Human Total MMP-7 Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Human Total MMP-7 Quantikine ELISA Kit Summary

Background
The Quantikine Human MMP-7 Immunoassay is a 4.5 hour solid phase ELISA designed to measure MMP-7 in cell culture supernates, serum, plasma, saliva, and urine. It contains NS0-expressed recombinant human MMP-7 and antibodies raised against the recombinant factor. The Quantikine kit detected both pro- and active forms of recombinant human MMP-7. Natural human MMP-7 showed dose-response curves ...that were parallel to the standard curves obtained using the kit standards, indicating that this kit can be used to determine relative levels of natural human MMP-7.
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Specificity
Natural and recombinant human MMP-7
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
MMP7

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DMP700.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Total MMP-7 Quantikine ELISA Kit

  • EC 3.4.24
  • EC 3.4.24.23
  • Matrilysin
  • matrin
  • matrix metallopeptidase 7 (matrilysin, uterine)
  • matrix metalloproteinase 7 (matrilysin, uterine)
  • Matrix metalloproteinase-7
  • MMP7
  • MMP-7
  • MPSL1
  • Pump-1 protease
  • PUMP1
  • PUMP-1
  • uterine matrilysin
  • Uterine metalloproteinase

Background

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for MMP-7 (DMP700)(31)

We have publications tested in 2 confirmed species: Human, Rabbit.


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Human
(28)
Rabbit
(1)
All Species
Showing Publications 1 - 10 of 31. Show All 31 Publications.
Publications using DMP700 Applications Species
L Chavez-Gal, A Ruiz, K Martinez-E, H Aguilar-Du, M Torres, R Falfan-Val, G Pérez-Rubi, M Selman, I Buendia-Ro Circulating Levels of PD-L1, TIM-3 and MMP-7 Are Promising Biomarkers to Differentiate COVID-19 Patients That Require Invasive Mechanical Ventilation Biomolecules, 2022;12(3):. 2022 [PMID: 35327637] (Human) Human
PT Kovács, T Mayer, A Csizmarik, M Váradi, C Oláh, Á Széles, S Tschirdewa, U Krafft, B Hadaschik, P Nyirády, P Riesz, T Szarvas Elevated Pre-Treatment Serum MMP-7 Levels Are Associated with the Presence of Metastasis and Poor Survival in Upper Tract Urothelial Carcinoma Biomedicines, 2022;10(3):. 2022 [PMID: 35327500] (Human) Human
S Ancona, E Orpianesi, C Bernardell, E Chiaramont, R Chiaramont, S Terraneo, F Di Marco, E Lesma Differential Modulation of Matrix Metalloproteinases-2 and -7 in LAM/TSC Cells Biomedicines, 2021;9(12):. 2021 [PMID: 34944575] (Human) Human
TV Tellman, LA Cruz, BJ Grindel, MC Farach-Car Cleavage of the Perlecan-Semaphorin 3A-Plexin A1-Neuropilin-1 (PSPN) Complex by Matrix Metalloproteinase 7/Matrilysin Triggers Prostate Cancer Cell Dyscohesion and Migration International Journal of Molecular Sciences, 2021;22(6):. 2021 [PMID: 33809984] (Human) Human
F Fang, W Luo, M Yang, P Yang, X Yang Urinary Matrix Metalloproteinase-7 and Prediction of AKI Progression Post Cardiac Surgery Dis. Markers, 2019;2019(0):9217571. 2019 [PMID: 31827648] (Human) Human
I Buendia-Ro, N Machuca, M Mejía, M Maldonado, A Pardo, M Selman Lower levels of α-Klotho in serum are associated with decreased lung function in individuals with interstitial lung abnormalities Sci Rep, 2019;9(1):10801. 2019 [PMID: 31346213] (Human) Human
JN Justice, AM Nambiar, T Tchkonia, NK LeBrasseur, R Pascual, SK Hashmi, L Prata, MM Masternak, SB Kritchevsk, N Musi, JL Kirkland Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study EBioMedicine, 2019;0(0):. 2019 [PMID: 30616998] (Human) Human
J Zhang, P Ren, Y Wang, S Feng, C Wang, X Shen, C Weng, X Lang, Z Chen, H Jiang, J Chen Serum Matrix Metalloproteinase-7 Level is Associated with Fibrosis and Renal Survival in Patients with IgA Nephropathy Kidney Blood Press. Res., 2017;42(3):541-552. 2017 [PMID: 28922659] (Human) Human
FA Piedra, M Mei, V Avadhanula, R Mehta, L Aideyan, RP Garofalo, PA Piedra The interdependencies of viral load, the innate immune response, and clinical outcome in children presenting to the emergency department with respiratory syncytial virus-associated bronchiolitis PLoS ONE, 2017;12(3):e0172953. 2017 [PMID: 28267794] (Human) Human
Anna Lundmark Mucin 4 and matrix metalloproteinase 7 as novel salivary biomarkers for periodontitis J. Clin. Periodontol, 2016;0(0):. 2016 [PMID: 28005264] (Human) Human
Show All 31 Publications.

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Bioinformatics Tool for MMP-7 (DMP700)

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Blogs on MMP-7.

Toll-like receptors in the intestinal epithelial cells
By Jamshed Arslan, Pharm. D., PhD. Toll-like receptors (TLRs) are microbe-sensing proteins that act as first responders to danger signals. TLRs help the intestinal epithelial cells (IECs) recognize commensal bacteria ...  Read full blog post.

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Bioinformatics

Gene Symbol MMP7