Human Pro-MMP-13 Quantikine ELISA Kit



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Reactivity HuSpecies Glossary
Applications ELISA

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Human Pro-MMP-13 Quantikine ELISA Kit Summary

The Quantikine Human Pro-MMP-13 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure pro-MMP-13 in cell culture supernates. It contains NS0-expressed recombinant human pro-MMP-13 and antibodies raised against the recombinant factor. The Quantikine kit will not detect recombinant human active MMP-13 existing in either free or TIMP-bound form. Natural human pro-MMP-13 showed dose-re...sponse curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards, indicating that this kit can be used to determine relative levels of natural human pro-MMP-13.
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Natural and recombinant human pro-MMP-13
Assay Type
Solid Phase Sandwich ELISA
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details


Application Notes
No significant interference observed with available related molecules.
Read Publications using DM1300.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Pro-MMP-13 Quantikine ELISA Kit

  • CLG 3
  • CLG3EC 3.4.24
  • collagenase 3
  • EC 3.4.24.-
  • EC
  • EC
  • EC
  • EC
  • EC
  • MANDP1
  • matrix metallopeptidase 13 (collagenase 3)
  • matrix metalloproteinase 13 (collagenase 3)
  • Matrix metalloproteinase-13
  • MMP13
  • MMP-13


The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to

Publications for MMP-13 (DM1300)(31)

We have publications tested in 2 confirmed species: Human, Guinea Pig.

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Showing Publications 1 - 10 of 31. Show All 31 Publications.
Publications using DM1300 Applications Species
T Hopkins, KT Wright, NJ Kuiper, S Roberts, P Jermin, P Gallacher, JH Kuiper An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans Cells, 2021;10(8):. 2021 [PMID: 34440671] (Human) Human
CS Kuo, JS Chen, LY Lin, GW Schmid-Sch, S Chien, PH Huang, JW Chen, SJ Lin Inhibition of Serine Protease Activity Protects Against High Fat Diet-Induced Inflammation and Insulin Resistance Sci Rep, 2020;10(1):1725. 2020 [PMID: 32015418] (Human) Human
A Wehrle, TM Witkos, S Unger, J Schneider, JA Follit, J Hermann, T Welting, V Fano, M Hietala, N Vatanavich, K Schoner, J Spranger, M Schmidts, B Zabel, GJ Pazour, A Bloch-Zupa, G Nishimura, A Superti-Fu, M Lowe, E Lausch Hypomorphic mutations of TRIP11 cause odontochondrodysplasia JCI Insight, 2019;4(3):. 2019 [PMID: 30728324] (Human) Human
NP Thomas, WJ Wu, BC Fleming, F Wei, Q Chen, L Wei Synovial inflammation plays a greater role in post-traumatic osteoarthritis compared to idiopathic osteoarthritis in the Hartley guinea pig knee BMC Musculoskelet Disord, 2017;18(1):556. 2017 [PMID: 29284451] (Guinea Pig) Guinea Pig
Y Yuan, H Tan, P Dai Kr�ppel-Like Factor 2 Regulates Degradation of Type II Collagen by Suppressing the Expression of Matrix Metalloproteinase (MMP)-13 Cell. Physiol. Biochem., 2017;42(6):2159-2168. 2017 [PMID: 28873368] (Human) Human
Z Liu, C Li, X Meng, Y Bai, J Qi, J Wang, Q Zhou, W Zhang, X Zhang Hypoxia-inducible factor-l? mediates aggrecan and collagen ? expression via NOTCH1 signaling in nucleus pulposus cells during intervertebral disc degeneration Biochem. Biophys. Res. Commun., 2017;0(0):. 2017 [PMID: 28526405] (Human) Human
Q Zhang, Q Luo, X Yuan, L Chai, D Li, J Liu, Z Lv Atmospheric particulate matter2.5 promotes the migration and invasion of hepatocellular carcinoma cells Oncol Lett, 2017;13(5):3445-3450. 2017 [PMID: 28521450] (Human) Human
Galectin-3 Induces a Pro-degradative/inflammatory Gene Signature in Human Chondrocytes, Teaming Up with Galectin-1 in Osteoarthritis Pathogenesis Sci Rep, 2016;6(0):39112. 2016 [PMID: 27982117] (Human) Human
Kostopoulou F, Gkretsi V, Malizos KN, Iliopoulos D, Oikonomou P, Poultsides L, Tsezou A Central role of SREBP-2 in the pathogenesis of osteoarthritis. PLoS ONE, 2012;7(5):e35753. 2012 [PMID: 22662110] (Human) Human
Wang JH, Shih KS, Liou JP, Wu YW, Chang AS, Wang KL, Tsai CL, Yang CR Anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model. PLoS ONE, 2012;7(2):e31368. 2012 [PMID: 22359588] (Human) Human
Show All 31 Publications.

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Product General Protocols

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FAQs for MMP-13 (DM1300). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP DM1300
HRP DM1300
HRP DM1300

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Gene Symbol MMP13