Trojanowsk, G Ligresti Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis Nature Communications, 2022-07-25;13(1):4170. 2022-07-25 [PMID: 35879310] (IHC, Mouse)
• Sung PS, Yang SP, Peng YC et al. CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation Journal of biomedical science 7/11/2022 [PMID: 35820906]
• NPK Le, AF do Nascime, D Schneberge, CC Quach, X Zhang, GK Aulakh, W Dawicki, L Liu, JR Gordon, B Singh Deficiency of leukocyte-specific protein 1 (LSP1) alleviates asthmatic inflammation in a mouse model Respiratory Research, 2022-06-22;23(1):165. 2022-06-22 [PMID: 35733161] (IHC, Mouse)
• D Ye, J Yao, W Du, C Chen, Y Yang, K Yan, J Li, Y Xu, S Zang, Y Zhang, X Rong, R Zhang, A Xu, J Guo Neutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/neutrophil Elastase Signaling in Mice Cellular and Molecular Gastroenterology and Hepatology, 2022-06-02;0(0):. 2022-06-02 [PMID: 35660025] (ICC, IHC, Western Blot, Mouse)
• C Arnholdt, K Kumaraswam, P Götz, M Kübler, M Lasch, E Deindl Depletion of gammadelta T Cells Leads to Reduced Angiogenesis and Increased Infiltration of Inflammatory M1-like Macrophages in Ischemic Muscle Tissue Cells, 2022-04-29;11(9):. 2022-04-29 [PMID: 35563796] (IHC, Mouse)
• Vijay M M. Ravindra, Frederik Denorme, Matthew D. Alexander, Robert A. Campbell, Ramesh Grandhi Endovascular mechanical thrombectomy in a child with COVID-19: Clot analysis reveals a novel pathway in the neuroinflammatory cascade resulting in large-vessel occlusion Interv Neuroradiol 4/21/2022 [PMID: 35450459]
• Jiang S, Chan CN, Rovira-ClavE X et al. Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments Immunity 4/12/2022 [PMID: 35447093]
• Paolo Carai, Laura Florit Florit González, Stijn Van Bruggen, Valerie Spalart, Daria De Giorgio, Nadéche Geuens et al. Neutrophil inhibition improves acute inflammation in a murine model of viral myocarditis Cardiovascular Research 1/18/2023 [PMID: 35426438]
• Frederik Denorme, Irina Portier, John L. Rustad, Mark J. Cody, Claudia V. de Araujo, Chieko Hoki et al. Neutrophil extracellular traps regulate ischemic stroke brain injury Journal of Clinical Investigation 2022-05-16 [PMID: 35358095] (Immunohistochemistry, Human, Mouse)
• Frederik Denorme, Irina Portier, John L. Rustad, Mark J. Cody, Claudia V. de Araujo, Chieko Hoki et al. Neutrophil extracellular traps regulate ischemic stroke brain injury Journal of Clinical Investigation 5/16/2022 [PMID: 35358095]
• Anthony C. Y. Yau, Maria Ascencion Globisch, Favour Chinyere Onyeogaziri, Lei L. Conze, Ross Smith, Suvi Jauhiainen et al. Inflammation and neutrophil extracellular traps in cerebral cavernous malformation Cellular and Molecular Life Sciences 4/1/2022 [PMID: 35333979]
• Kenji Namiguchi, Tomohisa Sakaue, Mikio Okazaki, Kaho Kanno, Yuhei Komoda, Fumiaki Shikata et al. Unique Angiogenesis From Cardiac Arterioles During Pericardial Adhesion Formation Frontiers in Cardiovascular Medicine 2/3/2022 [PMID: 35187100]
• H Wang, DJ Tumes, TR Hercus, KH Yip, C Aloe, R Vlahos, AF Lopez, N Wilson, CM Owczarek, S Bozinovski Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models Cell Death & Disease, 2022-02-10;13(2):137. 2022-02-10 [PMID: 35145069] (IHC, Mouse)
• JM Adrover, L Carrau, J Da beta ler-Ple, Y Bram, V Chandar, S Houghton, D Redmond, JR Merrill, M Shevik, BR tenOever, SK Lyons, RE Schwartz, M Egeblad Disulfiram inhibits neutrophil extracellular trap formation protecting rodents from acute lung injury and SARS-CoV-2 infection JCI Insight, 2022-03-08;0(0):. 2022-03-08 [PMID: 35133984] (IHC, Hamster)
• C Conrad, D Yildiz, SJ Cleary, A Margraf, L Cook, U Schlomann, B Panaretou, JL Bowser, H Karmouty-Q, J Li, NK Berg, SC Martin, A Aljohmani, SF Moussavi-H, KM Wang, JJ Tian, M Magnen, C Valet, L Qiu, JP Singer, HK Eltzschig, CAPSys Stu, W Bertrams, S Herold, N Suttorp, B Schmeck, ZT Ball, A Zarbock, MR Looney, JW Bartsch ADAM8 signaling drives neutrophil migration and ARDS severity JCI Insight, 2022-02-08;7(3):. 2022-02-08 [PMID: 35132956] (IHC, Mouse)
• Verena Staedtke, Tyler Gray-Bethke, Guanshu Liu, Eleni Liapi, Gregory J Riggins, Ren-Yuan Bai Neutrophil depletion enhanced the Clostridium novyi-NT therapy in mouse and rabbit tumor models Neuro-Oncology Advances 2/4/2022 [PMID: 35118381]
• Yasuyuki Fujii, Nelson Monteiro, Shyam Kishor Sah, Homan Javaheri, Yasuyoshi Ueki, Zhichao Fan et al. Tlr2/4‐Mediated Hyperinflammation Promotes Cherubism‐Like Jawbone Expansion in Sh3bp2 (P416R) Knockin Mice JBMR Plus 1/1/2022 [PMID: 35079675]
• Renata Finelli, Sara Darbandi, Peter Natesan Pushparaj, Ralf Henkel, Edmund Ko, Ashok Agarwal In Silico Sperm Proteome Analysis to Investigate DNA Repair Mechanisms in Varicocele Patients Front Endocrinol (Lausanne) 12/17/2021 [PMID: 34975746]
• KC Ngamsri, RA Putri, C Jans, K Schindler, A Fuhr, Y Zhang, J Gamper-Tsi, S Ehnert, FM Konrad CXCR4 and CXCR7 Inhibition Ameliorates the Formation of Platelet-Neutrophil Complexes and Neutrophil Extracellular Traps through Adora2b Signaling International Journal of Molecular Sciences, 2021-12-17;22(24):. 2021-12-17 [PMID: 34948374] (ICC, Human)
• Ruhela D, Bhopale VM, Kalakonda S et al. Astrocyte-derived microparticles initiate a neuroinflammatory cycle due to carbon monoxide poisoning Brain Behav Immun Health 12/1/2021 [PMID: 34917988]
• W Cao, MY Zhu, SH Lee, SB Lee, HJ Kim, BO Park, CH Yoon, D Khadka, GS Oh, H Shim, TH Kwak, HS So Modulation of Cellular NAD+ Attenuates Cancer-Associated Hypercoagulability and Thrombosis via the Inhibition of Tissue Factor and Formation of Neutrophil Extracellular Traps International Journal of Molecular Sciences, 2021-11-08;22(21):. 2021-11-08 [PMID: 34769515] (IHC, Mouse)
• Matthias Kübler, Philipp Götz, Anna Braumandl, Sebastian Beck, Hellen Ishikawa-Ankerhold, Elisabeth Deindl Impact of C57BL/6J and SV-129 Mouse Strain Differences on Ischemia-Induced Postnatal Angiogenesis and the Associated Leukocyte Infiltration in a Murine Hindlimb Model of Ischemia International Journal of Molecular Sciences 10/30/2021 [PMID: 34769229]
• R. Stalder, N. Brembilla, C. Conrad, N. Yawalkar, A. Navarini, W H Boehncke et al. Interleukin-17E, inducible nitric oxide synthase and arginase1 as new biomarkers in the identification of neutrophilic dermatoses Clin Exp Dermatol 12/17/2021 [PMID: 34669971]
• Y Lu, Y Huang, J Li, J Huang, L Zhang, J Feng, J Li, Q Xia, Q Zhao, L Huang, S Jiang, S Su Eosinophil extracellular traps drive asthma progression through neuro-immune signals Nature Cell Biology, 2021-10-06;23(10):1060-1072. 2021-10-06 [PMID: 34616019] (ICC, Mouse)
• F Harnischfe, F O'Connell, M Weiss, B Axelrod, A Hajnal, K Czaja, PM Di Lorenzo, R Dando Sprague Dawley Rats Gaining Weight on a High Energy Diet Exhibit Damage to Taste Tissue Even after Return to a Healthy Diet Nutrients, 2021-08-31;13(9):. 2021-08-31 [PMID: 34578940] (IHC, Rat)
• Takuto Tokuhiro, Akane Ishikawa, Haruka Sato, Shunya Takita, Ayuri Yoshikawa, Ryoko Anzai et al. Oxidized Phospholipids and Neutrophil Elastase Coordinately Play Critical Roles in NET Formation Frontiers in Cell and Developmental Biology 9/9/2021 [PMID: 34568331]
• Matthias Kübler, Sebastian Beck, Lisa Lilian Peffenköver, Philipp Götz, Hellen Ishikawa-Ankerhold, Klaus T. Preissner et al. The Absence of Extracellular Cold-Inducible RNA-Binding Protein (eCIRP) Promotes Pro-Angiogenic Microenvironmental Conditions and Angiogenesis in Muscle Tissue Ischemia International Journal of Molecular Sciences 2021-08-31 [PMID: 34502391] (Immunohistochemistry, Mouse)
• Matthias Kübler, Sebastian Beck, Lisa Lilian Peffenköver, Philipp Götz, Hellen Ishikawa-Ankerhold, Klaus T. Preissner et al. The Absence of Extracellular Cold-Inducible RNA-Binding Protein (eCIRP) Promotes Pro-Angiogenic Microenvironmental Conditions and Angiogenesis in Muscle Tissue Ischemia International Journal of Molecular Sciences 8/31/2021 [PMID: 34502391]
• Julien Stackowicz, Nicolas Gaudenzio, Nadine Serhan, Eva Conde, Ophélie Godon, Thomas Marichal et al. Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome Journal of Experimental Medicine 2021-10-04 [PMID: 34477811] (Immunohistochemistry, Mouse)
• Julien Stackowicz, Nicolas Gaudenzio, Nadine Serhan, Eva Conde, Ophélie Godon, Thomas Marichal et al. Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome Journal of Experimental Medicine 10/4/2021 [PMID: 34477811]
• S Arandjelov, JSA Perry, M Zhou, A Ceroi, I Smirnov, SF Walk, LS Shankman, I Cambré, S Onengut-Gu, D Elewaut, TP Conrads, KS Ravichandr ELMO1 signaling is a promoter of osteoclast function and bone loss Nature Communications, 2021-08-17;12(1):4974. 2021-08-17 [PMID: 34404802] (Western Blot, Mouse)
• Rainer Kaiser, Alexander Leunig, Kami Pekayvaz, Oliver Popp, Markus Joppich, Vivien Polewka et al. Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19 JCI Insight 9/22/2021 [PMID: 34403366]
• D Dora, S Ferenczi, R Stavely, VE Toth, ZV Varga, T Kovacs, I Bodi, R Hotta, KJ Kovacs, AM Goldstein, N Nagy Evidence of a Myenteric Plexus Barrier and Its Macrophage-Dependent Degradation During Murine Colitis: Implications in Enteric Neuroinflammation Cellular and Molecular Gastroenterology and Hepatology, 2021-07-08;0(0):. 2021-07-08 [PMID: 34246810] (IHC, Mouse)
• Jenying Deng, Yaan Kang, Chien-Chia Cheng, Xinqun Li, Bingbing Dai, Matthew H. Katz et al. DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis JCI Insight 9/8/2021 [PMID: 34237033]
• Amanda Vannitamby, Mohamed I. Saad, Christian Aloe, Hao Wang, Beena Kumar, Ross Vlahos et al. Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model Cancers (Basel) 6/28/2021 [PMID: 34203378]
• N Belforte, J Agostinone, L Alarcon-Ma, D Villafranc, F Dotigny, JL Cueva Varg, A Di Polo AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma Molecular Neurodegeneration, 2021-06-29;16(1):43. 2021-06-29 [PMID: 34187514] (IHC, Mouse)
• Takumi Shibuya, Asami Kamiyama, Hirotaka Sawada, Kenta Kikuchi, Mayu Maruyama, Rie Sawado et al. Immunoregulatory Monocyte Subset Promotes Metastasis Associated With Therapeutic Intervention for Primary Tumor Frontiers in Immunology 6/7/2021 [PMID: 34163472]
• Philipp Götz, Anna Braumandl, Matthias Kübler, Konda Kumaraswami, Hellen Ishikawa-Ankerhold, Manuel Lasch et al. C3 Deficiency Leads to Increased Angiogenesis and Elevated Pro-Angiogenic Leukocyte Recruitment in Ischemic Muscle Tissue International Journal of Molecular Sciences 5/28/2021 [PMID: 34071589]
• R Surolia, FJ Li, Z Wang, M Kashyap, RK Srivastava, AM Traylor, P Singh, KG Dsouza, H Kim, JF Pittet, JW Zmijewski, A Agarwal, M Athar, A Ahmad, VB Antony NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns JCI Insight, 2021-05-24;6(10):. 2021-05-24 [PMID: 34027893] (ICC, Human)
• M Kübler, S Beck, S Fischer, P Götz, K Kumaraswam, H Ishikawa-A, M Lasch, E Deindl Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization Biomedicines, 2021-04-07;9(4):. 2021-04-07 [PMID: 33916904] (IHC, Mouse)
• Dániel Kucsera, Viktória E. Tóth, Dorottya Gergő, Imre Vörös, Zsófia Onódi, Anikó Görbe et al. Characterization of the CDAA Diet-Induced Non-alcoholic Steatohepatitis Model: Sex-Specific Differences in Inflammation, Fibrosis, and Cholesterol Metabolism in Middle-Aged Mice Frontiers in Physiology 2/22/2021 [PMID: 33692700]
• L Klemke, T De Oliveir, D Witt, N Winkler, H Bohnenberg, R Bucala, LC Conradi, R Schulz-Hed Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer Cell Death & Disease, 2021-02-04;12(2):155. 2021-02-04 [PMID: 33542244] (IHC, Mouse)
• R Mehling, J Schwenck, C Lemberg, C Trautwein, L Zizmare, D Kramer, A Müller, B Fehrenbach, I Gonzalez-M, L Quintanill, K Schröder, RP Brandes, M Schaller, W Ruf, M Eichner, K Ghoreschi, M Röcken, BJ Pichler, M Kneilling Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions Theranostics, 2021-01-01;11(2):470-490. 2021-01-01 [PMID: 33391487] (IHC, Mouse)
• MJ Thomas, E Major, A Benedek, I Horváth, D Máthé, R Bergmann, AM Szász, T Krenács, Z Benyó Suppression of Metastatic Melanoma Growth in Lung by Modulated Electro-Hyperthermia Monitored by a Minimally Invasive Heat Stress Testing Approach in Mice Cancers, 2020-12-21;12(12):. 2020-12-21 [PMID: 33371498] (IHC, Mouse)
• Manuel Lasch, Konda Kumaraswami, Simona Nasiscionyte, Susanna Kircher, Dominic van den Heuvel, Sarah Meister et al. RNase A Treatment Interferes With Leukocyte Recruitment, Neutrophil Extracellular Trap Formation, and Angiogenesis in Ischemic Muscle Tissue Frontiers in Physiology 11/6/2020 [PMID: 33240100]
• Kerber, E L, Padberg, C Et al. The Importance of Hypoxia-Inducible Factors (HIF-1 and HIF-2) for the Pathophysiology of Inflammatory Bowel Disease. Int J Mol Sci 11/13/2020 [PMID: 33202783]
• L Moreira-Te, PJ Stimpson, E Stavropoul, S Hadebe, P Chakravart, M Ioannou, IV Aramburu, E Herbert, SL Priestnall, A Suarez-Bon, J Sousa, KL Fonseca, Q Wang, S Vashakidze, P Rodríguez-, C Vilaplana, M Saraiva, V Papayannop, A O'Garra Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis Nat Commun, 2020-11-04;11(1):5566. 2020-11-04 [PMID: 33149141] (ICC, Mouse)
• F Essig, AM Kollikowsk, M Pham, L Solymosi, G Stoll, KG Haeusler, P Kraft, MK Schuhmann Immunohistological Analysis of Neutrophils and Neutrophil Extracellular Traps in Human Thrombemboli Causing Acute Ischemic Stroke Int J Mol Sci, 2020-10-07;21(19):. 2020-10-07 [PMID: 33036337] (IHC, Human)
• WJ Ouwendijk, HJ van den Ha, MW Delany, JJ van Kampen, GP van Nierop, T Mehraban, F Zaaraoui-B, WF van IJcken, JM van den Br, RD De Vries, AC Andeweg, GM Verjans Alveolar barrier disruption in varicella pneumonia is associated with neutrophil extracellular trap formation JCI Insight, 2020-11-05;0(0):. 2020-11-05 [PMID: 33021967] (IHC, Primate)
• Verena Peek, Elena Neumann, Tomohiro Inoue, Sandy Koenig, Fabian Johannes Pflieger, Rüdiger Gerstberger et al. Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists Frontiers in Immunology 2020-08-19 [PMID: 32973755] (Immunohistochemistry, Rat)
• Verena Peek, Elena Neumann, Tomohiro Inoue, Sandy Koenig, Fabian Johannes Pflieger, Rüdiger Gerstberger et al. Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists Frontiers in Immunology 8/19/2020 [PMID: 32973755]
• Coraline Radermecker, Nancy Detrembleur, Julien Guiot, Etienne Cavalier, Monique Henket, Céline d’Emal et al. Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19 Journal of Experimental Medicine 12/7/2020 [PMID: 32926097]
• S Taylor, M Whitfield, J Barratt, A Didangelos The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix J. Immunol., 2020-09-11;0(0):. 2020-09-11 [PMID: 32917786] (IHC, Western Blot, Human, Rat)
• EY Lin, HJ Lai, YK Cheng, KQ Leong, LC Cheng, YC Chou, YC Peng, YH Hsu, HS Chiang Neutrophil Extracellular Traps Impair Intestinal Barrier Function during Experimental Colitis Biomedicines, 2020-08-05;8(8):. 2020-08-05 [PMID: 32764411] (ELISA Capture, IHC, Mouse)
• Leo Nicolai, Alexander Leunig, Sophia Brambs, Rainer Kaiser, Tobias Weinberger, Michael Weigand et al. Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy Circulation 9/22/2020 [PMID: 32755393]
• K Vaibhav, M Braun, K Alverson, H Khodadadi, A Kutiyanawa, A Ward, C Banerjee, T Sparks, A Malik, MH Rashid, MB Khan, MF Waters, DC Hess, AS Arbab, JR Vender, N Hoda, B Baban, KM Dhandapani Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury Sci Adv, 2020-05-29;6(22):eaax8847. 2020-05-29 [PMID: 32523980] (ICC, Mouse)
• TD Tsouroukts, A Warnatsch, M Ioannou, D Hoving, Q Wang, V Papayannop Histones, DNA, and Citrullination Promote Neutrophil Extracellular Trap Inflammation by Regulating the Localization and Activation of TLR4 Cell Rep, 2020-05-05;31(5):107602. 2020-05-05 [PMID: 32375035] (Western Blot, Human, Mouse)
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Reviews for Myeloperoxidase/MPO Antibody (AF3667) (3)

Average Rating: 4.7

(Based on 3 reviews)

We have 3 reviews tested in 2 species: Human, Rabbit.

reviewed by: Aida Meghraoui Imaging Mass Cytometry Human 10/05/2020

Summary

• Application: Other
• Sample Tested: FFPE
• Species: Human
• Lot: YBZ0319051

reviewed by: Verified Customer Immunofluorescence - paraffin Human 04/12/2019

Summary

• Application: Other
• Sample Tested: human tonsil
• Species: Human
• Lot: I don't have it any more

Comments

• Comments: pH9 antigen retrieval

reviewed by: Verified Customer IHC-P Rabbit 01/11/2017

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: Small intestine
• Species: Rabbit
• Lot: YBZ0216021

Comments

• Comments: We have tested the antibody for use in rabbit.
  PFA-fixed ileum embedded in paraffin was used, sections were 7 micrometer thick. Details about antigen retrieval are available upon request and outlined in the attached image.
  We also performed WB analysis with these rabbit samples. Image available upon request.
  Before trying with rabbit, we used samples from mouse (previously tested species) to confirm that the antibody is working in our hands. Details available upon request.
  Please don't hesitte to contact us in case of questions.
  We woud like to participate in the Innovator Reward. Thanks.

Bioinformatics

• Gene Symbol: MPO
• Uniprot:
  • P11247(Mouse)