MMP-2 Antibody (2C1) [Biotin] Summary
Activated recombinant human MMP2. [UniProt# P08253]
This is specific for pro and active MMP-2.
Protein G purified
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- Western Blot
This MMP2 (2C1) antibody is useful for ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry on frozen sections, Immunoprecipitation and Western Blot. This antibody is not recommended for Immunohistochemistry on paraffin sections.
Packaging, Storage & Formulations
Store at 4C in the dark.
0.05% Sodium Azide
Protein G purified
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Alternate Names for MMP-2 Antibody (2C1) [Biotin]
- 72 kDa gelatinase
- CLG4A72 kDa type IV collagenase
- collagenase type IV-A
- EC 3.4.24
- EC 184.108.40.206
- Gelatinase A
- matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)
- matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IVcollagenase)
- Matrix metalloproteinase-2
- matrix metalloproteinase-II
- neutrophil gelatinase
- TBE-1matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)
Loss of negative growth regulation and high invasive potential are neoplastic traits often associated with abnormal expression of matrix matalloproteinases. MMP-2, a protein involved in the signaling mechanism for cells to begin migration, triggers the movement when it splits laminin-5 and exposes and integrin-binding site on this component of epithelial basement membrane. The changed form of laminin was found in tumors and in tissues being altered. The activated form of MMP2, however, is not found in benign tumors. Thus, detection of the enzyme is a possible early indicator of tumor activity.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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