Western Blot: MD-2 Antibody [NB100-56655] - Western Blot Image of anti-MD2. Total protein from human colon (lane 1) and human spleen (lane 2) was separated on a 4-15% gel by SDS-PAGE, transferred to 0.2 um PVDF membrane ...read more
Immunohistochemistry-Paraffin: MD-2 Antibody [NB100-56655] - Analysis of MD2 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control antibody (top left) and MD2 antibody (bottom left, right) at ...read more
Immunohistochemistry: MD-2 Antibody [NB100-56655] - Staining of normal human brain using 100-56655 (MD-2)at 10 ug/ml.
Immunohistochemistry: MD-2 Antibody [NB100-56655] - Staining of normal human brain using control (rabbit Ig) at 10 ug/ml.
This antibody is reactive against Human, Mouse and Rat.
Alternate Names for MD-2 Antibody
lymphocyte antigen 96
myeloid differentiation protein-2
MD2 is a secreted glycoprotein associating with the extracellular domain of Toll-like receptor 4 (TLR4) and trafficking to and from the cell surface and the Golgi apparatus. It has a signal peptide, two N terminal glycosylation sites, and seven Cys residues and consists of a heterogeneous collection of disulfide-linked oligomers. MD2 is an essential accessory glycoprotein required for LPS recognition and associates with toll-like receptor 4 on the cell surface to confer responsiveness to lipopolysaccyaride (LPS), and hence provides a link between the receptor and LPS signaling. It can also function as a soluble receptor for cells that do not otherwise express it. MD2 contains multiple trypsin cleavage sites and its expression is correlated inversely with trypsin activity.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.