Mouse Neutrophil Elastase/ELA2 DuoSet ELISA, 5 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Neutrophil Elastase/ELA2 DuoSet ELISA, 5 Plate Summary

• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Elane

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Neutrophil Elastase/ELA2 DuoSet ELISA, 5 Plate

• Bone marrow serine protease
• EC 3.4.21
• EC 3.4.21.37
• ELA2
• ELA2granulocyte-derived elastase
• ELANE
• elastase 2, neutrophil
• elastase, neutrophil expressed
• Elastase-2
• GE
• HLEelastase-2
• HNE
• Human leukocyte elastase
• Leukocyte Elastase
• Medullasin
• NE
• Neutrophil Elastase
• PMN elastase
• PMN-E
• polymorphonuclear elastase
• SCN1

Background

Neutrophil Elastase (ELA2), also known as polymorphonuclear leukocyte elastase, is a serine protease belonging to the chymotrypsin family. Located primarily in the azurophil granules of polymorphonuclear leukocytes, ELA2 function results in the degradation of many extracellular matrix macromolecules. Alpha-1 Antitrypsin (Serpin A1) and secretory leukocyte protease inhibitor (SLPI) have been shown to inhibit ELA2 activity. ELA2 may be involved in lung emphysema, cystic fibrosis, the adult respiratory distress syndrome (ARDS), rheumatoid arthritis, tumor invasion and infectious diseases.

Publications for Neutrophil Elastase/ELA2 (DY4517-05)(12)

Publications using DY4517-05

• P Kumar, A Mittal, P Bansal, S Aggarwal, RK Rajnish, A Dadra, S Sharma Wound alpha defensin levels are significantly higher in patients with fracture related infection: A pilot, prospective cohort study Injury, 2022;0(0):. 2022 [PMID: 36567156] (Human)
• RA Keogh, AL Haeberle, CJ Langouët-A, JS Kavanaugh, EP Schmidt, GD Moore, AR Horswill, KS Doran Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment Science Advances, 2022;8(45):eadd3221. 2022 [PMID: 36367946] (Mouse)
• A Gupta, K Singh, S Fatima, S Ambreen, S Zimmermann, R Younis, S Krishnan, R Rana, I Gadi, C Schwab, R Biemann, K Shahzad, V Rani, S Ali, PR Mertens, S Kohli, B Isermann Neutrophil Extracellular Traps Promote NLRP3 Inflammasome Activation and Glomerular Endothelial Dysfunction in Diabetic Kidney Disease Nutrients, 2022;14(14):. 2022 [PMID: 35889923] (Mouse)
• KC Ngamsri, RA Putri, C Jans, K Schindler, A Fuhr, Y Zhang, J Gamper-Tsi, S Ehnert, FM Konrad CXCR4 and CXCR7 Inhibition Ameliorates the Formation of Platelet-Neutrophil Complexes and Neutrophil Extracellular Traps through Adora2b Signaling International Journal of Molecular Sciences, 2021;22(24):. 2021 [PMID: 34948374] (Mouse)
• P Saha, BS Yeoh, X Xiao, RM Golonka, V Singh, Y Wang, M Vijay-Kuma PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium Mucosal Immunol, 2019;0(0):. 2019 [PMID: 30710097] (Mouse)
• S Aggarwal, I Ahmad, A Lam, MA Carlisle, C Li, JM Wells, SV Raju, M Athar, SM Rowe, MT Dransfield, S Matalon Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema JCI Insight, 2018;3(21):. 2018 [PMID: 30385726] (Mouse)
• S Al-Salam, S Hashmi Myocardial Ischemia Reperfusion Injury: Apoptotic, Inflammatory and Oxidative Stress Role of Galectin-3 Cell. Physiol. Biochem., 2018;50(3):1123-1139. 2018 [PMID: 30355930] (Mouse)
• P Ochieng, S Nath, R Macarulay, E Eden, A Dabo, M Campos, XC Jiang, RF Foronjy, P Geraghty Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation Sci Rep, 2018;8(1):15394. 2018 [PMID: 30337619] (Mouse)
• X Xiao, P Saha, BS Yeoh, JA Hipp, V Singh, M Vijay-Kuma Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects J. Nutr. Biochem., 2018;62(0):28-34. 2018 [PMID: 30218980] (Mouse)
• G Wen, W An, J Chen, EM Maguire, Q Chen, F Yang, SWA Pearce, M Kyriakides, L Zhang, S Ye, S Nourshargh, Q Xiao Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis J Am Heart Assoc, 2018;7(4):. 2018 [PMID: 29437605] (Mouse)
• A Bao, KF Che, S Bozinovski, J Ji, JA Gregory, S Kumlien Ge, M Adner, LO Cardell, A Lindén Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo PLoS ONE, 2017;12(12):e0188909. 2017 [PMID: 29206862] (Mouse)
• XS Ren, L Ling, B Zhou, Y Han, YB Zhou, Q Chen, YH Li, YM Kang, GQ Zhu Silencing salusin-? attenuates cardiovascular remodeling and hypertension in spontaneously hypertensive rats Sci Rep, 2017;7(0):43259. 2017 [PMID: 28230187] (Rat)

Bioinformatics

• Gene Symbol: Elane