Human MMP-9 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human MMP-9 Quantikine ELISA Kit Summary

• Background: The Quantikine Human MMP-9 Immunoassay is a 3.5 hour solid phase ELISA designed to measure MMP-9 (92 kDa pro- and 82 kDa active forms but not the 65 kDa form) in cell culture supernates, saliva, serum, plasma, and urine. It is calibrated with CHO cell-expressed recombinant human pro-MMP-9 and the antibodies were raised against the recombinant factor. Natural human MMP-9 showed dose-response ...curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards, indicating that this kit can be used to determine relative mass values of natural human MMP-9.
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• Specificity: Natural and recombinant human 92 kDa Pro-MMP-9 and the 82 kDa active MMP-9
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: MMP9

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human MMP-9 Quantikine ELISA Kit

• 92 kDa gelatinase
• 92 kDa type IV collagenase
• CLG4B
• EC 3.4.24
• EC 3.4.24.35
• Gelatinase B
• GELB
• macrophage gelatinase
• MANDP2
• matrix metallopeptidase 9
• matrix metalloproteinase 9
• matrix metalloproteinase-9
• MMP9
• MMP-9
• type V collagenase

Background

Matrix metalloproteinases (MMPs), also called matrixins, constitute a family of zinc and calcium dependent endopeptidases that function in the breakdown of the extracellular matrix (ECM) and in the processing of a variety of molecules in different subcellular environments. They play an important role in many normal physiological processes such as embryonic development, morphogenesis, reproduction, and tissue remodeling (1, 2). They also participate in inflammatory and autoimmune disorders such as arthritis, cancer, and cardiovascular disease (3-5). While the amounts of newly synthesized MMPs are regulated mainly at the levels of transcription, the proteolytic activities of existing MMPs are controlled through both the activation of proenzymes or zymogens and the inhibition of active enzymes by endogenous inhibitors, alpha 2-Macroglobulin, and tissue inhibitors of metalloproteinases (TIMPs) (6). 

MMP-9 (also referred to as gelatinase B, 92 kDa type IV collagenase, 92 kDa gelatinase, and type V collagenase) is secreted as a glycosylated proenzyme (6-8). Activation of the proenzyme involves proteolytic removal of the N-terminal pro region, resulting in the 82 kDa active enzyme (9, 10). Active human MMP-9 shares 72% and 74% amino acid sequence identity with mouse and rat MMP-9, respectively. In addition to the zinc-binding site, the catalytic domain also contains three contiguous fibronectin type II homology units responsible for binding gelatin (11). A proline-rich hinge region links the catalytic domain to the C-terminal hemopexin-like domain. In vitro treatment of the proenzyme with 4-aminophenylmercuric acetate (APMA) produces not only the active enzyme but also a C-terminal truncated form with activity comparable to that of the active form (12). MMP-9 degrades components of the ECM with high specific activity for denatured collagens (gelatin). It can cleave native collagens of type III, IV, V, and XI, as well as Elastin, Nidogen-1, and Vitronectin (2, 3). MMP-9 can also cleave a variety of chemokines and growth factors (e.g. IL-1 beta , CXCL8/IL-8, CXCL7, CXCL4, CXCL1, Latent TGF-beta , membrane bound TNF-alpha , VEGF, and FGF basic), Amyloid beta peptide, Substance P, and Myelin Basic Protein (3, 13-15). This action can increase or decrease the biological activity of soluble factors and can also liberate them from association with the ECM (16, 17). MMP-9 can also trigger signaling through various transmembrane proteins or inhibit signaling by inducing their shedding from the cell surface (e.g. CD44, E-Cadherin, Integrins, ICAM-1, and IL-2 R alpha ) (3, 18-20). 

MMP-9 is produced by a variety of normal and transformed cells including neutrophils, monocytes, macrophages, astrocytes, fibroblasts, osteoclasts, chondrocytes, keratinocytes, endothelial and epithelial cells. It exerts physiological and pathological angiogenic and remodeling effects on the vasculature (21-25). Activated neutrophils release proMMP-9 which is free of TIMP-1, allowing the liberation of pro-angiogenic FGF-2 from the ECM (17). MMP-9 in complex with TIMP-1 does not induce FGF-2 release (17). Neutrophil-derived MMP-9 exacerbates the inflammatory response, in part by generating collagen-derived peptides that induce the release of additional neutrophil MMP9 (26). MMP-9 also plays a role in bone formation and remodeling (1, 21, 27), methamphetamineinduced behavioral sensitization and reward (28), the regulation of neuronal synapse remodeling (29), trophoblast invasion during implantation (30), and the inactivation of Serpin alpha 1-Proteinase Inhibitor (31). The shedding of adhesion proteins by MMP-9 has a direct effect on tumor cell invasiveness (18-20). 

Circulating levels of MMP-9 are increased in many inflammatory disorders including intraluminal thrombus formation (32), atherosclerosis (33), Crohn's disease (34), hepatitis C virus infection (35), colorectal cancer (36), and Duchenne muscular dystrophy (37). The ratio of MMP-9 to TIMP-1 is also increased in multiple sclerosis serum (38) and cystic fibrosis sputum (39), but it is decreased in the serum during cytomegalovirus infection (40). Levels of free MMP-9 and complexes of MMP-9 with Lipocalin-2/NGAL are elevated in the urine of ovarian cancer and uterine tract infection patients, respectively (41, 42).

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for MMP-9 (DMP900)(220)

Publications using DMP900

• Sengprasert, P;Waitayangkoon, P;Kamenkit, O;Sawatpanich, A;Chaichana, T;Wongphoom, J;Ngarmukos, S;Taweevisit, M;Lotinun, S;Tumwasorn, S;Tanavalee, A;Reantragoon, R; Catabolic mediators from TLR2-mediated proteoglycan aggrecan peptide-stimulated chondrocytes are reduced by Lactobacillus-conditioned media Scientific reports 2024-08-05 [PMID: 39103466] (Human)
• Brandt, E;Keskin, M;Räisänen, IT;Tervahartiala, T;Mäkitie, A;Harmankaya, ?;Karaçetin, D;Hagström, J;Rautava, J;Sorsa, T; Induction of Collagenolytic MMP-8 and -9 Tissue Destruction Cascade in Mouth by Head and Neck Cancer Radiotherapy: A Cohort Study Biomedicines 2023-12-21 [PMID: 38275388] (Human)
• Vahsen, BF;Nalluru, S;Morgan, GR;Farrimond, L;Carroll, E;Xu, Y;Cramb, KML;Amein, B;Scaber, J;Katsikoudi, A;Candalija, A;Carcolé, M;Dafinca, R;Isaacs, AM;Wade-Martins, R;Gray, E;Turner, MR;Cowley, SA;Talbot, K; C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9 Nature communications 2023-09-22 [PMID: 37736756] (Human)
• Al-Roub, A;Akhter, N;Al-Rashed, F;Wilson, A;Alzaid, F;Al-Mulla, F;Sindhu, S;Ahmad, R; TNF? induces matrix metalloproteinase-9 expression in monocytic cells through ACSL1/JNK/ERK/NF-kB signaling pathways Scientific reports 2023-09-01 [PMID: 37658104] (Human)
• Canela, VH;Bowen, WS;Ferreira, RM;Syed, F;Lingeman, JE;Sabo, AR;Barwinska, D;Winfree, S;Lake, BB;Cheng, YH;Gaut, JP;Ferkowicz, M;LaFavers, KA;Zhang, K;Coe, FL;Worcester, E;Kidney Precision Medicine Project, ;Jain, S;Eadon, MT;Williams, JC;El-Achkar, TM; A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease Nature communications 2023-07-19 [PMID: 37468493] (Human)
• Wadowska, K;Błasiak, P;Rzechonek, A;Śliwińska-Mossoń, M; Analysis of MMP-2-735C/T (rs2285053) and MMP-9-1562C/T (rs3918242) Polymorphisms in the Risk Assessment of Developing Lung Cancer International journal of molecular sciences 2023-06-24 [PMID: 37445754] (Human)
• Tsukamoto, S;Koma, YI;Kitamura, Y;Tanigawa, K;Azumi, Y;Miyako, S;Urakami, S;Hosono, M;Kodama, T;Nishio, M;Shigeoka, M;Yokozaki, H; Matrix Metalloproteinase 9 Induced in Esophageal Squamous Cell Carcinoma Cells via Close Contact with Tumor-Associated Macrophages Contributes to Cancer Progression and Poor Prognosis Cancers 2023-05-30 [PMID: 37296952] (Human)
• J Kudelski, A Tokarzewic, M Gudowska-S, B Mroczko, P Ch?osta, M Bruczko-Go, P Mitura, G M?ynarczyk The Significance of Matrix Metalloproteinase 9 (MMP-9) and Metalloproteinase 2 (MMP-2) in Urinary Bladder Cancer Biomedicines, 2023-03-20;11(3):. 2023-03-20 [PMID: 36979935] (Human)
• L Ostrowska, J Smarkusz-Z, A Gornowicz, K Lendzion, B Zy?k, D Pogodzi?sk Analysis of Selected Salivary Adipokines and Cytokines in Patients with Obesity-A Pilot Study International Journal of Molecular Sciences, 2023-02-18;24(4):. 2023-02-18 [PMID: 36835557] (Human)
• S Hobson, S Arefin, A Rahman, L Hernandez, T Ebert, H de Loor, P Evenepoel, P Stenvinkel, K Kublickien Indoxyl Sulphate Retention Is Associated with Microvascular Endothelial Dysfunction after Kidney Transplantation International Journal of Molecular Sciences, 2023-02-11;24(4):. 2023-02-11 [PMID: 36835051] (Human)
• B Zy?k, L Ostrowska, J Smarkusz-Z, K Witczak-Sa, A Gornowicz, A Bielawska Pro-Inflammatory Adipokine and Cytokine Profiles in the Saliva of Obese Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)-A Pilot Study International Journal of Molecular Sciences, 2023-02-02;24(3):. 2023-02-02 [PMID: 36769216] (Human)
• LY Wang, CS Tan, MKP Lai, S Hilal Factors Associated with RANTES, EMMPIRIN, MMP2 and MMP9, and the Association of These Biomarkers with Cardiovascular Disease in a Multi-Ethnic Population Journal of Clinical Medicine, 2022-12-08;11(24):. 2022-12-08 [PMID: 36555898] (Human)
• LTH Nguyen, SH Ahn, HM Shin, IJ Yang Anti-Psoriatic Effect of Rheum palmatum L. and Its Underlying Molecular Mechanisms International Journal of Molecular Sciences, 2022-12-15;23(24):. 2022-12-15 [PMID: 36555642] (Human)
• I Tsomidis, G Notas, C Xidakis, A Voumvourak, DN Samonakis, M Koulentaki, E Kouroumali Enzymes of Fibrosis in Chronic Liver Disease Biomedicines, 2022-12-08;10(12):. 2022-12-08 [PMID: 36551935] (Human)
• A Quesnel, N Coles, TM Polvikoski, GS Karagianni, C Angione, M Islam, AA Khundakar, PS Filippou The diagnostic and prognostic potential of the EGFR/MUC4/MMP9 axis in glioma patients Scientific Reports, 2022-11-18;12(1):19868. 2022-11-18 [PMID: 36400876] (Human)
• A Bahabayi, N Yang, T Xu, Y Xue, L Ma, X Gu, Y Wang, K Jia Expression of Matrix Metalloproteinase-2,-7,-9 in Serum during Pregnancy in Patients with Pre-Eclampsia: A Prospective Study International Journal of Environmental Research and Public Health, 2022-11-04;19(21):. 2022-11-04 [PMID: 36361378] (Human)
• JV Moxon, AK Kraeuter, J Phie, S Juliano, G Anderson, G Standley, C Sealey, RP White, J Golledge Serum angiopoietin-1 concentration does not distinguish patients with ischaemic stroke from those presenting to hospital with ischaemic stroke mimics BMC cardiovascular disorders, 2022-11-04;22(1):462. 2022-11-04 [PMID: 36333663] (Human)
• L Zhu, Y Wang, F Qiao microRNA-223 and microRNA-126 are clinical indicators for predicting the plaque stability in carotid atherosclerosis patients Journal of human hypertension, 2022-10-03;0(0):. 2022-10-03 [PMID: 36192429] (Human)
• GJ Wang, X Dong, Y Li Cluster of Differentiation 147 (CD147) serves as a promoter of atherosclerosis in patients with cerebral infarction European review for medical and pharmacological sciences, 2022-08-01;26(16):5710-5717. 2022-08-01 [PMID: 36066144] (Human)
• Y Lu, A Yang, C Quan, Y Pan, H Zhang, Y Li, C Gao, H Lu, X Wang, P Cao, H Chen, S Lu, G Zhou A single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma Nature Communications, 2022-08-06;13(1):4594. 2022-08-06 [PMID: 35933472] (Human)
• SA Maskarinec, M McKelvy, K Boyle, H Hotchkiss, ME Duarte, B Addison, N Amato, S Khandelwal, GM Arepally, GM Lee Neutrophil functional heterogeneity is a fixed phenotype and is associated with distinct gene expression profiles Journal of leukocyte biology, 2022-08-02;0(0):. 2022-08-02 [PMID: 35916035] (Human)
• H Ma, JR Albe, T Gilliland, CM McMillen, CL Gardner, DA Boyles, EL Cottle, MD Dunn, JD Lundy, N Salama, KJ O'Malley, I Pandrea, T Teichert, S Barrick, WB Klimstra, AL Hartman, DS Reed Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosolized Venezuelan equine encephalitis virus Oncogene, 2022-06-13;18(6):e1009946. 2022-06-13 [PMID: 35696423] (Cynomolgus Macaque)
• M de la Fuen, I Rodríguez-, E Vecino, E Astigarrag, A Acera, G Barreda-Gó Elevation of Tear MMP-9 Concentration as a Biomarker of Inflammation in Ocular Pathology by Antibody Microarray Immunodetection Assays International Journal of Molecular Sciences, 2022-05-18;23(10):. 2022-05-18 [PMID: 35628448] (Human)
• M Dreiner, T Munk, F Zaucke, AM Liphardt, A Niehoff Relationship between different serum cartilage biomarkers in the acute response to running and jumping in healthy male individuals Scientific Reports, 2022-04-19;12(1):6434. 2022-04-19 [PMID: 35440750] (Human)
• BG Jung, B Samten, K Dean, RJ Wallace, BA Brown-Elli, T Tucker, S Idell, JV Philley, R Vankayalap Early IL-17A production helps establish Mycobacterium intracellulare infection in mice PloS Pathogens, 2022-04-01;18(4):e1010454. 2022-04-01 [PMID: 35363832] (Human)
• J Jarecki, T Ma?ecka-Ma, E Kosior-Jar, W Widuchowsk, P Krasowski, M Gutbier, M Dobrzy?ski, T Blicharski Concentration of Selected Metalloproteinases and Osteocalcin in the Serum and Synovial Fluid of Obese Women with Advanced Knee Osteoarthritis International Journal of Environmental Research and Public Health, 2022-03-16;19(6):. 2022-03-16 [PMID: 35329213] (Human)
• C Xie, B Tang, K Wu, Q Meng, F Wang Increased serum LOXL2 concentration in pelvic inflammatory disease with pelvic adhesion Oncogene, 2022-03-04;22(1):59. 2022-03-04 [PMID: 35246120] (Human)
• S Okikawa, Y Morine, Y Saito, S Yamada, K Tokuda, H Teraoku, K Miyazaki, S Yamashita, T Ikemoto, S Imura, M Shimada Inhibition of the VEGF signaling pathway attenuates tumor?associated macrophage activity in liver cancer Oncology reports, 2022-02-16;47(4):. 2022-02-16 [PMID: 35169858] (Human)
• L Raimondi, A Gallo, N Cuscino, A De Luca, V Costa, V Carina, D Bellavia, M Bulati, R Alessandro, M Fini, PG Conaldi, G Giavaresi Potential Anti-Metastatic Role of the Novel miR-CT3 in Tumor Angiogenesis and Osteosarcoma Invasion International Journal of Molecular Sciences, 2022-01-09;23(2):. 2022-01-09 [PMID: 35054891] (Human)
• MM Ali, I Mirza, D Naquiallah, C Hassan, M Masrur, FM Bianco, AM Mahmoud CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults Journal of cardiovascular development and disease, 2021-12-28;9(1):. 2021-12-28 [PMID: 35050217] (Human)
• C Jiguet-Jig, S Boissonnea, E Denicolai, V Hein, R Lasseur, J Garcia, S Romain, R Appay, T Graillon, W Mason, AF Carpentier, AA Brandes, L' Ouafik, W Wick, A Baaziz, JP Gigan, RJ Argüello, D Figarella-, O Chinot, E Tabouret Plasmatic MMP9 released from tumor-infiltrating neutrophils is predictive for bevacizumab efficacy in glioblastoma patients: an AVAglio ancillary study Acta neuropathologica communications, 2022-01-03;10(1):1. 2022-01-03 [PMID: 34980260] (Human)
• F Kang, Q Yi, P Gu, Y Dong, Z Zhang, L Zhang, Y Bai Controlled growth factor delivery system with osteogenic-angiogenic coupling effect for bone regeneration Journal of Orthopaedic Translation, 2021-12-11;31(0):110-125. 2021-12-11 [PMID: 34976731] (Human)
• D Bakkalci, A Jay, A Rezaei, CA Howard, HJ Haugen, J Pape, S Kishida, M Kishida, G Jell, TR Arnett, S Fedele, U Cheema Bioengineering the ameloblastoma tumour to study its effect on bone nodule formation Scientific Reports, 2021-12-16;11(1):24088. 2021-12-16 [PMID: 34916549] (Human)
• S Nawrocka-M, J Biegus, M Hurkacz, M Guzik, M Rosiek-Bie, EA Jankowska, P Ponikowski, R Zymli?ski Differences in the Biomarker Profile of De Novo Acute Heart Failure versus Decompensation of Chronic Heart Failure Biomolecules, 2021-11-16;11(11):. 2021-11-16 [PMID: 34827701] (Human)
• A Kuzumi, A Yoshizaki, KM Matsuda, H Kotani, Y Norimatsu, M Fukayama, S Ebata, T Fukasawa, A Yoshizaki-, Y Asano, K Morikawa, Y Kazoe, K Mawatari, T Kitamori, S Sato Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis Nature Communications, 2021-10-12;12(1):5947. 2021-10-12 [PMID: 34642338] (Human)
• K Wadowska, P B?asiak, A Rzechonek, I Bil-Lula, M ?liwi?ska- New Insights on Old Biomarkers Involved in Tumor Microenvironment Changes and Their Diagnostic Relevance in Non-Small Cell Lung Carcinoma Biomolecules, 2021-08-13;11(8):. 2021-08-13 [PMID: 34439874] (Human)
• L Scola, RM Giarratana, V Marinello, V Cancila, C Pisano, G Ruvolo, G Frati, D Lio, CR Balistreri Polymorphisms of Pro-Inflammatory IL-6 and IL-1&beta Cytokines in Ascending Aortic Aneurysms as Genetic Modifiers and Predictive and Prognostic Biomarkers Biomolecules, 2021-06-25;11(7):. 2021-06-25 [PMID: 34202072] (Human)
• Y Wu, K Brennan, AB Fernández, MM Mc Gee Cyclophilin A regulates secretion of tumour-derived extracellular vesicles Translational Oncology, 2021-05-10;14(8):101112. 2021-05-10 [PMID: 33984826] (Human)
• M Jamka, P Bogda?ski, P Krzy?anows, A Mi?kiewicz, J Karolkiewi, M Du?-?uchow, R M?dry, A Lisowska, A Gotz-Wi?ck, S Iskakova, J Walkowiak, E M?dry Endurance Training Depletes Antioxidant System but Does Not Affect Endothelial Functions in Women with Abdominal Obesity: A Randomized Trial with a Comparison to Endurance-Strength Training Journal of Clinical Medicine, 2021-04-12;10(8):. 2021-04-12 [PMID: 33921520] (Human)
• J Jarecki, T Ma?ecka-Ma, I Polkowska, B Potoczniak, E Kosior-Jar, I Szerb, E Tomaszewsk, M Gutbier, M Dobrzy?ski, T Blicharski Level of Adiponectin, Leptin and Selected Matrix Metalloproteinases in Female Overweight Patients with Primary Gonarthrosis Journal of Clinical Medicine, 2021-03-18;10(6):. 2021-03-18 [PMID: 33803785] (Human)
• YJ Shin, H Vu, JH Lee, HD Kim Diagnostic and prognostic ability of salivary MMP-9 for oral squamous cell carcinoma: A pre-/post-surgery case and matched control study PLoS ONE, 2021-03-18;16(3):e0248167. 2021-03-18 [PMID: 33735248] (Human)
• S Sriphoosan, K Thanapirom, SJ Kerr, S Suksawatam, P Thaimai, S Sittisomwo, K Sonsiri, N Srisoontho, N Teeratorn, N Tanpowpong, B Chaopathom, S Treepraser, Y Poovorawan, P Komolmit Effect of vitamin D supplementation in patients with chronic hepatitis C after direct-acting antiviral treatment: a randomized, double-blind, placebo-controlled trial PeerJ, 2021-02-09;9(0):e10709. 2021-02-09 [PMID: 33614272] (Human)
• C Guo, L Sun, L Zhang, F Dong, X Zhang, L Yao, C Chang Serum sphingolipid profile in asthma Journal of leukocyte biology, 2021-02-18;0(0):. 2021-02-18 [PMID: 33600023] (Human)
• JR Albe, H Ma, TH Gilliland, CM McMillen, CL Gardner, DA Boyles, EL Cottle, MD Dunn, JD Lundy, KJ O'Malley, N Salama, AW Walters, I Pandrea, T Teichert, WB Klimstra, DS Reed, AL Hartman Physiological and immunological changes in the brain associated with lethal eastern equine encephalitis virus in macaques PloS Pathogens, 2021-02-03;17(2):e1009308. 2021-02-03 [PMID: 33534855] (Primate)
• X Li, F Zhu, Z Liu, X Tang, Y Han, J Jiang, C Ma, Y He High expression of Rab31 confers a poor prognosis and enhances cell proliferation and invasion in oral squamous cell carcinoma Oncology reports, 2021-01-18;0(0):. 2021-01-18 [PMID: 33469675] (Human)
• VG Arcos-Sacr, CL Sampieri, VH Sandoval-L, RA Orozco-Ort, MA Acuña-Hern, J Morales-Ro, ME Hernández-, A Rodríguez- Urinary MMP-9/UCr association with albumin concentration and albumin-creatinine-ratio in Mexican patients with type 2 diabetes mellitus PeerJ, 2020-12-16;8(0):e10474. 2020-12-16 [PMID: 33362965] (Human)
• J Jandova, GT Wondrak Genomic GLO1 deletion modulates TXNIP expression, glucose metabolism, and redox homeostasis while accelerating human A375 malignant melanoma tumor growth Redox Biology, 2020-12-17;39(0):101838. 2020-12-17 [PMID: 33360689] (Human)
• A Waszczykow, M Podgórski, M Waszczykow, Z Gerlicz-Ko, P Jurowski Matrix Metalloproteinases MMP-2 and MMP-9, Their Inhibitors TIMP-1 and TIMP-2, Vascular Endothelial Growth Factor and sVEGFR-2 as Predictive Markers of Ischemic Retinopathy in Patients with Systemic Sclerosis-Case Series Report Int J Mol Sci, 2020-11-18;21(22):. 2020-11-18 [PMID: 33218057] (Human)
• H Kook, DH Jang, JH Kim, JY Cho, HJ Joo, SA Cho, JH Park, SJ Hong, CW Yu, DS Lim Identification of plaque ruptures using a novel discriminative model comprising biomarkers in patients with acute coronary syndrome Sci Rep, 2020-11-19;10(1):20228. 2020-11-19 [PMID: 33214686] (Human)
• MMS Balla, S Patwardhan, PK Melwani, P Purwar, A Kumar, CS Pramesh, S Laskar, BN Pandey Prognosis of metastasis based on age and serum analytes after follow-up of non-metastatic lung cancer patients Transl Oncol, 2020-11-11;14(1):100933. 2020-11-11 [PMID: 33188981] (Human)
• T Phillips, L Huitema, R Cepeda, DL Cobos, RIM Perez, MS Garza, F Ringpfeil, B Dasgeb, J Uitto, JC Salas-Alan, V Alexeev, O Igoucheva Aberrant recruitment of leukocytes defines poor wound healing in patients with recessive dystrophic epidermolysis bullosa J Dermatol Sci, 2020-10-17;0(0):. 2020-10-17 [PMID: 33143962] (Human)
• JJ Noh, MS Kim, YJ Cho, SY Jeong, YY Lee, JY Ryu, JJ Choi, I Bae, Z Wu, BG Kim, JR Hwang, JW Lee Anti-Cancer Activity of As4O6 and its Efficacy in a Series of Patient-Derived Xenografts for Human Cervical Cancer Pharmaceutics, 2020-10-19;12(10):. 2020-10-19 [PMID: 33086573] (Human)
• L Raimondi, A De Luca, S Fontana, N Amodio, V Costa, V Carina, D Bellavia, S Raimondo, S Siragusa, F Monteleone, R Alessandro, M Fini, G Giavaresi Multiple Myeloma-Derived Extracellular Vesicles Induce Osteoclastogenesis through the Activation of the XBP1/IRE1alpha Axis Cancers (Basel), 2020-08-04;12(8):. 2020-08-04 [PMID: 32759820] (Human)
• J Jandova, J Perer, A Hua, JA Snell, GT Wondrak Genetic Target Modulation Employing CRISPR/Cas9 Identifies Glyoxalase 1 as a Novel Molecular Determinant of Invasion and Metastasis in A375 Human Malignant Melanoma Cells In Vitro and In Vivo Cancers (Basel), 2020-05-26;12(6):. 2020-05-26 [PMID: 32466621] (Human)
• S Hayat, O Ahmad, I Mahmud, MZH Howlader, Z Islam Association of matrix metalloproteinase-9 polymorphism with severity of Guillain-Barr� syndrome J. Neurol. Sci., 2020-05-16;415(0):116908. 2020-05-16 [PMID: 32447054] (Human)
• AE Stanciu, A Zamfir-Chi, MM Stanciu, A Pantea-Sto, C Nitipir, DC Gheorghe Serum melatonin is inversely associated with matrix metalloproteinase-9 in oral squamous cell carcinoma Oncol Lett, 2020-02-13;19(4):3011-3020. 2020-02-13 [PMID: 32218858] (Human)
• YY Liu, SY Wang, YN Li, WJ Bian, LQ Zhang, YH Li, L Long, X Liu, XW Zhang, ZG Li Activity of fibroblast-like synoviocytes in rheumatoid arthritis was impaired by dickkopf-1 targeting siRNA Chin. Med. J., 2020-03-20;0(6):679-686. 2020-03-20 [PMID: 32068606] (Human)
• CS Kuo, JS Chen, LY Lin, GW Schmid-Sch, S Chien, PH Huang, JW Chen, SJ Lin Inhibition of Serine Protease Activity Protects Against High Fat Diet-Induced Inflammation and Insulin Resistance Sci Rep, 2020-02-03;10(1):1725. 2020-02-03 [PMID: 32015418] (Human)
• Z Wang, D Ye, J Ye, M Wang, J Liu, H Jiang, Y Xu, J Zhang, J Chen, J Wan ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease Dis. Markers, 2019-12-16;2019(0):6129748. 2019-12-16 [PMID: 31929842] (Human)
• M Yamauchi, T Kinjo, G Parrott, K Miyagi, S Haranaga, Y Nakayama, K Chibana, K Fujita, A Nakamoto, F Higa, I Owan, K Yonemoto, J Fujita Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia PLoS ONE, 2020-01-09;15(1):e0227636. 2020-01-09 [PMID: 31917802] (Human)
• A Kobus, J Bagi?ska, J ?api?ska-A, S ?awicki, A Kierklo Levels of Selected Matrix Metalloproteinases, Their Inhibitors in Saliva, and Oral Status in Juvenile Idiopathic Arthritis Patients vs. Healthy Controls Biomed Res Int, 2019-10-28;2019(0):7420345. 2019-10-28 [PMID: 31781639] (Human)
• HL Lung, ML Lung, S Law Serum amyloid A1 polymorphisms as risk factors in oesophageal squamous cell carcinoma Hong Kong Med J, 2019-10-01;25(5):4-8. 2019-10-01 [PMID: 31761762] (Human)
• DP Zhang, YF Peng, HL Zhang, JG Ma, M Zhao, S Yin, TT Wei Basilar Artery Tortuosity Is Associated With White Matter Hyperintensities by TIMP-1 Front Neurosci, 2019-08-14;13(0):836. 2019-08-14 [PMID: 31474817] (Human)
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• Mroczko B, Groblewska M, Okulczyk B, Kedra B, Szmitkowski M The diagnostic value of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) determination in the sera of colorectal adenoma and cancer patients. Int J Colorectal Dis, 2010-06-17;25(10):1177-84. 2010-06-17 [PMID: 20556397] (Human)
• Liu ZB, Hou YF, Zhu J Inhibition of EGFR pathway signaling and the metastatic potential of breast cancer cells by PA-MSHA mediated by type 1 fimbriae via a mannose-dependent manner. Oncogene, 2010-03-15;29(20):2996-3009. 2010-03-15 [PMID: 20228837] (Human)
• Buralli S, Dini FL, Ballo P, Conti U, Fontanive P, Duranti E, Metelli MR, Marzilli M, Taddei S Circulating matrix metalloproteinase-3 and metalloproteinase-9 and tissue Doppler measures of diastolic dysfunction to risk stratify patients with systolic heart failure. Am. J. Cardiol., 2010-03-15;105(6):853-6. 2010-03-15 [PMID: 20211331] (Human)
• Ghanim H, Sia CL, Upadhyay M, Korzeniewski K, Viswanathan P, Abuaysheh S, Mohanty P, Dandona P Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am. J. Clin. Nutr., 2010-03-03;91(4):940-9. 2010-03-03 [PMID: 20200256] (Human)
• Teles RM, Teles RB, Amadeu TP, Moura DF, Mendonca-Lima L, Ferreira H, Santos IM, Nery JA, Sarno EN, Sampaio EP High matrix metalloproteinase production correlates with immune activation and leukocyte migration in leprosy reactional lesions. Infect. Immun., 2009-12-14;78(3):1012-21. 2009-12-14 [PMID: 20008541] (Human)
• Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation. Eur. J. Haematol., 2009-11-17;84(3):239-51. 2009-11-17 [PMID: 19922462] (Human)
• Sesso R, Franco MC Abnormalities in metalloproteinase pathways and IGF-I axis: a link between birth weight, hypertension, and vascular damage in childhood. Am. J. Hypertens., 2009-11-05;23(1):6-11. 2009-11-05 [PMID: 19893495] (Human)
• Karapanagiotidis GT, Antonitsis P, Charokopos N, Foroulis CN, Anastasiadis K, Rouska E, Argiriadou H, Rammos K, Papakonstantinou C Serum levels of matrix metalloproteinases -1,-2,-3 and -9 in thoracic aortic diseases and acute myocardial ischemia. J Cardiothorac Surg, 2009-11-03;4(0):59. 2009-11-03 [PMID: 19886986] (Human)
• Wood LG, Powell H, Gibson PG Mannitol challenge for assessment of airway responsiveness, airway inflammation and inflammatory phenotype in asthma. Clin. Exp. Allergy, 2009-10-30;40(2):232-41. 2009-10-30 [PMID: 19878195] (Human)
• Krishnatry AS, Brazeau DA, Fung HL Broad regulation of matrix and adhesion molecules in THP-1 human macrophages by nitroglycerin. Nitric Oxide, 2009-10-15;22(1):11-7. 2009-10-15 [PMID: 19836459] (Human)
• Lorente L, Martin MM, Labarta L, Diaz C, Sole-Violan J, Blanquer J, Orbe J, Rodriguez JA, Jimenez A, Borreguero-Leon JM, Belmonte F, Medina JC, Lliminana MC, Ferrer-Aguero JM, Ferreres J, Mora ML, Lubillo S, Sanchez M, Barrios Y, Sierra A, Paramo JA Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis. Crit Care, 2009-10-02;13(5):R158. 2009-10-02 [PMID: 19799791] (Human)
• Schneider P, Costa O, Legrand E In vitro secretion of matrix metalloprotease 9 is a prognostic marker in childhood acute lymphoblastic leukemia. Leuk. Res., 2009-09-12;34(1):24-31. 2009-09-12 [PMID: 19748669] (Human)
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• Soler-Garcia AA, Rakhmanina NY, Mattison PC, Ray PE A urinary biomarker profile for children with HIV-associated renal diseases. Kidney Int., 2009-04-08;76(2):207-14. 2009-04-08 [PMID: 19357719] (Human)
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• Vishnubhotla R, Sun S, Huq J, Bulic M, Ramesh A, Guzman G, Cho M, Glover SC ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging. Lab. Invest., 2007-09-17;87(11):1149-58. 2007-09-17 [PMID: 17876296] (Human, Rat)
• Kleinman ME, Greives MR, Churgin SS, Blechman KM, Chang EI, Ceradini DJ, Tepper OM, Gurtner GC Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma. Arterioscler. Thromb. Vasc. Biol., 2007-09-13;27(12):2664-70. 2007-09-13 [PMID: 17872454] (Human)
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• Bodet C, Andrian E, Tanabe S, Grenier D Actinobacillus actinomycetemcomitans lipopolysaccharide regulates matrix metalloproteinase, tissue inhibitors of matrix metalloproteinase, and plasminogen activator production by human gingival fibroblasts: a potential role in connective tissue destruction. J. Cell. Physiol., 2007-07-01;212(1):189-94. 2007-07-01 [PMID: 17299802] (Human)
• Ma DH, Yao JY, Kuo MT, See LC, Lin KY, Chen SC, Chen JK, Chao AS, Wang SF, Lin KK Generation of endostatin by matrix metalloproteinase and cathepsin from human limbocorneal epithelial cells cultivated on amniotic membrane. Invest. Ophthalmol. Vis. Sci., 2007-02-01;48(2):644-51. 2007-02-01 [PMID: 17251461] (Human)
• Yee LD, Williams N, Wen P, Young DC, Lester J, Johnson MV, Farrar WB, Walker MJ, Povoski SP, Suster S, Eng C Pilot study of rosiglitazone therapy in women with breast cancer: effects of short-term therapy on tumor tissue and serum markers. Clin. Cancer Res., 2007-01-01;13(1):246-52. 2007-01-01 [PMID: 17200362] (Human)
• Sherman JA, Hall A, Malenka DJ, De Muinck ED, Simons M Humoral and cellular factors responsible for coronary collateral formation. Am. J. Cardiol., 2006-08-31;98(9):1194-7. 2006-08-31 [PMID: 17056326] (Human)
• Johannsen A, Rylander G, Soder B, Asberg M Dental plaque, gingival inflammation, and elevated levels of interleukin-6 and cortisol in gingival crevicular fluid from women with stress-related depression and exhaustion. J. Periodontol., 2006-08-01;77(8):1403-9. 2006-08-01 [PMID: 16937592] (Human)
• Borrelli V, di Marzo L, Sapienza P, Colasanti M, Moroni E, Cavallaro A Role of platelet-derived growth factor and transforming growth factor beta1 the in the regulation of metalloproteinase expressions. Surgery, 2006-09-01;140(3):454-63. 2006-09-01 [PMID: 16934609] (Human)
• Molica S, Vitelli G, Mirabelli R, Digiesu G, Giannarelli D, Cuneo A, Ribatti D, Vacca A Serum levels of syndecan-1 in B-cell chronic lymphocytic leukemia: correlation with the extent of angiogenesis and disease-progression risk in early disease. Leuk. Lymphoma, 2006-06-01;47(6):1034-40. 2006-06-01 [PMID: 16840194] (Human)
• Rofstad EK, Mathiesen B, Kindem K, Galappathi K Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res., 2006-07-01;66(13):6699-707. 2006-07-01 [PMID: 16818644] (Human)
• Lee KS, Min KH, Kim SR, Park SJ, Park HS, Jin GY, Lee YC Vascular endothelial growth factor modulates matrix metalloproteinase-9 expression in asthma. Am. J. Respir. Crit. Care Med., 2006-04-27;174(2):161-70. 2006-04-27 [PMID: 16645174] (Human)
• Merck E, Gaillard C, Scuiller M, Scapini P, Cassatella MA, Trinchieri G, Bates EE Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils. J. Immunol., 2006-03-01;176(5):3149-56. 2006-03-01 [PMID: 16493074] (Human)
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• Adelroth E, Hedlund U, Blomberg A, Helleday R, Ledin MC, Levin JO, Pourazar J, Sandstrom T, Jarvholm B Airway inflammation in iron ore miners exposed to dust and diesel exhaust. Eur. Respir. J., 2006-02-02;27(4):714-9. 2006-02-02 [PMID: 16455836] (Human)
• Niessner A, Richter B, Penka M, Steiner S, Strasser B, Ziegler S, Heeb-Elze E, Zorn G, Leitner-Heinschink A, Niessner C, Wojta J, Huber K Endurance training reduces circulating inflammatory markers in persons at risk of coronary events: impact on plaque stabilization? Atherosclerosis, 2005-08-09;186(1):160-5. 2005-08-09 [PMID: 16084517] (Human)
• Figueredo CM, Fischer RG, Gustafsson A Aberrant neutrophil reactions in periodontitis. J. Periodontol., 2005-06-01;76(6):951-5. 2005-06-01 [PMID: 15948690] (Human)
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• Simpson JL, Scott RJ, Boyle MJ, Gibson PG Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma. Am. J. Respir. Crit. Care Med., 2005-05-18;172(5):559-65. 2005-05-18 [PMID: 15901607] (Human)
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FAQs for MMP-9 (DMP900). (Showing 1 - 1 of 1 FAQs).

1.  I’m looking for a pair of antibodies to MMP-9 that can be used in a sandwich assay. Do you carry any? 
   • We have 10 primary antibodies for MMP-9 that have been tested in ELISA, seen here.It looks like 2 have been tested for capture (please note the tested species for each of these), seen here.6 have been tested for detection, seen here.

Bioinformatics

• Gene Symbol: MMP9